CY1108998T1 - Πρωτεϊνες που δεσμευονται με οστεοπροτεγερινη και υποδοχεις - Google Patents

Πρωτεϊνες που δεσμευονται με οστεοπροτεγερινη και υποδοχεις

Info

Publication number
CY1108998T1
CY1108998T1 CY20071100833T CY071100833T CY1108998T1 CY 1108998 T1 CY1108998 T1 CY 1108998T1 CY 20071100833 T CY20071100833 T CY 20071100833T CY 071100833 T CY071100833 T CY 071100833T CY 1108998 T1 CY1108998 T1 CY 1108998T1
Authority
CY
Cyprus
Prior art keywords
osteoprotein
binding
receptors
treatment
production
Prior art date
Application number
CY20071100833T
Other languages
English (en)
Inventor
William J Boyle
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/842,842 external-priority patent/US5843678A/en
Priority claimed from EP98918244.9A external-priority patent/EP0975754B2/en
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of CY1108998T1 publication Critical patent/CY1108998T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)

Abstract

Ένα πρωτότυπο πολυπεπτίδιο, πρωτεΐνη που δεσμεύεται με οστεοπροτεγερίνη, που εμπλέκεται σε ωρίμανση οστεοκλαστών, ταυτοποιήθηκε με βάση την συγγένεια του για οστεοπροτεγερίνη. Περιγράφονται επίσης αλληλουχίες νουκλεϊκών οξέων που κωδικοποιούν το πολυπεπτίδιο, ή θραύσμα, ανάλογο ή παράγωγο αυτού, φορείς και κύτταρα-ξενιστές για παραγωγή, μέθοδοι παρασκευής πρωτεΐνης που δεσμεύεται με οστεοπροτεγερίνη, και προσδιορισμοί δέσμευσης. Παρέχονται επίσης συνθέσεις και μέθοδοι για την θεραπευτική αγωγή ασθενειών οστών όπως οστεοπόρωση, απώλεια οστού λόγω αρθρίτιδας ή μετάστασης, υπερασβεστιαιμία, και νόσος Paget. Περιγράφονται επίσης υποδοχείς για πρωτεΐνες που δεσμεύονται με οστεοπροτεγερίνη. Οι υποδοχείς, και αγωνιστές και ανταγωνιστές αυτών, μπορούν να χρησιμοποιηθούν για θεραπευτική αγωγή ασθενειών οστών.
CY20071100833T 1997-04-16 2007-06-21 Πρωτεϊνες που δεσμευονται με οστεοπροτεγερινη και υποδοχεις CY1108998T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/842,842 US5843678A (en) 1997-04-16 1997-04-16 Osteoprotegerin binding proteins
US88085597A 1997-06-23 1997-06-23
US09/052,521 US6316408B1 (en) 1997-04-16 1998-03-30 Methods of use for osetoprotegerin binding protein receptors
EP98918244.9A EP0975754B2 (en) 1997-04-16 1998-04-15 Osteoprotegerin binding proteins and their receptors

Publications (1)

Publication Number Publication Date
CY1108998T1 true CY1108998T1 (el) 2014-07-02

Family

ID=27126366

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100833T CY1108998T1 (el) 1997-04-16 2007-06-21 Πρωτεϊνες που δεσμευονται με οστεοπροτεγερινη και υποδοχεις

Country Status (15)

Country Link
US (4) US6316408B1 (el)
EP (1) EP2311955A3 (el)
JP (2) JP2009001566A (el)
KR (2) KR101328809B1 (el)
CN (1) CN103990122B (el)
CA (1) CA2706609A1 (el)
CY (1) CY1108998T1 (el)
GE (1) GEP20033002B (el)
IL (1) IL132304A (el)
LT (1) LTC0975754I2 (el)
ME (2) MEP32808A (el)
NO (1) NO2010022I2 (el)
PT (1) PT975754E (el)
RO (1) RO122495B1 (el)
RS (1) RS50358B (el)

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KR20120108046A (ko) 2012-10-04
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CN103990122A (zh) 2014-08-20
US7097834B1 (en) 2006-08-29
US20030100488A1 (en) 2003-05-29
YU50699A (sh) 2000-10-30
US7807795B2 (en) 2010-10-05
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EP2311955A2 (en) 2011-04-20
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CA2706609A1 (en) 1998-10-22
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EP2311955A3 (en) 2012-12-12
RO122495B1 (ro) 2009-07-30
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RS50358B (sr) 2009-11-10
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US20050003400A1 (en) 2005-01-06
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