HUP0100780A2 - Új dezintegrin metalloproteáz, mutánsai, fragmentumai és hasonlók alkalmazása - Google Patents
Új dezintegrin metalloproteáz, mutánsai, fragmentumai és hasonlók alkalmazásaInfo
- Publication number
- HUP0100780A2 HUP0100780A2 HU0100780A HUP0100780A HUP0100780A2 HU P0100780 A2 HUP0100780 A2 HU P0100780A2 HU 0100780 A HU0100780 A HU 0100780A HU P0100780 A HUP0100780 A HU P0100780A HU P0100780 A2 HUP0100780 A2 HU P0100780A2
- Authority
- HU
- Hungary
- Prior art keywords
- disintegrin
- metalloprotease
- relates
- mutants
- fragments
- Prior art date
Links
- 101800001224 Disintegrin Proteins 0.000 title abstract 6
- 102000005741 Metalloproteases Human genes 0.000 title abstract 3
- 108010006035 Metalloproteases Proteins 0.000 title abstract 3
- 239000012634 fragment Substances 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000003259 recombinant expression Methods 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
A találmány a dezintegrin proteinhez kötődni képes vegyületekazonosítására, valamint egy mintában egy dezintegrin proteinhezkötődni képes vegyület mennyiségének az affinitásnak meghatározásáraszolgáló eljárásra vonatkozik. A találmány egy olyan gazdasejtre isvonatkozik, amely dezintegrin proteinre alkalmazható rekombinánsexpressziós vektort tartalmaz. Vonatkozik továbbá egy dezintegrinproteint kódoló rekombináns expressziós vektorra, a humán dezintegrinmetalloproteázra, ennek ilyen célokra használható fragmentumára vagymutánsára. A találmány tárgya ezenkívül egy in vivo vagy in vitroeljárás osteoarthritis és más, metalloproteázon alapuló betegségszűrésére. Ó
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81015397A | 1997-02-25 | 1997-02-25 | |
| PCT/US1997/003217 WO1997031931A1 (en) | 1996-03-01 | 1997-02-28 | A novel disintegrin metalloprotease and methods of use |
| PCT/US1998/003490 WO1998037092A2 (en) | 1997-02-25 | 1998-02-25 | Use of a novel disintegrin metalloprotease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0100780A2 true HUP0100780A2 (hu) | 2001-06-28 |
Family
ID=26792372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0100780A HUP0100780A2 (hu) | 1997-02-25 | 1998-02-25 | Új dezintegrin metalloproteáz, mutánsai, fragmentumai és hasonlók alkalmazása |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0977775A2 (hu) |
| JP (1) | JP2001514494A (hu) |
| AU (1) | AU6181798A (hu) |
| CA (1) | CA2281085A1 (hu) |
| HU (1) | HUP0100780A2 (hu) |
| NO (1) | NO994056L (hu) |
| WO (1) | WO1998037092A2 (hu) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6436629B1 (en) | 2000-10-27 | 2002-08-20 | The Regents Of The University Of California | Modulating angiogenesis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU712759C (en) * | 1995-06-08 | 2001-08-09 | Immunex Corporation | TNF-alpha converting enzyme |
| WO1997031931A1 (en) * | 1996-03-01 | 1997-09-04 | The Procter & Gamble Company | A novel disintegrin metalloprotease and methods of use |
-
1998
- 1998-02-25 AU AU61817/98A patent/AU6181798A/en not_active Abandoned
- 1998-02-25 EP EP98906648A patent/EP0977775A2/en not_active Withdrawn
- 1998-02-25 CA CA002281085A patent/CA2281085A1/en not_active Abandoned
- 1998-02-25 JP JP53694698A patent/JP2001514494A/ja active Pending
- 1998-02-25 HU HU0100780A patent/HUP0100780A2/hu unknown
- 1998-02-25 WO PCT/US1998/003490 patent/WO1998037092A2/en not_active Application Discontinuation
-
1999
- 1999-08-23 NO NO994056A patent/NO994056L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU6181798A (en) | 1998-09-09 |
| EP0977775A2 (en) | 2000-02-09 |
| CA2281085A1 (en) | 1998-08-27 |
| WO1998037092A3 (en) | 1998-11-05 |
| JP2001514494A (ja) | 2001-09-11 |
| NO994056L (no) | 1999-10-25 |
| WO1998037092A2 (en) | 1998-08-27 |
| NO994056D0 (no) | 1999-08-23 |
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