NO994056L - Anvendelse av disintegrin metalloprotease samt mutanter og fragmenter derav - Google Patents

Anvendelse av disintegrin metalloprotease samt mutanter og fragmenter derav

Info

Publication number
NO994056L
NO994056L NO994056A NO994056A NO994056L NO 994056 L NO994056 L NO 994056L NO 994056 A NO994056 A NO 994056A NO 994056 A NO994056 A NO 994056A NO 994056 L NO994056 L NO 994056L
Authority
NO
Norway
Prior art keywords
disintegrin
protein
well
metalloprotease
mutants
Prior art date
Application number
NO994056A
Other languages
English (en)
Other versions
NO994056D0 (no
Inventor
Michael Howard Tindal
Tarig Mehmood Haggi
Original Assignee
Procter & Gamble
Univ Case Western Reserve
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1997/003217 external-priority patent/WO1997031931A1/en
Application filed by Procter & Gamble, Univ Case Western Reserve filed Critical Procter & Gamble
Publication of NO994056D0 publication Critical patent/NO994056D0/no
Publication of NO994056L publication Critical patent/NO994056L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Det er beskrevet en fremgangsmåte for å identifisere for- bindelser som er i stand til å binde til et disintegrinpro- tein og bestemme mengden og affiniteten av en forbindelse som er i stand til å binde til et disintegrinprotein i en prøve. Det er også beskrevet en vertscelle omfattende en rekombinant ekspresjonsvektor til disintegrinproteinet, samt en rekombinant ekspresjonsvektor som koder for disin- te^rinproteinet og det humane disintegrin-metalloprotease- protein, fragment eller mutant derav som er anvendelig for disse formål. Det er også beskrevet en in vivo eller in vi tro metode for å diagnostisere osteoartritt og andre me- talloproteasebaserte sykdommer og som er i stand til å bli fremstilt og anvendt i form av et sett.
NO994056A 1997-02-25 1999-08-23 Anvendelse av disintegrin metalloprotease samt mutanter og fragmenter derav NO994056L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81015397A 1997-02-25 1997-02-25
PCT/US1997/003217 WO1997031931A1 (en) 1996-03-01 1997-02-28 A novel disintegrin metalloprotease and methods of use
PCT/US1998/003490 WO1998037092A2 (en) 1997-02-25 1998-02-25 Use of a novel disintegrin metalloprotease

Publications (2)

Publication Number Publication Date
NO994056D0 NO994056D0 (no) 1999-08-23
NO994056L true NO994056L (no) 1999-10-25

Family

ID=26792372

Family Applications (1)

Application Number Title Priority Date Filing Date
NO994056A NO994056L (no) 1997-02-25 1999-08-23 Anvendelse av disintegrin metalloprotease samt mutanter og fragmenter derav

Country Status (7)

Country Link
EP (1) EP0977775A2 (no)
JP (1) JP2001514494A (no)
AU (1) AU6181798A (no)
CA (1) CA2281085A1 (no)
HU (1) HUP0100780A2 (no)
NO (1) NO994056L (no)
WO (1) WO1998037092A2 (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436629B1 (en) 2000-10-27 2002-08-20 The Regents Of The University Of California Modulating angiogenesis
JP2021099234A (ja) * 2019-12-20 2021-07-01 横河電機株式会社 新規創薬スクリーニング方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2227598T3 (es) * 1995-06-08 2005-04-01 Immunex Corporation Enzima conversiva de tnf-alfa.
EP0888375A4 (en) * 1996-03-01 2001-04-11 Procter & Gamble NOVEL DISINTEGRIN-METALLOPROTEASE AND METHODS OF USE

Also Published As

Publication number Publication date
CA2281085A1 (en) 1998-08-27
WO1998037092A2 (en) 1998-08-27
JP2001514494A (ja) 2001-09-11
HUP0100780A2 (hu) 2001-06-28
NO994056D0 (no) 1999-08-23
EP0977775A2 (en) 2000-02-09
WO1998037092A3 (en) 1998-11-05
AU6181798A (en) 1998-09-09

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Legal Events

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RE Reestablishment of rights (par. 72 patents act)
FC2A Withdrawal, rejection or dismissal of laid open patent application