DK147735C - Analogifremgangsmaade til fremstilling af 3-oxo-androst-4-en-17beta-thiocarboxylsyreestere - Google Patents

Analogifremgangsmaade til fremstilling af 3-oxo-androst-4-en-17beta-thiocarboxylsyreestere

Info

Publication number
DK147735C
DK147735C DK136579A DK136579A DK147735C DK 147735 C DK147735 C DK 147735C DK 136579 A DK136579 A DK 136579A DK 136579 A DK136579 A DK 136579A DK 147735 C DK147735 C DK 147735C
Authority
DK
Denmark
Prior art keywords
thiocarboxyl
17beta
androst
oxo
preparing
Prior art date
Application number
DK136579A
Other languages
Danish (da)
English (en)
Other versions
DK147735B (da
DK136579A (da
Inventor
John A Edwards
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of DK136579A publication Critical patent/DK136579A/da
Publication of DK147735B publication Critical patent/DK147735B/da
Application granted granted Critical
Publication of DK147735C publication Critical patent/DK147735C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK136579A 1978-04-05 1979-04-03 Analogifremgangsmaade til fremstilling af 3-oxo-androst-4-en-17beta-thiocarboxylsyreestere DK147735C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89338878 1978-04-05
US05/893,388 US4188385A (en) 1978-04-05 1978-04-05 Thioetianic acid derivatives

Publications (3)

Publication Number Publication Date
DK136579A DK136579A (da) 1979-10-06
DK147735B DK147735B (da) 1984-11-26
DK147735C true DK147735C (da) 1985-08-19

Family

ID=25401484

Family Applications (1)

Application Number Title Priority Date Filing Date
DK136579A DK147735C (da) 1978-04-05 1979-04-03 Analogifremgangsmaade til fremstilling af 3-oxo-androst-4-en-17beta-thiocarboxylsyreestere

Country Status (28)

Country Link
US (1) US4188385A (ja)
EP (1) EP0004741B1 (ja)
JP (2) JPS54141758A (ja)
AR (1) AR226035A1 (ja)
AT (1) AT368168B (ja)
AU (1) AU526025B2 (ja)
CA (1) CA1134345A (ja)
CS (1) CS203956B2 (ja)
DE (2) DE2912331A1 (ja)
DK (1) DK147735C (ja)
ES (1) ES479271A1 (ja)
FI (1) FI66393C (ja)
FR (1) FR2421912A1 (ja)
GB (1) GB2018256B (ja)
GR (1) GR67275B (ja)
HK (1) HK41284A (ja)
HU (1) HU179314B (ja)
IL (1) IL56972A0 (ja)
IT (1) IT1120954B (ja)
MY (1) MY8500575A (ja)
NO (1) NO152935C (ja)
NZ (1) NZ190076A (ja)
PL (1) PL121469B1 (ja)
PT (1) PT69409A (ja)
SG (1) SG6786G (ja)
SU (1) SU1052161A3 (ja)
YU (1) YU40929B (ja)
ZA (1) ZA791635B (ja)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261984A (en) * 1978-04-05 1981-04-14 Syntex (U.S.A.) Inc. 17β-thiocarboxylic acid esters of 3-oxo-4-halo-16β-methylandrost-4-enes
US4263289A (en) * 1978-04-05 1981-04-21 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
US4310466A (en) * 1979-08-31 1982-01-12 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
SE452468B (sv) * 1980-02-15 1987-11-30 Glaxo Group Ltd Androstankarbotioater, forfarande for framstellning av dessa samt kompositioner
PH24267A (en) * 1980-02-15 1990-05-29 Glaxo Group Ltd Androstane carbothioates and pharmaceutical compositions containing the same
GB2137206B (en) * 1980-02-15 1985-04-03 Glaxo Group Ltd Androstane 17-carbothioc acid derivatives
US4578221A (en) * 1980-04-23 1986-03-25 Glaxo Group Limited Androstane carbothioic acids
SE449106B (sv) * 1980-07-10 1987-04-06 Otsuka Pharma Co Ltd Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
GB9225923D0 (en) * 1992-12-11 1993-02-03 Rhone Poulenc Rorer Ltd New compositions of matter
ES2107806T3 (es) * 1992-12-24 1997-12-01 Rhone Poulenc Rorer Ltd Nuevos esteroides.
SI0876392T1 (en) * 1995-12-29 2000-12-31 Glaxo Group Limited Lactone derivatives of 17.beta.-carboxy, carbothio and amide androstane derivatives
US5981517A (en) * 1996-05-09 1999-11-09 Soft Drugs, Inc. Androstene derivatives
US20020133032A1 (en) * 2000-02-25 2002-09-19 Jufang Barkalow Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
GB0017988D0 (en) * 2000-07-21 2000-09-13 Glaxo Group Ltd Novel process
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6787532B2 (en) * 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6750210B2 (en) * 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
ES2292604T5 (es) * 2000-08-05 2015-06-01 Glaxo Group Limited Éster S-fluorometílico del ácido 6 ,9 -difluoro-17 -[(2-furanilcarbonil)oxi]-11 -hidroxi-16 -metil-3-oxo-androsta-1,4-dien-17 -carbotioico como agente antiinflamatorio
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) * 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6858593B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6777400B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
UA77656C2 (en) * 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
CN1302007C (zh) * 2001-04-30 2007-02-28 葛兰素集团有限公司 具有抗炎性的在17.α位上具有环酯基的雄甾烷的17.β.－硫代羧酸酯衍生物
ATE399174T1 (de) * 2001-06-12 2008-07-15 Glaxo Group Ltd Neue anti inflammatorische 17.alpha.- heterozyklische ester von 17.beta.-carbothioat androstan derivativen
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
IL150654A (en) 2002-07-09 2006-12-10 Ori Lerman Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate
JP2006522028A (ja) * 2003-04-04 2006-09-28 アルファーマ エーピーエス ステロイド性カルボチオ酸誘導体の製造方法および中間体
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
AR059216A1 (es) * 2006-01-27 2008-03-19 Sun Pharmaceutical Ind Ltd 11b-hidroxiandrosta-4-eno-3-onas
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
MX2010007023A (es) * 2007-12-21 2010-09-30 Schering Corp Agonistas del receptor glucocorticoide sustituido de c20-c21.
MX2011013679A (es) 2009-06-16 2012-01-20 Schering Corp Esteroides de heteroarilo [3.2-c] novedosos como agonistas de receptor de glucocorticoide composiciones y uso de los mismos.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2509171A (en) * 1946-02-06 1950-05-23 Ciba Ltd Primary alcohols from thiocarboxylic acids and esters
US3636010A (en) * 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
US3989686A (en) * 1972-06-15 1976-11-02 Glaxo Laboratories Limited Anaesthetic steroids of the androstane series and process for preparing same
GB1438940A (en) * 1972-07-19 1976-06-09 Glaxo Lab Ltd 17beta-haloalkoxycarbonyl-17alpha-oxysteroids
CH628355A5 (de) * 1976-02-24 1982-02-26 Ciba Geigy Ag Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze.

Also Published As

Publication number Publication date
US4188385A (en) 1980-02-12
NO791140L (no) 1979-10-08
GB2018256B (en) 1983-02-02
JPS611038B2 (ja) 1986-01-13
IT1120954B (it) 1986-03-26
SU1052161A3 (ru) 1983-10-30
PL214676A1 (ja) 1980-01-02
GR67275B (ja) 1981-06-26
PL121469B1 (en) 1982-05-31
CS203956B2 (en) 1981-03-31
DE2960096D1 (en) 1981-03-19
FR2421912A1 (fr) 1979-11-02
FI66393B (fi) 1984-06-29
EP0004741B1 (en) 1981-01-28
EP0004741A3 (en) 1979-11-14
JPS6069019A (ja) 1985-04-19
ZA791635B (en) 1980-11-26
NO152935B (no) 1985-09-09
JPS54141758A (en) 1979-11-05
FI66393C (fi) 1984-10-10
SG6786G (en) 1986-08-01
CA1134345A (en) 1982-10-26
HU179314B (en) 1982-09-28
DE2912331A1 (de) 1979-10-18
IL56972A0 (en) 1979-05-31
AU526025B2 (en) 1982-12-16
NO152935C (no) 1985-12-18
FR2421912B1 (ja) 1981-03-20
FI791081A (fi) 1979-10-06
DK147735B (da) 1984-11-26
HK41284A (en) 1984-05-18
NZ190076A (en) 1984-07-31
YU80379A (en) 1983-04-30
ES479271A1 (es) 1980-01-16
YU40929B (en) 1986-08-31
GB2018256A (en) 1979-10-17
JPS6140648B2 (ja) 1986-09-10
EP0004741A2 (en) 1979-10-17
AU4558379A (en) 1979-10-18
AT368168B (de) 1982-09-27
IT7967652A0 (it) 1979-03-28
PT69409A (en) 1979-04-01
DK136579A (da) 1979-10-06
AR226035A1 (es) 1982-05-31
MY8500575A (en) 1985-12-31
ATA251979A (de) 1982-01-15

Similar Documents

Publication Publication Date Title
DK147735C (da) Analogifremgangsmaade til fremstilling af 3-oxo-androst-4-en-17beta-thiocarboxylsyreestere
DK43279A (da) Fremgangsmaade til fremstilling af 2-penem-3-carboxylsyreforbindelser
DK156056C (da) Analogifremgangsmaade til fremstilling af 4-amino-3-quinolin-carboxylsyrederivater
DK149023C (da) Analogifremgangsmaade til fremstilling af tiazolidinderivater
DK446179A (da) Fremgangsmaade til fremstilling af substituerede 1-carbadethiapen-2-em-3-carboxylsyrer
DK7579A (da) Fremgangsmaade til fremstilling af (%n-diethylmeta-toluamid
DK19579A (da) Fremgangsmaade til fremstilling af spirothienohydantoinderivater
DK196077A (da) Fremgangsmaade til fremstilling af di-n-propyleddikesyre
DK149773C (da) Analogifremgangsmaade til fremstilling af 3-quinolincarboxylsyrederivater
DK161198C (da) Analogifremgangsmaade til fremstilling af substituerede omega-aroylpropionyl-l-proliner
DK215079A (da) Fremgangsmaade til fremstilling af phenylaminothiothiopheneddikesyrer
DK149473C (da) Fremgangsmaade til fremstilling af aminomethan-phosphonsyrer
DK156953C (da) Fremgangsmaade til fremstilling af phenylglyoxylsyreestere
DK157677C (da) Fremgangsmaade til fremstilling af cyclopropancarboxylsyreesterderivater
DK159771C (da) Fremgangsmaade til fremstillingen af cyklopropancarboxylsyreestere
DK444279A (da) Fremgangsmaade til fremstilling af 6-hydroxymethyl-2-(beta-aminoethylthio)-1-carbadethiapen-2-em-3-carboxylsyre
DK145422C (da) Fremgangsmaade til fremstilling af ursodesoxycholsyre
DK163667C (da) Fremgangsmaade til fremstilling af 7-amino-3-chlor-3-cephem-4-carboxylsyreestere
DK157613C (da) Fremgangsmaade til fremstilling af cyclopropancarboxylsyreesterderivater
DK285178A (da) Fremgangsmaade til fremstilling af puridinkarboxylsyre-piperazider
DK250679A (da) Fremgangsmaade til fremstilling af 2-isopropylaminopyrimidin
DK154292C (da) Analogifremgangsmaade til fremstilling af aroylpyrrolylcarboxylsyreforbindelser
DK390277A (da) Fremgangsmaade til fremstilling af thiocarbaminsyreestere
DK429279A (da) Fremgangsmaade til fremstilling af di-n-propyleddikesyre
DK277379A (da) Fremgangsmaade til fremstilling af acylaminomethanphosphonsyrer

Legal Events

Date Code Title Description
PBP Patent lapsed