DK147484C - Fremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid - Google Patents

Fremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid

Info

Publication number
DK147484C
DK147484C DK160679A DK160679A DK147484C DK 147484 C DK147484 C DK 147484C DK 160679 A DK160679 A DK 160679A DK 160679 A DK160679 A DK 160679A DK 147484 C DK147484 C DK 147484C
Authority
DK
Denmark
Prior art keywords
vincaleucoblastin
desacetyl
carbox
hydrazide
preparing derivatives
Prior art date
Application number
DK160679A
Other languages
Danish (da)
English (en)
Other versions
DK160679A (da
DK147484B (da
Inventor
George Joseph Cullinan
Koert Gerzon
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK160679A publication Critical patent/DK160679A/da
Priority to DK13983A priority Critical patent/DK148655C/da
Priority to DK14083A priority patent/DK148510C/da
Publication of DK147484B publication Critical patent/DK147484B/da
Application granted granted Critical
Publication of DK147484C publication Critical patent/DK147484C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK160679A 1978-04-20 1979-04-19 Fremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid DK147484C (da)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DK13983A DK148655C (da) 1978-04-20 1983-01-14 Analogifremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid
DK14083A DK148510C (da) 1978-04-20 1983-01-14 Analogifremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89903278 1978-04-20
US05/899,032 US4166810A (en) 1978-04-20 1978-04-20 Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (3)

Publication Number Publication Date
DK160679A DK160679A (da) 1979-10-21
DK147484B DK147484B (da) 1984-08-27
DK147484C true DK147484C (da) 1985-03-25

Family

ID=25410402

Family Applications (1)

Application Number Title Priority Date Filing Date
DK160679A DK147484C (da) 1978-04-20 1979-04-19 Fremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid

Country Status (32)

Country Link
US (1) US4166810A (cs)
EP (1) EP0005051B1 (cs)
JP (1) JPS54141798A (cs)
AR (1) AR228940A1 (cs)
AT (1) AT369010B (cs)
AU (1) AU527109B2 (cs)
BE (1) BE875652A (cs)
BG (3) BG33296A3 (cs)
CA (1) CA1097629A (cs)
CH (1) CH643269A5 (cs)
CS (3) CS218584B2 (cs)
DD (1) DD143075A5 (cs)
DE (1) DE2964130D1 (cs)
DK (1) DK147484C (cs)
EG (1) EG14867A (cs)
ES (2) ES479753A1 (cs)
FI (1) FI791286A7 (cs)
FR (1) FR2423495A1 (cs)
GB (1) GB2019396B (cs)
GR (1) GR69987B (cs)
HU (1) HU181431B (cs)
IE (1) IE48213B1 (cs)
IL (1) IL57168A (cs)
LU (1) LU81166A1 (cs)
NZ (1) NZ190213A (cs)
PH (1) PH14163A (cs)
PL (3) PL215911A1 (cs)
PT (1) PT69496A (cs)
RO (3) RO81037A (cs)
SU (3) SU893135A3 (cs)
YU (1) YU93179A (cs)
ZA (1) ZA791856B (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322351A (en) * 1980-08-25 1982-03-30 Eli Lilly And Company Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
DK167984A (da) * 1983-03-30 1984-10-01 Lilly Industries Ltd Alkaloidderivater
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
DE60231868D1 (de) * 2001-04-24 2009-05-20 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
ATE426414T1 (de) * 2002-05-15 2009-04-15 Endocyte Inc Vitamin-mitomycin-konjugate
AR042942A1 (es) 2003-01-27 2005-07-06 Endocyte Inc Conjugados de administracion de drogas de union de receptores de vitaminas
US8288557B2 (en) * 2004-07-23 2012-10-16 Endocyte, Inc. Bivalent linkers and conjugates thereof
US8044200B2 (en) * 2005-03-16 2011-10-25 Endocyte, Inc. Synthesis and purification of pteroic acid and conjugates thereof
US8465724B2 (en) 2005-08-19 2013-06-18 Endocyte, Inc. Multi-drug ligand conjugates
EP1948240A2 (en) 2005-08-19 2008-07-30 Endocyte, Inc. Ligand conjugates of vinca alkaloids, analogs and derivatives
WO2008100591A2 (en) * 2007-02-14 2008-08-21 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
WO2008101231A2 (en) 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
JP5829793B2 (ja) * 2007-03-14 2015-12-09 エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． 結合性リガンドが結合したツブリシンの薬剤送達結合体
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
EP2176293B1 (en) * 2007-06-25 2019-04-03 Endocyte, Inc. Conjugates containing hydrophilic spacer linkers
AU2008316835B2 (en) 2007-10-25 2015-07-16 Endocyte, Inc. Tubulysins and processes for preparing
JP5780961B2 (ja) * 2009-09-07 2015-09-16 ニプロパッチ株式会社 経皮吸収型製剤
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
JP2015536323A (ja) 2012-10-16 2015-12-21 エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． 非天然アミノ酸を含む薬物送達結合体および使用方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3205220A (en) * 1961-10-26 1965-09-07 Lilly Co Eli Leurosidine and leurocristine and their production
US3392173A (en) * 1964-03-09 1968-07-09 Lilly Co Eli Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) * 1964-04-27 1968-02-20 Lilly Co Eli Leurosine
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) * 1974-05-06 1975-06-03 Lilly Co Eli Vincadioline
US3890325A (en) * 1974-05-15 1975-06-17 Lilly Co Eli Leurocolombine
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

Also Published As

Publication number Publication date
DE2964130D1 (en) 1983-01-05
PL125470B1 (en) 1983-05-31
PT69496A (en) 1979-05-01
AR228940A1 (es) 1983-05-13
EG14867A (en) 1986-09-30
DK160679A (da) 1979-10-21
ES479754A1 (es) 1980-08-16
SU1061698A3 (ru) 1983-12-15
FI791286A7 (fi) 1981-01-01
FR2423495A1 (fr) 1979-11-16
PH14163A (en) 1981-03-19
DD143075A5 (de) 1980-07-30
US4166810A (en) 1979-09-04
AT369010B (de) 1982-11-25
IE790795L (en) 1979-10-20
RO81114B (ro) 1983-01-30
AU4609779A (en) 1979-10-25
BG33297A3 (bg) 1983-01-14
IL57168A0 (en) 1979-07-25
NZ190213A (en) 1982-12-21
CS218585B2 (en) 1983-02-25
PL215911A1 (cs) 1980-03-24
CA1097629A (en) 1981-03-17
RO81114A (ro) 1983-02-01
FR2423495B1 (cs) 1983-02-11
IE48213B1 (en) 1984-10-31
SU893135A3 (ru) 1981-12-23
RO81037A (ro) 1983-02-01
ES479753A1 (es) 1980-08-16
PL119416B1 (en) 1981-12-31
DK147484B (da) 1984-08-27
HU181431B (en) 1983-07-28
RO80084A (ro) 1983-02-01
GB2019396B (en) 1982-09-15
BG33296A3 (bg) 1983-01-14
EP0005051B1 (en) 1982-12-01
BG33294A3 (bg) 1983-01-14
SU1225490A3 (ru) 1986-04-15
ZA791856B (en) 1980-11-26
RO80084B (ro) 1983-01-30
CS218583B2 (en) 1983-02-25
RO81037B (ro) 1983-01-30
AU527109B2 (en) 1983-02-17
GR69987B (cs) 1982-07-22
GB2019396A (en) 1979-10-31
IL57168A (en) 1983-10-31
EP0005051A1 (en) 1979-10-31
JPS6245873B2 (cs) 1987-09-29
BE875652A (fr) 1979-10-18
CS218584B2 (en) 1983-02-25
LU81166A1 (fr) 1979-09-07
CH643269A5 (fr) 1984-05-30
ATA291279A (de) 1982-04-15
JPS54141798A (en) 1979-11-05
YU93179A (en) 1983-01-21

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