IL57168A - N-substituted derivatives of 4-desacetyl vlb c-3 carbohydrazide,their preparation and pharmaceutical compositions containing them - Google Patents

N-substituted derivatives of 4-desacetyl vlb c-3 carbohydrazide,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL57168A
IL57168A IL57168A IL5716879A IL57168A IL 57168 A IL57168 A IL 57168A IL 57168 A IL57168 A IL 57168A IL 5716879 A IL5716879 A IL 5716879A IL 57168 A IL57168 A IL 57168A
Authority
IL
Israel
Prior art keywords
carbohydrazide
preparation
pharmaceutical compositions
compositions containing
substituted derivatives
Prior art date
Application number
IL57168A
Other languages
English (en)
Other versions
IL57168A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL57168A0 publication Critical patent/IL57168A0/xx
Publication of IL57168A publication Critical patent/IL57168A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL57168A 1978-04-20 1979-04-29 N-substituted derivatives of 4-desacetyl vlb c-3 carbohydrazide,their preparation and pharmaceutical compositions containing them IL57168A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/899,032 US4166810A (en) 1978-04-20 1978-04-20 Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (2)

Publication Number Publication Date
IL57168A0 IL57168A0 (en) 1979-07-25
IL57168A true IL57168A (en) 1983-10-31

Family

ID=25410402

Family Applications (1)

Application Number Title Priority Date Filing Date
IL57168A IL57168A (en) 1978-04-20 1979-04-29 N-substituted derivatives of 4-desacetyl vlb c-3 carbohydrazide,their preparation and pharmaceutical compositions containing them

Country Status (32)

Country Link
US (1) US4166810A (cs)
EP (1) EP0005051B1 (cs)
JP (1) JPS54141798A (cs)
AR (1) AR228940A1 (cs)
AT (1) AT369010B (cs)
AU (1) AU527109B2 (cs)
BE (1) BE875652A (cs)
BG (3) BG33296A3 (cs)
CA (1) CA1097629A (cs)
CH (1) CH643269A5 (cs)
CS (3) CS218584B2 (cs)
DD (1) DD143075A5 (cs)
DE (1) DE2964130D1 (cs)
DK (1) DK147484C (cs)
EG (1) EG14867A (cs)
ES (2) ES479753A1 (cs)
FI (1) FI791286A (cs)
FR (1) FR2423495A1 (cs)
GB (1) GB2019396B (cs)
GR (1) GR69987B (cs)
HU (1) HU181431B (cs)
IE (1) IE48213B1 (cs)
IL (1) IL57168A (cs)
LU (1) LU81166A1 (cs)
NZ (1) NZ190213A (cs)
PH (1) PH14163A (cs)
PL (3) PL215911A1 (cs)
PT (1) PT69496A (cs)
RO (3) RO81037A (cs)
SU (3) SU893135A3 (cs)
YU (1) YU93179A (cs)
ZA (1) ZA791856B (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322351A (en) * 1980-08-25 1982-03-30 Eli Lilly And Company Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
DK167984A (da) * 1983-03-30 1984-10-01 Lilly Industries Ltd Alkaloidderivater
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
ATE427948T1 (de) 2001-04-24 2009-04-15 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
KR20040106547A (ko) * 2002-05-15 2004-12-17 엔도사이트, 인코포레이티드 비타민-마이토마이신 공액체
EP2517730A3 (en) 2003-01-27 2013-01-02 Endocyte, Inc. Vitamin receptor binding drug delivery conjugates
US8288557B2 (en) * 2004-07-23 2012-10-16 Endocyte, Inc. Bivalent linkers and conjugates thereof
US8044200B2 (en) * 2005-03-16 2011-10-25 Endocyte, Inc. Synthesis and purification of pteroic acid and conjugates thereof
ES2468240T3 (es) 2005-08-19 2014-06-16 Endocyte, Inc. Conjugados de ligando de múltiples fármacos
JP2009504783A (ja) * 2005-08-19 2009-02-05 エンドサイト，インコーポレイテッド ビンカアルカロイド、類似体および誘導体のリガンド結合体
WO2008100591A2 (en) * 2007-02-14 2008-08-21 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
WO2008101231A2 (en) 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
EP2481427A1 (en) * 2007-03-14 2012-08-01 Endocyte, Inc. Folate-Tubulysin conjugates
CN101784565B (zh) 2007-06-25 2014-12-10 恩多塞特公司 含有亲水性间隔区接头的共轭物
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
CA2703491C (en) 2007-10-25 2017-06-13 Endocyte, Inc. Tubulysins and processes for preparing
US9168232B2 (en) * 2009-09-07 2015-10-27 Nipro Patch Co., Ltd. Transdermally absorbable preparation
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
AU2013331440A1 (en) 2012-10-16 2015-04-30 Endocyte, Inc. Drug delivery conjugates containing unnatural amino acids and methods for using

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3205220A (en) * 1961-10-26 1965-09-07 Lilly Co Eli Leurosidine and leurocristine and their production
US3392173A (en) * 1964-03-09 1968-07-09 Lilly Co Eli Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) * 1964-04-27 1968-02-20 Lilly Co Eli Leurosine
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) * 1974-05-06 1975-06-03 Lilly Co Eli Vincadioline
US3890325A (en) * 1974-05-15 1975-06-17 Lilly Co Eli Leurocolombine
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

Also Published As

Publication number Publication date
DK147484B (da) 1984-08-27
CS218585B2 (en) 1983-02-25
YU93179A (en) 1983-01-21
IE790795L (en) 1979-10-20
CS218584B2 (en) 1983-02-25
SU1061698A3 (ru) 1983-12-15
GB2019396B (en) 1982-09-15
IL57168A0 (en) 1979-07-25
CS218583B2 (en) 1983-02-25
SU1225490A3 (ru) 1986-04-15
LU81166A1 (fr) 1979-09-07
GB2019396A (en) 1979-10-31
DK160679A (da) 1979-10-21
PL119416B1 (en) 1981-12-31
FI791286A (fi) 1979-10-21
NZ190213A (en) 1982-12-21
CA1097629A (en) 1981-03-17
JPS54141798A (en) 1979-11-05
FR2423495A1 (fr) 1979-11-16
ATA291279A (de) 1982-04-15
PL215911A1 (cs) 1980-03-24
ZA791856B (en) 1980-11-26
CH643269A5 (fr) 1984-05-30
US4166810A (en) 1979-09-04
AU4609779A (en) 1979-10-25
RO80084A (ro) 1983-02-01
BG33297A3 (en) 1983-01-14
DE2964130D1 (en) 1983-01-05
PL125470B1 (en) 1983-05-31
DK147484C (da) 1985-03-25
IE48213B1 (en) 1984-10-31
RO81037A (ro) 1983-02-01
ES479753A1 (es) 1980-08-16
AT369010B (de) 1982-11-25
GR69987B (cs) 1982-07-22
AU527109B2 (en) 1983-02-17
HU181431B (en) 1983-07-28
RO80084B (ro) 1983-01-30
RO81114B (ro) 1983-01-30
PT69496A (en) 1979-05-01
BG33294A3 (en) 1983-01-14
JPS6245873B2 (cs) 1987-09-29
DD143075A5 (de) 1980-07-30
PH14163A (en) 1981-03-19
FR2423495B1 (cs) 1983-02-11
RO81037B (ro) 1983-01-30
AR228940A1 (es) 1983-05-13
EP0005051B1 (en) 1982-12-01
SU893135A3 (ru) 1981-12-23
BE875652A (fr) 1979-10-18
ES479754A1 (es) 1980-08-16
EP0005051A1 (en) 1979-10-31
BG33296A3 (en) 1983-01-14
RO81114A (ro) 1983-02-01
EG14867A (en) 1986-09-30

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