DK1414444T3 - Hidtil ukendte imidasolidinderivater, deres fremstilling og deres anvendelse som VLA-4-antagonister - Google Patents
Hidtil ukendte imidasolidinderivater, deres fremstilling og deres anvendelse som VLA-4-antagonisterInfo
- Publication number
- DK1414444T3 DK1414444T3 DK02764740T DK02764740T DK1414444T3 DK 1414444 T3 DK1414444 T3 DK 1414444T3 DK 02764740 T DK02764740 T DK 02764740T DK 02764740 T DK02764740 T DK 02764740T DK 1414444 T3 DK1414444 T3 DK 1414444T3
- Authority
- DK
- Denmark
- Prior art keywords
- sup
- formula
- compounds
- vla
- cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10137595A DE10137595A1 (de) | 2001-08-01 | 2001-08-01 | Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung |
| PCT/EP2002/008106 WO2003011288A1 (en) | 2001-08-01 | 2002-07-20 | Novel imidazolidine derivatives, their preparation and their use as vla-4 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1414444T3 true DK1414444T3 (da) | 2008-08-04 |
Family
ID=7693930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02764740T DK1414444T3 (da) | 2001-08-01 | 2002-07-20 | Hidtil ukendte imidasolidinderivater, deres fremstilling og deres anvendelse som VLA-4-antagonister |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6962937B2 (ja) |
| EP (1) | EP1414444B1 (ja) |
| JP (1) | JP4676697B2 (ja) |
| KR (1) | KR100910930B1 (ja) |
| CN (1) | CN1537000B (ja) |
| AR (1) | AR036349A1 (ja) |
| AT (1) | ATE391504T1 (ja) |
| AU (1) | AU2002328931B2 (ja) |
| BR (1) | BR0211535A (ja) |
| CA (1) | CA2455966C (ja) |
| CO (1) | CO5550452A2 (ja) |
| DE (2) | DE10137595A1 (ja) |
| DK (1) | DK1414444T3 (ja) |
| ES (1) | ES2301673T3 (ja) |
| HK (1) | HK1066166A1 (ja) |
| HR (1) | HRP20040108A2 (ja) |
| HU (1) | HUP0401406A3 (ja) |
| IL (2) | IL160093A0 (ja) |
| MX (1) | MXPA04000041A (ja) |
| MY (1) | MY133467A (ja) |
| NO (1) | NO326696B1 (ja) |
| NZ (1) | NZ530887A (ja) |
| PE (1) | PE20030348A1 (ja) |
| PL (1) | PL365396A1 (ja) |
| PT (1) | PT1414444E (ja) |
| RS (1) | RS6104A (ja) |
| RU (1) | RU2318815C2 (ja) |
| TW (1) | TWI325863B (ja) |
| WO (1) | WO2003011288A1 (ja) |
| ZA (1) | ZA200400194B (ja) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7691843B2 (en) | 2002-07-11 | 2010-04-06 | Pfizer Inc. | N-hydroxyamide derivatives possessing antibacterial activity |
| EP2093218A1 (en) * | 2008-02-22 | 2009-08-26 | Ruggero Fariello | Arylalkyl substituted imidazolidinones |
| US20090275529A1 (en) * | 2008-05-05 | 2009-11-05 | Reiss Allison B | Method for improving cardiovascular risk profile of cox inhibitors |
| US20130337470A1 (en) | 2010-10-25 | 2013-12-19 | Biogen Idec Ma Inc. | METHODS FOR DETERMINING DIFFERENCES IN ALPHA-4 INTEGRIN ACTIVITY BY CORRELATING DIFFERENCES IN sVCAM AND/OR sMadCAM LEVELS |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE235866C (ja) | ||||
| DE4009506A1 (de) | 1990-03-24 | 1991-09-26 | Hoechst Ag | Hydantoinderivate |
| DE4126277A1 (de) | 1991-08-08 | 1993-02-11 | Cassella Ag | Hydantoinderivate |
| DK0626861T4 (da) | 1992-01-13 | 2004-08-16 | Biogen Inc | Behandling af astma. |
| DE69309906T2 (de) | 1992-02-12 | 1997-11-06 | Biogen, Inc., Cambridge, Mass. | Behandlung für entzündungserkrankung des darmes |
| DE4207254A1 (de) | 1992-03-07 | 1993-09-09 | Cassella Ag | 4-oxo-2-thioxoimidazolidin-derivate |
| DE4213634A1 (de) | 1992-04-24 | 1993-10-28 | Cassella Ag | 2,4-Dioxo-imidazolidin-Derivate |
| DE4224414A1 (de) | 1992-07-24 | 1994-01-27 | Cassella Ag | Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung |
| DE4228717A1 (de) | 1992-08-28 | 1994-03-03 | Cassella Ag | Imidazolidin-Derivate |
| EP0677060A1 (en) | 1993-01-08 | 1995-10-18 | Tanabe Seiyaku Co., Ltd. | Peptide inhibitors of cell adhesion |
| AU688751B2 (en) | 1993-01-12 | 1998-03-19 | Biogen Idec Ma Inc. | Recombinant anti-VLA4 antibody molecules |
| WO1994017828A2 (en) | 1993-02-09 | 1994-08-18 | Biogen, Inc. | Treatment for insulin dependent diabetes |
| DE4308034A1 (de) | 1993-03-13 | 1994-09-15 | Cassella Ag | Neue Heterocyclen, ihre Herstellung und ihre Verwendung |
| DE4427979A1 (de) | 1993-11-15 | 1996-02-15 | Cassella Ag | Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung |
| WO1995015973A1 (en) | 1993-12-06 | 1995-06-15 | Cytel Corporation | Cs-1 peptidomimetics, compositions and methods of using the same |
| ES2424292T3 (es) | 1994-01-25 | 2013-09-30 | Biogen Idec Ma Inc. | Anticuerpos humanizados contra la molécula de adhesión leucocitaria VLA-4 |
| WO1996000581A1 (en) | 1994-06-29 | 1996-01-11 | Texas Biotechnology Corporation | Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin |
| US5811391A (en) | 1994-08-25 | 1998-09-22 | Cytel Corporation | Cyclic CS-1 peptidomimetics, compositions and methods of using same |
| GB9524630D0 (en) | 1994-12-24 | 1996-01-31 | Zeneca Ltd | Chemical compounds |
| US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| DE19515177A1 (de) | 1995-04-28 | 1996-10-31 | Cassella Ag | Hydantoinderivate als Zwischenprodukte für pharmazeutische Wirkstoffe |
| US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
| ES2171768T3 (es) | 1996-03-20 | 2002-09-16 | Hoechst Ag | Inhibidores de la resorcion osea y antagonistas de receptores de vitronectina. |
| WO1998004913A1 (en) | 1996-07-25 | 1998-02-05 | Biogen, Inc. | Molecular model for vla-4 inhibitors |
| DE19647380A1 (de) | 1996-11-15 | 1998-05-20 | Hoechst Ag | 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
| DE19647382A1 (de) | 1996-11-15 | 1998-05-20 | Hoechst Ag | Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
| DE19647381A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
| WO1998042656A1 (en) | 1997-03-21 | 1998-10-01 | Cytel Corporation | Novel compounds |
| DE19741235A1 (de) | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE19741873A1 (de) | 1997-09-23 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| KR20010031557A (ko) | 1997-10-31 | 2001-04-16 | 추후제출 | 치환 아닐리드 |
| GB9723789D0 (en) | 1997-11-12 | 1998-01-07 | Zeneca Ltd | Chemical compounds |
| DE19751251A1 (de) * | 1997-11-19 | 1999-05-20 | Hoechst Marion Roussel De Gmbh | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
| AU3716499A (en) | 1998-04-21 | 1999-11-08 | Aventis Pharma Limited | Substituted diamines and their use as cell adhesion inhibitors |
| DE19821483A1 (de) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| JP3676677B2 (ja) | 1998-06-30 | 2005-07-27 | ファイザー・プロダクツ・インク | 炎症性疾患、自己免疫疾患および呼吸疾患の治療において有用なｖｌａ−４依存性細胞結合の非ペプチジル阻害薬 |
| WO2000002903A1 (en) | 1998-07-10 | 2000-01-20 | Cytel Corporation | Cs-1 peptidomimetics, compositions and methods of using the same |
| DE19922462A1 (de) * | 1999-05-17 | 2000-11-23 | Aventis Pharma Gmbh | Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate |
-
2001
- 2001-08-01 DE DE10137595A patent/DE10137595A1/de not_active Withdrawn
-
2002
- 2002-07-20 DK DK02764740T patent/DK1414444T3/da active
- 2002-07-20 JP JP2003516518A patent/JP4676697B2/ja not_active Expired - Fee Related
- 2002-07-20 IL IL16009302A patent/IL160093A0/xx unknown
- 2002-07-20 EP EP02764740A patent/EP1414444B1/en not_active Expired - Lifetime
- 2002-07-20 PL PL02365396A patent/PL365396A1/xx not_active Application Discontinuation
- 2002-07-20 HU HU0401406A patent/HUP0401406A3/hu unknown
- 2002-07-20 CN CN028151046A patent/CN1537000B/zh not_active Expired - Fee Related
- 2002-07-20 KR KR1020047001524A patent/KR100910930B1/ko not_active IP Right Cessation
- 2002-07-20 MX MXPA04000041A patent/MXPA04000041A/es active IP Right Grant
- 2002-07-20 BR BR0211535-2A patent/BR0211535A/pt active Search and Examination
- 2002-07-20 NZ NZ530887A patent/NZ530887A/en not_active IP Right Cessation
- 2002-07-20 DE DE60226032T patent/DE60226032T2/de not_active Expired - Lifetime
- 2002-07-20 PT PT02764740T patent/PT1414444E/pt unknown
- 2002-07-20 WO PCT/EP2002/008106 patent/WO2003011288A1/en active IP Right Grant
- 2002-07-20 ES ES02764740T patent/ES2301673T3/es not_active Expired - Lifetime
- 2002-07-20 RS YU6104A patent/RS6104A/sr unknown
- 2002-07-20 RU RU2004105966/04A patent/RU2318815C2/ru not_active IP Right Cessation
- 2002-07-20 AT AT02764740T patent/ATE391504T1/de active
- 2002-07-20 CA CA2455966A patent/CA2455966C/en not_active Expired - Fee Related
- 2002-07-20 AU AU2002328931A patent/AU2002328931B2/en not_active Ceased
- 2002-07-26 PE PE2002000672A patent/PE20030348A1/es not_active Application Discontinuation
- 2002-07-30 MY MYPI20022873A patent/MY133467A/en unknown
- 2002-07-30 AR ARP020102868A patent/AR036349A1/es active IP Right Grant
- 2002-07-30 TW TW091116941A patent/TWI325863B/zh not_active IP Right Cessation
- 2002-07-31 US US10/208,182 patent/US6962937B2/en not_active Expired - Lifetime
-
2004
- 2004-01-12 ZA ZA200400194A patent/ZA200400194B/xx unknown
- 2004-01-26 CO CO04005444A patent/CO5550452A2/es not_active Application Discontinuation
- 2004-01-27 IL IL160093A patent/IL160093A/en not_active IP Right Cessation
- 2004-01-30 HR HR20040108A patent/HRP20040108A2/hr not_active Application Discontinuation
- 2004-01-30 NO NO20040426A patent/NO326696B1/no not_active IP Right Cessation
- 2004-11-18 HK HK04109104.0A patent/HK1066166A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE455788T1 (de) | Imidazolidinderivate, ihre herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate | |
| MY118313A (en) | Substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them | |
| MY123865A (en) | Novel heterocycles as inhibitors of leucocyte adhesion and as vla-4 antagonists | |
| MY118176A (en) | Heterocycles as inhibitors of leucocyte adhesion and as vla-4-antagonists | |
| MX9708782A (es) | Heterociclos de 5 anillos como inhibidores de la adhesion de leucocitos y antagonistas de vla-4. | |
| NZ514477A (en) | Adamantane derivatives | |
| BR0307351A (pt) | Composto, composição farmacêutica, método para tratar uma condição ou estado de doença mediados pela atividade de p38 quinase ou mediados por citocinas produzidas pela atividade de p38 quinase, uso de um composto, e, processo para preparar um composto | |
| DK0889876T3 (da) | Meta-substituerede phenylensulfonamidderivater | |
| TNSN04199A1 (en) | Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use | |
| MY121745A (en) | 2,4-substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them. | |
| BRPI0512703A (pt) | composto ou um sal ou pró-droga farmaceuticamente aceitável do mesmo, composição farmacêutica, e, métodos para o tratamento de uma condição ou doença inflamatória ou imune em um indivìduo e para a modulação da função cxcr3 | |
| DE60041763D1 (de) | Inhibitoren von c-jun n-terminal kinasen (jnk) | |
| DE60221505D1 (de) | FAKTOR Xa BENZAMIDIN INHIBITOREN | |
| MY134191A (en) | Novel 5-membered ring heterocycles, their preparation their use and pharmaceutical preparations comprising them | |
| DK1725536T3 (da) | Imidazolin-derivater med CB1-antagonistisk aktivitet | |
| DK1414444T3 (da) | Hidtil ukendte imidasolidinderivater, deres fremstilling og deres anvendelse som VLA-4-antagonister | |
| TR200103856T2 (tr) | Naftiridin türevleri, bunların preparasyon işlemleri, kullanımları ve farmasötik kompozisyonlar. | |
| YU70803A (sh) | Derivati imidazolidina, njihovo dobijanje i njihova upotreba kao antiinflamatornih agensa | |
| TWI256386B (en) | Spiroimidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them | |
| TR200103858T2 (tr) | Hücre yapışmasının önleyicileri olarak ikame edilmiş purin türevleri | |
| WO2001070695A8 (en) | Pyridine derivatives as inhibitors of p38 | |
| EA201070040A1 (ru) | Новые соединения, соединения, которые влияют на клеточные везикулярные системы, фармацевтические композиции и их применение | |
| MA28930B1 (fr) | Derives pyridiniques d'indolin-2-one , leur preparation et leur application en therapeutique | |
| SE9901079D0 (sv) | Novel compounds | |
| TH64558A (ja) |