WO2001070695A8 - Pyridine derivatives as inhibitors of p38 - Google Patents

Pyridine derivatives as inhibitors of p38

Info

Publication number
WO2001070695A8
WO2001070695A8 PCT/US2001/009256 US0109256W WO0170695A8 WO 2001070695 A8 WO2001070695 A8 WO 2001070695A8 US 0109256 W US0109256 W US 0109256W WO 0170695 A8 WO0170695 A8 WO 0170695A8
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitors
aromatic carbocyclic
methods
aromatic
relates
Prior art date
Application number
PCT/US2001/009256
Other languages
French (fr)
Other versions
WO2001070695A1 (en
Inventor
Francesco Salituro
Guy Bemis
Ghotas Evindar
Original Assignee
Vertex Pharma
Francesco Salituro
Guy Bemis
Ghotas Evindar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma, Francesco Salituro, Guy Bemis, Ghotas Evindar filed Critical Vertex Pharma
Priority to AU2001247700A priority Critical patent/AU2001247700A1/en
Priority to MXPA02009319A priority patent/MXPA02009319A/en
Priority to CA002403828A priority patent/CA2403828A1/en
Priority to JP2001568907A priority patent/JP2003528084A/en
Publication of WO2001070695A1 publication Critical patent/WO2001070695A1/en
Publication of WO2001070695A8 publication Critical patent/WO2001070695A8/en

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes

Abstract

The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli, having the formula (III), or tautomers thereof or pharmaceutically acceptable salts thereof, wherein: each of Q1 and Q2 are independently selected from 5-6 membered aromatic carbocyclic or heterocyclic ring systems, or 8-10 membered bicyclic ring systems comprising aromatic carbocyclic rings, aromatic heterocyclic rings or a combination of an aromatic carbocyclic ring and an aromatic heterocyclic ring. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
PCT/US2001/009256 2000-03-22 2001-03-22 Pyridine derivatives as inhibitors of p38 WO2001070695A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2001247700A AU2001247700A1 (en) 2000-03-22 2001-03-22 Inhibitors of p38
MXPA02009319A MXPA02009319A (en) 2000-03-22 2001-03-22 Pyridine derivatives as inhibitors of p38.
CA002403828A CA2403828A1 (en) 2000-03-22 2001-03-22 Inhibitors of p38
JP2001568907A JP2003528084A (en) 2000-03-22 2001-03-22 inhibitors of p38

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19135800P 2000-03-22 2000-03-22
US60/191,358 2000-03-22

Publications (2)

Publication Number Publication Date
WO2001070695A1 WO2001070695A1 (en) 2001-09-27
WO2001070695A8 true WO2001070695A8 (en) 2001-11-29

Family

ID=22705152

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/009256 WO2001070695A1 (en) 2000-03-22 2001-03-22 Pyridine derivatives as inhibitors of p38

Country Status (6)

Country Link
JP (1) JP2003528084A (en)
AU (1) AU2001247700A1 (en)
CA (1) CA2403828A1 (en)
MX (1) MXPA02009319A (en)
TW (1) TWI282334B (en)
WO (1) WO2001070695A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2418389A1 (en) 2000-08-11 2002-02-21 Vertex Pharmaceuticals Incorporated Pyridine derivatives as inhibitors of p38
GB0124933D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
PT1864975E (en) 2002-02-12 2010-12-27 Glaxosmithkline Llc Nicotinamide derivates useful as p38 inhibitors
GB0308201D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0308186D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0318814D0 (en) * 2003-08-11 2003-09-10 Smithkline Beecham Corp Novel compounds
GB0908317D0 (en) * 2009-05-14 2009-06-24 Argenta Discovery Ltd Pharmaceutical compounds and compositions
WO2017151409A1 (en) 2016-02-29 2017-09-08 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6147080A (en) * 1996-12-18 2000-11-14 Vertex Pharmaceuticals Incorporated Inhibitors of p38
US5945418A (en) * 1996-12-18 1999-08-31 Vertex Pharmaceuticals Incorporated Inhibitors of p38
JP2002502380A (en) * 1997-05-22 2002-01-22 ジー．ディー．サール アンド カンパニー Pyrazole derivatives as p38 kinase inhibitors
DK1043995T3 (en) * 1997-12-22 2007-03-05 Bayer Pharmaceuticals Corp Inhibition of p38 kinase activity using aryl- and heteroaryl-substituted heterocyclic ureas
MY132496A (en) * 1998-05-11 2007-10-31 Vertex Pharma Inhibitors of p38

Also Published As

Publication number Publication date
WO2001070695A1 (en) 2001-09-27
TWI282334B (en) 2007-06-11
JP2003528084A (en) 2003-09-24
AU2001247700A1 (en) 2001-10-03
CA2403828A1 (en) 2001-09-27
MXPA02009319A (en) 2003-03-12

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