KR100361933B1
(ko)
*
|
1993-09-08 |
2003-02-14 |
라 졸라 파마슈티칼 컴파니 |
화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
|
US6057287A
(en)
|
1994-01-11 |
2000-05-02 |
Dyax Corp. |
Kallikrein-binding "Kunitz domain" proteins and analogues thereof
|
US5545553A
(en)
*
|
1994-09-26 |
1996-08-13 |
The Rockefeller University |
Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
US6371975B2
(en)
|
1998-11-06 |
2002-04-16 |
Neomend, Inc. |
Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
|
US20030191496A1
(en)
|
1997-03-12 |
2003-10-09 |
Neomend, Inc. |
Vascular sealing device with microwave antenna
|
US6448369B1
(en)
*
|
1997-11-06 |
2002-09-10 |
Shearwater Corporation |
Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
|
US7642323B2
(en)
|
1997-11-06 |
2010-01-05 |
Nektar Therapeutics |
Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
|
DK1411075T3
(da)
*
|
1998-03-12 |
2008-10-27 |
Nektar Therapeutics Al Corp |
Fremgangsmåde til fremstilling af polymerkonjugater
|
US6153655A
(en)
|
1998-04-17 |
2000-11-28 |
Enzon, Inc. |
Terminally-branched polymeric linkers and polymeric conjugates containing the same
|
US6994686B2
(en)
|
1998-08-26 |
2006-02-07 |
Neomend, Inc. |
Systems for applying cross-linked mechanical barriers
|
US6458147B1
(en)
|
1998-11-06 |
2002-10-01 |
Neomend, Inc. |
Compositions, systems, and methods for arresting or controlling bleeding or fluid leakage in body tissue
|
EP1121156B1
(en)
|
1998-10-16 |
2006-02-22 |
Biogen Idec MA Inc. |
Polymer conjugates of interferon beta- 1a and their uses
|
BR9915548A
(pt)
*
|
1998-10-16 |
2001-08-14 |
Biogen Inc |
Proteìnas de fusão de interferon-beta e usos
|
US7279001B2
(en)
|
1998-11-06 |
2007-10-09 |
Neomend, Inc. |
Systems, methods, and compositions for achieving closure of vascular puncture sites
|
US6949114B2
(en)
|
1998-11-06 |
2005-09-27 |
Neomend, Inc. |
Systems, methods, and compositions for achieving closure of vascular puncture sites
|
US6830756B2
(en)
|
1998-11-06 |
2004-12-14 |
Neomend, Inc. |
Systems, methods, and compositions for achieving closure of vascular puncture sites
|
US6899889B1
(en)
|
1998-11-06 |
2005-05-31 |
Neomend, Inc. |
Biocompatible material composition adaptable to diverse therapeutic indications
|
US20010010818A1
(en)
*
|
1998-12-09 |
2001-08-02 |
Engle Steven B. |
Methods and formulations for reducing circulating antibodies
|
US6458953B1
(en)
*
|
1998-12-09 |
2002-10-01 |
La Jolla Pharmaceutical Company |
Valency platform molecules comprising carbamate linkages
|
CA2376057A1
(en)
*
|
1999-06-08 |
2000-12-14 |
La Jolla Pharmaceutical Company |
Valency platform molecules comprising aminooxy groups
|
US6828412B1
(en)
*
|
1999-09-03 |
2004-12-07 |
School Of Pharmacy, University Of London |
Degradable polymers
|
DE60032255T2
(de)
*
|
1999-10-04 |
2007-06-28 |
Nektar Therapeutics Al, Corp., Huntsville |
Polymer-stabilisierte neuropeptide
|
AU781336B2
(en)
*
|
1999-10-08 |
2005-05-19 |
Nektar Therapeutics |
Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
|
MXPA02005236A
(es)
*
|
1999-11-28 |
2004-03-19 |
Jolla Pharma |
Metodos de tratamiento de lupus con base en la afinidad de anticuerpos y metodos de separacion por exclusion y composiciones para el uso de los mismos.
|
US7074878B1
(en)
*
|
1999-12-10 |
2006-07-11 |
Harris J Milton |
Hydrolytically degradable polymers and hydrogels made therefrom
|
MXPA02006215A
(es)
*
|
1999-12-22 |
2003-10-15 |
Nektar Therapeutics Al Corp |
Metodo para preparar esteres de 1-benzotriazolil carbonato de poli(etilenglicol).
|
MXPA02006216A
(es)
*
|
1999-12-22 |
2004-02-26 |
Nektar Therapeutics Al Corp |
Derivados estericamente impedidos de polimeros solubles en agua.
|
US7727547B2
(en)
|
2000-04-04 |
2010-06-01 |
Tissuemed Limited |
Tissue-adhesive formulations
|
GB0013810D0
(en)
|
2000-06-06 |
2000-07-26 |
Celltech Chiroscience Ltd |
Biological products
|
AU2001268228A1
(en)
*
|
2000-06-08 |
2001-12-17 |
La Jolla Pharmaceutical Company |
Multivalent platform molecules comprising high molecular weight polyethylene oxide
|
DE10048417A1
(de)
*
|
2000-09-29 |
2002-04-11 |
Roche Diagnostics Gmbh |
Verbindungen mit verzweigtem Linker
|
TW593427B
(en)
*
|
2000-12-18 |
2004-06-21 |
Nektar Therapeutics Al Corp |
Synthesis of high molecular weight non-peptidic polymer derivatives
|
US7053150B2
(en)
|
2000-12-18 |
2006-05-30 |
Nektar Therapeutics Al, Corporation |
Segmented polymers and their conjugates
|
TWI246524B
(en)
*
|
2001-01-19 |
2006-01-01 |
Shearwater Corp |
Multi-arm block copolymers as drug delivery vehicles
|
US7265186B2
(en)
|
2001-01-19 |
2007-09-04 |
Nektar Therapeutics Al, Corporation |
Multi-arm block copolymers as drug delivery vehicles
|
DE60236796D1
(de)
|
2001-01-30 |
2010-08-05 |
Kyowa Hakko Kirin Co Ltd |
Verzweigte polyalkylenglykole
|
US8114418B2
(en)
|
2001-06-21 |
2012-02-14 |
Dynavax Technologies Corporation |
Chimeric immunomodulatory compounds and methods of using the same—IV
|
US20030114405A1
(en)
*
|
2001-08-13 |
2003-06-19 |
Linnik Matthew D. |
Methods of treating systemic lupus erythematosus in individuals having significantly impaired renal function
|
US7157277B2
(en)
|
2001-11-28 |
2007-01-02 |
Neose Technologies, Inc. |
Factor VIII remodeling and glycoconjugation of Factor VIII
|
US7795210B2
(en)
|
2001-10-10 |
2010-09-14 |
Novo Nordisk A/S |
Protein remodeling methods and proteins/peptides produced by the methods
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
US7179617B2
(en)
*
|
2001-10-10 |
2007-02-20 |
Neose Technologies, Inc. |
Factor IX: remolding and glycoconjugation of Factor IX
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
US7696163B2
(en)
|
2001-10-10 |
2010-04-13 |
Novo Nordisk A/S |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
DK1578771T3
(da)
|
2001-10-10 |
2013-06-10 |
Novo Nordisk As |
Remodellering og glycokonjugering af peptider
|
US8008252B2
(en)
*
|
2001-10-10 |
2011-08-30 |
Novo Nordisk A/S |
Factor VII: remodeling and glycoconjugation of Factor VII
|
US7399613B2
(en)
*
|
2001-10-10 |
2008-07-15 |
Neose Technologies, Inc. |
Sialic acid nucleotide sugars
|
DK2279753T3
(en)
|
2001-10-10 |
2015-11-23 |
Novo Nordisk As |
The conversion of peptides and glycokonjugering
|
US7105135B2
(en)
*
|
2001-10-16 |
2006-09-12 |
Lockheed Martin Corporation |
System and method for large scale detection of hazardous materials in the mail or in other objects
|
MXPA04003597A
(es)
*
|
2001-10-18 |
2004-07-30 |
Nektar Therapeutics Al Corp |
Conjugados polimericos de antagonistas opiaceos.
|
CA2466027C
(en)
|
2001-11-07 |
2013-01-08 |
Nektar Therapeutics Al, Corporation |
Branched polymers and their conjugates
|
US6956135B2
(en)
*
|
2001-12-11 |
2005-10-18 |
Sun Bio, Inc. |
Monofunctional polyethylene glycol aldehydes
|
US6916962B2
(en)
*
|
2001-12-11 |
2005-07-12 |
Sun Bio, Inc. |
Monofunctional polyethylene glycol aldehydes
|
KR100488351B1
(ko)
*
|
2001-12-11 |
2005-05-11 |
선바이오(주) |
신규한 폴리에틸렌글리콜-프로피온알데히드 유도체
|
US7041855B2
(en)
*
|
2001-12-11 |
2006-05-09 |
Sun Bio, Inc. |
Monofunctional polyethylene glycol aldehydes
|
PT3025726T
(pt)
*
|
2002-01-18 |
2020-01-09 |
Biogen Ma Inc |
Compostos do polímero polialquileno e utilizações dos mesmos
|
WO2003066069A1
(en)
*
|
2002-02-01 |
2003-08-14 |
Intradigm Corporation |
Polymers for delivering peptides and small molecules in vivo
|
EA200401565A1
(ru)
*
|
2002-05-24 |
2005-04-28 |
Неофарм, Инк. |
Способ получения кардиолипина или аналога кардиолипина (варианты), способ получения липосомы и композиция кардиолипина для лечения заболеваний (варианты)
|
WO2003099830A2
(en)
*
|
2002-05-24 |
2003-12-04 |
Neopharm, Inc. |
Cardiolipin compositions, methods of preparation and use
|
US7153829B2
(en)
|
2002-06-07 |
2006-12-26 |
Dyax Corp. |
Kallikrein-inhibitor therapies
|
PT1531791E
(pt)
*
|
2002-06-07 |
2010-12-16 |
Dyax Corp |
Prevenção e redução da isquémia
|
DE60336555D1
(de)
*
|
2002-06-21 |
2011-05-12 |
Novo Nordisk Healthcare Ag |
Pegylierte glykoformen von faktor vii
|
US20050277611A1
(en)
*
|
2002-10-16 |
2005-12-15 |
Neopharm, Inc. |
Cationic cardiolipin analoges and its use thereof
|
AU2003303524A1
(en)
*
|
2002-12-27 |
2004-07-29 |
La Jolla Pharmaceutical Company |
Methods of improving health-related quality of life in individuals with systemic lupus erythematosus
|
WO2004061094A1
(en)
|
2002-12-30 |
2004-07-22 |
Gryphon Therapeutics, Inc. |
Water-soluble thioester and selenoester compounds and methods for making and using the same
|
AU2003303519C1
(en)
*
|
2002-12-31 |
2010-08-12 |
Nektar Therapeutics |
Polymeric reagents comprising a ketone or a related functional group
|
DE60322111D1
(de)
|
2002-12-31 |
2008-08-21 |
Nektar Therapeutics Al Co |
Verfahren zur herstellung von hydrogelen aus thiosulfonat-zusammensetzungen und ihre verwendungen
|
US20050130892A1
(en)
*
|
2003-03-07 |
2005-06-16 |
Xencor, Inc. |
BAFF variants and methods thereof
|
US20050221443A1
(en)
*
|
2003-01-06 |
2005-10-06 |
Xencor, Inc. |
Tumor necrosis factor super family agonists
|
US7553930B2
(en)
*
|
2003-01-06 |
2009-06-30 |
Xencor, Inc. |
BAFF variants and methods thereof
|
US20060014248A1
(en)
*
|
2003-01-06 |
2006-01-19 |
Xencor, Inc. |
TNF super family members with altered immunogenicity
|
PT1603541E
(pt)
|
2003-03-05 |
2010-02-19 |
Halozyme Inc |
Glicoproteína hialuronidase solúvel (shasegp), processo para preparação da mesma, suas utilizações e composições farmacêuticas que a compreendem.
|
US7871607B2
(en)
|
2003-03-05 |
2011-01-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
US20090123367A1
(en)
*
|
2003-03-05 |
2009-05-14 |
Delfmems |
Soluble Glycosaminoglycanases and Methods of Preparing and Using Soluble Glycosaminoglycanases
|
MXPA05009726A
(es)
|
2003-03-14 |
2005-11-04 |
Neose Technologies Inc |
Polimeros ramificados, solubles en agua y sus conjugados.
|
JP2006520840A
(ja)
*
|
2003-03-18 |
2006-09-14 |
ネオス テクノロジーズ インコーポレイテッド |
水溶性高分子の活性化形
|
WO2004089422A2
(en)
*
|
2003-03-30 |
2004-10-21 |
La Jolla Pharmaceutical Co. |
Methods of treating and monitoring systemic lupus erythematosus in individuals
|
US7642340B2
(en)
|
2003-03-31 |
2010-01-05 |
Xencor, Inc. |
PEGylated TNF-α variant proteins
|
US7610156B2
(en)
*
|
2003-03-31 |
2009-10-27 |
Xencor, Inc. |
Methods for rational pegylation of proteins
|
AU2004227937B2
(en)
*
|
2003-03-31 |
2007-09-20 |
Xencor, Inc |
Methods for rational pegylation of proteins
|
CA2522345A1
(en)
|
2003-04-09 |
2004-11-18 |
Neose Technologies, Inc. |
Glycopegylation methods and proteins/peptides produced by the methods
|
US7691603B2
(en)
*
|
2003-04-09 |
2010-04-06 |
Novo Nordisk A/S |
Intracellular formation of peptide conjugates
|
US8791070B2
(en)
|
2003-04-09 |
2014-07-29 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
ATE540055T1
(de)
|
2003-05-09 |
2012-01-15 |
Biogenerix Ag |
Zusammensetzungen und verfahren zur herstellung von glykosylierungsmutanten des menschlichen wachstumshormons
|
GB0316294D0
(en)
*
|
2003-07-11 |
2003-08-13 |
Polytherics Ltd |
Conjugated biological molecules and their preparation
|
DE602004025949D1
(de)
|
2003-07-22 |
2010-04-22 |
Nektar Therapeutics |
Verfahren zur herstellung von funktionalisierten polymeren aus polymeralkoholen
|
WO2005012484A2
(en)
|
2003-07-25 |
2005-02-10 |
Neose Technologies, Inc. |
Antibody-toxin conjugates
|
AU2004268145B2
(en)
*
|
2003-08-29 |
2010-09-16 |
Takeda Pharmaceutical Company Limited |
Poly-PEGylated protease inhibitors
|
LT1675622T
(lt)
|
2003-09-17 |
2017-09-11 |
Nektar Therapeutics |
Daugiašakio polimero provaistai
|
CA2542353A1
(en)
|
2003-10-10 |
2005-04-21 |
Xencor, Inc. |
Protein based tnf-alpha variants for the treatment of tnf-alpha related disorders
|
EP1725572B1
(de)
|
2003-11-05 |
2017-05-31 |
AGCT GmbH |
Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
|
US20050214250A1
(en)
|
2003-11-06 |
2005-09-29 |
Harris J M |
Method of preparing carboxylic acid functionalized polymers
|
US8633157B2
(en)
*
|
2003-11-24 |
2014-01-21 |
Novo Nordisk A/S |
Glycopegylated erythropoietin
|
CA2547140A1
(en)
*
|
2003-11-24 |
2005-06-09 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
US20080305992A1
(en)
*
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
US20080318850A1
(en)
*
|
2003-12-03 |
2008-12-25 |
Neose Technologies, Inc. |
Glycopegylated Factor Ix
|
US20060040856A1
(en)
|
2003-12-03 |
2006-02-23 |
Neose Technologies, Inc. |
Glycopegylated factor IX
|
US7956032B2
(en)
*
|
2003-12-03 |
2011-06-07 |
Novo Nordisk A/S |
Glycopegylated granulocyte colony stimulating factor
|
ES2422187T3
(es)
*
|
2003-12-03 |
2013-09-09 |
Biogenerix Ag |
Factor estimulante de colonias de granulocitos glicopegilados
|
US7790835B2
(en)
|
2003-12-03 |
2010-09-07 |
Nektar Therapeutics |
Method of preparing maleimide functionalized polymers
|
US20060182692A1
(en)
|
2003-12-16 |
2006-08-17 |
Fishburn C S |
Chemically modified small molecules
|
WO2005058367A2
(en)
|
2003-12-16 |
2005-06-30 |
Nektar Therapeutics Al, Corporation |
Pegylated small molecules
|
GB0329825D0
(en)
*
|
2003-12-23 |
2004-01-28 |
Celltech R&D Ltd |
Biological products
|
US20050153371A1
(en)
*
|
2004-01-07 |
2005-07-14 |
Ambit Biosciences Corporation |
Conjugated small molecules
|
US8361961B2
(en)
|
2004-01-08 |
2013-01-29 |
Biogenerix Ag |
O-linked glycosylation of peptides
|
EP1756173B1
(en)
|
2004-01-21 |
2019-04-03 |
Nektar Therapeutics |
Method of preparing propionic acid-terminated polymers
|
AU2005211385B2
(en)
*
|
2004-02-02 |
2008-12-11 |
Ambrx, Inc. |
Modified human growth hormone polypeptides and their uses
|
CN101132812A
(zh)
*
|
2004-03-15 |
2008-02-27 |
阿拉巴马耐科塔医药公司 |
Hiv进入抑制剂的聚合物基组合物和结合物
|
US20070265200A1
(en)
*
|
2004-03-17 |
2007-11-15 |
Eli Lilly And Company |
Glycol Linked Fgf-21 Compounds
|
US8470315B2
(en)
*
|
2004-04-13 |
2013-06-25 |
Quintessence Biosciences, Inc. |
Non-natural ribonuclease conjugates as cytotoxic agents
|
US9085659B2
(en)
*
|
2004-05-03 |
2015-07-21 |
Nektar Therapeutics |
Polymer derivatives comprising an imide branching point
|
WO2005108463A2
(en)
|
2004-05-03 |
2005-11-17 |
Nektar Therapeutics Al, Corporation |
Branched polyethylen glycol derivates comprising an acetal or ketal branching point
|
US7282584B2
(en)
|
2004-06-16 |
2007-10-16 |
Straumann Holding Ag |
Methylene blue
|
DE602004011660T2
(de)
|
2004-06-16 |
2009-01-29 |
Straumann Holding Ag |
Abdeckmembran
|
JP2008503217A
(ja)
|
2004-06-18 |
2008-02-07 |
アンブレツクス・インコーポレイテツド |
新規抗原結合ポリペプチド及びそれらの使用
|
EP2258399A3
(en)
|
2004-07-08 |
2011-08-10 |
Elan Pharmaceuticals Inc. |
Multivalent VLA-4 antagonists comprising polymer moieties
|
WO2006010143A2
(en)
|
2004-07-13 |
2006-01-26 |
Neose Technologies, Inc. |
Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
|
WO2006019904A1
(en)
|
2004-07-14 |
2006-02-23 |
University Of Utha Research Foundation |
Netrin-related compositions and uses
|
EP1771573A4
(en)
*
|
2004-07-21 |
2009-02-18 |
Ambrx Inc |
BIOSYNTHETIC POLYPEPTIDES OBTAINED FROM NON-NATURALLY CITED AMINO ACIDS
|
RU2396985C2
(ru)
*
|
2004-08-03 |
2010-08-20 |
Тиссьюмед Лимитед |
Материалы, обладающие адгезией к тканям
|
EP1799249A2
(en)
*
|
2004-09-10 |
2007-06-27 |
Neose Technologies, Inc. |
Glycopegylated interferon alpha
|
US7235530B2
(en)
|
2004-09-27 |
2007-06-26 |
Dyax Corporation |
Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
|
EP3061461A1
(en)
|
2004-10-29 |
2016-08-31 |
ratiopharm GmbH |
Remodeling and glycopegylation of fibroblast growth factor (fgf)
|
US7816320B2
(en)
|
2004-12-22 |
2010-10-19 |
Ambrx, Inc. |
Formulations of human growth hormone comprising a non-naturally encoded amino acid at position 35
|
BRPI0519568C8
(pt)
|
2004-12-22 |
2022-06-14 |
Ambrx Inc |
Aminoacil-trna sintetase (rs), composições que compreendem a dita aminoacil-trna sintetase, célula de levedura, célula fúngica, célula não eucariótica, vetor que codifica uma rs, polinucleotídeo e ainda método para produzir um polipeptídeo em uma célula com um aminoácido selecionado em uma posição especificada
|
JP2008525032A
(ja)
*
|
2004-12-22 |
2008-07-17 |
アンブレツクス・インコーポレイテツド |
組換えヒト成長ホルモンを発現及び精製するための方法
|
SG160437A1
(en)
*
|
2004-12-22 |
2010-04-29 |
Ambrx Inc |
Modified human growth hormone
|
WO2006074279A1
(en)
*
|
2005-01-06 |
2006-07-13 |
Neose Technologies, Inc. |
Glycoconjugation using saccharyl fragments
|
NZ556436A
(en)
|
2005-01-10 |
2010-11-26 |
Biogenerix Ag |
Glycopegylated granulocyte colony stimulating factor
|
US20060233740A1
(en)
*
|
2005-03-23 |
2006-10-19 |
Bossard Mary J |
Conjugates of an hGH moiety and a polymer
|
CN100381420C
(zh)
*
|
2005-03-23 |
2008-04-16 |
于勇海 |
一种n-乙酰基半胱氨酸衍生物与应用
|
EP1866427A4
(en)
*
|
2005-03-30 |
2010-09-01 |
Novo Nordisk As |
MANUFACTURING PROCESS FOR THE PRODUCTION OF CULTIVE PEPTIDES IN CELL LINES OF INSECTS
|
CA2602654A1
(en)
|
2005-04-05 |
2006-10-12 |
Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa |
Method for shielding functional sites or epitopes on proteins
|
EP2386571B1
(en)
|
2005-04-08 |
2016-06-01 |
ratiopharm GmbH |
Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
|
US8273339B2
(en)
*
|
2005-04-12 |
2012-09-25 |
Nektar Therapeutics |
Polymer-based compositions and conjugates of antimicrobial agents
|
PT1881850E
(pt)
|
2005-05-13 |
2010-11-26 |
Lilly Co Eli |
Compostos peguilados de glp-1
|
JP5216580B2
(ja)
|
2005-05-25 |
2013-06-19 |
ノヴォ ノルディスク アー/エス |
グリコペグ化第ix因子
|
WO2006127910A2
(en)
*
|
2005-05-25 |
2006-11-30 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin formulations
|
WO2006133088A2
(en)
|
2005-06-03 |
2006-12-14 |
Ambrx, Inc. |
Improved human interferon molecules and their uses
|
RS53968B1
(en)
|
2005-06-16 |
2015-08-31 |
Nektar Therapeutics |
CONJUGATES WHICH HAVE A COUPLING WHICH MAY BE DEGRADED AND POLYMER REAGENTS USED FOR THE PREPARATION OF SUCH CONJUGATES
|
WO2006138463A2
(en)
*
|
2005-06-17 |
2006-12-28 |
Nektar Therapeutics Al, Corporation |
Polymer-based compositions and conjugates of non-steroidal anti-inflammatory drugs
|
MX2008000291A
(es)
*
|
2005-07-08 |
2008-04-04 |
Elan Pharm Inc |
Preparacion de conjugados polimericos de compuestos de aditivos terapeuticos, agricolas y alimentarios.
|
WO2007011802A1
(en)
|
2005-07-18 |
2007-01-25 |
Nektar Therapeutics Al, Corporation |
Method for preparing branched functionalized polymers using branched polyol cores
|
JP5600240B2
(ja)
*
|
2005-07-19 |
2014-10-01 |
ウェルズ ファーゴ バンク ナショナル アソシエイション |
重合体マレイミド類を調製する方法
|
AU2006275473B2
(en)
|
2005-07-29 |
2012-07-05 |
Nektar Therapeutics |
Methods for preparing carbonate esters of poly(ethylene glycol)
|
JP2009515508A
(ja)
*
|
2005-08-19 |
2009-04-16 |
ネオス テクノロジーズ インコーポレイテッド |
グリコpeg化因子viiおよび因子viia
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
US20090048440A1
(en)
|
2005-11-03 |
2009-02-19 |
Neose Technologies, Inc. |
Nucleotide Sugar Purification Using Membranes
|
US20090018029A1
(en)
|
2005-11-16 |
2009-01-15 |
Ambrx, Inc. |
Methods and Compositions Comprising Non-Natural Amino Acids
|
US8293869B2
(en)
|
2005-12-16 |
2012-10-23 |
Nektar Therapeutics |
Polymer conjugates of GLP-1
|
KR20080102152A
(ko)
|
2006-02-03 |
2008-11-24 |
티슈메드 리미티드 |
조직-접착 물질
|
US20090018575A1
(en)
*
|
2006-03-01 |
2009-01-15 |
Tissuemed Limited |
Tissue-adhesive formulations
|
EP2573111A1
(en)
|
2006-04-20 |
2013-03-27 |
Amgen Inc. |
GLP-1 compounds
|
KR20090024166A
(ko)
*
|
2006-05-22 |
2009-03-06 |
엘란 파마슈티칼스, 인크. |
치료학적, 농업적 및 식품 첨가제 화합물의 폴리머 콘주게이트의 제조
|
US8840882B2
(en)
*
|
2006-06-23 |
2014-09-23 |
Quintessence Biosciences, Inc. |
Modified ribonucleases
|
EP2049151A4
(en)
|
2006-07-17 |
2010-03-24 |
Quintessence Biosciences Inc |
METHOD AND COMPOSITIONS FOR THE TREATMENT OF CANCER
|
WO2008011165A2
(en)
|
2006-07-21 |
2008-01-24 |
Nektar Therapeutics Al, Corporation |
Polymeric reagents comprising a terminal vinylic group and conjugates formed therefrom
|
US20080248959A1
(en)
*
|
2006-07-21 |
2008-10-09 |
Neose Technologies, Inc. |
Glycosylation of peptides via o-linked glycosylation sequences
|
MX2009002460A
(es)
|
2006-09-08 |
2009-03-20 |
Ambrx Inc |
Arnt supresor hibrido para celulas de vertebrados.
|
EP2064333B1
(en)
|
2006-09-08 |
2014-02-26 |
Ambrx, Inc. |
Suppressor trna transcription in vertebrate cells
|
EP2615108B1
(en)
*
|
2006-09-08 |
2016-10-26 |
Ambrx, Inc. |
Modified human plasma polypeptide or fc scaffolds and thier uses
|
MX2009002857A
(es)
*
|
2006-09-15 |
2009-03-30 |
Enzon Pharmaceuticals Inc |
Enlazadores polimericos basados en lisina.
|
CA2662962A1
(en)
*
|
2006-09-15 |
2008-03-20 |
Enzon Pharmaceuticals, Inc. |
Polyalkylene oxides having hindered ester-based biodegradable linkers
|
CA2662978A1
(en)
*
|
2006-09-15 |
2008-03-20 |
Enzon Pharmaceuticals, Inc. |
Hindered ester-based biodegradable linkers for oligonucleotide delivery
|
US7985783B2
(en)
|
2006-09-21 |
2011-07-26 |
The Regents Of The University Of California |
Aldehyde tags, uses thereof in site-specific protein modification
|
JP2010505874A
(ja)
*
|
2006-10-03 |
2010-02-25 |
ノヴォ ノルディスク アー/エス |
ポリペプチドコンジュゲートの精製方法
|
RU2460543C2
(ru)
*
|
2006-10-04 |
2012-09-10 |
Ново Нордиск А/С |
Глицерин-связанные пэгилированные сахара и гликопептиды
|
US20080207487A1
(en)
*
|
2006-11-02 |
2008-08-28 |
Neose Technologies, Inc. |
Manufacturing process for the production of polypeptides expressed in insect cell-lines
|
AU2007325631B9
(en)
|
2006-11-30 |
2014-01-30 |
Nektar Therapeutics |
Method for preparing a polymer conjugate
|
MX2009007146A
(es)
*
|
2006-12-27 |
2009-07-09 |
Nektar Therapeutics Al Corp |
Conjugados porcion del factor ix-polimero que tienen ligadura que se puede liberar.
|
US8133865B2
(en)
*
|
2006-12-27 |
2012-03-13 |
Nektar Therapeutics |
von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage
|
ES2615454T3
(es)
|
2007-01-18 |
2017-06-07 |
Eli Lilly And Company |
Fab pegilado contra el amiloide beta
|
WO2008106485A2
(en)
|
2007-02-27 |
2008-09-04 |
Trustees Of Tufts College |
Tissue-engineered silk organs
|
DK2068909T3
(da)
|
2007-03-30 |
2012-08-06 |
Ambrx Inc |
Modificerede FGF-21-polypeptider og anvendelse heraf
|
NZ580030A
(en)
|
2007-04-03 |
2012-06-29 |
Biogenerix Ag |
Methods of treatment using glycopegylated g-csf
|
BRPI0810622A2
(pt)
|
2007-05-02 |
2020-10-13 |
Ambrx, Inc. |
polipeptídeos de interferon beta modificados e seus usos
|
US20090053167A1
(en)
*
|
2007-05-14 |
2009-02-26 |
Neose Technologies, Inc. |
C-, S- and N-glycosylation of peptides
|
DK2211876T3
(en)
|
2007-05-29 |
2015-01-12 |
Tufts College |
PROCESS FOR silk fibroin-GELATION USING sonication
|
EP2162535A4
(en)
*
|
2007-06-04 |
2011-02-23 |
Novo Nordisk As |
O-linked glycosylation using N-acetylglucosamine transferases
|
EP2170919B8
(en)
|
2007-06-12 |
2016-01-20 |
ratiopharm GmbH |
Improved process for the production of nucleotide sugars
|
AU2007357885A1
(en)
*
|
2007-08-20 |
2009-02-26 |
Enzon Pharmaceuticals, Inc. |
Polymeric linkers containing pyridyl disulfide moieties
|
JP2010536870A
(ja)
*
|
2007-08-21 |
2010-12-02 |
ジェンザイム・コーポレーション |
カリクレイン阻害剤を用いた治療
|
US8207112B2
(en)
*
|
2007-08-29 |
2012-06-26 |
Biogenerix Ag |
Liquid formulation of G-CSF conjugate
|
CA2702043A1
(en)
*
|
2007-10-08 |
2009-04-16 |
Quintessence Biosciences, Inc. |
Compositions and methods for ribonuclease-based therapies
|
CN101918026B
(zh)
|
2007-11-20 |
2016-03-02 |
Ambrx公司 |
经修饰胰岛素多肽和其用途
|
CA2711503A1
(en)
*
|
2008-01-08 |
2009-07-16 |
Biogenerix Ag |
Glycoconjugation of polypeptides using oligosaccharyltransferases
|
CA2712606A1
(en)
|
2008-02-08 |
2009-08-13 |
Ambrx, Inc. |
Modified leptin polypeptides and their uses
|
CA2715465C
(en)
|
2008-02-27 |
2017-03-21 |
Novo Nordisk A/S |
Conjugated factor viii molecules
|
TWI395593B
(zh)
|
2008-03-06 |
2013-05-11 |
Halozyme Inc |
可活化的基質降解酵素之活體內暫時性控制
|
US20100003238A1
(en)
|
2008-04-14 |
2010-01-07 |
Frost Gregory I |
Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions
|
TWI394580B
(zh)
|
2008-04-28 |
2013-05-01 |
Halozyme Inc |
超快起作用胰島素組成物
|
WO2009143412A2
(en)
*
|
2008-05-23 |
2009-11-26 |
Enzon Pharmaceuticals, Inc. |
Polymeric systems containing intracellular releasable disulfide linker for the delivery of oligonucleotides
|
BRPI0916515B8
(pt)
|
2008-07-23 |
2021-07-27 |
Ambrx Inc |
polipeptídeo de fator estimulante de colônias de granulócitos bovino (bg-csf), formulação farmacêutica e composição compreendendo o mesmo
|
WO2010014258A2
(en)
*
|
2008-08-01 |
2010-02-04 |
Nektar Therapeutics Al, Corporation |
Conjugates having a releasable linkage
|
CA2732508C
(en)
|
2008-08-11 |
2016-03-15 |
Nektar Therapeutics |
Multi-arm polymeric alkanoate conjugates
|
WO2010021718A1
(en)
|
2008-08-19 |
2010-02-25 |
Nektar Therapeutics |
Complexes of small-interfering nucleic acids
|
JP5766118B2
(ja)
|
2008-09-11 |
2015-08-19 |
ウェルズ ファーゴ バンク ナショナル アソシエイション |
ポリマー性アルファ−ヒドロキシアルデヒドおよびケトン反応剤ならびに抱合方法
|
US20110237524A1
(en)
*
|
2008-09-19 |
2011-09-29 |
Nektar Therapeutics |
Polymer conjugates of aod-like peptides
|
WO2010033207A1
(en)
*
|
2008-09-19 |
2010-03-25 |
Nektar Therapeutics |
Polymer conjugates of therapeutic peptides
|
EP2334333A1
(en)
*
|
2008-09-19 |
2011-06-22 |
Nektar Therapeutics |
Polymer conjugates of v681-like peptides
|
WO2010042145A1
(en)
*
|
2008-09-19 |
2010-04-15 |
Nektar Therapeutics |
Polymer conjugates of glp-2-like peptides
|
EP2334337A1
(en)
*
|
2008-09-19 |
2011-06-22 |
Nektar Therapeutics |
Polymer conjugates of opioid growth factor peptides
|
EP2340047A1
(en)
*
|
2008-09-19 |
2011-07-06 |
Nektar Therapeutics |
Polymer conjugates of kiss1 peptides
|
US20110165112A1
(en)
*
|
2008-09-19 |
2011-07-07 |
Nektar Therapeutics |
Polymer conjugates of c-peptides
|
EP2340045B1
(en)
|
2008-09-19 |
2017-04-12 |
Nektar Therapeutics |
Polymer conjugates of protegrin peptides
|
WO2010033222A2
(en)
*
|
2008-09-19 |
2010-03-25 |
Netkar Therapeutics |
Polymer conjugates of ziconotide peptides
|
WO2010033218A1
(en)
*
|
2008-09-19 |
2010-03-25 |
Nektar Therapeutics |
Polymer conjugates of osteocalcin peptides
|
WO2010033220A2
(en)
*
|
2008-09-19 |
2010-03-25 |
Nektar Therapeutics |
Modified therapeutics peptides, methods of their preparation and use
|
WO2010033216A1
(en)
*
|
2008-09-19 |
2010-03-25 |
Nektar Therapeutics |
Polymer conjugates of nesiritide peptides
|
WO2010033227A1
(en)
*
|
2008-09-19 |
2010-03-25 |
Nektar Therapeutics |
Polymer conjugates of thymosin alpha 1 peptides
|
UA106731C2
(uk)
|
2008-09-26 |
2014-10-10 |
Амбркс, Інк. |
Модифіковані поліпептиди еритропоетину тварин та їх застосування
|
PT2337846T
(pt)
|
2008-09-26 |
2018-04-05 |
Ambrx Inc |
Vacinas e microrganismos dependentes da replicação de aminoácidos não naturais
|
US8029782B2
(en)
|
2008-10-01 |
2011-10-04 |
Quintessence Biosciences, Inc. |
Therapeutic ribonucleases
|
CN102307993B
(zh)
|
2008-12-09 |
2014-06-25 |
哈洛齐梅公司 |
延长的可溶性ph20多肽及其用途
|
US7728175B1
(en)
*
|
2008-12-23 |
2010-06-01 |
E. I. Du Pont De Nemours And Company |
Linear amine functionalized poly(trimethylene ether) compositions
|
CN102307594A
(zh)
|
2009-01-06 |
2012-01-04 |
戴埃克斯有限公司 |
用激肽释放酶抑制剂治疗粘膜炎
|
GB0922354D0
(en)
|
2009-12-21 |
2010-02-03 |
Polytherics Ltd |
Novel polymer conjugates
|
US9005598B2
(en)
|
2009-03-04 |
2015-04-14 |
Polytherics Limited |
Conjugated proteins and peptides
|
US8013065B2
(en)
*
|
2009-06-09 |
2011-09-06 |
International Business Machines Corporation |
Methods for making multi-branched polymers
|
AU2010258752B2
(en)
|
2009-06-09 |
2015-07-09 |
Prolong Pharmaceuticals, LLC |
Hemoglobin compositions
|
KR101441768B1
(ko)
|
2009-09-17 |
2014-09-17 |
박스터 헬쓰케어 에스에이 |
히알루로니다아제 및 면역글로불린의 안정한 복합제제, 및 그 사용방법
|
WO2011035065A1
(en)
|
2009-09-17 |
2011-03-24 |
Nektar Therapeutics |
Monoconjugated chitosans as delivery agents for small interfering nucleic acids
|
CA2775706A1
(en)
|
2009-09-28 |
2011-03-31 |
Trustees Of Tufts College |
Drawn silk egel fibers and methods of making same
|
US20110081398A1
(en)
*
|
2009-10-01 |
2011-04-07 |
Tyco Healthcare Group Lp |
Multi-mechanism surgical compositions
|
US8968785B2
(en)
*
|
2009-10-02 |
2015-03-03 |
Covidien Lp |
Surgical compositions
|
US20110081701A1
(en)
*
|
2009-10-02 |
2011-04-07 |
Timothy Sargeant |
Surgical compositions
|
US8475652B2
(en)
*
|
2009-10-19 |
2013-07-02 |
Jan A. K. Paul |
Method for purification of uncatalyzed natural fuels from metal ions by means of at least one hemeprotein and use of the at least on hemeprotein
|
WO2011050938A1
(de)
|
2009-10-26 |
2011-05-05 |
Genovoxx Gmbh |
Konjugate von nukleotiden und methoden zu deren anwendung
|
CN107337734A
(zh)
|
2009-12-04 |
2017-11-10 |
弗·哈夫曼-拉罗切有限公司 |
多特异性抗体、抗体类似物、组合物和方法
|
NZ600363A
(en)
|
2009-12-21 |
2014-07-25 |
Ambrx Inc |
Modified porcine somatotropin polypeptides and their uses
|
CA2784793A1
(en)
|
2009-12-21 |
2011-07-21 |
Ambrx, Inc. |
Modified bovine somatotropin polypeptides and their uses
|
JO2976B1
(en)
|
2009-12-22 |
2016-03-15 |
ايلي ليلي اند كومباني |
Axentomodulin polypeptide
|
AR079344A1
(es)
|
2009-12-22 |
2012-01-18 |
Lilly Co Eli |
Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad
|
PT3459564T
(pt)
|
2010-01-06 |
2022-01-31 |
Takeda Pharmaceuticals Co |
Proteínas de ligação à calicreína plasmática
|
US8816099B2
(en)
|
2010-03-31 |
2014-08-26 |
Nof Corporation |
Polyfunctional polyoxyalkylene compound, and producing method and intermediate thereof
|
CN103119055A
(zh)
|
2010-05-17 |
2013-05-22 |
塞比克斯公司 |
聚乙二醇化c肽
|
US10040761B2
(en)
|
2010-06-25 |
2018-08-07 |
Nof Corporation |
Branched hetero polyethylene glycol and intermediate
|
KR20130125753A
(ko)
|
2010-07-20 |
2013-11-19 |
할로자임, 아이엔씨 |
항-히알루로난제 투여와 관련된 유해 부작용의 치료
|
PL2605789T3
(pl)
|
2010-08-17 |
2019-11-29 |
Ambrx Inc |
Zmodyfikowane polipeptydy relaksyny i ich zastosowania
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
AR083006A1
(es)
|
2010-09-23 |
2013-01-23 |
Lilly Co Eli |
Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas
|
JP5937092B2
(ja)
|
2010-10-19 |
2016-06-22 |
トラスティーズ オブ タフツ カレッジ |
シルクフィブロインベースのマイクロニードルおよびその製造方法
|
WO2012054822A1
(en)
|
2010-10-22 |
2012-04-26 |
Nektar Therapeutics |
Pharmacologically active polymer-glp-1 conjugates
|
WO2012054861A1
(en)
|
2010-10-22 |
2012-04-26 |
Nektar Therapeutics |
Glp-1 polymer conjugates having a releasable linkage
|
CA3144697A1
(en)
|
2010-11-12 |
2012-05-18 |
Nektar Therapeutics |
Conjugates of an il-2 moiety and a polymer
|
WO2012088422A1
(en)
|
2010-12-22 |
2012-06-28 |
Nektar Therapeutics |
Multi-arm polymeric prodrug conjugates of taxane-based compounds
|
WO2012088445A1
(en)
|
2010-12-22 |
2012-06-28 |
Nektar Therapeutics |
Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
|
KR102320178B1
(ko)
|
2011-01-06 |
2021-11-02 |
다케다 파머수티컬 컴패니 리미티드 |
혈장 칼리크레인 결합 단백질
|
US8440309B2
(en)
|
2011-01-31 |
2013-05-14 |
Confluent Surgical, Inc. |
Crosslinked polymers with the crosslinker as therapeutic for sustained release
|
WO2012109387A1
(en)
|
2011-02-08 |
2012-08-16 |
Halozyme, Inc. |
Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia
|
US10335519B2
(en)
|
2011-04-20 |
2019-07-02 |
Trustees Of Tufts College |
Dynamic silk coatings for implantable devices
|
AU2012271361B2
(en)
|
2011-06-17 |
2017-03-02 |
Halozyme, Inc. |
Continuous subcutaneous insulin infusion methods with a hyaluronan degrading enzyme
|
US20130011378A1
(en)
|
2011-06-17 |
2013-01-10 |
Tzung-Horng Yang |
Stable formulations of a hyaluronan-degrading enzyme
|
WO2013006706A1
(en)
|
2011-07-05 |
2013-01-10 |
Bioasis Technologies Inc. |
P97-antibody conjugates and methods of use
|
WO2013020079A2
(en)
|
2011-08-04 |
2013-02-07 |
Nektar Therapeutics |
Conjugates of an il-11 moiety and a polymer
|
US20130071394A1
(en)
|
2011-09-16 |
2013-03-21 |
John K. Troyer |
Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and methods of use
|
SG11201401797TA
(en)
|
2011-10-24 |
2014-09-26 |
Halozyme Inc |
Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof
|
ES2749620T3
(es)
|
2011-12-30 |
2020-03-23 |
Halozyme Inc |
Variantes de polipéptidos de PH20, formulaciones y usos de los mismos
|
DK2831237T3
(en)
|
2012-03-30 |
2018-03-05 |
Univ Oklahoma |
HIGH-MOLECULAR HEPAROSAN POLYMERS AND METHODS OF PRODUCING AND USING THEREOF
|
PT2833905T
(pt)
|
2012-04-04 |
2018-08-06 |
Halozyme Inc |
Terapia de combinação com hialuronidase e um taxano dirigido a tumor
|
SI2859017T1
(sl)
|
2012-06-08 |
2019-05-31 |
Sutro Biopharma, Inc. |
Protitelesa, ki vsebujejo specifične nenaravne aminokislinske ostanke, postopki njihove priprave in postopki njihove uporabe
|
US9732161B2
(en)
|
2012-06-26 |
2017-08-15 |
Sutro Biopharma, Inc. |
Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
|
ES2647082T3
(es)
|
2012-07-31 |
2017-12-19 |
Bioasis Technologies Inc |
Proteínas desfosforiladas de la enfermedad de depósito lisosómico y métodos de uso de las mismas
|
ES2907763T3
(es)
|
2012-08-31 |
2022-04-26 |
Sutro Biopharma Inc |
Aminoácidos modificados que comprenden un grupo azido
|
WO2014062856A1
(en)
|
2012-10-16 |
2014-04-24 |
Halozyme, Inc. |
Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
|
WO2014074218A1
(en)
|
2012-11-12 |
2014-05-15 |
Redwood Bioscience, Inc. |
Compounds and methods for producing a conjugate
|
US9310374B2
(en)
|
2012-11-16 |
2016-04-12 |
Redwood Bioscience, Inc. |
Hydrazinyl-indole compounds and methods for producing a conjugate
|
EP2920148B1
(en)
|
2012-11-16 |
2019-06-12 |
The Regents of the University of California |
Pictet-spengler ligation for protein chemical modification
|
JP6586412B2
(ja)
|
2013-03-13 |
2019-10-02 |
バイオアシス テクノロジーズ インコーポレイテッド |
p97のフラグメントおよびその使用
|
TW201534726A
(zh)
|
2013-07-03 |
2015-09-16 |
Halozyme Inc |
熱穩定ph20玻尿酸酶變異體及其用途
|
US9764039B2
(en)
|
2013-07-10 |
2017-09-19 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
WO2015031673A2
(en)
|
2013-08-28 |
2015-03-05 |
Bioasis Technologies Inc. |
Cns-targeted conjugates having modified fc regions and methods of use thereof
|
WO2015048355A1
(en)
|
2013-09-26 |
2015-04-02 |
Northwestern University |
Poly(ethylene glycol) cross-linking of soft materials to tailor viscoelastic properties for bioprinting
|
EP3055298B1
(en)
|
2013-10-11 |
2020-04-29 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
WO2015081282A1
(en)
|
2013-11-27 |
2015-06-04 |
Redwood Bioscience, Inc. |
Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
|
CN112043835B
(zh)
|
2013-12-06 |
2022-10-21 |
韩捷 |
用于含氮和羟基的药物的生物可逆引入基团
|
IL295414A
(en)
|
2014-03-27 |
2022-10-01 |
Takeda Pharmaceuticals Co |
Compositions and methods for treating macular edema as a result of diabetes
|
MA39711A
(fr)
|
2014-04-03 |
2015-10-08 |
Nektar Therapeutics |
Conjugués d'une fraction d'il-15 et d'un polymère
|
WO2015175774A1
(en)
|
2014-05-14 |
2015-11-19 |
Trustees Of Dartmouth College |
Deimmunized lysostaphin and methods of use
|
PT3186281T
(pt)
|
2014-08-28 |
2019-07-10 |
Halozyme Inc |
Terapia de combinação com uma enzima de degradação de hialuronano e um inibidor de pontos de verificação imunológica
|
CA3126536C
(en)
|
2014-10-14 |
2023-07-25 |
Halozyme, Inc. |
Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same
|
CN106794259B
(zh)
*
|
2014-10-14 |
2021-07-16 |
宝力泰锐克斯有限公司 |
采用包含含有peg部分的离去基团的试剂缀合肽或蛋白质的方法
|
US9434778B2
(en)
|
2014-10-24 |
2016-09-06 |
Bristol-Myers Squibb Company |
Modified FGF-21 polypeptides comprising an internal deletion and uses thereof
|
EP3220956B1
(en)
*
|
2014-10-24 |
2023-08-09 |
Abzena (UK) Limited |
Conjugates and conjugating reagents
|
US20160151511A1
(en)
|
2014-12-02 |
2016-06-02 |
Antriabio, Inc. |
Proteins and protein conjugates with increased hydrophobicity
|
US10098960B2
(en)
|
2015-04-03 |
2018-10-16 |
Ucl Business Plc |
Polymer conjugate
|
US10220075B2
(en)
|
2015-06-04 |
2019-03-05 |
Rezolute, Inc. |
Amine pegylation methods for the preparation of site-specific protein conjugates
|
US10335406B2
(en)
|
2015-10-01 |
2019-07-02 |
Elysium Therapeutics, Inc. |
Opioid compositions resistant to overdose and abuse
|
WO2017059459A1
(en)
|
2015-10-01 |
2017-04-06 |
Elysium Therapeutics, Inc. |
Polysubunit opioid prodrugs resistant to overdose and abuse
|
CN108291025A
(zh)
*
|
2015-12-03 |
2018-07-17 |
桑福德有限合伙人公司 |
基于噁唑啉的粘着剂调配物
|
US11286307B2
(en)
|
2015-12-11 |
2022-03-29 |
Takeda Pharmaceutical Company Limited |
Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
|
WO2018017923A1
(en)
|
2016-07-22 |
2018-01-25 |
Nektar Therapeutics |
Conjugates of a factor viii moiety having an oxime-containing linkage
|
WO2018031361A2
(en)
|
2016-08-09 |
2018-02-15 |
Eli Lilly And Company |
Combination therapy
|
US10266578B2
(en)
|
2017-02-08 |
2019-04-23 |
Bristol-Myers Squibb Company |
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
|
JP7234130B2
(ja)
|
2017-03-17 |
2023-03-07 |
エリージウム セラピューティクス, インコーポレイテッド |
過剰摂取および乱用に対して抵抗性のポリサブユニットオピオイドプロドラッグ
|
CN111107870A
(zh)
|
2017-06-22 |
2020-05-05 |
催化剂生物科学公司 |
经修饰的膜型丝氨酸蛋白酶1(mtsp-1)多肽及其使用方法
|
EP3688007A1
(en)
|
2017-09-27 |
2020-08-05 |
The University of York |
Bioconjugation of polypeptides
|
CN111094462A
(zh)
|
2017-12-26 |
2020-05-01 |
贝克顿·迪金森公司 |
深紫外线可激发的水溶剂化聚合物染料
|
EP3775261A4
(en)
|
2018-03-26 |
2021-11-24 |
Rootpath Genomics, Inc. |
COMPOSITIONS OF TARGET UNITS AND METHODS OF USE
|
JP2021519841A
(ja)
|
2018-03-30 |
2021-08-12 |
ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company |
ペンダントクロモフォアを有する水溶性ポリマー色素
|
US20190351031A1
(en)
|
2018-05-16 |
2019-11-21 |
Halozyme, Inc. |
Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
|
EP3813867A1
(en)
|
2018-07-22 |
2021-05-05 |
Bioasis Technologies Inc. |
Treatment of lymmphatic metastases
|
CN111212661B
(zh)
|
2018-09-11 |
2023-09-12 |
北京泰德制药股份有限公司 |
白介素-2多肽偶联物及其用途
|
AU2019361206A1
(en)
|
2018-10-19 |
2021-06-03 |
Ambrx, Inc. |
Interleukin-10 polypeptide conjugates, dimers thereof, and their uses
|
JP2022516725A
(ja)
|
2018-12-28 |
2022-03-02 |
カタリスト・バイオサイエンシーズ・インコーポレイテッド |
改変ウロキナーゼ型プラスミノゲンアクティベータポリペプチドおよび使用方法
|
US11613744B2
(en)
|
2018-12-28 |
2023-03-28 |
Vertex Pharmaceuticals Incorporated |
Modified urokinase-type plasminogen activator polypeptides and methods of use
|
CA3125320A1
(en)
|
2019-01-28 |
2020-08-06 |
Toray Industries, Inc. |
Polyethylene glycol-modified form of hepatocyte growth factor or active fragment thereof
|
US20220226488A1
(en)
|
2019-02-12 |
2022-07-21 |
Ambrx, Inc. |
Compositions containing, methods and uses of antibody-tlr agonist conjugates
|
KR20240046306A
(ko)
|
2020-01-14 |
2024-04-08 |
신테카인, 인크. |
편향된 il2 뮤테인 방법 및 조성물
|
IL296099A
(en)
|
2020-03-11 |
2022-11-01 |
Ambrx Inc |
Interleukin-2 polypeptide conjugates and methods of using them
|
KR20230004682A
(ko)
|
2020-04-22 |
2023-01-06 |
머크 샤프 앤드 돔 엘엘씨 |
인터류킨-2 수용체 베타 감마c 이량체에 대해 편향되고 비펩티드성 수용성 중합체에 접합된 인간 인터류킨-2 접합체
|
US20210355468A1
(en)
|
2020-05-18 |
2021-11-18 |
Bioasis Technologies, Inc. |
Compositions and methods for treating lewy body dementia
|
US20210393787A1
(en)
|
2020-06-17 |
2021-12-23 |
Bioasis Technologies, Inc. |
Compositions and methods for treating frontotemporal dementia
|
US11739166B2
(en)
|
2020-07-02 |
2023-08-29 |
Davol Inc. |
Reactive polysaccharide-based hemostatic agent
|
AU2021327396A1
(en)
|
2020-08-20 |
2023-03-23 |
Ambrx, Inc. |
Antibody-TLR agonist conjugates, methods and uses thereof
|
IL307282A
(en)
|
2021-04-03 |
2023-11-01 |
Ambrx Inc |
Antidote conjugates against HER2 and their applications
|
EP4155349A1
(en)
|
2021-09-24 |
2023-03-29 |
Becton, Dickinson and Company |
Water-soluble yellow green absorbing dyes
|
WO2024007016A2
(en)
|
2022-07-01 |
2024-01-04 |
Beckman Coulter, Inc. |
Novel fluorescent dyes and polymers from dihydrophenanthrene derivatives
|
WO2024044327A1
(en)
|
2022-08-26 |
2024-02-29 |
Beckman Coulter, Inc. |
Dhnt monomers and polymer dyes with modified photophysical properties
|