DK140597B - Analogifremgangsmåde til fremstilling af phthalidester af 6-(D(-) alfa-aminophenylacetamido) penicillansyre eller syreadditionssalte deraf. - Google Patents

Analogifremgangsmåde til fremstilling af phthalidester af 6-(D(-) alfa-aminophenylacetamido) penicillansyre eller syreadditionssalte deraf.

Info

Publication number
DK140597B
DK140597B DK286572AA DK286572A DK140597B DK 140597 B DK140597 B DK 140597B DK 286572A A DK286572A A DK 286572AA DK 286572 A DK286572 A DK 286572A DK 140597 B DK140597 B DK 140597B
Authority
DK
Denmark
Prior art keywords
aminophenylacetamido
alpha
preparation
acid
addition salts
Prior art date
Application number
DK286572AA
Other languages
Danish (da)
English (en)
Other versions
DK140597C (de
Inventor
Harry Ferres
John Peter Clayton
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Priority to DK128178A priority Critical patent/DK143803C/da
Publication of DK140597B publication Critical patent/DK140597B/da
Application granted granted Critical
Publication of DK140597C publication Critical patent/DK140597C/da
Priority to DK137580A priority patent/DK137580A/da
Priority to DK137680A priority patent/DK137680A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/31—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation of cyclic compounds with ring-splitting
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
DK286572AA 1971-06-09 1972-06-08 Analogifremgangsmåde til fremstilling af phthalidester af 6-(D(-) alfa-aminophenylacetamido) penicillansyre eller syreadditionssalte deraf. DK140597B (da)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DK128178A DK143803C (da) 1971-06-09 1978-03-21 6-aminopenicillansyrederivat til anvendelse som mellemproduktved fremstilling af phthalidester af 6-(d(-)alfa-aminophenylacetamido)penicillansyre eller syreadditionssalte deraf
DK137580A DK137580A (da) 1971-06-09 1980-03-28 6-aminopenicillansyrederivater til anvendelse som mellemprodukter ved fremstilling af phthalidester af 6-(d(-)alfa-aminophenylacetamido)-penicillansyre eller syreadditionssalte deraf
DK137680A DK137680A (da) 1971-06-09 1980-03-28 6-aminopenicillansyrederivater til anvendelse som mellemprodukter ved fremstilling af phthalidester af 6-(d(-)alfa-aminophenylacetamido)-penicillansyre eller syreadditionssalte deraf

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1960471A GB1364672A (en) 1971-06-09 1971-06-09 Penicillins

Publications (2)

Publication Number Publication Date
DK140597B true DK140597B (da) 1979-10-08
DK140597C DK140597C (de) 1980-02-25

Family

ID=10132139

Family Applications (1)

Application Number Title Priority Date Filing Date
DK286572AA DK140597B (da) 1971-06-09 1972-06-08 Analogifremgangsmåde til fremstilling af phthalidester af 6-(D(-) alfa-aminophenylacetamido) penicillansyre eller syreadditionssalte deraf.

Country Status (33)

Country Link
US (7) US3860579A (de)
JP (8) JPS5235678B1 (de)
AR (2) AR192944A1 (de)
AT (4) AT320155B (de)
AU (2) AU463395B2 (de)
BE (2) BE784699A (de)
CA (3) CA1126258A (de)
CH (4) CH587267A5 (de)
CS (1) CS198111B2 (de)
CY (1) CY861A (de)
DD (1) DD99802A5 (de)
DE (2) DE2228012C3 (de)
DK (1) DK140597B (de)
ES (4) ES403672A1 (de)
FI (1) FI58642C (de)
FR (3) FR2140616B1 (de)
GB (1) GB1364672A (de)
HK (1) HK71676A (de)
HU (1) HU166360B (de)
IE (3) IE37758B1 (de)
IL (3) IL47578A (de)
IS (1) IS923B6 (de)
KE (2) KE2632A (de)
MY (2) MY7600196A (de)
NL (2) NL178006C (de)
NO (1) NO144169C (de)
OA (1) OA04101A (de)
PL (2) PL96668B1 (de)
SE (7) SE390415B (de)
SU (2) SU507244A3 (de)
YU (2) YU36029B (de)
ZA (2) ZA723799B (de)
ZM (1) ZM9172A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1377661A (en) * 1971-06-05 1974-12-18 Yamanouchi Pharma Co Ltd Oxofuryl ester derivatives of penicillin and cephalosporin
GB1364672A (en) * 1971-06-09 1974-08-29 Beecham Group Ltd Penicillins
GB1450043A (en) * 1972-09-08 1976-09-22 Beecham Group Ltd Penicillins
US4107433A (en) * 1974-02-21 1978-08-15 Beecham Group Limited Phthalidyl ester of 3-carbomoyloxy cephalosporin derivatives
US4115646A (en) * 1975-02-22 1978-09-19 Beecham Group Limited Process for preparing 7-aminocephalosporanic acid derivatives
GB1565656A (en) * 1975-12-13 1980-04-23 Beecham Group Ltd Preparation of substituted penicillin acid esters
NZ189945A (en) * 1978-04-01 1981-04-24 Beecham Group Ltd Ampicillin phthalidyl ester naphthalene 2-sulphonate also pharmaceutical compositions
US4206218A (en) * 1978-08-31 1980-06-03 E. R. Squibb & Sons, Inc. Phthalidyl esters of the acetone adduct of epicillin
EP0014651B1 (de) * 1979-02-05 1982-08-04 Sanofi S.A. Talampicillin 2-Methoxyphenoxyacetat, Verfahren zu seiner Herstellung und es enthaltende Arzneimittel
DE3001590A1 (de) * 1980-01-11 1981-07-23 E.R. Squibb & Sons, Inc., 08540 Princeton, N.J. Phthalidylester des aceton-addukts von epicillin und diese verbindungen enthaltende arzneimittel
US4340539A (en) * 1980-01-21 1982-07-20 Bristol-Myers Company Derivatives of 6-bromo penicillanic acid
IT1130969B (it) * 1980-03-14 1986-06-18 Dob Far Spa Esteri della cefapirina,loro sali e procedimento per il loro ottenimento
CA1212105A (en) 1980-04-30 1986-09-30 Shoji Ikeda Ampicillin esters and production thereof
IT1190897B (it) * 1982-06-29 1988-02-24 Opos Biochimica Srl Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico
GB2157284B (en) * 1984-04-11 1987-11-04 Leo Pharm Prod Ltd 6-b-halopenicillanic acid salts
IT1180207B (it) * 1984-07-30 1987-09-23 Istituto Biochimico Italiano Procedimento per la preparazione, con resa e purezza elevate, di antibiotici beta-lattamici
US4675210A (en) * 1984-10-10 1987-06-23 Hercules Incorporated Maleic modified butene copolymers for adhering polypropylene
JPH01148353A (ja) * 1987-12-02 1989-06-09 Sadami Ujima 遠心脱水機
US5695473A (en) * 1994-07-27 1997-12-09 Sims Deltec, Inc. Occlusion detection system for an infusion pump
US7232924B2 (en) * 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
AU2002310409C1 (en) 2001-06-11 2008-04-17 Xenoport, Inc. Orally administered dosage forms of GABA analog prodrugs having reduced toxicity
US8048917B2 (en) * 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) * 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
KR20110097942A (ko) * 2003-08-20 2011-08-31 제노포트 인코포레이티드 아실옥시알킬 카르바메이트 프로드러그, 합성 및 사용 방법
EP2354120A1 (de) 2003-08-20 2011-08-10 XenoPort, Inc. Synthese von Acyloxyalkylcarbamat-Prodrugs und Zwischenprodukten davon
MX2007005306A (es) 2004-11-04 2007-06-11 Xenoport Inc Formas de dosis oral de liberacion sostenida de la prodroga gabapentina.
CA2612292C (en) 2005-06-20 2013-09-03 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use
WO2011028234A1 (en) * 2009-09-04 2011-03-10 Xenoport, Inc. Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid
WO2011091164A1 (en) * 2010-01-22 2011-07-28 Xenoport, Inc. Oral dosage forms having a high loading of a tranexamic acid prodrug

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985648A (en) * 1958-10-06 1961-05-23 Doyle Frank Peter Alpha-aminobenzylpenicillins
US3652546A (en) * 1965-07-22 1972-03-28 Bristol Myers Co Esters of 6-aminopenicillanic acid
GB1175590A (en) * 1967-08-09 1969-12-23 Beecham Group Ltd Therapeutic Compositions
US3697507A (en) * 1968-09-26 1972-10-10 Leo Pharm Prod Ltd Esters of {60 -aminobenzylpenicillin
FR2020209A1 (en) * 1968-10-09 1970-07-10 Sarath Antibiotic acylxymethyl 7-(alpha-amino-alpha-phenyl- - acetamido)-3-methyl-delta-3-cephem-4-carboxylates
GB1234426A (de) * 1968-10-23 1971-06-03
IE34019B1 (en) * 1969-03-18 1975-01-08 Leo Pharm Prod Ltd New semi-synthetic penicillin esters
BE754141A (fr) * 1969-08-04 1971-02-01 Pfizer Esters d'alpha-carboxyarylmethyl penicillines
BE758782A (fr) * 1969-11-11 1971-05-10 Leo Pharm Prod Ltd Nouveaux derives d'acide 6-amidino penicillanique leur procede de preparation et leurs applications comme antibiotiques
US3726861A (en) * 1971-06-03 1973-04-10 American Home Prod Ureido derivatives of 6-aminopenicillanic acid saccharimide
GB1377661A (en) * 1971-06-05 1974-12-18 Yamanouchi Pharma Co Ltd Oxofuryl ester derivatives of penicillin and cephalosporin
GB1364672A (en) * 1971-06-09 1974-08-29 Beecham Group Ltd Penicillins

Also Published As

Publication number Publication date
JPS5235678B1 (de) 1977-09-10
BE784699A (fr) 1972-12-11
SE7600561L (sv) 1976-01-20
US3963702A (en) 1976-06-15
NL7207820A (de) 1972-12-12
DE2228255C2 (de) 1983-12-08
US4036829A (en) 1977-07-19
FI58642C (fi) 1981-03-10
FR2299857A1 (fr) 1976-09-03
US3919196A (en) 1975-11-11
US3860579A (en) 1975-01-14
JPS5253887A (en) 1977-04-30
JPS5253889A (en) 1977-04-30
SE390415B (sv) 1976-12-20
JPS6021594B2 (ja) 1985-05-28
AU463395B2 (en) 1975-07-24
FI58642B (fi) 1980-11-28
MY7600196A (en) 1976-12-31
DE2228012B2 (de) 1979-05-23
IE36461L (en) 1972-12-09
SE7809237L (sv) 1978-09-01
IL39771A (en) 1975-12-31
YU36377B (en) 1983-06-30
AU476038B2 (en) 1976-09-09
IE36461B1 (en) 1976-11-10
CY861A (en) 1976-12-17
KE2632A (en) 1976-06-11
AT317427B (de) 1974-08-26
JPS5253886A (en) 1977-04-30
BE784698A (fr) 1972-12-11
ZA723799B (en) 1973-03-28
SU507244A3 (ru) 1976-03-15
IL39772A (en) 1977-03-31
HK71676A (en) 1976-11-26
CA1131620A (en) 1982-09-14
FR2299857B1 (de) 1978-11-17
FR2140617B1 (de) 1976-07-02
AT318147B (de) 1974-09-25
JPS6021593B2 (ja) 1985-05-28
NL7207626A (de) 1972-12-12
SU578887A3 (ru) 1977-10-30
CH587265A5 (de) 1977-04-29
AT320155B (de) 1975-01-27
JPS5659780A (en) 1981-05-23
NO144169B (no) 1981-03-30
NL178006B (nl) 1985-08-01
IL47578A (en) 1975-12-31
GB1364672A (en) 1974-08-29
SE7809236L (sv) 1978-09-01
DK140597C (de) 1980-02-25
YU36029B (en) 1981-11-13
CH577514A5 (de) 1976-07-15
IE37757L (en) 1972-12-09
FR2140617A1 (de) 1973-01-19
DE2228012C3 (de) 1980-01-17
OA04101A (fr) 1979-11-15
ES431086A1 (es) 1976-11-01
JPS5659779A (en) 1981-05-23
SE433939B (sv) 1984-06-25
HU166360B (de) 1975-03-28
SE430605B (sv) 1983-11-28
DE2228255A1 (de) 1972-12-28
IS923B6 (is) 1976-03-30
SE433938B (sv) 1984-06-25
ES403667A1 (es) 1976-01-01
IE37758B1 (en) 1977-10-12
SE432102B (sv) 1984-03-19
CS198111B2 (en) 1980-05-30
DD99802A5 (de) 1973-08-20
IL39772A0 (en) 1972-08-30
ZA723800B (en) 1973-03-28
PL87735B1 (en) 1976-07-31
ES403672A1 (es) 1975-07-01
ZM9172A1 (en) 1973-01-22
NO144169C (no) 1981-07-08
JPS602310B1 (de) 1985-01-21
YU153772A (en) 1981-04-30
SE430606B (sv) 1983-11-28
AT318806B (de) 1974-11-25
USRE29650E (en) 1978-05-30
YU186679A (en) 1981-11-13
DE2228012A1 (de) 1972-12-28
CH587267A5 (de) 1977-04-29
AU4331472A (en) 1973-12-13
PL96668B1 (pl) 1978-01-31
MY7600195A (en) 1976-12-31
SE7809241L (sv) 1978-09-01
US3963704A (en) 1976-06-15
JPS5253888A (en) 1977-04-30
FR2140616A1 (de) 1973-01-19
SE7600562L (sv) 1976-01-20
AU4331372A (en) 1973-12-13
AR193581A1 (es) 1973-04-30
AR192944A1 (es) 1973-03-21
NL178006C (nl) 1986-01-02
IS2078A7 (is) 1972-12-10
FR2140616B1 (de) 1976-08-20
US3939180A (en) 1976-02-17
CA1126260A (en) 1982-06-22
KE2631A (en) 1976-06-11
IE37757B1 (en) 1977-10-12
CA1126258A (en) 1982-06-22
CH605986A5 (de) 1978-10-13
IL39771A0 (en) 1972-08-30
ES431087A1 (es) 1976-11-01

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