YU36377B - Process for obtaining the phthalide ester of 6-(d(-)-aminophenylacetamido)penicillanic acid - Google Patents

Process for obtaining the phthalide ester of 6-(d(-)-aminophenylacetamido)penicillanic acid

Info

Publication number
YU36377B
YU36377B YU01866/79A YU186679A YU36377B YU 36377 B YU36377 B YU 36377B YU 01866/79 A YU01866/79 A YU 01866/79A YU 186679 A YU186679 A YU 186679A YU 36377 B YU36377 B YU 36377B
Authority
YU
Yugoslavia
Prior art keywords
aminophenylacetamido
obtaining
penicillanic acid
phthalide ester
phthalide
Prior art date
Application number
YU01866/79A
Other languages
English (en)
Other versions
YU186679A (en
Inventor
Ferres Harry
Harry Ferres
Clayton Peter
Peter Clayton
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of YU186679A publication Critical patent/YU186679A/xx
Publication of YU36377B publication Critical patent/YU36377B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/31—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation of cyclic compounds with ring-splitting
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
YU01866/79A 1971-06-09 1979-07-31 Process for obtaining the phthalide ester of 6-(d(-)-aminophenylacetamido)penicillanic acid YU36377B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1960471A GB1364672A (en) 1971-06-09 1971-06-09 Penicillins

Publications (2)

Publication Number Publication Date
YU186679A YU186679A (en) 1981-11-13
YU36377B true YU36377B (en) 1983-06-30

Family

ID=10132139

Family Applications (2)

Application Number Title Priority Date Filing Date
YU1537/72A YU36029B (en) 1971-06-09 1972-06-08 Process for obtaining 6-(d(-)-alfa-aminophenylacetamido) penicillanic acid phthalide ester
YU01866/79A YU36377B (en) 1971-06-09 1979-07-31 Process for obtaining the phthalide ester of 6-(d(-)-aminophenylacetamido)penicillanic acid

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU1537/72A YU36029B (en) 1971-06-09 1972-06-08 Process for obtaining 6-(d(-)-alfa-aminophenylacetamido) penicillanic acid phthalide ester

Country Status (33)

Country Link
US (7) US3860579A (xx)
JP (8) JPS602310B1 (xx)
AR (2) AR192944A1 (xx)
AT (4) AT320155B (xx)
AU (2) AU463395B2 (xx)
BE (2) BE784699A (xx)
CA (3) CA1126260A (xx)
CH (4) CH577514A5 (xx)
CS (1) CS198111B2 (xx)
CY (1) CY861A (xx)
DD (1) DD99802A5 (xx)
DE (2) DE2228012C3 (xx)
DK (1) DK140597B (xx)
ES (4) ES403672A1 (xx)
FI (1) FI58642C (xx)
FR (3) FR2140616B1 (xx)
GB (1) GB1364672A (xx)
HK (1) HK71676A (xx)
HU (1) HU166360B (xx)
IE (3) IE37757B1 (xx)
IL (3) IL39772A (xx)
IS (1) IS923B6 (xx)
KE (2) KE2632A (xx)
MY (2) MY7600196A (xx)
NL (2) NL178006C (xx)
NO (1) NO144169C (xx)
OA (1) OA04101A (xx)
PL (2) PL87735B1 (xx)
SE (7) SE390415B (xx)
SU (2) SU507244A3 (xx)
YU (2) YU36029B (xx)
ZA (2) ZA723800B (xx)
ZM (1) ZM9172A1 (xx)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1377661A (en) * 1971-06-05 1974-12-18 Yamanouchi Pharma Co Ltd Oxofuryl ester derivatives of penicillin and cephalosporin
GB1364672A (en) * 1971-06-09 1974-08-29 Beecham Group Ltd Penicillins
GB1450043A (en) * 1972-09-08 1976-09-22 Beecham Group Ltd Penicillins
US4107433A (en) * 1974-02-21 1978-08-15 Beecham Group Limited Phthalidyl ester of 3-carbomoyloxy cephalosporin derivatives
US4115646A (en) * 1975-02-22 1978-09-19 Beecham Group Limited Process for preparing 7-aminocephalosporanic acid derivatives
GB1565656A (en) * 1975-12-13 1980-04-23 Beecham Group Ltd Preparation of substituted penicillin acid esters
NZ189945A (en) * 1978-04-01 1981-04-24 Beecham Group Ltd Ampicillin phthalidyl ester naphthalene 2-sulphonate also pharmaceutical compositions
US4206218A (en) * 1978-08-31 1980-06-03 E. R. Squibb & Sons, Inc. Phthalidyl esters of the acetone adduct of epicillin
EP0014651B1 (fr) * 1979-02-05 1982-08-04 Sanofi S.A. 2-Méthoxyphénoxyacétate de talampicilline, procédé pour sa préparation et médicaments le renfermant
DE3001590A1 (de) * 1980-01-11 1981-07-23 E.R. Squibb & Sons, Inc., 08540 Princeton, N.J. Phthalidylester des aceton-addukts von epicillin und diese verbindungen enthaltende arzneimittel
US4340539A (en) * 1980-01-21 1982-07-20 Bristol-Myers Company Derivatives of 6-bromo penicillanic acid
IT1130969B (it) * 1980-03-14 1986-06-18 Dob Far Spa Esteri della cefapirina,loro sali e procedimento per il loro ottenimento
CA1212105A (en) 1980-04-30 1986-09-30 Shoji Ikeda Ampicillin esters and production thereof
IT1190897B (it) * 1982-06-29 1988-02-24 Opos Biochimica Srl Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico
GB2157284B (en) * 1984-04-11 1987-11-04 Leo Pharm Prod Ltd 6-b-halopenicillanic acid salts
IT1180207B (it) * 1984-07-30 1987-09-23 Istituto Biochimico Italiano Procedimento per la preparazione, con resa e purezza elevate, di antibiotici beta-lattamici
US4675210A (en) * 1984-10-10 1987-06-23 Hercules Incorporated Maleic modified butene copolymers for adhering polypropylene
JPH01148353A (ja) * 1987-12-02 1989-06-09 Sadami Ujima 遠心脱水機
US5695473A (en) * 1994-07-27 1997-12-09 Sims Deltec, Inc. Occlusion detection system for an infusion pump
CA2449673A1 (en) 2001-06-11 2002-12-19 Xenoport, Inc. Orally administered dosage forms of gaba analog prodrugs having reduced toxicity
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) * 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) * 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US6818787B2 (en) * 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7109239B2 (en) * 2003-08-20 2006-09-19 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
EP2354120A1 (en) 2003-08-20 2011-08-10 XenoPort, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
MX2007005306A (es) * 2004-11-04 2007-06-11 Xenoport Inc Formas de dosis oral de liberacion sostenida de la prodroga gabapentina.
KR20080022203A (ko) 2005-06-20 2008-03-10 제노포트 인코포레이티드 트라넥삼산의 아실옥시알킬 카르바메이트 프로드러그, 합성방법 및 용도
US20110060040A1 (en) * 2009-09-04 2011-03-10 Xenoport, Inc. Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid
US20110184060A1 (en) * 2010-01-22 2011-07-28 Xenoport, Inc. Oral dosage forms having a high loading of a tranexamic acid prodrug

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985648A (en) * 1958-10-06 1961-05-23 Doyle Frank Peter Alpha-aminobenzylpenicillins
US3652546A (en) * 1965-07-22 1972-03-28 Bristol Myers Co Esters of 6-aminopenicillanic acid
GB1175590A (en) * 1967-08-09 1969-12-23 Beecham Group Ltd Therapeutic Compositions
US3697507A (en) * 1968-09-26 1972-10-10 Leo Pharm Prod Ltd Esters of {60 -aminobenzylpenicillin
FR2020209A1 (en) * 1968-10-09 1970-07-10 Sarath Antibiotic acylxymethyl 7-(alpha-amino-alpha-phenyl- - acetamido)-3-methyl-delta-3-cephem-4-carboxylates
GB1234426A (xx) * 1968-10-23 1971-06-03
IE34019B1 (en) * 1969-03-18 1975-01-08 Leo Pharm Prod Ltd New semi-synthetic penicillin esters
BE754141A (fr) * 1969-08-04 1971-02-01 Pfizer Esters d'alpha-carboxyarylmethyl penicillines
BE758782A (fr) * 1969-11-11 1971-05-10 Leo Pharm Prod Ltd Nouveaux derives d'acide 6-amidino penicillanique leur procede de preparation et leurs applications comme antibiotiques
US3726861A (en) * 1971-06-03 1973-04-10 American Home Prod Ureido derivatives of 6-aminopenicillanic acid saccharimide
GB1377661A (en) * 1971-06-05 1974-12-18 Yamanouchi Pharma Co Ltd Oxofuryl ester derivatives of penicillin and cephalosporin
GB1364672A (en) * 1971-06-09 1974-08-29 Beecham Group Ltd Penicillins

Also Published As

Publication number Publication date
IE37757B1 (en) 1977-10-12
DK140597C (xx) 1980-02-25
SE7809237L (sv) 1978-09-01
ES431087A1 (es) 1976-11-01
JPS6021593B2 (ja) 1985-05-28
AR193581A1 (es) 1973-04-30
CY861A (en) 1976-12-17
CA1126258A (en) 1982-06-22
DD99802A5 (xx) 1973-08-20
AR192944A1 (es) 1973-03-21
NL7207820A (xx) 1972-12-12
JPS6021594B2 (ja) 1985-05-28
KE2631A (en) 1976-06-11
DE2228012A1 (de) 1972-12-28
CH587267A5 (xx) 1977-04-29
MY7600196A (en) 1976-12-31
AU4331372A (en) 1973-12-13
NL178006C (nl) 1986-01-02
NO144169C (no) 1981-07-08
BE784699A (fr) 1972-12-11
IE36461B1 (en) 1976-11-10
SE430605B (sv) 1983-11-28
FR2140617B1 (xx) 1976-07-02
JPS602310B1 (xx) 1985-01-21
ZA723800B (en) 1973-03-28
SE432102B (sv) 1984-03-19
KE2632A (en) 1976-06-11
DE2228255A1 (de) 1972-12-28
US3939180A (en) 1976-02-17
FR2140617A1 (xx) 1973-01-19
YU36029B (en) 1981-11-13
AU476038B2 (en) 1976-09-09
JPS5235678B1 (xx) 1977-09-10
SE390415B (sv) 1976-12-20
CS198111B2 (en) 1980-05-30
AT318806B (de) 1974-11-25
DE2228012B2 (de) 1979-05-23
DE2228012C3 (de) 1980-01-17
AU4331472A (en) 1973-12-13
JPS5253887A (en) 1977-04-30
FR2140616A1 (xx) 1973-01-19
USRE29650E (en) 1978-05-30
PL87735B1 (en) 1976-07-31
ZM9172A1 (en) 1973-01-22
MY7600195A (en) 1976-12-31
US3860579A (en) 1975-01-14
HU166360B (xx) 1975-03-28
IE37757L (en) 1972-12-09
IL39772A (en) 1977-03-31
AT318147B (de) 1974-09-25
FI58642B (fi) 1980-11-28
OA04101A (fr) 1979-11-15
CH577514A5 (xx) 1976-07-15
US4036829A (en) 1977-07-19
IL39771A (en) 1975-12-31
IL39771A0 (en) 1972-08-30
HK71676A (en) 1976-11-26
IL39772A0 (en) 1972-08-30
CA1131620A (en) 1982-09-14
IE37758B1 (en) 1977-10-12
DE2228255C2 (de) 1983-12-08
US3919196A (en) 1975-11-11
ZA723799B (en) 1973-03-28
AU463395B2 (en) 1975-07-24
NL178006B (nl) 1985-08-01
JPS5659779A (en) 1981-05-23
IE36461L (en) 1972-12-09
FR2299857B1 (xx) 1978-11-17
SE7809236L (sv) 1978-09-01
NO144169B (no) 1981-03-30
AT317427B (de) 1974-08-26
CH587265A5 (xx) 1977-04-29
ES403672A1 (es) 1975-07-01
YU153772A (en) 1981-04-30
ES403667A1 (es) 1976-01-01
SE433938B (sv) 1984-06-25
SE7600561L (sv) 1976-01-20
BE784698A (fr) 1972-12-11
JPS5253888A (en) 1977-04-30
SE430606B (sv) 1983-11-28
IL47578A (en) 1975-12-31
SU578887A3 (ru) 1977-10-30
AT320155B (de) 1975-01-27
JPS5659780A (en) 1981-05-23
SE7600562L (sv) 1976-01-20
NL7207626A (xx) 1972-12-12
JPS5253889A (en) 1977-04-30
PL96668B1 (pl) 1978-01-31
IS2078A7 (is) 1972-12-10
US3963702A (en) 1976-06-15
CA1126260A (en) 1982-06-22
YU186679A (en) 1981-11-13
JPS5253886A (en) 1977-04-30
SU507244A3 (ru) 1976-03-15
IS923B6 (is) 1976-03-30
GB1364672A (en) 1974-08-29
SE433939B (sv) 1984-06-25
CH605986A5 (xx) 1978-10-13
ES431086A1 (es) 1976-11-01
FI58642C (fi) 1981-03-10
FR2140616B1 (xx) 1976-08-20
DK140597B (da) 1979-10-08
SE7809241L (sv) 1978-09-01
US3963704A (en) 1976-06-15
FR2299857A1 (fr) 1976-09-03

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