ATE469880T1 - Acyloxyalkylcarbamat-prodrugs von tranexansäure und anwendung - Google Patents

Acyloxyalkylcarbamat-prodrugs von tranexansäure und anwendung

Info

Publication number
ATE469880T1
ATE469880T1 AT06785134T AT06785134T ATE469880T1 AT E469880 T1 ATE469880 T1 AT E469880T1 AT 06785134 T AT06785134 T AT 06785134T AT 06785134 T AT06785134 T AT 06785134T AT E469880 T1 ATE469880 T1 AT E469880T1
Authority
AT
Austria
Prior art keywords
prodrugs
aminomethyl
trans
pharmaceutical compositions
acyloxyalkylcarbamat
Prior art date
Application number
AT06785134T
Other languages
English (en)
Inventor
Bernd Jandeleit
Yunxiao Li
Noa Zerangue
Mark Gallop
Original Assignee
Xenoport Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenoport Inc filed Critical Xenoport Inc
Application granted granted Critical
Publication of ATE469880T1 publication Critical patent/ATE469880T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AT06785134T 2005-06-20 2006-06-20 Acyloxyalkylcarbamat-prodrugs von tranexansäure und anwendung ATE469880T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69262505P 2005-06-20 2005-06-20
PCT/US2006/023873 WO2007002013A2 (en) 2005-06-20 2006-06-20 Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use

Publications (1)

Publication Number Publication Date
ATE469880T1 true ATE469880T1 (de) 2010-06-15

Family

ID=37460256

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06785134T ATE469880T1 (de) 2005-06-20 2006-06-20 Acyloxyalkylcarbamat-prodrugs von tranexansäure und anwendung

Country Status (15)

Country Link
US (4) US7351740B2 (de)
EP (1) EP1919859B1 (de)
JP (1) JP4938771B2 (de)
KR (1) KR20080022203A (de)
CN (1) CN101253148B (de)
AT (1) ATE469880T1 (de)
AU (1) AU2006262386B2 (de)
CA (1) CA2612292C (de)
DE (1) DE602006014694D1 (de)
ES (1) ES2345784T3 (de)
IL (1) IL188172A (de)
NO (1) NO20076508L (de)
NZ (1) NZ564468A (de)
WO (1) WO2007002013A2 (de)
ZA (1) ZA200800311B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050025825A1 (en) * 2003-07-31 2005-02-03 Xanodyne Pharmacal, Inc. Tranexamic acid formulations with reduced adverse effects
US20090214644A1 (en) * 2003-07-31 2009-08-27 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations with reduced adverse effects
US20050244495A1 (en) 2004-03-04 2005-11-03 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US20090215898A1 (en) * 2004-03-04 2009-08-27 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US7947739B2 (en) 2004-03-04 2011-05-24 Ferring B.V. Tranexamic acid formulations
US20050245614A1 (en) * 2004-03-04 2005-11-03 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US8022106B2 (en) * 2004-03-04 2011-09-20 Ferring B.V. Tranexamic acid formulations
ATE469880T1 (de) * 2005-06-20 2010-06-15 Xenoport Inc Acyloxyalkylcarbamat-prodrugs von tranexansäure und anwendung
EP2407448A3 (de) * 2006-03-16 2012-07-25 Vertex Pharmaceuticals Incorporated Verfahren und Zwischenprodukte zur Herstellung von sterischen Verbindungen
WO2009033079A1 (en) * 2007-09-07 2009-03-12 Xenoport, Inc. Externally masked neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
WO2009033054A1 (en) * 2007-09-07 2009-03-12 Xenoport, Inc. Complex pantoic acid ester neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
US7989641B2 (en) 2008-08-07 2011-08-02 Xenoport, Inc. Methods of synthesizing N-hydroxysuccinimidyl carbonates
WO2010017504A1 (en) * 2008-08-07 2010-02-11 Xenoport, Inc. Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs
US20100280117A1 (en) * 2009-04-30 2010-11-04 Xanodyne Pharmaceuticals, Inc. Menorrhagia Instrument and Method for the Treatment of Menstrual Bleeding Disorders
WO2011028234A1 (en) 2009-09-04 2011-03-10 Xenoport, Inc. Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid
US20110184060A1 (en) 2010-01-22 2011-07-28 Xenoport, Inc. Oral dosage forms having a high loading of a tranexamic acid prodrug
US8597683B2 (en) 2010-11-30 2013-12-03 Watson Pharmaceuticals, Inc. Modified release tranexamic acid formulation
DE202012012713U1 (de) * 2011-03-04 2014-01-23 Arstat, Inc. Intravaginale Arzneimittelabgabevorrichtung
DE202011110392U1 (de) 2011-04-12 2014-01-16 Arstat, Inc. Oral verabreichbare pharmazeutische Zusammensetzung zur behandlung von Menstruationsschmerzen, die von übermäßigem menstruellem Blutverlust begleitet sind
FI125336B (fi) * 2012-10-31 2015-08-31 Kone Corp Hissijärjestely
CA2937049C (en) 2013-12-16 2024-01-16 The University Of British Columbia Self-fueled particles for propulsion through flowing aqueous fluids
EP3681479B1 (de) * 2017-09-15 2024-01-31 Dyve Biosciences, Inc. Natriumhydrogencarbonat zur verwendung in der behandlung von gicht und verwandten erkrankungen
WO2020074160A1 (en) 2018-10-10 2020-04-16 Curovir Ab Condensed pyrimidine or pyridazine derivatives as antiviral agents
JP2020090453A (ja) * 2018-12-05 2020-06-11 ポーラ化成工業株式会社 日焼け抑制用組成物
WO2022033202A1 (zh) * 2020-08-13 2022-02-17 南京海融医药科技股份有限公司 布洛芬酯类前药、药物组合物以及制备方法和应用
EP4273135A4 (de) * 2020-12-31 2024-11-20 Scinnohub Pharmaceutical Co., Ltd Plasmininhibitor sowie herstellungsverfahren dafür und anwendung davon
EP4134362B1 (de) * 2021-06-29 2024-02-28 Nanjing Heron Pharmaceutical Science and Technology Co., Ltd. Ibuprofenesterderivat und emulsionsformulierung davon

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2996431A (en) 1953-12-16 1961-08-15 Barry Richard Henry Friable tablet and process for manufacturing same
US3402240A (en) 1957-06-25 1968-09-17 Pfizer & Co C Medicinal tablet and process of making same
US3139383A (en) 1961-06-26 1964-06-30 Norton Co Encapsulated time release pellets and method for encapsulating the same
US3499925A (en) 1964-03-23 1970-03-10 Daiichi Seiyaku Co Process for the production of trans-4-aminomethylcyclohexane - 1 - carboxylic acid
GB1364672A (en) 1971-06-09 1974-08-29 Beecham Group Ltd Penicillins
US3962414A (en) 1972-04-27 1976-06-08 Alza Corporation Structured bioerodible drug delivery device
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3811444A (en) 1972-12-27 1974-05-21 Alza Corp Bioerodible ocular device
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
DE2336218C3 (de) 1973-07-17 1985-11-14 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Orale Arzneiform
US4048222A (en) 1974-03-04 1977-09-13 Kureha Kagaku Kogyo Kabushiki Kaisha Process for preparing trans-4-aminomethyl-cyclohexane-1-carboxylic acid
US3992518A (en) 1974-10-24 1976-11-16 G. D. Searle & Co. Method for making a microsealed delivery device
GB1478759A (en) 1974-11-18 1977-07-06 Alza Corp Process for forming outlet passageways in pills using a laser
US4093709A (en) 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
JPS51138651A (en) 1975-05-27 1976-11-30 Kureha Chem Ind Co Ltd Process for pr eparing trans-4-aminomethyo-cyclohexane
US4055580A (en) 1975-08-22 1977-10-25 Rorer Italiana S.P.A. Derivatives of aminomethylcyclohexanecarboxylic acid
US4063064A (en) 1976-02-23 1977-12-13 Coherent Radiation Apparatus for tracking moving workpiece by a laser beam
US4079038A (en) 1976-03-05 1978-03-14 Alza Corporation Poly(carbonates)
US4066747A (en) 1976-04-08 1978-01-03 Alza Corporation Polymeric orthoesters housing beneficial drug for controlled release therefrom
US4070347A (en) 1976-08-16 1978-01-24 Alza Corporation Poly(orthoester) co- and homopolymers and poly(orthocarbonate) co- and homopolymers having carbonyloxy functionality
US4285987A (en) 1978-10-23 1981-08-25 Alza Corporation Process for manufacturing device with dispersion zone
US4200098A (en) 1978-10-23 1980-04-29 Alza Corporation Osmotic system with distribution zone for dispensing beneficial agent
US4290905A (en) 1979-12-26 1981-09-22 Kabushiki Kaisha Suwa Seikosha Ester compound
EP0079872B1 (de) 1981-11-17 1985-03-20 KabiVitrum AB Verbindungen mit antifibrinolytischer Wirksamkeit
US4434153A (en) 1982-03-22 1984-02-28 Alza Corporation Drug delivery system comprising a reservoir containing a plurality of tiny pills
US4421736A (en) 1982-05-20 1983-12-20 Merrel Dow Pharmaceuticals Inc. Sustained release diethylpropion compositions
US4426391A (en) 1982-09-15 1984-01-17 Merck & Co., Inc. [(Alkoxycarbonyl)oxy]alkyl esters of methyldopa
IL67445A (en) 1982-12-09 1985-11-29 Teva Pharma Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids
US4721613A (en) 1982-12-13 1988-01-26 Alza Corporation Delivery system comprising means for shielding a multiplicity of reservoirs in selected environment of use
US4760057A (en) 1983-06-23 1988-07-26 Merck & Co., Inc. (Acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs
US4916230A (en) 1984-07-02 1990-04-10 Merck & Co., Inc. Process for preparing novel N-(acyloxy-alkoxy)carbonyl derivatives useful as bioreversible prodrug moieties for primary and secondary amine functions in drugs
US4820523A (en) 1986-04-15 1989-04-11 Warner-Lambert Company Pharmaceutical composition
US4752470A (en) 1986-11-24 1988-06-21 Mehta Atul M Controlled release indomethacin
US4851423A (en) * 1986-12-10 1989-07-25 Schering Corporation Pharmaceutically active compounds
US4816263A (en) 1987-10-02 1989-03-28 Alza Corporation Dosage form for treating cardiovascular diseases comprising isradipine
US4853229A (en) 1987-10-26 1989-08-01 Alza Corporation Method for adminstering tiny pills
EP0416689B1 (de) 1989-09-06 1995-11-29 Merck & Co. Inc. Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren
GB9001405D0 (en) 1990-01-22 1990-03-21 Leo Pharm Prod Ltd New intermediates,their production and use
US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
US5229135A (en) 1991-11-22 1993-07-20 Prographarm Laboratories Sustained release diltiazem formulation
DE69316681T2 (de) 1992-08-27 1998-05-14 Shiseido Co Ltd Äusserliche, auf der Haut anzuwendende Depigmentierungsmittel enthaltende Zusammensetzung
SE9300013L (sv) 1992-12-30 1994-07-01 Kabi Pharmacia Ab Nytt förfarande och mellanprodukter för framställning av pro- läkemedel
JPH07165555A (ja) 1993-12-09 1995-06-27 Shiseido Co Ltd 皮膚外用剤
US5466811A (en) 1994-07-18 1995-11-14 Merck & Co., Inc. Dioxolenylmethyl carbamates pro moieties for amine drugs
US5684018A (en) 1994-12-13 1997-11-04 Merck & Co., Inc. Acyloxyisopropyl carbamates as prodrugs for amine drugs
KR100424931B1 (ko) 1994-12-19 2004-07-05 다이이찌 세이야꾸 가부시기가이샤 서방성입상제제및그제조방법
JP3483988B2 (ja) * 1995-06-01 2004-01-06 株式会社資生堂 皮膚外用剤
JP3814881B2 (ja) 1996-08-07 2006-08-30 味の素株式会社 シクロヘキシルアミノ酸類の製造方法
US6375987B1 (en) 1996-10-01 2002-04-23 Gattefossé, S.A. Process for the manufacture of pharmaceutical composition with modified release of active principle comprising the matrix
FR2779651B1 (fr) 1998-06-16 2001-04-20 Gattefosse Ets Sa Procede pour la fabrication de comprimes a liberation prolongee de principe(s) actif(s) presentant une cinetique de dissolution d'ordre zero
US6171615B1 (en) 1998-07-06 2001-01-09 Gattefoss{acute over (e)} Sustained release theophylline formulations, excipient systems and methods of production
CN1373770A (zh) 1999-07-15 2002-10-09 伊莱利利公司 假单胞菌素前药
US6627223B2 (en) 2000-02-11 2003-09-30 Eurand Pharmaceuticals Ltd. Timed pulsatile drug delivery systems
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
ATE540678T1 (de) * 2001-06-11 2012-01-15 Xenoport Inc Prodrugs aus gaba-analoga, zusammensetzungen und ihre verwendungen
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6927036B2 (en) 2002-02-19 2005-08-09 Xero Port, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
ITMI20030882A1 (it) 2003-04-30 2004-11-01 Eni Spa Metodo per inibire l'acidificazione biologica di acque in contatto con materiali contenenti zolfo
US7662987B2 (en) 2003-07-15 2010-02-16 Xenoport, Inc. Methods for synthesis of acyloxyalkyl compounds
US7860074B2 (en) * 2003-07-31 2010-12-28 Motorola, Inc. Method and apparatus for allocating communication resources
WO2005019163A2 (en) * 2003-08-20 2005-03-03 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
NZ546381A (en) 2003-10-14 2010-01-29 Xenoport Inc Crystalline form of gamma-aminobutyric acid analog
CN102702065A (zh) * 2003-12-30 2012-10-03 什诺波特有限公司 酰氧基烃基氨基甲酸酯前药及其中间体的合成
US20050244495A1 (en) 2004-03-04 2005-11-03 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
RU2440112C2 (ru) 2004-11-04 2012-01-20 Ксенопорт, Инк. Пероральная дозированная форма габапентина замедленного высвобождения
ATE469880T1 (de) 2005-06-20 2010-06-15 Xenoport Inc Acyloxyalkylcarbamat-prodrugs von tranexansäure und anwendung
US7332924B2 (en) 2005-11-15 2008-02-19 Agere Systems, Inc. Embedded test circuitry and a method for testing a semiconductor device for breakdown, wearout or failure
US7770070B2 (en) * 2007-06-21 2010-08-03 Xerox Corporation Test automation via RFID technology
US7989641B2 (en) 2008-08-07 2011-08-02 Xenoport, Inc. Methods of synthesizing N-hydroxysuccinimidyl carbonates
WO2010017504A1 (en) 2008-08-07 2010-02-11 Xenoport, Inc. Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs
CN102186804A (zh) 2008-10-20 2011-09-14 克塞诺波特公司 合成左旋多巴酯前药的方法
EP2403481A1 (de) 2009-03-06 2012-01-11 XenoPort, Inc. Orale dosierformen mit einer hohen ladung eines gabapentin-prodrugs

Also Published As

Publication number Publication date
US20110009483A1 (en) 2011-01-13
CA2612292C (en) 2013-09-03
WO2007002013A2 (en) 2007-01-04
JP2008546717A (ja) 2008-12-25
ZA200800311B (en) 2009-04-29
DE602006014694D1 (de) 2010-07-15
EP1919859B1 (de) 2010-06-02
NO20076508L (no) 2008-03-17
WO2007002013A3 (en) 2007-03-22
US7351740B2 (en) 2008-04-01
US7592369B2 (en) 2009-09-22
CA2612292A1 (en) 2007-01-04
AU2006262386B2 (en) 2012-02-02
AU2006262386A1 (en) 2007-01-04
CN101253148A (zh) 2008-08-27
US8372881B2 (en) 2013-02-12
IL188172A (en) 2013-02-28
US20080153898A1 (en) 2008-06-26
IL188172A0 (en) 2008-03-20
ES2345784T3 (es) 2010-10-01
US7777070B2 (en) 2010-08-17
JP4938771B2 (ja) 2012-05-23
HK1117824A1 (en) 2009-01-23
KR20080022203A (ko) 2008-03-10
EP1919859A2 (de) 2008-05-14
CN101253148B (zh) 2013-01-02
NZ564468A (en) 2011-05-27
US20070027210A1 (en) 2007-02-01
US20100036148A1 (en) 2010-02-11

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