DE602006014694D1 - Acyloxyalkylcarbamat-prodrugs von tranexansäure und anwendung - Google Patents

Acyloxyalkylcarbamat-prodrugs von tranexansäure und anwendung

Info

Publication number
DE602006014694D1
DE602006014694D1 DE602006014694T DE602006014694T DE602006014694D1 DE 602006014694 D1 DE602006014694 D1 DE 602006014694D1 DE 602006014694 T DE602006014694 T DE 602006014694T DE 602006014694 T DE602006014694 T DE 602006014694T DE 602006014694 D1 DE602006014694 D1 DE 602006014694D1
Authority
DE
Germany
Prior art keywords
acid
aminomethyl
trans
prodrugs
acyloxyalkyl carbamate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006014694T
Other languages
English (en)
Inventor
Bernd Jandeleit
Yunxiao Li
Noa Zerangue
Mark A Gallop
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
XenoPort Inc
Original Assignee
XenoPort Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by XenoPort Inc filed Critical XenoPort Inc
Publication of DE602006014694D1 publication Critical patent/DE602006014694D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE602006014694T 2005-06-20 2006-06-20 Acyloxyalkylcarbamat-prodrugs von tranexansäure und anwendung Active DE602006014694D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69262505P 2005-06-20 2005-06-20
PCT/US2006/023873 WO2007002013A2 (en) 2005-06-20 2006-06-20 Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use

Publications (1)

Publication Number Publication Date
DE602006014694D1 true DE602006014694D1 (de) 2010-07-15

Family

ID=37460256

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006014694T Active DE602006014694D1 (de) 2005-06-20 2006-06-20 Acyloxyalkylcarbamat-prodrugs von tranexansäure und anwendung

Country Status (16)

Country Link
US (4) US7351740B2 (de)
EP (1) EP1919859B1 (de)
JP (1) JP4938771B2 (de)
KR (1) KR20080022203A (de)
CN (1) CN101253148B (de)
AT (1) ATE469880T1 (de)
AU (1) AU2006262386B2 (de)
CA (1) CA2612292C (de)
DE (1) DE602006014694D1 (de)
ES (1) ES2345784T3 (de)
HK (1) HK1117824A1 (de)
IL (1) IL188172A (de)
NO (1) NO20076508L (de)
NZ (1) NZ564468A (de)
WO (1) WO2007002013A2 (de)
ZA (1) ZA200800311B (de)

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EP3984989A4 (de) * 2020-08-13 2023-11-22 Nanjing Heron Pharmaceutical Science and Technology Co., Ltd. Ibuprofenester-prodrug, pharmazeutische zusammensetzung sowie herstellungsverfahren und verwendung
JP2024507433A (ja) * 2020-12-31 2024-02-20 シノハブ ファーマシューティカルズ カンパニー リミテッド プラスミン阻害剤、そのための調製方法及びその応用
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Also Published As

Publication number Publication date
US7777070B2 (en) 2010-08-17
US7351740B2 (en) 2008-04-01
US7592369B2 (en) 2009-09-22
IL188172A0 (en) 2008-03-20
CN101253148B (zh) 2013-01-02
HK1117824A1 (en) 2009-01-23
WO2007002013A3 (en) 2007-03-22
US20080153898A1 (en) 2008-06-26
AU2006262386B2 (en) 2012-02-02
CA2612292C (en) 2013-09-03
CN101253148A (zh) 2008-08-27
US8372881B2 (en) 2013-02-12
JP4938771B2 (ja) 2012-05-23
EP1919859B1 (de) 2010-06-02
AU2006262386A1 (en) 2007-01-04
ZA200800311B (en) 2009-04-29
NZ564468A (en) 2011-05-27
IL188172A (en) 2013-02-28
WO2007002013A2 (en) 2007-01-04
EP1919859A2 (de) 2008-05-14
NO20076508L (no) 2008-03-17
CA2612292A1 (en) 2007-01-04
ES2345784T3 (es) 2010-10-01
ATE469880T1 (de) 2010-06-15
JP2008546717A (ja) 2008-12-25
US20110009483A1 (en) 2011-01-13
US20100036148A1 (en) 2010-02-11
US20070027210A1 (en) 2007-02-01
KR20080022203A (ko) 2008-03-10

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