DK1337549T3 - Fremgangsmåde til foldning af kemisk syntetiserede polypeptider - Google Patents
Fremgangsmåde til foldning af kemisk syntetiserede polypeptiderInfo
- Publication number
- DK1337549T3 DK1337549T3 DK01990489T DK01990489T DK1337549T3 DK 1337549 T3 DK1337549 T3 DK 1337549T3 DK 01990489 T DK01990489 T DK 01990489T DK 01990489 T DK01990489 T DK 01990489T DK 1337549 T3 DK1337549 T3 DK 1337549T3
- Authority
- DK
- Denmark
- Prior art keywords
- chemically synthesized
- folding
- synthesized polypeptides
- cysteine
- reducing agent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00204207 | 2000-11-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1337549T3 true DK1337549T3 (da) | 2006-07-31 |
Family
ID=8172340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01990489T DK1337549T3 (da) | 2000-11-27 | 2001-11-27 | Fremgangsmåde til foldning af kemisk syntetiserede polypeptider |
Country Status (22)
Country | Link |
---|---|
US (2) | US20020082384A1 (ru) |
EP (2) | EP1679318A1 (ru) |
JP (1) | JP2004516300A (ru) |
KR (1) | KR20030081315A (ru) |
CN (2) | CN1249078C (ru) |
AT (1) | ATE322501T1 (ru) |
AU (2) | AU2002229603B2 (ru) |
BR (1) | BR0113091A (ru) |
CA (1) | CA2416054A1 (ru) |
CU (1) | CU23034A3 (ru) |
DE (1) | DE60118598T2 (ru) |
DK (1) | DK1337549T3 (ru) |
ES (1) | ES2261509T4 (ru) |
HU (1) | HUP0302395A3 (ru) |
IL (1) | IL155506A0 (ru) |
MX (1) | MXPA03003576A (ru) |
NO (1) | NO20032356L (ru) |
NZ (1) | NZ523679A (ru) |
PL (1) | PL364932A1 (ru) |
RU (1) | RU2275377C2 (ru) |
WO (1) | WO2002050099A2 (ru) |
ZA (1) | ZA200300642B (ru) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7091310B2 (en) * | 2002-09-13 | 2006-08-15 | Chemokine Therapeutics Corporation | Chemokine analogs for the treatment of human disease |
WO2004099231A2 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
TW200637872A (en) * | 2004-10-26 | 2006-11-01 | Lonza Ag | Thiol group protection and cyclization in solid-phase peptide synthesis |
EP1814573B1 (en) | 2004-10-29 | 2016-03-09 | ratiopharm GmbH | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
CA2593682C (en) | 2005-01-10 | 2016-03-22 | Neose Technologies, Inc. | Glycopegylated granulocyte colony stimulating factor |
US9187546B2 (en) | 2005-04-08 | 2015-11-17 | Novo Nordisk A/S | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
EP1893632B1 (en) * | 2005-06-17 | 2015-08-12 | Novo Nordisk Health Care AG | Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
US20090081145A1 (en) * | 2005-12-23 | 2009-03-26 | Aplagen Gmbh | Process for forming disulphide bridges |
WO2007130275A2 (en) * | 2006-05-03 | 2007-11-15 | Mallinckrodt Inc. | Composition and method for the release of protected peptides from a resin |
JP2009544327A (ja) | 2006-07-21 | 2009-12-17 | ノヴォ ノルディスク アー/エス | O−結合型グリコシル化配列によるペプチドのグリコシル化 |
EP2054521A4 (en) | 2006-10-03 | 2012-12-19 | Novo Nordisk As | METHODS OF PURIFYING CONJUGATES OF POLYPEPTIDES |
WO2008077621A1 (de) * | 2006-12-23 | 2008-07-03 | Aplagen Gmbh | Verfahren zur ausbildung von disulfidbrücken |
KR20150064246A (ko) | 2007-04-03 | 2015-06-10 | 바이오제너릭스 게엠베하 | 글리코페길화 g―csf를 이용하는 치료 방법 |
ES2551123T3 (es) | 2007-06-12 | 2015-11-16 | Ratiopharm Gmbh | Proceso mejorado para la producción de azúcares de nucleótido |
CN101965200B (zh) | 2008-02-27 | 2013-06-19 | 诺沃-诺迪斯克有限公司 | 缀合的因子ⅷ分子 |
CN104844693B (zh) * | 2015-06-10 | 2018-08-03 | 成都圣诺生物科技股份有限公司 | 一种合成利那洛肽的方法 |
WO2019149918A1 (en) | 2018-02-02 | 2019-08-08 | Novo Nordisk A/S | Drug injection device with deflectable transducer |
CN111100188A (zh) * | 2018-10-25 | 2020-05-05 | 成都医学院 | 一种制备蜘蛛抗菌肽的方法 |
CN109593119A (zh) * | 2019-01-27 | 2019-04-09 | 上海丽珠制药有限公司 | 一种[2-d-组氨酸]-醋酸亮丙瑞林的制备方法 |
JP7453745B2 (ja) * | 2019-03-28 | 2024-03-21 | 株式会社ヤクルト本社 | 毒性タンパク質の活性を阻害するペプチドのスクリーニング方法及び毒性タンパク質の製造方法 |
CN110845595A (zh) * | 2019-11-14 | 2020-02-28 | 连云港职业技术学院 | 一种固相合成5-tmara标记的铁调素-25的方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2923787A1 (de) * | 1979-06-12 | 1980-12-18 | Max Planck Gesellschaft | Verfahren zur selektiven bildung von disulfidbruecken in polypeptiden und die dabei erhaltenen produkte als wirkstoffe enthaltende arzneimittel |
DE3236849A1 (de) * | 1982-10-05 | 1984-04-05 | Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Neue thiohydrazin-1,2-dicarbonsaeure-derivate, verfahren zu ihrer herstellung und ihre verwendung |
IL96682A0 (en) * | 1989-12-15 | 1991-09-16 | Amgen Inc | Production of biologically active platelet-derived growth factor from high expression host cell systems |
CA2072249C (en) * | 1991-06-28 | 2003-06-17 | Saiko Hosokawa | Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane |
CN1105029A (zh) * | 1993-05-24 | 1995-07-12 | 花王株式会社 | 制备溶解蛋白质的方法 |
US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
DE4431317A1 (de) * | 1994-09-02 | 1996-03-07 | Biotechnolog Forschung Gmbh | Schutz- bzw. Ankergruppen und deren Verwendung |
-
2001
- 2001-11-27 NZ NZ523679A patent/NZ523679A/en unknown
- 2001-11-27 DK DK01990489T patent/DK1337549T3/da active
- 2001-11-27 CN CNB018147968A patent/CN1249078C/zh not_active Expired - Fee Related
- 2001-11-27 WO PCT/EP2001/014163 patent/WO2002050099A2/en active IP Right Grant
- 2001-11-27 CN CNA2006100047520A patent/CN1830999A/zh active Pending
- 2001-11-27 KR KR10-2003-7004957A patent/KR20030081315A/ko not_active Application Discontinuation
- 2001-11-27 JP JP2002551992A patent/JP2004516300A/ja active Pending
- 2001-11-27 HU HU0302395A patent/HUP0302395A3/hu unknown
- 2001-11-27 MX MXPA03003576A patent/MXPA03003576A/es active IP Right Grant
- 2001-11-27 IL IL15550601A patent/IL155506A0/xx unknown
- 2001-11-27 AU AU2002229603A patent/AU2002229603B2/en not_active Expired - Fee Related
- 2001-11-27 CU CU20030094A patent/CU23034A3/es unknown
- 2001-11-27 ES ES01990489T patent/ES2261509T4/es not_active Expired - Lifetime
- 2001-11-27 AU AU2960302A patent/AU2960302A/xx active Pending
- 2001-11-27 AT AT01990489T patent/ATE322501T1/de not_active IP Right Cessation
- 2001-11-27 US US09/995,335 patent/US20020082384A1/en not_active Abandoned
- 2001-11-27 EP EP06075237A patent/EP1679318A1/en not_active Withdrawn
- 2001-11-27 EP EP01990489A patent/EP1337549B1/en not_active Expired - Lifetime
- 2001-11-27 RU RU2003119075/04A patent/RU2275377C2/ru not_active IP Right Cessation
- 2001-11-27 DE DE60118598T patent/DE60118598T2/de not_active Expired - Fee Related
- 2001-11-27 BR BR0113091-9A patent/BR0113091A/pt not_active IP Right Cessation
- 2001-11-27 PL PL01364932A patent/PL364932A1/xx not_active Application Discontinuation
- 2001-11-27 CA CA002416054A patent/CA2416054A1/en not_active Abandoned
-
2003
- 2003-01-23 ZA ZA200300642A patent/ZA200300642B/en unknown
- 2003-05-26 NO NO20032356A patent/NO20032356L/no unknown
-
2005
- 2005-05-19 US US11/132,987 patent/US20050239162A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2002050099A2 (en) | 2002-06-27 |
ATE322501T1 (de) | 2006-04-15 |
DE60118598D1 (de) | 2006-05-18 |
WO2002050099A3 (en) | 2002-09-19 |
EP1679318A1 (en) | 2006-07-12 |
JP2004516300A (ja) | 2004-06-03 |
IL155506A0 (en) | 2003-11-23 |
NO20032356D0 (no) | 2003-05-26 |
CN1830999A (zh) | 2006-09-13 |
ES2261509T3 (es) | 2006-11-16 |
AU2002229603B2 (en) | 2007-11-08 |
ES2261509T4 (es) | 2008-02-16 |
EP1337549B1 (en) | 2006-04-05 |
HUP0302395A2 (hu) | 2003-10-28 |
BR0113091A (pt) | 2003-07-08 |
AU2960302A (en) | 2002-07-01 |
KR20030081315A (ko) | 2003-10-17 |
NO20032356L (no) | 2003-05-26 |
PL364932A1 (en) | 2004-12-27 |
HUP0302395A3 (en) | 2007-05-02 |
MXPA03003576A (es) | 2003-10-14 |
US20020082384A1 (en) | 2002-06-27 |
CU23034A3 (es) | 2005-03-22 |
NZ523679A (en) | 2005-10-28 |
CN1449406A (zh) | 2003-10-15 |
RU2275377C2 (ru) | 2006-04-27 |
CN1249078C (zh) | 2006-04-05 |
US20050239162A1 (en) | 2005-10-27 |
EP1337549A2 (en) | 2003-08-27 |
ZA200300642B (en) | 2004-07-16 |
DE60118598T2 (de) | 2007-02-15 |
CA2416054A1 (en) | 2002-06-27 |
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