BR0113091A - Processo para a multiplicação de polipeptìdeos sintetizados quimicamente e processo para a preparação de proteìnas biologicamente ativas - Google Patents

Processo para a multiplicação de polipeptìdeos sintetizados quimicamente e processo para a preparação de proteìnas biologicamente ativas

Info

Publication number
BR0113091A
BR0113091A BR0113091-9A BR0113091A BR0113091A BR 0113091 A BR0113091 A BR 0113091A BR 0113091 A BR0113091 A BR 0113091A BR 0113091 A BR0113091 A BR 0113091A
Authority
BR
Brazil
Prior art keywords
multiplication
biologically active
synthesized polypeptides
chemically synthesized
active proteins
Prior art date
Application number
BR0113091-9A
Other languages
English (en)
Inventor
Antonio Verdini
Giampietro Corradin
Mario Roggero
Original Assignee
Rmf Dictagene Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rmf Dictagene Sa filed Critical Rmf Dictagene Sa
Publication of BR0113091A publication Critical patent/BR0113091A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"PROCESSO PARA A MULTIPLICAçãO DE POLIPEPTìDEOS SINTETIZADOS QUIMICAMENTE E PROCESSO PARA A PREPARAçãO DE PROTEìNAS BIOLOGICAMENTE ATIVAS". A presente invenção refere-se a um processo para a multiplicação de polipeptídeos sintetizados quimicamente, compreendendo tratar um polipeptídeo e/ou proteína que compreenda dois ou mais derivados de radicais cisteínas com um agente redutor em um tampão de multiplicação possuindo um pH e temperatura predeterminados, onde o derivado de radical cisteína corresponde ao radical S-butil-tio-cisteína e onde o agente redutor é a cisteína.
BR0113091-9A 2000-11-27 2001-11-27 Processo para a multiplicação de polipeptìdeos sintetizados quimicamente e processo para a preparação de proteìnas biologicamente ativas BR0113091A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00204207 2000-11-27
PCT/EP2001/014163 WO2002050099A2 (en) 2000-11-27 2001-11-27 Process for folding chemically synthesized polypeptides

Publications (1)

Publication Number Publication Date
BR0113091A true BR0113091A (pt) 2003-07-08

Family

ID=8172340

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0113091-9A BR0113091A (pt) 2000-11-27 2001-11-27 Processo para a multiplicação de polipeptìdeos sintetizados quimicamente e processo para a preparação de proteìnas biologicamente ativas

Country Status (22)

Country Link
US (2) US20020082384A1 (pt)
EP (2) EP1337549B1 (pt)
JP (1) JP2004516300A (pt)
KR (1) KR20030081315A (pt)
CN (2) CN1830999A (pt)
AT (1) ATE322501T1 (pt)
AU (2) AU2002229603B2 (pt)
BR (1) BR0113091A (pt)
CA (1) CA2416054A1 (pt)
CU (1) CU23034A3 (pt)
DE (1) DE60118598T2 (pt)
DK (1) DK1337549T3 (pt)
ES (1) ES2261509T4 (pt)
HU (1) HUP0302395A3 (pt)
IL (1) IL155506A0 (pt)
MX (1) MXPA03003576A (pt)
NO (1) NO20032356D0 (pt)
NZ (1) NZ523679A (pt)
PL (1) PL364932A1 (pt)
RU (1) RU2275377C2 (pt)
WO (1) WO2002050099A2 (pt)
ZA (1) ZA200300642B (pt)

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US7091310B2 (en) * 2002-09-13 2006-08-15 Chemokine Therapeutics Corporation Chemokine analogs for the treatment of human disease
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
MXPA05010773A (es) 2003-04-09 2005-12-12 Neose Technologies Inc Metodos de glicopegilacion y proteinas/peptidos producidos por los metodos.
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
JP2008529969A (ja) * 2004-10-26 2008-08-07 ロンザ ア−ゲ− 固相合成におけるｓ−アルキル−スルフェニル保護基
JP5948627B2 (ja) 2004-10-29 2016-07-20 レイショファーム ゲーエムベーハー 線維芽細胞成長因子（ｆｇｆ）のリモデリングと糖質ペグ化
EP1858543B1 (en) 2005-01-10 2013-11-27 BioGeneriX AG Glycopegylated granulocyte colony stimulating factor
US20070154992A1 (en) 2005-04-08 2007-07-05 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
EP1893632B1 (en) * 2005-06-17 2015-08-12 Novo Nordisk Health Care AG Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
US20090081145A1 (en) * 2005-12-23 2009-03-26 Aplagen Gmbh Process for forming disulphide bridges
CA2651070A1 (en) * 2006-05-03 2007-11-15 Mallinckrodt Inc. Composition and method for the release of protected peptides from a resin
CN101516388B (zh) 2006-07-21 2012-10-31 诺和诺德公司 通过o-联糖基化序列的肽的糖基化
EP2054521A4 (en) 2006-10-03 2012-12-19 Novo Nordisk As METHODS OF PURIFYING CONJUGATES OF POLYPEPTIDES
EP2125863A1 (de) * 2006-12-23 2009-12-02 AplaGen GmbH Verfahren zur ausbildung von disulfidbrücken
RS52845B (en) 2007-04-03 2013-12-31 Biogenerix Ag TREATMENT PROCEDURES USING GLYCOPEGILATED G-CSF
US9493499B2 (en) 2007-06-12 2016-11-15 Novo Nordisk A/S Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography
EP2257311B1 (en) 2008-02-27 2014-04-16 Novo Nordisk A/S Conjugated factor viii molecules
CN104844693B (zh) * 2015-06-10 2018-08-03 成都圣诺生物科技股份有限公司 一种合成利那洛肽的方法
CN111655314B (zh) 2018-02-02 2022-11-18 诺和诺德股份有限公司 具有可偏转换能器的药物注射装置
CN111100188A (zh) * 2018-10-25 2020-05-05 成都医学院 一种制备蜘蛛抗菌肽的方法
CN109593119A (zh) * 2019-01-27 2019-04-09 上海丽珠制药有限公司 一种[2-d-组氨酸]-醋酸亮丙瑞林的制备方法
JP7453745B2 (ja) * 2019-03-28 2024-03-21 株式会社ヤクルト本社 毒性タンパク質の活性を阻害するペプチドのスクリーニング方法及び毒性タンパク質の製造方法
CN110845595A (zh) * 2019-11-14 2020-02-28 连云港职业技术学院 一种固相合成5-tmara标记的铁调素-25的方法

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
DE2923787A1 (de) * 1979-06-12 1980-12-18 Max Planck Gesellschaft Verfahren zur selektiven bildung von disulfidbruecken in polypeptiden und die dabei erhaltenen produkte als wirkstoffe enthaltende arzneimittel
DE3236849A1 (de) * 1982-10-05 1984-04-05 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Neue thiohydrazin-1,2-dicarbonsaeure-derivate, verfahren zu ihrer herstellung und ihre verwendung
IL96682A0 (en) * 1989-12-15 1991-09-16 Amgen Inc Production of biologically active platelet-derived growth factor from high expression host cell systems
CA2072249C (en) * 1991-06-28 2003-06-17 Saiko Hosokawa Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane
CN1105029A (zh) * 1993-05-24 1995-07-12 花王株式会社 制备溶解蛋白质的方法
US5663304A (en) * 1993-08-20 1997-09-02 Genentech, Inc. Refolding of misfolded insulin-like growth factor-I
DE4431317A1 (de) * 1994-09-02 1996-03-07 Biotechnolog Forschung Gmbh Schutz- bzw. Ankergruppen und deren Verwendung

Also Published As

Publication number Publication date
ES2261509T4 (es) 2008-02-16
AU2960302A (en) 2002-07-01
DE60118598T2 (de) 2007-02-15
US20050239162A1 (en) 2005-10-27
MXPA03003576A (es) 2003-10-14
DK1337549T3 (da) 2006-07-31
CU23034A3 (es) 2005-03-22
RU2275377C2 (ru) 2006-04-27
US20020082384A1 (en) 2002-06-27
CN1449406A (zh) 2003-10-15
CN1249078C (zh) 2006-04-05
EP1337549A2 (en) 2003-08-27
IL155506A0 (en) 2003-11-23
CN1830999A (zh) 2006-09-13
HUP0302395A3 (en) 2007-05-02
WO2002050099A2 (en) 2002-06-27
NO20032356L (no) 2003-05-26
NO20032356D0 (no) 2003-05-26
KR20030081315A (ko) 2003-10-17
NZ523679A (en) 2005-10-28
EP1679318A1 (en) 2006-07-12
EP1337549B1 (en) 2006-04-05
PL364932A1 (en) 2004-12-27
ZA200300642B (en) 2004-07-16
ATE322501T1 (de) 2006-04-15
WO2002050099A3 (en) 2002-09-19
JP2004516300A (ja) 2004-06-03
AU2002229603B2 (en) 2007-11-08
HUP0302395A2 (hu) 2003-10-28
DE60118598D1 (de) 2006-05-18
ES2261509T3 (es) 2006-11-16
CA2416054A1 (en) 2002-06-27

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 NA RPI 2021 DE 29/09/2009.