DK1311504T3 - Tetrazolyl-phenylacetamid-glucokinase-aktivatorer - Google Patents

Tetrazolyl-phenylacetamid-glucokinase-aktivatorer

Info

Publication number
DK1311504T3
DK1311504T3 DK01962926T DK01962926T DK1311504T3 DK 1311504 T3 DK1311504 T3 DK 1311504T3 DK 01962926 T DK01962926 T DK 01962926T DK 01962926 T DK01962926 T DK 01962926T DK 1311504 T3 DK1311504 T3 DK 1311504T3
Authority
DK
Denmark
Prior art keywords
tetrazolyl
phenyl
glucokinase activators
glucokinase
activators
Prior art date
Application number
DK01962926T
Other languages
Danish (da)
English (en)
Inventor
Achyutharao Sidduri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1311504T3 publication Critical patent/DK1311504T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK01962926T 2000-08-15 2001-08-09 Tetrazolyl-phenylacetamid-glucokinase-aktivatorer DK1311504T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22549400P 2000-08-15 2000-08-15
PCT/EP2001/009207 WO2002014312A1 (en) 2000-08-15 2001-08-09 Tetrazolyl-phenyl acetamide glucokinase activators

Publications (1)

Publication Number Publication Date
DK1311504T3 true DK1311504T3 (da) 2005-10-17

Family

ID=22845106

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01962926T DK1311504T3 (da) 2000-08-15 2001-08-09 Tetrazolyl-phenylacetamid-glucokinase-aktivatorer

Country Status (20)

Country Link
US (3) US6369232B1 (OSRAM)
EP (1) EP1311504B1 (OSRAM)
JP (1) JP3961948B2 (OSRAM)
KR (1) KR100518061B1 (OSRAM)
CN (1) CN1209362C (OSRAM)
AR (1) AR031718A1 (OSRAM)
AT (1) ATE297921T1 (OSRAM)
AU (2) AU2001283998B2 (OSRAM)
BR (1) BR0113312A (OSRAM)
CA (1) CA2419416C (OSRAM)
DE (1) DE60111540T2 (OSRAM)
DK (1) DK1311504T3 (OSRAM)
ES (1) ES2243541T3 (OSRAM)
MX (1) MXPA03001275A (OSRAM)
PA (1) PA8525201A1 (OSRAM)
PE (1) PE20020386A1 (OSRAM)
PT (1) PT1311504E (OSRAM)
UY (1) UY26885A1 (OSRAM)
WO (1) WO2002014312A1 (OSRAM)
ZA (1) ZA200300904B (OSRAM)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
US7078423B2 (en) * 2002-07-18 2006-07-18 Inotek Pharmaceuticals Corporation 5-Aryltetrazole compounds, compositions thereof, and uses therefor
US7087631B2 (en) * 2002-07-18 2006-08-08 Inotek Pharmaceuticals Corporation Aryltetrazole compounds, and compositions thereof
JP2006509774A (ja) * 2002-10-03 2006-03-23 ノバルティス アクチエンゲゼルシャフト ２型糖尿病の処置において有用なグルコキナーゼアクチベーターとしての置換（チアゾール−２−イル）−アミドまたはスルホンアミド
GB0226931D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
US7132425B2 (en) 2002-12-12 2006-11-07 Hoffmann-La Roche Inc. 5-substituted-six-membered heteroaromatic glucokinase activators
AU2003294376A1 (en) * 2003-01-06 2004-08-10 Eli Lilly And Company Heteroaryl compounds
US7262196B2 (en) * 2003-02-11 2007-08-28 Prosidion Limited Tri(cyclo) substituted amide glucokinase activator compounds
PL378117A1 (pl) * 2003-02-11 2006-03-06 Prosidion Limited Tricyklopodstawione związki amidowe
JP2007530631A (ja) * 2004-04-02 2007-11-01 ノバルティス アクチエンゲゼルシャフト チアゾロピリジン誘導体、それを含む医薬組成物およびグルコキナーゼ介在性状態の処置法
ATE524479T1 (de) * 2004-04-02 2011-09-15 Novartis Ag Sulfonamidthiazolpyridinderivate als zur behandlung von typ-2-diabetes geeignete glucokinaseaktivatoren
NZ575512A (en) 2005-07-09 2009-11-27 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
KR100965040B1 (ko) * 2005-07-11 2010-06-21 미쓰비시 타나베 파마 코퍼레이션 옥심 유도체 및 그의 제조 방법
BRPI0615236A2 (pt) 2005-08-31 2011-05-10 Astellas Pharma Inc derivado de tiazol
JP2007063225A (ja) * 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
EP1931337B1 (en) 2005-09-29 2013-10-23 Sanofi Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals
GT200600428A (es) * 2005-09-30 2007-05-21 Compuestos organicos
GT200600429A (es) * 2005-09-30 2007-04-30 Compuestos organicos
WO2007051845A1 (en) * 2005-11-03 2007-05-10 Prosidion Ltd Tricyclo substituted amides
JP2009515997A (ja) * 2005-11-18 2009-04-16 タケダ サン ディエゴ インコーポレイテッド グルコキナーゼ活性剤
US7994339B2 (en) * 2005-12-15 2011-08-09 Nihon Nohyaku Co., Ltd. Phthalamide derivative, agricultural or horticultural pesticide, and use of the pesticide
JP5302012B2 (ja) 2006-03-08 2013-10-02 タケダ カリフォルニア インコーポレイテッド グルコキナーゼ活性剤
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
JP5386350B2 (ja) 2006-05-31 2014-01-15 タケダ カリフォルニア インコーポレイテッド グルコキナーゼ活性剤としての、インダゾールおよびイソインドール誘導体
US7910747B2 (en) * 2006-07-06 2011-03-22 Bristol-Myers Squibb Company Phosphonate and phosphinate pyrazolylamide glucokinase activators
US7902248B2 (en) 2006-12-14 2011-03-08 Hoffmann-La Roche Inc. Oxime glucokinase activators
WO2008079787A2 (en) 2006-12-20 2008-07-03 Takeda San Diego, Inc. Glucokinase activators
TW200831081A (en) * 2006-12-25 2008-08-01 Kyorin Seiyaku Kk Glucokinase activator
EP2105435A4 (en) * 2007-01-10 2011-06-15 Mitsubishi Tanabe Pharma Corp Hydrazone derivative
AU2008225613B2 (en) * 2007-03-07 2012-06-14 Kyorin Pharmaceutical Co., Ltd. Glucokinase activator
US8173645B2 (en) * 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
JP5580201B2 (ja) * 2007-10-08 2014-08-27 アドビヌス・セラピューティクス・プライベート・リミテッド グルコキナーゼアクチベータとしてのアセトアミド誘導体、その製法及び医薬応用
PE20091313A1 (es) * 2008-01-15 2009-09-03 Lilly Co Eli (r)-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida cristalina
MX2010007853A (es) * 2008-01-18 2010-10-06 Astellas Pharma Inc Derivado de fenilacetamida.
MX2010011778A (es) 2008-04-28 2010-11-30 Kyorin Seiyaku Kk Derivados de ciclopentil acrilamida.
AU2011235212B2 (en) 2010-03-31 2014-07-31 The Scripps Research Institute Reprogramming cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3776917A (en) * 1972-06-05 1973-12-04 Schering Corp 2-amino-6-phenalkyl-aminopyridines and derivatives thereof
GB8909574D0 (en) 1989-04-26 1989-06-14 Ici Plc Chemical process
US5859052A (en) * 1993-01-14 1999-01-12 G. D. Searle & Co. Fatty acid analogs and prodrugs
US5468867A (en) * 1994-05-27 1995-11-21 Syntex (U.S.A.) Inc. Process for preparing1-butyl-2-[2'-(2H-tetrazol-5-yl)biphenyl-4-ylmethyl1-1H-indole-3-carboxylic acid
US5461049A (en) * 1994-05-27 1995-10-24 Warner-Lambert Company Amide tetrazole ACAT inhibitors
WO1998032753A1 (en) * 1997-01-28 1998-07-30 Merck & Co., Inc. THIAZOLE BENZENESULFONAMIDES AS β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY
MXPA01009814A (es) * 1999-03-29 2002-04-24 Hoffmann La Roche Activadores de la glucoquinasa.

Also Published As

Publication number Publication date
DE60111540D1 (de) 2005-07-21
EP1311504A1 (en) 2003-05-21
KR20030022408A (ko) 2003-03-15
CN1466584A (zh) 2004-01-07
DE60111540T2 (de) 2006-03-16
JP2004506632A (ja) 2004-03-04
CN1209362C (zh) 2005-07-06
EP1311504B1 (en) 2005-06-15
KR100518061B1 (ko) 2005-09-28
BR0113312A (pt) 2003-07-01
CA2419416A1 (en) 2002-02-21
US6369232B1 (en) 2002-04-09
PA8525201A1 (es) 2002-07-30
AU2001283998B2 (en) 2005-10-20
ES2243541T3 (es) 2005-12-01
AU8399801A (en) 2002-02-25
AR031718A1 (es) 2003-10-01
PE20020386A1 (es) 2002-05-13
US20020035267A1 (en) 2002-03-21
US6388088B1 (en) 2002-05-14
US20020035266A1 (en) 2002-03-21
UY26885A1 (es) 2002-02-28
US6441180B1 (en) 2002-08-27
ATE297921T1 (de) 2005-07-15
ZA200300904B (en) 2004-04-30
CA2419416C (en) 2009-10-13
PT1311504E (pt) 2005-10-31
WO2002014312A1 (en) 2002-02-21
US20020065275A1 (en) 2002-05-30
JP3961948B2 (ja) 2007-08-22
MXPA03001275A (es) 2003-06-30

Similar Documents

Publication Publication Date Title
DE60134470D1 (de) Para-amin substituierte phenylamid glukokinase activatoren
DK1311504T3 (da) Tetrazolyl-phenylacetamid-glucokinase-aktivatorer
DE60014610D1 (de) Glukokinase aktivatoren
NO20022863L (no) Trans-olefiniske glycokinase aktivatorer
DK1280801T3 (da) Hydantoinholdige glucokinaseaktivatorer
ATE290000T1 (de) Muscarinagonisten
ATE252099T1 (de) Biarylcarboxamide
DE10136334B8 (de) Hochgeschwindigkeitsvertikalresonatoroberflächenemissionslaser
ATE312098T1 (de) Thiazinoxazolidinon
ATA2932001A (de) Schneefräse
DE50100710D1 (de) Wischblatt
ATE262530T1 (de) Indolochinazolinone
ATE298751T1 (de) 7-oxopyridoryrimidine
DE10192638T1 (de) Bohrstangenladevorrichtung
AR028336A1 (es) 4-hidroxi-tetrahidropiridonas fenilsubstituidas
ATE509008T1 (de) Sulfonylguanidine
DE10196064T1 (de) Halbleiterfotodektionsgerät
DE50100817D1 (de) Kugelgelenk
DE50011511D1 (de) Blowby-Heizung
DE10052925B4 (de) Schaukelbett
DE50007634D1 (de) Kardioplegieballonkatheter
ATE476423T1 (de) Benzoylpyridazine
DE10195909T1 (de) Viehfüttervorrichtung
DE10085445T1 (de) Drahterodierbearbeitungseinrichtung
DE10195992T1 (de) Oberflächenendbearbeitungsbelag