AU2001283998B2 - Tetrazolyl-phenyl acetamide glucokinase activators - Google Patents

Tetrazolyl-phenyl acetamide glucokinase activators Download PDF

Info

Publication number
AU2001283998B2
AU2001283998B2 AU2001283998A AU2001283998A AU2001283998B2 AU 2001283998 B2 AU2001283998 B2 AU 2001283998B2 AU 2001283998 A AU2001283998 A AU 2001283998A AU 2001283998 A AU2001283998 A AU 2001283998A AU 2001283998 B2 AU2001283998 B2 AU 2001283998B2
Authority
AU
Australia
Prior art keywords
mmol
reaction mixture
phenyl
methyl
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2001283998A
Other languages
English (en)
Other versions
AU2001283998A1 (en
Inventor
Achyutharao Sidduri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU2001283998A1 publication Critical patent/AU2001283998A1/en
Application granted granted Critical
Publication of AU2001283998B2 publication Critical patent/AU2001283998B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2001283998A 2000-08-15 2001-08-09 Tetrazolyl-phenyl acetamide glucokinase activators Ceased AU2001283998B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22549400P 2000-08-15 2000-08-15
US60/225,494 2000-08-15
PCT/EP2001/009207 WO2002014312A1 (en) 2000-08-15 2001-08-09 Tetrazolyl-phenyl acetamide glucokinase activators

Publications (2)

Publication Number Publication Date
AU2001283998A1 AU2001283998A1 (en) 2002-05-23
AU2001283998B2 true AU2001283998B2 (en) 2005-10-20

Family

ID=22845106

Family Applications (2)

Application Number Title Priority Date Filing Date
AU8399801A Pending AU8399801A (en) 2000-08-15 2001-08-09 Tetrazolyl-phenyl acetamide glucokinase activators
AU2001283998A Ceased AU2001283998B2 (en) 2000-08-15 2001-08-09 Tetrazolyl-phenyl acetamide glucokinase activators

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU8399801A Pending AU8399801A (en) 2000-08-15 2001-08-09 Tetrazolyl-phenyl acetamide glucokinase activators

Country Status (20)

Country Link
US (3) US6369232B1 (OSRAM)
EP (1) EP1311504B1 (OSRAM)
JP (1) JP3961948B2 (OSRAM)
KR (1) KR100518061B1 (OSRAM)
CN (1) CN1209362C (OSRAM)
AR (1) AR031718A1 (OSRAM)
AT (1) ATE297921T1 (OSRAM)
AU (2) AU8399801A (OSRAM)
BR (1) BR0113312A (OSRAM)
CA (1) CA2419416C (OSRAM)
DE (1) DE60111540T2 (OSRAM)
DK (1) DK1311504T3 (OSRAM)
ES (1) ES2243541T3 (OSRAM)
MX (1) MXPA03001275A (OSRAM)
PA (1) PA8525201A1 (OSRAM)
PE (1) PE20020386A1 (OSRAM)
PT (1) PT1311504E (OSRAM)
UY (1) UY26885A1 (OSRAM)
WO (1) WO2002014312A1 (OSRAM)
ZA (1) ZA200300904B (OSRAM)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
US7078423B2 (en) * 2002-07-18 2006-07-18 Inotek Pharmaceuticals Corporation 5-Aryltetrazole compounds, compositions thereof, and uses therefor
US7087631B2 (en) * 2002-07-18 2006-08-08 Inotek Pharmaceuticals Corporation Aryltetrazole compounds, and compositions thereof
RU2005113713A (ru) * 2002-10-03 2006-01-20 Новартис АГ (CH) Замещенные (тиазол-2-ил)амиды или сульфонамиды в качестве активаторов глюкокиназы, которые могут применяться при лечении диабета типа 2
GB0226931D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
US7132425B2 (en) 2002-12-12 2006-11-07 Hoffmann-La Roche Inc. 5-substituted-six-membered heteroaromatic glucokinase activators
AU2003294376A1 (en) * 2003-01-06 2004-08-10 Eli Lilly And Company Heteroaryl compounds
PL378117A1 (pl) * 2003-02-11 2006-03-06 Prosidion Limited Tricyklopodstawione związki amidowe
JP4621198B2 (ja) * 2003-02-11 2011-01-26 プロシディオン・リミテッド トリ（シクロ）置換アミドグルコキナーゼ活性化化合物
ATE524479T1 (de) 2004-04-02 2011-09-15 Novartis Ag Sulfonamidthiazolpyridinderivate als zur behandlung von typ-2-diabetes geeignete glucokinaseaktivatoren
WO2005095417A1 (en) 2004-04-02 2005-10-13 Novartis Ag Thiazolopyridine derivates, pharmaceutical conditions containing them and methods of treating glucokinase mediated conditions
BRPI0622261A2 (pt) 2005-07-09 2011-08-09 Astrazeneca Ab composto, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, processo para a preparação de um composto
TWI359149B (en) 2005-07-11 2012-03-01 Mitsubishi Tanabe Pharma Corp An oxime derivative and preparations thereof
BRPI0615236A2 (pt) 2005-08-31 2011-05-10 Astellas Pharma Inc derivado de tiazol
JP2007063225A (ja) * 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
RU2008112198A (ru) 2005-09-29 2009-10-10 Санофи-Авентис (Fr) Производные фенил-1,2,4-оксадиазолона, способы их получения и их применение в качестве фармацевтических средств
GT200600428A (es) 2005-09-30 2007-05-21 Compuestos organicos
GT200600429A (es) 2005-09-30 2007-04-30 Compuestos organicos
US20090005391A1 (en) * 2005-11-03 2009-01-01 Matthew Colin Thor Fyfe Tricyclo Substituted Amides
EP1948614A2 (en) * 2005-11-18 2008-07-30 Takeda San Diego, Inc. Glucokinase activators
US7994339B2 (en) * 2005-12-15 2011-08-09 Nihon Nohyaku Co., Ltd. Phthalamide derivative, agricultural or horticultural pesticide, and use of the pesticide
EP2001875A2 (en) 2006-03-08 2008-12-17 Takeda San Diego, Inc. Glucokinase activators
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
ATE522518T1 (de) 2006-05-31 2011-09-15 Takeda San Diego Inc Indazol- und isoindolderivate als glucokinaseaktivierende stoffe
US7910747B2 (en) * 2006-07-06 2011-03-22 Bristol-Myers Squibb Company Phosphonate and phosphinate pyrazolylamide glucokinase activators
US7902248B2 (en) 2006-12-14 2011-03-08 Hoffmann-La Roche Inc. Oxime glucokinase activators
US8163779B2 (en) 2006-12-20 2012-04-24 Takeda San Diego, Inc. Glucokinase activators
TW200831081A (en) 2006-12-25 2008-08-01 Kyorin Seiyaku Kk Glucokinase activator
WO2008084872A1 (ja) 2007-01-10 2008-07-17 Mitsubishi Tanabe Pharma Corporation ヒドラゾン誘導体
WO2008111473A1 (ja) 2007-03-07 2008-09-18 Kyorin Pharmaceutical Co., Ltd. グルコキナーゼ活性化物質
WO2008116107A2 (en) * 2007-03-21 2008-09-25 Takeda San Diego, Inc. Piperazine derivatives as glucokinase activators
CA2700783C (en) * 2007-10-08 2015-03-17 Advinus Therapeutics Private Limited Acetamide derivatives as glucokinase activators, their process and medicinal applications
CL2009000004A1 (es) * 2008-01-15 2010-02-19 Lilly Co Eli Forma cristalina de r-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida; composicion farmaceutica que comprende a dicha forma cristalina; y uso para el tratamiento de diabetes o hiperglicemia.
KR20100113518A (ko) 2008-01-18 2010-10-21 아스텔라스세이야쿠 가부시키가이샤 페닐아세트아미드 유도체
SI2275414T1 (sl) 2008-04-28 2015-10-30 Kyorin Pharmaceutical Co., Ltd., Ciklopentilakrilamidni derivat
ES2893699T3 (es) 2010-03-31 2022-02-09 Scripps Research Inst Reprogramación de células

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3776917A (en) * 1972-06-05 1973-12-04 Schering Corp 2-amino-6-phenalkyl-aminopyridines and derivatives thereof
GB8909574D0 (en) 1989-04-26 1989-06-14 Ici Plc Chemical process
US5859052A (en) * 1993-01-14 1999-01-12 G. D. Searle & Co. Fatty acid analogs and prodrugs
US5461049A (en) * 1994-05-27 1995-10-24 Warner-Lambert Company Amide tetrazole ACAT inhibitors
US5468867A (en) * 1994-05-27 1995-11-21 Syntex (U.S.A.) Inc. Process for preparing1-butyl-2-[2'-(2H-tetrazol-5-yl)biphenyl-4-ylmethyl1-1H-indole-3-carboxylic acid
HUP0002053A3 (en) * 1997-01-28 2001-09-28 Merck & Co Inc Thiazole benzenesulfonamides as beta3 agonists for the treatment of diabetes and obesity
CN1151140C (zh) * 1999-03-29 2004-05-26 霍夫曼-拉罗奇有限公司 葡糖激酶活化剂

Also Published As

Publication number Publication date
DE60111540D1 (de) 2005-07-21
MXPA03001275A (es) 2003-06-30
CA2419416A1 (en) 2002-02-21
US20020035266A1 (en) 2002-03-21
PE20020386A1 (es) 2002-05-13
JP2004506632A (ja) 2004-03-04
CN1209362C (zh) 2005-07-06
UY26885A1 (es) 2002-02-28
ATE297921T1 (de) 2005-07-15
AR031718A1 (es) 2003-10-01
DK1311504T3 (da) 2005-10-17
EP1311504A1 (en) 2003-05-21
JP3961948B2 (ja) 2007-08-22
ZA200300904B (en) 2004-04-30
US6441180B1 (en) 2002-08-27
KR100518061B1 (ko) 2005-09-28
CA2419416C (en) 2009-10-13
KR20030022408A (ko) 2003-03-15
AU8399801A (en) 2002-02-25
PA8525201A1 (es) 2002-07-30
DE60111540T2 (de) 2006-03-16
US20020065275A1 (en) 2002-05-30
ES2243541T3 (es) 2005-12-01
US6388088B1 (en) 2002-05-14
PT1311504E (pt) 2005-10-31
US6369232B1 (en) 2002-04-09
US20020035267A1 (en) 2002-03-21
WO2002014312A1 (en) 2002-02-21
BR0113312A (pt) 2003-07-01
EP1311504B1 (en) 2005-06-15
CN1466584A (zh) 2004-01-07

Similar Documents

Publication Publication Date Title
AU2001283998B2 (en) Tetrazolyl-phenyl acetamide glucokinase activators
AU2001283998A1 (en) Tetrazolyl-phenyl acetamide glucokinase activators
CA2407763C (en) Para-amine substituted phenylamide glucokinase activators
AU781029B2 (en) Trans olefinic glucokinase activators
US7223868B2 (en) Heteroaromatic glucokinase activators
EP1282611B1 (en) Substituted phenylacetamides and their use as glucokinase activators
AU2001265914A1 (en) Para-amine substituted phenylamide glucokinase activators
MXPA02010745A (es) Activadores de glucocinasa heteroaromaticos de alquinil-fenilo.
JP2002540196A (ja) グルコキナーゼ活性化物質
US6489485B2 (en) Para-amine substituted phenylamide glucokinase activators

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired