DK1216091T3 - Fremgangsmåde til indkapsling af aktivstoffer ved coacervering af polymerer i ikke-chloreret oplösningsmiddel - Google Patents

Fremgangsmåde til indkapsling af aktivstoffer ved coacervering af polymerer i ikke-chloreret oplösningsmiddel

Info

Publication number
DK1216091T3
DK1216091T3 DK00958741T DK00958741T DK1216091T3 DK 1216091 T3 DK1216091 T3 DK 1216091T3 DK 00958741 T DK00958741 T DK 00958741T DK 00958741 T DK00958741 T DK 00958741T DK 1216091 T3 DK1216091 T3 DK 1216091T3
Authority
DK
Denmark
Prior art keywords
coacervation
active principle
solvent
hardening
polymers
Prior art date
Application number
DK00958741T
Other languages
English (en)
Inventor
Joel Richard
Jean-Pierre Benoit
Elvire Fournier
Sonia Liu
Original Assignee
Mainelab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mainelab filed Critical Mainelab
Application granted granted Critical
Publication of DK1216091T3 publication Critical patent/DK1216091T3/da

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
DK00958741T 1999-08-27 2000-08-25 Fremgangsmåde til indkapsling af aktivstoffer ved coacervering af polymerer i ikke-chloreret oplösningsmiddel DK1216091T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9910854A FR2797784B1 (fr) 1999-08-27 1999-08-27 Procede d'encapsulation de matieres actives par coacervation de polymeres en solvant organique non-chlore

Publications (1)

Publication Number Publication Date
DK1216091T3 true DK1216091T3 (da) 2004-07-12

Family

ID=9549384

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00958741T DK1216091T3 (da) 1999-08-27 2000-08-25 Fremgangsmåde til indkapsling af aktivstoffer ved coacervering af polymerer i ikke-chloreret oplösningsmiddel

Country Status (18)

Country Link
EP (1) EP1216091B9 (da)
JP (1) JP5217070B2 (da)
KR (1) KR100661093B1 (da)
CN (1) CN1317064C (da)
AT (1) ATE261338T1 (da)
AU (1) AU776959B2 (da)
CA (1) CA2382697C (da)
DE (1) DE60008894T2 (da)
DK (1) DK1216091T3 (da)
ES (1) ES2215718T3 (da)
FR (1) FR2797784B1 (da)
HU (1) HU228747B1 (da)
IL (2) IL148316A0 (da)
MX (1) MXPA02002250A (da)
NO (1) NO322106B1 (da)
PT (1) PT1216091E (da)
WO (1) WO2001015799A1 (da)
ZA (1) ZA200201543B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1404516A2 (en) 2000-12-13 2004-04-07 Purdue Research Foundation Microencapsulation of drugs by solvent exchange
US6767637B2 (en) 2000-12-13 2004-07-27 Purdue Research Foundation Microencapsulation using ultrasonic atomizers
EP1343480B2 (en) † 2000-12-21 2016-02-17 Alrise Biosystems GmbH Induced phase transition method for the production of microparticles containing hydrophobic active agents
FR2824756B1 (fr) * 2001-05-16 2005-07-08 Mainelab Microcapsules a base de proteines vegetales
FR2832312B1 (fr) * 2001-11-21 2004-01-16 Inst Nat Sante Rech Med Procede de preparation de microparticules sans solvant toxique, microparticules obtenues selon ce procede, utilisations et compositions pharmaceutiques
US9480631B2 (en) 2008-11-10 2016-11-01 Colgate-Palmolive Company Shelf stable capsules

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
JPS5966425A (ja) * 1982-10-08 1984-04-14 Mitsui Toatsu Chem Inc 生体分解性重合体を用いた微小粒子の製造方法
JPS62213840A (ja) * 1986-03-14 1987-09-19 Snow Brand Milk Prod Co Ltd マイクロカプセルの乾燥方法
JPS6365945A (ja) * 1986-09-05 1988-03-24 Eisai Co Ltd マイクロカプセルの製造方法
US5234520A (en) * 1987-03-20 1993-08-10 Morgan Adhesives Co. Method of making an adhesive construction
JP2670680B2 (ja) * 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
US5324520A (en) * 1988-12-19 1994-06-28 Vipont Pharmaceutical, Inc. Intragingival delivery systems for treatment of periodontal disease
JP3114245B2 (ja) * 1991-06-03 2000-12-04 藤沢薬品工業株式会社 持続性製剤の製造方法
DK0674506T3 (da) * 1992-12-02 2001-01-08 Alkermes Inc Væksthormonholdige mikrosfærer med styret frigivelse
ES2172574T5 (es) * 1993-11-19 2012-11-29 Alkermes, Inc. Preparación de micropartículas biodegradables que contienen un agente biológicamente activo
US5650173A (en) * 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
ES2236700T3 (es) * 1993-11-19 2005-07-16 Janssen Pharmaceutica N.V. 1,2-benzazoles microencapsulados.
US5792477A (en) * 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent

Also Published As

Publication number Publication date
NO20020881L (no) 2002-04-25
ATE261338T1 (de) 2004-03-15
CA2382697A1 (fr) 2001-03-08
FR2797784B1 (fr) 2001-11-30
PT1216091E (pt) 2004-08-31
IL148316A0 (en) 2002-09-12
HU0203199D0 (da) 2002-10-28
CN1317064C (zh) 2007-05-23
CA2382697C (fr) 2009-05-05
ES2215718T3 (es) 2004-10-16
HU228747B1 (en) 2013-05-28
FR2797784A1 (fr) 2001-03-02
EP1216091B9 (fr) 2005-01-19
WO2001015799A1 (fr) 2001-03-08
JP2003508195A (ja) 2003-03-04
MXPA02002250A (es) 2003-08-20
KR20020046284A (ko) 2002-06-20
ZA200201543B (en) 2002-11-27
AU776959B2 (en) 2004-09-30
NO322106B1 (no) 2006-08-14
DE60008894D1 (de) 2004-04-15
IL148316A (en) 2006-10-31
EP1216091A1 (fr) 2002-06-26
AU7016800A (en) 2001-03-26
KR100661093B1 (ko) 2006-12-22
CN1371301A (zh) 2002-09-25
EP1216091B1 (fr) 2004-03-10
HUP0203199A2 (en) 2003-03-28
NO20020881D0 (no) 2002-02-22
JP5217070B2 (ja) 2013-06-19
DE60008894T2 (de) 2005-03-03

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