IL148316A0 - Method for encapsulating active substances by coacervation of polymers in non-chlorinated organic solvent - Google Patents

Method for encapsulating active substances by coacervation of polymers in non-chlorinated organic solvent

Info

Publication number
IL148316A0
IL148316A0 IL14831600A IL14831600A IL148316A0 IL 148316 A0 IL148316 A0 IL 148316A0 IL 14831600 A IL14831600 A IL 14831600A IL 14831600 A IL14831600 A IL 14831600A IL 148316 A0 IL148316 A0 IL 148316A0
Authority
IL
Israel
Prior art keywords
coacervation
active principle
organic solvent
polymers
solvent
Prior art date
Application number
IL14831600A
Other languages
English (en)
Original Assignee
Mainelab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mainelab filed Critical Mainelab
Publication of IL148316A0 publication Critical patent/IL148316A0/xx

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
IL14831600A 1999-08-27 2000-08-25 Method for encapsulating active substances by coacervation of polymers in non-chlorinated organic solvent IL148316A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9910854A FR2797784B1 (fr) 1999-08-27 1999-08-27 Procede d'encapsulation de matieres actives par coacervation de polymeres en solvant organique non-chlore
PCT/FR2000/002376 WO2001015799A1 (fr) 1999-08-27 2000-08-25 Procede d'encapsulation de matieres actives par coacervation de polymeres en solvant organique non-chlore

Publications (1)

Publication Number Publication Date
IL148316A0 true IL148316A0 (en) 2002-09-12

Family

ID=9549384

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14831600A IL148316A0 (en) 1999-08-27 2000-08-25 Method for encapsulating active substances by coacervation of polymers in non-chlorinated organic solvent
IL148316A IL148316A (en) 1999-08-27 2002-02-21 A method of encapsulating active substances by growing polymers in compressed matter in organic solvents which do not contain chlorine

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL148316A IL148316A (en) 1999-08-27 2002-02-21 A method of encapsulating active substances by growing polymers in compressed matter in organic solvents which do not contain chlorine

Country Status (18)

Country Link
EP (1) EP1216091B9 (xx)
JP (1) JP5217070B2 (xx)
KR (1) KR100661093B1 (xx)
CN (1) CN1317064C (xx)
AT (1) ATE261338T1 (xx)
AU (1) AU776959B2 (xx)
CA (1) CA2382697C (xx)
DE (1) DE60008894T2 (xx)
DK (1) DK1216091T3 (xx)
ES (1) ES2215718T3 (xx)
FR (1) FR2797784B1 (xx)
HU (1) HU228747B1 (xx)
IL (2) IL148316A0 (xx)
MX (1) MXPA02002250A (xx)
NO (1) NO322106B1 (xx)
PT (1) PT1216091E (xx)
WO (1) WO2001015799A1 (xx)
ZA (1) ZA200201543B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001298061A1 (en) 2000-12-13 2003-07-09 Purdue Research Foundation Microencapsulation of drugs by solvent exchange
US6767637B2 (en) 2000-12-13 2004-07-27 Purdue Research Foundation Microencapsulation using ultrasonic atomizers
AU2002232824A1 (en) * 2000-12-21 2002-07-01 Inhale Therapeutic Systems, Inc. Induced phase transition method for the production of microparticles containing hydrophobic active agents
FR2824756B1 (fr) * 2001-05-16 2005-07-08 Mainelab Microcapsules a base de proteines vegetales
FR2832312B1 (fr) * 2001-11-21 2004-01-16 Inst Nat Sante Rech Med Procede de preparation de microparticules sans solvant toxique, microparticules obtenues selon ce procede, utilisations et compositions pharmaceutiques
AU2008363816B2 (en) * 2008-11-10 2012-12-06 Colgate-Palmolive Company Shelf stable capsules

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
JPS5966425A (ja) * 1982-10-08 1984-04-14 Mitsui Toatsu Chem Inc 生体分解性重合体を用いた微小粒子の製造方法
JPS62213840A (ja) * 1986-03-14 1987-09-19 Snow Brand Milk Prod Co Ltd マイクロカプセルの乾燥方法
JPS6365945A (ja) * 1986-09-05 1988-03-24 Eisai Co Ltd マイクロカプセルの製造方法
US5234520A (en) * 1987-03-20 1993-08-10 Morgan Adhesives Co. Method of making an adhesive construction
JP2670680B2 (ja) * 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
US5324520A (en) * 1988-12-19 1994-06-28 Vipont Pharmaceutical, Inc. Intragingival delivery systems for treatment of periodontal disease
JP3114245B2 (ja) * 1991-06-03 2000-12-04 藤沢薬品工業株式会社 持続性製剤の製造方法
EP0674506B1 (en) * 1992-12-02 2000-08-23 Alkermes Controlled Therapeutics, Inc. Controlled release growth hormone containing microspheres
RO119224B1 (ro) * 1993-11-19 2004-06-30 Janssenápharmaceuticaán.V. Compoziţie farmaceutică pentru tratamentul unor afecţiuni psihotice şi utilizarea acesteia
US5650173A (en) * 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
PT729353E (pt) * 1993-11-19 2002-07-31 Alkermes Inc Preparacao de microparticulas biodegradaveis contendo um agente biologicamente activo
US5792477A (en) * 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent

Also Published As

Publication number Publication date
NO20020881L (no) 2002-04-25
DE60008894D1 (de) 2004-04-15
FR2797784A1 (fr) 2001-03-02
CA2382697C (fr) 2009-05-05
NO20020881D0 (no) 2002-02-22
EP1216091B1 (fr) 2004-03-10
EP1216091B9 (fr) 2005-01-19
ATE261338T1 (de) 2004-03-15
CA2382697A1 (fr) 2001-03-08
KR100661093B1 (ko) 2006-12-22
ZA200201543B (en) 2002-11-27
CN1371301A (zh) 2002-09-25
DE60008894T2 (de) 2005-03-03
JP5217070B2 (ja) 2013-06-19
PT1216091E (pt) 2004-08-31
HU0203199D0 (xx) 2002-10-28
AU776959B2 (en) 2004-09-30
JP2003508195A (ja) 2003-03-04
WO2001015799A1 (fr) 2001-03-08
DK1216091T3 (da) 2004-07-12
HUP0203199A2 (en) 2003-03-28
AU7016800A (en) 2001-03-26
HU228747B1 (en) 2013-05-28
NO322106B1 (no) 2006-08-14
KR20020046284A (ko) 2002-06-20
EP1216091A1 (fr) 2002-06-26
MXPA02002250A (es) 2003-08-20
CN1317064C (zh) 2007-05-23
ES2215718T3 (es) 2004-10-16
FR2797784B1 (fr) 2001-11-30
IL148316A (en) 2006-10-31

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Legal Events

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FF Patent granted
KB Patent renewed