IL148316A0 - Method for encapsulating active substances by coacervation of polymers in non-chlorinated organic solvent - Google Patents
Method for encapsulating active substances by coacervation of polymers in non-chlorinated organic solventInfo
- Publication number
- IL148316A0 IL148316A0 IL14831600A IL14831600A IL148316A0 IL 148316 A0 IL148316 A0 IL 148316A0 IL 14831600 A IL14831600 A IL 14831600A IL 14831600 A IL14831600 A IL 14831600A IL 148316 A0 IL148316 A0 IL 148316A0
- Authority
- IL
- Israel
- Prior art keywords
- coacervation
- active principle
- organic solvent
- polymers
- solvent
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
- Extraction Or Liquid Replacement (AREA)
- Encapsulation Of And Coatings For Semiconductor Or Solid State Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Abstract
The invention concerns a method for microencapsulation of an active principle by coacervation which consists in controlled desolvation or coacervation of a polymer dissolved in an organic solvent containing said active principle, said coacervation being induced by adding a non-solvent causing the polymer to be deposited at the surface of the active principle, and by hardening the polymer deposit by adding a hardening agent, said hardening being leading to the formation of a continuous film coating the active principle. The invention is characterised in that the solvent is selected among ethyl acetate, N-methylpyrrolidone, methylethylacetone and acetic acid. The non-solvent is advantageously an alcohol comprising two to five carbon atoms and the hardening agent being for instance selected among water, alcohols comprising four carbon atoms and mixtures thereof.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9910854A FR2797784B1 (en) | 1999-08-27 | 1999-08-27 | PROCESS FOR THE ENCAPSULATION OF ACTIVE MATERIALS BY COACERVATION OF POLYMERS IN NON-CHLORINE ORGANIC SOLVENT |
PCT/FR2000/002376 WO2001015799A1 (en) | 1999-08-27 | 2000-08-25 | Method for encapsulating active substances by coacervation of polymers in non-chlorinated organic solvent |
Publications (1)
Publication Number | Publication Date |
---|---|
IL148316A0 true IL148316A0 (en) | 2002-09-12 |
Family
ID=9549384
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14831600A IL148316A0 (en) | 1999-08-27 | 2000-08-25 | Method for encapsulating active substances by coacervation of polymers in non-chlorinated organic solvent |
IL148316A IL148316A (en) | 1999-08-27 | 2002-02-21 | Method for encapsulating active substances by coacervation of polymers in non-chlorinated organic solvent |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL148316A IL148316A (en) | 1999-08-27 | 2002-02-21 | Method for encapsulating active substances by coacervation of polymers in non-chlorinated organic solvent |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP1216091B9 (en) |
JP (1) | JP5217070B2 (en) |
KR (1) | KR100661093B1 (en) |
CN (1) | CN1317064C (en) |
AT (1) | ATE261338T1 (en) |
AU (1) | AU776959B2 (en) |
CA (1) | CA2382697C (en) |
DE (1) | DE60008894T2 (en) |
DK (1) | DK1216091T3 (en) |
ES (1) | ES2215718T3 (en) |
FR (1) | FR2797784B1 (en) |
HU (1) | HU228747B1 (en) |
IL (2) | IL148316A0 (en) |
MX (1) | MXPA02002250A (en) |
NO (1) | NO322106B1 (en) |
PT (1) | PT1216091E (en) |
WO (1) | WO2001015799A1 (en) |
ZA (1) | ZA200201543B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6599627B2 (en) | 2000-12-13 | 2003-07-29 | Purdue Research Foundation | Microencapsulation of drugs by solvent exchange |
US6767637B2 (en) | 2000-12-13 | 2004-07-27 | Purdue Research Foundation | Microencapsulation using ultrasonic atomizers |
AU2002235253A8 (en) * | 2000-12-21 | 2005-10-06 | Inhale Therapeutic Syst | Induced phase transition method for the production of microparticles containing hydrophilic active agents |
FR2824756B1 (en) * | 2001-05-16 | 2005-07-08 | Mainelab | MICROCAPSULES BASED ON PLANT PROTEINS |
FR2832312B1 (en) * | 2001-11-21 | 2004-01-16 | Inst Nat Sante Rech Med | PROCESS FOR THE PREPARATION OF MICROPARTICLES WITHOUT TOXIC SOLVENT, MICROPARTICLES OBTAINED ACCORDING TO THIS PROCESS, USES AND PHARMACEUTICAL COMPOSITIONS |
BRPI0823242A2 (en) | 2008-11-10 | 2015-06-16 | Colgate Palmolive Co | Capsule Paste, Toothpaste Composition, and Method for Reducing Leakage of Coacervated Capsules |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
JPS5966425A (en) * | 1982-10-08 | 1984-04-14 | Mitsui Toatsu Chem Inc | Preparation of fine particle using biodegradable polymer |
JPS62213840A (en) * | 1986-03-14 | 1987-09-19 | Snow Brand Milk Prod Co Ltd | Method for drying microcapsule |
JPS6365945A (en) * | 1986-09-05 | 1988-03-24 | Eisai Co Ltd | Preparation of microcapsule |
US5234520A (en) * | 1987-03-20 | 1993-08-10 | Morgan Adhesives Co. | Method of making an adhesive construction |
JP2670680B2 (en) * | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | Polylactic acid microspheres containing physiologically active substance and method for producing the same |
US5324520A (en) * | 1988-12-19 | 1994-06-28 | Vipont Pharmaceutical, Inc. | Intragingival delivery systems for treatment of periodontal disease |
JP3114245B2 (en) * | 1991-06-03 | 2000-12-04 | 藤沢薬品工業株式会社 | Method for producing sustained-release preparation |
DE69329295T2 (en) * | 1992-12-02 | 2001-03-15 | Alkermes Controlled Therapeutics, Inc. | GROWTH HORMONE CONTAINING MICROSPHERES WITH CONTROLLED RELEASE |
US5650173A (en) * | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
AU684324B2 (en) * | 1993-11-19 | 1997-12-11 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
JP3645906B2 (en) * | 1993-11-19 | 2005-05-11 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
US5792477A (en) * | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
-
1999
- 1999-08-27 FR FR9910854A patent/FR2797784B1/en not_active Expired - Fee Related
-
2000
- 2000-08-25 WO PCT/FR2000/002376 patent/WO2001015799A1/en active IP Right Grant
- 2000-08-25 CN CNB008121311A patent/CN1317064C/en not_active Expired - Fee Related
- 2000-08-25 MX MXPA02002250A patent/MXPA02002250A/en active IP Right Grant
- 2000-08-25 PT PT00958741T patent/PT1216091E/en unknown
- 2000-08-25 JP JP2001520202A patent/JP5217070B2/en not_active Expired - Lifetime
- 2000-08-25 DE DE60008894T patent/DE60008894T2/en not_active Expired - Lifetime
- 2000-08-25 KR KR1020027002467A patent/KR100661093B1/en not_active IP Right Cessation
- 2000-08-25 CA CA002382697A patent/CA2382697C/en not_active Expired - Fee Related
- 2000-08-25 AU AU70168/00A patent/AU776959B2/en not_active Ceased
- 2000-08-25 IL IL14831600A patent/IL148316A0/en active IP Right Grant
- 2000-08-25 EP EP00958741A patent/EP1216091B9/en not_active Expired - Lifetime
- 2000-08-25 ES ES00958741T patent/ES2215718T3/en not_active Expired - Lifetime
- 2000-08-25 DK DK00958741T patent/DK1216091T3/en active
- 2000-08-25 AT AT00958741T patent/ATE261338T1/en active
- 2000-09-25 HU HU0203199A patent/HU228747B1/en not_active IP Right Cessation
-
2002
- 2002-02-21 IL IL148316A patent/IL148316A/en not_active IP Right Cessation
- 2002-02-22 NO NO20020881A patent/NO322106B1/en not_active IP Right Cessation
- 2002-02-26 ZA ZA200201543A patent/ZA200201543B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU7016800A (en) | 2001-03-26 |
CN1317064C (en) | 2007-05-23 |
EP1216091B1 (en) | 2004-03-10 |
ES2215718T3 (en) | 2004-10-16 |
AU776959B2 (en) | 2004-09-30 |
DK1216091T3 (en) | 2004-07-12 |
NO20020881L (en) | 2002-04-25 |
CA2382697C (en) | 2009-05-05 |
HUP0203199A2 (en) | 2003-03-28 |
HU0203199D0 (en) | 2002-10-28 |
MXPA02002250A (en) | 2003-08-20 |
FR2797784A1 (en) | 2001-03-02 |
ATE261338T1 (en) | 2004-03-15 |
DE60008894T2 (en) | 2005-03-03 |
JP2003508195A (en) | 2003-03-04 |
FR2797784B1 (en) | 2001-11-30 |
EP1216091B9 (en) | 2005-01-19 |
KR100661093B1 (en) | 2006-12-22 |
CN1371301A (en) | 2002-09-25 |
KR20020046284A (en) | 2002-06-20 |
DE60008894D1 (en) | 2004-04-15 |
EP1216091A1 (en) | 2002-06-26 |
PT1216091E (en) | 2004-08-31 |
HU228747B1 (en) | 2013-05-28 |
WO2001015799A1 (en) | 2001-03-08 |
NO20020881D0 (en) | 2002-02-22 |
JP5217070B2 (en) | 2013-06-19 |
IL148316A (en) | 2006-10-31 |
NO322106B1 (en) | 2006-08-14 |
ZA200201543B (en) | 2002-11-27 |
CA2382697A1 (en) | 2001-03-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed |