IL148316A0 - Method for encapsulating active substances by coacervation of polymers in non-chlorinated organic solvent - Google Patents

Method for encapsulating active substances by coacervation of polymers in non-chlorinated organic solvent

Info

Publication number
IL148316A0
IL148316A0 IL14831600A IL14831600A IL148316A0 IL 148316 A0 IL148316 A0 IL 148316A0 IL 14831600 A IL14831600 A IL 14831600A IL 14831600 A IL14831600 A IL 14831600A IL 148316 A0 IL148316 A0 IL 148316A0
Authority
IL
Israel
Prior art keywords
coacervation
active principle
organic solvent
polymers
solvent
Prior art date
Application number
IL14831600A
Original Assignee
Mainelab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mainelab filed Critical Mainelab
Publication of IL148316A0 publication Critical patent/IL148316A0/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Abstract

The invention concerns a method for microencapsulation of an active principle by coacervation which consists in controlled desolvation or coacervation of a polymer dissolved in an organic solvent containing said active principle, said coacervation being induced by adding a non-solvent causing the polymer to be deposited at the surface of the active principle, and by hardening the polymer deposit by adding a hardening agent, said hardening being leading to the formation of a continuous film coating the active principle. The invention is characterised in that the solvent is selected among ethyl acetate, N-methylpyrrolidone, methylethylacetone and acetic acid. The non-solvent is advantageously an alcohol comprising two to five carbon atoms and the hardening agent being for instance selected among water, alcohols comprising four carbon atoms and mixtures thereof.
IL14831600A 1999-08-27 2000-08-25 Method for encapsulating active substances by coacervation of polymers in non-chlorinated organic solvent IL148316A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9910854A FR2797784B1 (en) 1999-08-27 1999-08-27 PROCESS FOR THE ENCAPSULATION OF ACTIVE MATERIALS BY COACERVATION OF POLYMERS IN NON-CHLORINE ORGANIC SOLVENT
PCT/FR2000/002376 WO2001015799A1 (en) 1999-08-27 2000-08-25 Method for encapsulating active substances by coacervation of polymers in non-chlorinated organic solvent

Publications (1)

Publication Number Publication Date
IL148316A0 true IL148316A0 (en) 2002-09-12

Family

ID=9549384

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14831600A IL148316A0 (en) 1999-08-27 2000-08-25 Method for encapsulating active substances by coacervation of polymers in non-chlorinated organic solvent
IL148316A IL148316A (en) 1999-08-27 2002-02-21 Method for encapsulating active substances by coacervation of polymers in non-chlorinated organic solvent

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL148316A IL148316A (en) 1999-08-27 2002-02-21 Method for encapsulating active substances by coacervation of polymers in non-chlorinated organic solvent

Country Status (18)

Country Link
EP (1) EP1216091B9 (en)
JP (1) JP5217070B2 (en)
KR (1) KR100661093B1 (en)
CN (1) CN1317064C (en)
AT (1) ATE261338T1 (en)
AU (1) AU776959B2 (en)
CA (1) CA2382697C (en)
DE (1) DE60008894T2 (en)
DK (1) DK1216091T3 (en)
ES (1) ES2215718T3 (en)
FR (1) FR2797784B1 (en)
HU (1) HU228747B1 (en)
IL (2) IL148316A0 (en)
MX (1) MXPA02002250A (en)
NO (1) NO322106B1 (en)
PT (1) PT1216091E (en)
WO (1) WO2001015799A1 (en)
ZA (1) ZA200201543B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001298061A1 (en) 2000-12-13 2003-07-09 Purdue Research Foundation Microencapsulation of drugs by solvent exchange
US6767637B2 (en) 2000-12-13 2004-07-27 Purdue Research Foundation Microencapsulation using ultrasonic atomizers
AU2002232824A1 (en) * 2000-12-21 2002-07-01 Inhale Therapeutic Systems, Inc. Induced phase transition method for the production of microparticles containing hydrophobic active agents
FR2824756B1 (en) * 2001-05-16 2005-07-08 Mainelab MICROCAPSULES BASED ON PLANT PROTEINS
FR2832312B1 (en) * 2001-11-21 2004-01-16 Inst Nat Sante Rech Med PROCESS FOR THE PREPARATION OF MICROPARTICLES WITHOUT TOXIC SOLVENT, MICROPARTICLES OBTAINED ACCORDING TO THIS PROCESS, USES AND PHARMACEUTICAL COMPOSITIONS
AU2008363816B2 (en) * 2008-11-10 2012-12-06 Colgate-Palmolive Company Shelf stable capsules

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
JPS5966425A (en) * 1982-10-08 1984-04-14 Mitsui Toatsu Chem Inc Preparation of fine particle using biodegradable polymer
JPS62213840A (en) * 1986-03-14 1987-09-19 Snow Brand Milk Prod Co Ltd Method for drying microcapsule
JPS6365945A (en) * 1986-09-05 1988-03-24 Eisai Co Ltd Preparation of microcapsule
US5234520A (en) * 1987-03-20 1993-08-10 Morgan Adhesives Co. Method of making an adhesive construction
JP2670680B2 (en) * 1988-02-24 1997-10-29 株式会社ビーエムジー Polylactic acid microspheres containing physiologically active substance and method for producing the same
US5324520A (en) * 1988-12-19 1994-06-28 Vipont Pharmaceutical, Inc. Intragingival delivery systems for treatment of periodontal disease
JP3114245B2 (en) * 1991-06-03 2000-12-04 藤沢薬品工業株式会社 Method for producing sustained-release preparation
EP0674506B1 (en) * 1992-12-02 2000-08-23 Alkermes Controlled Therapeutics, Inc. Controlled release growth hormone containing microspheres
RO119224B1 (en) * 1993-11-19 2004-06-30 Janssenápharmaceuticaán.V. Pharmaceutical composition for the treatment of psychotic diseases
US5650173A (en) * 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
PT729353E (en) * 1993-11-19 2002-07-31 Alkermes Inc PREPARATION OF BIODEGRADABLE MICROPARTICLES CONTAINING A BIOLOGICALLY ACTIVE AGENT
US5792477A (en) * 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent

Also Published As

Publication number Publication date
NO20020881L (en) 2002-04-25
DE60008894D1 (en) 2004-04-15
FR2797784A1 (en) 2001-03-02
CA2382697C (en) 2009-05-05
NO20020881D0 (en) 2002-02-22
EP1216091B1 (en) 2004-03-10
EP1216091B9 (en) 2005-01-19
ATE261338T1 (en) 2004-03-15
CA2382697A1 (en) 2001-03-08
KR100661093B1 (en) 2006-12-22
ZA200201543B (en) 2002-11-27
CN1371301A (en) 2002-09-25
DE60008894T2 (en) 2005-03-03
JP5217070B2 (en) 2013-06-19
PT1216091E (en) 2004-08-31
HU0203199D0 (en) 2002-10-28
AU776959B2 (en) 2004-09-30
JP2003508195A (en) 2003-03-04
WO2001015799A1 (en) 2001-03-08
DK1216091T3 (en) 2004-07-12
HUP0203199A2 (en) 2003-03-28
AU7016800A (en) 2001-03-26
HU228747B1 (en) 2013-05-28
NO322106B1 (en) 2006-08-14
KR20020046284A (en) 2002-06-20
EP1216091A1 (en) 2002-06-26
MXPA02002250A (en) 2003-08-20
CN1317064C (en) 2007-05-23
ES2215718T3 (en) 2004-10-16
FR2797784B1 (en) 2001-11-30
IL148316A (en) 2006-10-31

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Legal Events

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KB Patent renewed