NO20020881L - Process for Encapsulation of Active Substances by Accumulation of Polymers in Non-Chlorinated Organic Solvents - Google Patents

Process for Encapsulation of Active Substances by Accumulation of Polymers in Non-Chlorinated Organic Solvents

Info

Publication number
NO20020881L
NO20020881L NO20020881A NO20020881A NO20020881L NO 20020881 L NO20020881 L NO 20020881L NO 20020881 A NO20020881 A NO 20020881A NO 20020881 A NO20020881 A NO 20020881A NO 20020881 L NO20020881 L NO 20020881L
Authority
NO
Norway
Prior art keywords
accumulation
active principle
encapsulation
polymers
solvent
Prior art date
Application number
NO20020881A
Other languages
Norwegian (no)
Other versions
NO322106B1 (en
NO20020881D0 (en
Inventor
Jean-Pierre Benoit
Joel Richard
Elvire Fourier
Sonia Liu
Original Assignee
Mainelab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mainelab filed Critical Mainelab
Publication of NO20020881D0 publication Critical patent/NO20020881D0/en
Publication of NO20020881L publication Critical patent/NO20020881L/en
Publication of NO322106B1 publication Critical patent/NO322106B1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Abstract

Foreliggende oppfinnelse angår en fremgangsmåte for en mikroinnkapsling av et aktivt prinsipp ved - samopphopning, som består i en kontrollert løsing eller samopphopning av en polymer løst i et organisk løsemiddel inneholdende nevnte aktive prinsipp, og hvor nevnte samopphopning induseres ved å tilsette et ikke-løsemiddel som gjør at polymeren avsettes på overflaten av det aktive prinsippet, og deretter herde den avsatte polymeren ved å tilsette et herdemiddel, og hvor nevnte herding fører til dannelsen av et kontinuerlig filmbelegg på det aktive prinsippet. Oppfinnelsen erat løsemiddelet er valgt fra etylacetat, N-metylpyrrolidon, metyletylketon og eddiksyre. Ikke-løsemiddelet er fordelaktig en alkohol med fra 2 til 5 karbonatomer, mens herdemiddelet for eksempel er valgt fra vann, alkoholer med opp til 4 karbonatomer og blandinger av disse.The present invention relates to a process for a microencapsulation of an active principle by co-accumulation, which consists in a controlled solution or co-accumulation of a polymer dissolved in an organic solvent containing said active principle, and wherein said co-accumulation is induced by adding a non-solvent which causing the polymer to be deposited on the surface of the active principle, and then curing the deposited polymer by adding a curing agent, said curing leading to the formation of a continuous film coating on the active principle. The invention is the solvent selected from ethyl acetate, N-methylpyrrolidone, methyl ethyl ketone and acetic acid. The non-solvent is advantageously an alcohol having from 2 to 5 carbon atoms, while the curing agent is, for example, selected from water, alcohols having up to 4 carbon atoms and mixtures thereof.

NO20020881A 1999-08-27 2002-02-22 Process for Encapsulation of Active Substances by Phase Separation of Polymers in Non-Chlorinated Organic Solvents NO322106B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9910854A FR2797784B1 (en) 1999-08-27 1999-08-27 PROCESS FOR THE ENCAPSULATION OF ACTIVE MATERIALS BY COACERVATION OF POLYMERS IN NON-CHLORINE ORGANIC SOLVENT
PCT/FR2000/002376 WO2001015799A1 (en) 1999-08-27 2000-08-25 Method for encapsulating active substances by coacervation of polymers in non-chlorinated organic solvent

Publications (3)

Publication Number Publication Date
NO20020881D0 NO20020881D0 (en) 2002-02-22
NO20020881L true NO20020881L (en) 2002-04-25
NO322106B1 NO322106B1 (en) 2006-08-14

Family

ID=9549384

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020881A NO322106B1 (en) 1999-08-27 2002-02-22 Process for Encapsulation of Active Substances by Phase Separation of Polymers in Non-Chlorinated Organic Solvents

Country Status (18)

Country Link
EP (1) EP1216091B9 (en)
JP (1) JP5217070B2 (en)
KR (1) KR100661093B1 (en)
CN (1) CN1317064C (en)
AT (1) ATE261338T1 (en)
AU (1) AU776959B2 (en)
CA (1) CA2382697C (en)
DE (1) DE60008894T2 (en)
DK (1) DK1216091T3 (en)
ES (1) ES2215718T3 (en)
FR (1) FR2797784B1 (en)
HU (1) HU228747B1 (en)
IL (2) IL148316A0 (en)
MX (1) MXPA02002250A (en)
NO (1) NO322106B1 (en)
PT (1) PT1216091E (en)
WO (1) WO2001015799A1 (en)
ZA (1) ZA200201543B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1404516A2 (en) 2000-12-13 2004-04-07 Purdue Research Foundation Microencapsulation of drugs by solvent exchange
US6767637B2 (en) 2000-12-13 2004-07-27 Purdue Research Foundation Microencapsulation using ultrasonic atomizers
EP1343480B2 (en) † 2000-12-21 2016-02-17 Alrise Biosystems GmbH Induced phase transition method for the production of microparticles containing hydrophobic active agents
FR2824756B1 (en) * 2001-05-16 2005-07-08 Mainelab MICROCAPSULES BASED ON PLANT PROTEINS
FR2832312B1 (en) * 2001-11-21 2004-01-16 Inst Nat Sante Rech Med PROCESS FOR THE PREPARATION OF MICROPARTICLES WITHOUT TOXIC SOLVENT, MICROPARTICLES OBTAINED ACCORDING TO THIS PROCESS, USES AND PHARMACEUTICAL COMPOSITIONS
US9480631B2 (en) 2008-11-10 2016-11-01 Colgate-Palmolive Company Shelf stable capsules

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
JPS5966425A (en) * 1982-10-08 1984-04-14 Mitsui Toatsu Chem Inc Preparation of fine particle using biodegradable polymer
JPS62213840A (en) * 1986-03-14 1987-09-19 Snow Brand Milk Prod Co Ltd Method for drying microcapsule
JPS6365945A (en) * 1986-09-05 1988-03-24 Eisai Co Ltd Preparation of microcapsule
US5234520A (en) * 1987-03-20 1993-08-10 Morgan Adhesives Co. Method of making an adhesive construction
JP2670680B2 (en) * 1988-02-24 1997-10-29 株式会社ビーエムジー Polylactic acid microspheres containing physiologically active substance and method for producing the same
US5324520A (en) * 1988-12-19 1994-06-28 Vipont Pharmaceutical, Inc. Intragingival delivery systems for treatment of periodontal disease
JP3114245B2 (en) * 1991-06-03 2000-12-04 藤沢薬品工業株式会社 Method for producing sustained-release preparation
DK0674506T3 (en) * 1992-12-02 2001-01-08 Alkermes Inc Controlled release growth hormone-containing microspheres
ES2172574T5 (en) * 1993-11-19 2012-11-29 Alkermes, Inc. Preparation of biodegradable microparticles containing a biologically active agent
US5650173A (en) * 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
ES2236700T3 (en) * 1993-11-19 2005-07-16 Janssen Pharmaceutica N.V. 1,2-MICROENCAPSULATED BENZAZOLS.
US5792477A (en) * 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent

Also Published As

Publication number Publication date
ATE261338T1 (en) 2004-03-15
CA2382697A1 (en) 2001-03-08
FR2797784B1 (en) 2001-11-30
PT1216091E (en) 2004-08-31
IL148316A0 (en) 2002-09-12
HU0203199D0 (en) 2002-10-28
CN1317064C (en) 2007-05-23
CA2382697C (en) 2009-05-05
ES2215718T3 (en) 2004-10-16
HU228747B1 (en) 2013-05-28
FR2797784A1 (en) 2001-03-02
EP1216091B9 (en) 2005-01-19
WO2001015799A1 (en) 2001-03-08
JP2003508195A (en) 2003-03-04
MXPA02002250A (en) 2003-08-20
KR20020046284A (en) 2002-06-20
ZA200201543B (en) 2002-11-27
AU776959B2 (en) 2004-09-30
NO322106B1 (en) 2006-08-14
DE60008894D1 (en) 2004-04-15
IL148316A (en) 2006-10-31
EP1216091A1 (en) 2002-06-26
AU7016800A (en) 2001-03-26
DK1216091T3 (en) 2004-07-12
KR100661093B1 (en) 2006-12-22
CN1371301A (en) 2002-09-25
EP1216091B1 (en) 2004-03-10
HUP0203199A2 (en) 2003-03-28
NO20020881D0 (en) 2002-02-22
JP5217070B2 (en) 2013-06-19
DE60008894T2 (en) 2005-03-03

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