AU2001228653A1 - Coated implants - Google Patents

Coated implants

Info

Publication number
AU2001228653A1
AU2001228653A1 AU2001228653A AU2865301A AU2001228653A1 AU 2001228653 A1 AU2001228653 A1 AU 2001228653A1 AU 2001228653 A AU2001228653 A AU 2001228653A AU 2865301 A AU2865301 A AU 2865301A AU 2001228653 A1 AU2001228653 A1 AU 2001228653A1
Authority
AU
Australia
Prior art keywords
polymer
stent
meth
acrylate
cross
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001228653A
Inventor
Gerald Laurence Hughes
Terrence Albert Vick
Jin Hai Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Vascular Devices Ltd
Original Assignee
Biocompatibles Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocompatibles Ltd filed Critical Biocompatibles Ltd
Publication of AU2001228653A1 publication Critical patent/AU2001228653A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/256—Antibodies, e.g. immunoglobulins, vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/258—Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31855—Of addition polymer from unsaturated monomers

Abstract

An implant, usually a stent, has a coating of a cross-linked water swellable polymer matrix preferably having a dry thickness of at least 0.1 mum, and a pharmaceutically active compound, the polymer having pendant cationic and pendant zwitterionic groups. The active is usually an anionic compound such as a nucleic acid. The polymer is peferably formed from 2-methacyloy-loxyethyl-2'-trimethylammoniumethyl phosphate inner salt, trialkylammoniumalkyl(meth)acrylate and a cross-linkable monomer such as omega-(trialkoxysilyl)alkyl(meth)acrylate, optionally with a termonomer such as a higher alkyl (meth)acrylate. The stent is coated with polymer, cross-linked then contacted with a solution or dispersion of active compound in a solvent which swells the polymer whereby the active is absorbed into the polymer matrix. The stent is delivered by usual means into a body lumen and the actives released over an extended period of time into the wall of the lumen and/or fluid flowing therein.
AU2001228653A 2000-01-24 2001-01-24 Coated implants Abandoned AU2001228653A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00300509 2000-01-24
EP00300509 2000-01-24
PCT/GB2001/000281 WO2001052915A1 (en) 2000-01-24 2001-01-24 Coated implants

Publications (1)

Publication Number Publication Date
AU2001228653A1 true AU2001228653A1 (en) 2001-07-31

Family

ID=8172662

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001228653A Abandoned AU2001228653A1 (en) 2000-01-24 2001-01-24 Coated implants

Country Status (7)

Country Link
US (2) US6746686B2 (en)
EP (1) EP1250164B1 (en)
JP (1) JP5000826B2 (en)
AT (1) ATE310542T1 (en)
AU (1) AU2001228653A1 (en)
DE (1) DE60115203T2 (en)
WO (1) WO2001052915A1 (en)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040254635A1 (en) 1998-03-30 2004-12-16 Shanley John F. Expandable medical device for delivery of beneficial agent
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
AU4941400A (en) * 1999-05-27 2001-01-22 Biocompatibles Limited Local drug delivery
EP2103284B1 (en) 2000-10-16 2016-12-21 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
GB0100761D0 (en) 2001-01-11 2001-02-21 Biocompatibles Ltd Drug delivery from stents
US20040073294A1 (en) * 2002-09-20 2004-04-15 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US20040204756A1 (en) * 2004-02-11 2004-10-14 Diaz Stephen Hunter Absorbent article with improved liquid acquisition capacity
US7682669B1 (en) * 2001-07-30 2010-03-23 Advanced Cardiovascular Systems, Inc. Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device
US20040249443A1 (en) * 2001-08-20 2004-12-09 Shanley John F. Expandable medical device for treating cardiac arrhythmias
US20040137066A1 (en) * 2001-11-26 2004-07-15 Swaminathan Jayaraman Rationally designed therapeutic intravascular implant coating
US20030050648A1 (en) 2001-09-11 2003-03-13 Spiration, Inc. Removable lung reduction devices, systems, and methods
US6592594B2 (en) 2001-10-25 2003-07-15 Spiration, Inc. Bronchial obstruction device deployment system and method
IL162734A0 (en) 2002-02-01 2005-11-20 Ariad Gene Therapeutics Inc Phosphorus-containing compounds & uses thereof
US6929637B2 (en) 2002-02-21 2005-08-16 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US20060235432A1 (en) * 2002-02-21 2006-10-19 Devore Lauri J Intra-bronchial obstructing device that controls biological interaction with the patient
US20030216769A1 (en) 2002-05-17 2003-11-20 Dillard David H. Removable anchored lung volume reduction devices and methods
US20030181922A1 (en) 2002-03-20 2003-09-25 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US7758636B2 (en) * 2002-09-20 2010-07-20 Innovational Holdings Llc Expandable medical device with openings for delivery of multiple beneficial agents
WO2004043509A1 (en) * 2002-11-08 2004-05-27 Conor Medsystems, Inc. Expandable medical device and method for treating chronic total occlusions with local delivery of an angiogenic factor
EP1560613A1 (en) * 2002-11-08 2005-08-10 Conor Medsystems, Inc. Method and apparatus for reducing tissue damage after ischemic injury
US20050079199A1 (en) * 2003-02-18 2005-04-14 Medtronic, Inc. Porous coatings for drug release from medical devices
EP1610823B1 (en) 2003-03-28 2011-09-28 Innovational Holdings, LLC Implantable medical device with continuous agent concentration gradient
US20050010170A1 (en) * 2004-02-11 2005-01-13 Shanley John F Implantable medical device with beneficial agent concentration gradient
US7100616B2 (en) 2003-04-08 2006-09-05 Spiration, Inc. Bronchoscopic lung volume reduction method
US7533671B2 (en) 2003-08-08 2009-05-19 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
WO2005027991A1 (en) * 2003-09-19 2005-03-31 Cambridge University Technical Services Ltd Orthopaedic devices
US7785653B2 (en) 2003-09-22 2010-08-31 Innovational Holdings Llc Method and apparatus for loading a beneficial agent into an expandable medical device
US20050100577A1 (en) * 2003-11-10 2005-05-12 Parker Theodore L. Expandable medical device with beneficial agent matrix formed by a multi solvent system
WO2005075003A1 (en) * 2004-01-21 2005-08-18 Medtronic Vascular Inc. Implantable medical devices for treating or preventing restenosis
US20050208093A1 (en) 2004-03-22 2005-09-22 Thierry Glauser Phosphoryl choline coating compositions
US20050287287A1 (en) * 2004-06-24 2005-12-29 Parker Theodore L Methods and systems for loading an implantable medical device with beneficial agent
GB2420976B (en) * 2004-11-19 2006-12-20 Zvi Finkelstein Therapeutic implant
US9101949B2 (en) 2005-08-04 2015-08-11 Eilaz Babaev Ultrasonic atomization and/or seperation system
US7896539B2 (en) 2005-08-16 2011-03-01 Bacoustics, Llc Ultrasound apparatus and methods for mixing liquids and coating stents
US20070048349A1 (en) * 2005-08-29 2007-03-01 Bausch & Lomb Incorporated Surface-modified medical devices and methods of making
US7691151B2 (en) 2006-03-31 2010-04-06 Spiration, Inc. Articulable Anchor
US8568764B2 (en) 2006-05-31 2013-10-29 Advanced Cardiovascular Systems, Inc. Methods of forming coating layers for medical devices utilizing flash vaporization
US20080097588A1 (en) * 2006-10-18 2008-04-24 Conor Medsystems, Inc. Systems and Methods for Producing a Medical Device
CN101622493A (en) * 2006-12-04 2010-01-06 科锐Led照明科技公司 Lighting device and lighting method
EP2157976A4 (en) * 2007-04-19 2012-03-07 Univ Massachusetts Medical Thermal responsive polymer siloxanes, compositions, and methods and applications related thereto
US8802184B2 (en) * 2007-05-30 2014-08-12 Abbott Cardiovascular Systems Inc. Medical devices containing biobeneficial particles
US7753285B2 (en) 2007-07-13 2010-07-13 Bacoustics, Llc Echoing ultrasound atomization and/or mixing system
US7780095B2 (en) 2007-07-13 2010-08-24 Bacoustics, Llc Ultrasound pumping apparatus
US8043301B2 (en) 2007-10-12 2011-10-25 Spiration, Inc. Valve loader method, system, and apparatus
JP5570993B2 (en) 2007-10-12 2014-08-13 スピレーション インコーポレイテッド Valve loader methods, systems, and apparatus
US8679571B2 (en) 2008-04-09 2014-03-25 Alexander Rübben Method for producing a bioactive surface on an endoprosthesis or on the balloon of a balloon catheter
EP2437684B1 (en) 2009-06-03 2022-06-15 ForSight Vision5, Inc. Anterior segment drug delivery
EP2380602B1 (en) * 2010-04-14 2015-04-22 Hans Kosak Nucleic acids containing plastics in complexed form and method for producing same
US9295747B2 (en) 2010-10-20 2016-03-29 Nof Corporation Contact lens care preparation and packaging solution
US8795241B2 (en) 2011-05-13 2014-08-05 Spiration, Inc. Deployment catheter
EP4094734A1 (en) 2011-09-14 2022-11-30 Forsight Vision5, Inc. Ocular insert apparatus
WO2013053483A1 (en) 2011-10-11 2013-04-18 Secutech International Pte. Ltd. Method for producing plastics containing nucleic acids in complexed form
KR101797275B1 (en) * 2012-03-02 2017-11-13 니치유 가부시키가이샤 Contact lens care preparation and packaging solution
SI2911623T1 (en) 2012-10-26 2019-12-31 Forsight Vision5, Inc. Ophthalmic system for sustained release of drug to eye
JP6111052B2 (en) * 2012-11-22 2017-04-05 国立大学法人 東京大学 Water-soluble surface treatment agent for imparting stain resistance, and surface treatment method
JP6100893B2 (en) * 2013-05-27 2017-03-22 Jsr株式会社 Surface treatment agent for surface composed of inorganic material, instrument and apparatus with modified surface, and method for producing instrument and apparatus
JPWO2014203668A1 (en) 2013-06-20 2017-02-23 住友ゴム工業株式会社 Surface modification method and surface modified body
JP6008213B2 (en) * 2014-08-06 2016-10-19 リューベン，アレクサンダー Method for producing bioactive surface on endoprosthesis or balloon of balloon catheter
JP6371165B2 (en) * 2014-09-02 2018-08-08 住友ゴム工業株式会社 Metal medical tools
WO2016168141A1 (en) 2015-04-13 2016-10-20 Forsight Vision5, Inc. Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent
JP6613692B2 (en) 2015-08-03 2019-12-04 住友ゴム工業株式会社 Surface modification method and surface modified elastic body
KR20190020318A (en) 2016-06-13 2019-02-28 메사추세츠 인스티튜트 오브 테크놀로지 Biocompatible coatings and hydrogels to reduce foreign material reactions and fibrosis

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5674192A (en) 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
AU666485B2 (en) 1991-07-05 1996-02-15 Biocompatibles Uk Limited Polymeric surface coatings
DK0818479T3 (en) * 1991-08-08 2001-01-15 Biocompatibles Ltd Polymer surface coatings
US5342621A (en) 1992-09-15 1994-08-30 Advanced Cardiovascular Systems, Inc. Antithrombogenic surface
ES2167358T3 (en) 1993-01-07 2002-05-16 Univ Jefferson ANTISENTIDE INHIBITION OF C-MYC TO MODULATE THE PROLIFERATION OF SMOOTH MUSCLE CELLS.
CZ274596A3 (en) 1994-03-18 1997-03-12 Lynx Therapeutics Oligonucleotide n3 - p5 phosphoramidates and process of their synthesis and hybridization
US6090618A (en) * 1996-10-07 2000-07-18 Arch Development Corporation DNA constructs and viral vectors comprising a smooth muscle promoter
US5876433A (en) 1996-05-29 1999-03-02 Ethicon, Inc. Stent and method of varying amounts of heparin coated thereon to control treatment
WO1997047253A1 (en) 1996-06-14 1997-12-18 Kriton Medical, Inc. Methods and devices for reducing angina, enhancing myocardial perfusion and increasing cardiac function
GB9624130D0 (en) 1996-11-20 1997-01-08 Biocompatibles Ltd Biocompatible compositions
ES2251073T3 (en) 1997-02-20 2006-04-16 Cook Incorporated IMPLANTABLE MEDICAL DEVICE WITH A COVER.
DE19713214A1 (en) * 1997-03-28 1998-12-10 Ruebben Alexander Dr Med Covered stent, e.g. for treating vascular stenosis or aneurysms
US6776792B1 (en) 1997-04-24 2004-08-17 Advanced Cardiovascular Systems Inc. Coated endovascular stent
US6221425B1 (en) * 1998-01-30 2001-04-24 Advanced Cardiovascular Systems, Inc. Lubricious hydrophilic coating for an intracorporeal medical device
EP1019111B1 (en) * 1998-04-27 2002-06-26 Surmodics Inc. Bioactive agent release coating
AU4941400A (en) 1999-05-27 2001-01-22 Biocompatibles Limited Local drug delivery

Also Published As

Publication number Publication date
ATE310542T1 (en) 2005-12-15
EP1250164B1 (en) 2005-11-23
US6746686B2 (en) 2004-06-08
JP5000826B2 (en) 2012-08-15
EP1250164A1 (en) 2002-10-23
DE60115203T2 (en) 2006-08-03
DE60115203D1 (en) 2005-12-29
JP2003520107A (en) 2003-07-02
WO2001052915A1 (en) 2001-07-26
US20030086957A1 (en) 2003-05-08
US20040197585A1 (en) 2004-10-07

Similar Documents

Publication Publication Date Title
AU2001228653A1 (en) Coated implants
EP0922386A3 (en) Controlled release compositions
EP0636366A3 (en) Controlled release formulations coated with aqueous dispersions of acrylic polymers
WO1998029095A3 (en) Sustained release cisapride mini-tablet formulation
GB0100761D0 (en) Drug delivery from stents
EP1166866A3 (en) Encapsulated chemicals for use in controlled time release applications
WO2001030408A3 (en) Adhesive composition over a bioactive polymerization initiator
ES2179646T3 (en) COATING THAT RELEASES A BIOACTIVE AGENT.
CA2236182A1 (en) Drug-releasing coatings for medical devices
AU2002254036A1 (en) Taste masked pharmaceutical compositions
CA2315329A1 (en) Improved hmg coa reductase inhibitor extended release formulation
AU1728901A (en) Electropolymerizable monomers and polymeric coatings on implantable devices
WO2001002449A3 (en) Poly(meth)acrylic photochromic coating
CA2214100A1 (en) Sustained release formulation containing three different types of polymers
CA2312710A1 (en) Sustained release formulation containing three different types of polymers and tablet formed therefrom
ES2172664T3 (en) IMPREGNATED APPLICATOR POINT.
CA2019410A1 (en) Liquid polymer composition, and method of use
EP1076239A3 (en) Coating with cross-linked hydrophilic polymers
WO2002024174A3 (en) Sustained release composition containing clarithromycin
CA2338070A1 (en) Diltiazem controlled release formulation and method of manufacture
ATE167201T1 (en) POLYMER SURFACE COATING COMPOSITION
WO2002000800A3 (en) Acrylic adhesive compositions comprising acrylate microspheres
CY1109042T1 (en) Cohesively-bonded hydrophilic coating compositions for implants
CA2361602A1 (en) Firm hold hair mousse
BR9917374A (en) Wet sticky pressure sensitive adhesive, article comprising a wet sticky pressure sensitive adhesive and adhesive, and processes for producing a wet sticky pressure sensitive adhesive and for using adhesive article