US20030050648A1 - Removable lung reduction devices, systems, and methods - Google Patents

Removable lung reduction devices, systems, and methods Download PDF

Info

Publication number
US20030050648A1
US20030050648A1 US09951105 US95110501A US2003050648A1 US 20030050648 A1 US20030050648 A1 US 20030050648A1 US 09951105 US09951105 US 09951105 US 95110501 A US95110501 A US 95110501A US 2003050648 A1 US2003050648 A1 US 2003050648A1
Authority
US
Grant status
Application
Patent type
Prior art keywords
device
air
passageway
lung
frame
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US09951105
Inventor
Clifton Alferness
Hugo Gonzalez
David Dillard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Spiration Inc
Original Assignee
Spiration Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12104Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in an air passage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12027Type of occlusion
    • A61B17/12036Type of occlusion partial occlusion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12172Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/04Tracheal tubes
    • A61M16/0402Special features for tracheal tubes not otherwise provided for
    • A61M16/0404Special features for tracheal tubes not otherwise provided for with means for selective or partial lung respiration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205Introduction devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205Introduction devices
    • A61B2017/12054Details concerning the detachment of the occluding device from the introduction device
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2002/043Bronchi

Abstract

An air passageway obstruction device includes a frame structure and a flexible membrane overlying the frame structure. The frame structure is collapsible upon advancement of the device into the air passageway, expandable into a rigid structure upon deploying in the air passageway and recollapsible upon removal from the air passageway. The flexible membrane obstructs inhaled air flow into a lung portion communicating with the air passageway. The device may be removed after deployment in an air passageway by recollapsing the device and pulling the device proximally through a catheter.

Description

    BACKGROUND OF THE INVENTION
  • [0001]
    The present invention is generally directed to a treatment of Chronic Obstructive Pulmonary Disease (COPD). The present invention is more particularly directed to removable air passageway obstruction devices, and systems and methods for removing the devices.
  • [0002]
    Chronic Obstructive Pulmonary Disease (COPD) has become a major cause of morbidity and mortality in the United States over the last three decades. COPD is characterized by the presence of airflow obstruction due to chronic bronchitis or emphysema. The airflow obstruction in COPD is due largely to structural abnormalities in the smaller airways. Important causes are inflammation, fibrosis, goblet cell metaplasia, and smooth muscle hypertrophy in terminal bronchioles.
  • [0003]
    The incidence, prevalence, and health-related costs of COPD are on the rise. Mortality due to COPD is also on the rise. In 1991 COPD was the fourth leading cause of death in the United States and had increased 33% since 1979.
  • [0004]
    COPD affects the patients whole life. It has three main symptoms: cough; breathlessness; and wheeze. At first, breathlessness may be noticed when running for a bus, digging in the garden, or walking up hill. Later, it may be noticed when simply walking in the kitchen. Over time, it may occur with less and less effort until it is present all of the time.
  • [0005]
    COPD is a progressive disease and currently has no cure. Current treatments for COPD include the prevention of further respiratory damage, pharmacotherapy, and surgery. Each is discussed below.
  • [0006]
    The prevention of further respiratory damage entails the adoption of a healthy lifestyle. Smoking cessation is believed to be the single most important therapeutic intervention. However, regular exercise and weight control are also important. Patients whose symptoms restrict their daily activities or who otherwise have an impaired quality of life may require a pulmonary rehabilitation program including ventilatory muscle training and breathing retraining. Long-term oxygen therapy may also become necessary.
  • [0007]
    Pharmacotherapy may include bronchodilator therapy to open up the airways as much as possible or inhaled β-agonists. For those patients who respond poorly to the foregoing or who have persistent symptoms, Ipratropium bromide may be indicated. Further, courses of steroids, such as corticosteroids, may be required. Lastly, antibiotics may be required to prevent infections and influenza and pheumococcal vaccines may be routinely administered. Unfortunately, there is no evidence that early, regular use of pharmacotherapy will alter the progression of COPD.
  • [0008]
    About 40 years ago, it was first postulated that the tethering force that tends to keep the intrathoracic airways open was lost in emphysema and that by surgically removing the most affected parts of the lungs, the force could be partially restored. Although the surgery was deemed promising, the procedure was abandoned.
  • [0009]
    The lung volume reduction surgery (LVRS) was later revived. In the early 1990's, hundreds of patients underwent the procedure. However, the procedure has fallen out of favor due to the fact that Medicare stopping reimbursing for LVRS. Unfortunately, data is relatively scarce and many factors conspire to make what data exists difficult to interpret. The procedure is currently under review in a controlled clinical trial. What data does exist tends to indicate that patients benefited from the procedure in terms of an increase in forced expiratory volume, a decrease in total lung capacity, and a significant improvement in lung function, dyspnea, and quality of life. However, the surgery is not without potential complications. Lung tissue is very thin and fragile. Hence, it is difficult to suture after sectioning. This gives rise to potential infection and air leaks. In fact, nearly thirty percent (30%) of such surgeries result in air leaks.
  • [0010]
    Improvements in pulmonary function after LVRS have been attributed to at least four possible mechanisms. These include enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory muscaulature, and improved right ventricular filling.
  • [0011]
    Lastly, lung transplantation is also an option. Today, COPD is the most common diagnosis for which lung transplantation is considered. Unfortunately, this consideration is given for only those with advanced COPD. Given the limited availability of donor organs, lung transplant is far from being available to all patients.
  • [0012]
    In view of the need in the art for new and improved therapies for COPD which provide more permanent results than pharmacotherapy while being less invasive and traumatic than LVRS, at least two new therapies have recently been proposed.
  • [0013]
    Both of these new therapies provide lung size reduction by permanently collapsing at least a portion of a lung.
  • [0014]
    In accordance with a first one of these therapies, and as described in U.S. Pat. No. 6,258,100 assigned to the assignee of the present invention and incorporated herein by reference, a lung may be collapsed by obstructing an air passageway communicating with the lung portion to be collapsed. The air passageway may be obstructed by placing an obstructing member in the air passageway. The obstructing member may be a plug-like device which precludes air flow in both directions or a one-way valve which permits air to be exhaled from the lung portion to be collapsed while precluding air from being inhaled into the lung portion. Once the air passageway is sealed, the residual air within the lung will be absorbed over time to cause the lung portion to collapse.
  • [0015]
    As further described in U.S. Pat. No. 6,258,100, the lung portion may be collapsed by inserting a conduit into the air passageway communicating with the lung portion to be collapsed. An obstruction device, such as a one-way valve is then advanced down the conduit into the air passageway. The obstruction device is then deployed in the air passageway for sealing the air passageway and causing the lung portion to be collapsed.
  • [0016]
    The second therapy is fully described in copending U.S. application Ser. No. 09/534,244, filed Mar. 23, 2000, for LUNG CONSTRICTION APPARATUS AND METHOD and, is also assigned to the assignee of the present invention. As described therein, a lung constriction device including a sleeve of elastic material is configured to cover at least a portion of a lung. The sleeve has a pair of opened ends to permit the lung portion to be drawn into the sleeve. Once drawn therein, the lung portion is constricted by the sleeve to reduce the size of the lung portion.
  • [0017]
    Both therapies hold great promise for treating COPD. Neither therapy requires sectioning and suturing of lung tissue.
  • [0018]
    While either therapy alone would be effective in providing lung size reduction and treatment of COPD, it has recently been proposed that the therapies may be combined for more effective treatment. More specifically, it has been proposed that the therapies could be administered in series, with the first mentioned therapy first applied acutely for evaluation of the effectiveness of lung size reduction in a patient and which lung portions should be reduced in size to obtain the best results. The first therapy is ideal for this as it is noninvasive and could be administered in a physician's office. Once the effectiveness of lung size reduction is confirmed and the identity of the lung portions to be collapsed is determined, the more invasive second mentioned therapy may be administered.
  • [0019]
    In order to combine these therapies, or simply administer the first therapy for evaluation, it will be necessary for at least some of the deployed air passageway obstruction devices to be removable. Unfortunately, such devices as currently known in the art are not suited for removal. While such devices are expandable for permanent deployment, such devices are not configured or adapted for recollapse after having once been deployed in an air passageway to facilitate removal. Hence, there is a need in the art for air passageway obstruction devices which are removable after having been deployed and systems and methods for removing them.
  • SUMMARY OF THE INVENTION
  • [0020]
    The invention provides device for reducing the size of a lung comprising an obstructing structure dimensioned for insertion into an air passageway communicating with a portion of the lung to be reduced in size, the obstructing structure having an outer dimension which is so dimensioned when deployed in the air passageway to preclude air from flowing into the lung portion to collapse the portion of the lung for reducing the size of the lung, the obstructing structure being collapsible to permit removal of the obstruction device from the air passageway.
  • [0021]
    The invention further provides an assembly comprising a device for reducing the size of a lung, the device being dimensioned for insertion into an air passageway communicating with a portion of the lung to be reduced in size, the device having an outer dimension which is so dimensioned when deployed in the air passageway to preclude air from flowing into the lung portion to collapse the portion of the lung for reducing the size of the lung, a catheter having an internal lumen and being configured to be passed down a trachea, into the air passageway, and a retractor dimensioned to be passed down the internal lumen of the catheter, seizing the device, and pulling the obstruction device proximally into the internal lumen to remove the device from the air passageway. The device is collapsible after having been deployed to permit the device to be pulled proximally into the internal lumen of the catheter by the retractor.
  • [0022]
    The invention further provides a method of removing a deployed air passageway obstruction device from an air passageway in which the device is deployed. The method includes the steps of passing a catheter, having an internal lumen, down a trachea and into the air passageway, advancing a retractor down the internal lumen of the catheter to the device, seizing the device with the retractor, collapsing the device to free the device from deployment in the air passageway, and pulling the device with the retractor proximally into the internal lumen of the catheter.
  • [0023]
    The invention still further provides an air passageway obstruction device comprising a frame structure, and a flexible membrane overlying the frame structure. The frame structure is collapsible upon advancement of the device into the air passageway, expandable into a rigid structure upon deployment in the air passageway whereby the flexible membrane obstructs inhaled air flow into a lung portion communicating with the air passageway, and re-collapsible upon removal from the air passageway.
  • [0024]
    The invention still further provides an air passageway obstruction device comprising frame means for forming a support structure, and flexible membrane means overlying the support structure. The frame means is expandable to an expanded state within an air passageway to position the membrane means for obstructing air flow within the air passageway and is collapsible for removal of the device from the air passageway.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0025]
    The features of the present invention which are believed to be novel are set forth with particularity in the appended claims. The invention, together with further objects and advantages thereof, may best be understood by making reference to the following description taken in conjunction with the accompanying drawings, in the several figures of which like referenced numerals identify identical elements, and wherein:
  • [0026]
    [0026]FIG. 1 is a simplified sectional view of a thorax illustrating a healthy respiratory system;
  • [0027]
    [0027]FIG. 2 is a sectional view similar to FIG. 1 but illustrating a respiratory system suffering from COPD and the execution of a first step in treating the COPD condition in accordance with the present invention;
  • [0028]
    [0028]FIG. 3 is a perspective view, illustrating the frame structure of a removable air passageway obstruction device embodying the present invention;
  • [0029]
    [0029]FIG. 4 is a perspective view of the complete air passageway obstruction device of FIG. 3;
  • [0030]
    [0030]FIG. 5 is an end view of the device of FIG. 3 illustrating its operation for obstructing inhaled air flow;
  • [0031]
    [0031]FIG. 6 is another end view of the device of FIG. 3 illustrating its operation for permitting exhaled air flow;
  • [0032]
    [0032]FIG. 7 is a perspective view of the device of FIG. 3, illustrating its operation for permitting partial exhaled air flow;
  • [0033]
    [0033]FIG. 8 is a side view illustrating a first step in removing the device of FIG. 3 in accordance with one embodiment of the present invention;
  • [0034]
    [0034]FIG. 9 is another side view illustrating the collapse of the device of FIG. 3 as it is removed from an air passageway;
  • [0035]
    [0035]FIG. 10 is a side view illustrating an initial step in the removal of the device of FIG. 3 in accordance with another embodiment of the present invention;
  • [0036]
    [0036]FIG. 11 is a side view illustrating engagement of the frame structure of the device with a catheter during removal of the device;
  • [0037]
    [0037]FIG. 12 is a side view illustrating the collapse of the device by the catheter during removal of the device;
  • [0038]
    [0038]FIG. 13 is a side view of another air passageway obstruction device embodying the present invention during an initial step in its removal from an air passageway;
  • [0039]
    [0039]FIG. 14 is another side view of the device of FIG. 13 illustrating its collapse during removal from the air passageway;
  • [0040]
    [0040]FIG. 15 is a perspective view of the frame structure of another removable air passageway obstruction device embodying the present invention;
  • [0041]
    [0041]FIG. 16 is a cross-sectional side view of the device of FIG. 15 shown in a deployed state;
  • [0042]
    [0042]FIG. 17 is a perspective side view of the device of FIG. 15 shown in a deployed state;
  • [0043]
    [0043]FIG. 18 is a side view illustrating an initial step in removing the device of FIG. 15 from an air passageway;
  • [0044]
    [0044]FIG. 19 is a side view illustrating an intermediate step in the removal of the device of FIG. 15; and
  • [0045]
    [0045]FIG. 20 is a side view illustrating the collapse of the device of FIG. 15 during its removal from an air passageway.
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • [0046]
    Referring now to FIG. 1, it is a sectional view of a healthy respiratory system. The respiratory system 20 resides within the thorax 22 which occupies a space defined by the chest wall 24 and the diaphragm 26.
  • [0047]
    The respiratory system 20 includes the trachea 28, the left mainstem bronchus 30, the right mainstem bronchus 32, the bronchial branches 34, 36, 38, 40, and 42 and sub-branches 44, 46, 48, and 50. The respiratory system 20 further includes left lung lobes 52 and 54 and right lung lobes 56, 58, and 60. Each bronchial branch and sub-branch communicates with a respective different portion of a lung lobe, either the entire lung lobe or a portion thereof. As used herein, the term “air passageway” is meant to denote either a bronchial branch or sub-branch which communicates with a corresponding individual lung lobe or lung lobe portion to provide inhaled air thereto or conduct exhaled air therefrom.
  • [0048]
    Characteristic of a healthy respiratory system is the arched or inwardly arcuate diaphragm 26. As the individual inhales, the diaphragm 26 straightens to increase the volume of the thorax 22. This causes a negative pressure within the thorax. The negative pressure within the thorax in turn causes the lung lobes to fill with air. When the individual exhales, the diaphragm returns to its original arched condition to decrease the volume of the thorax. The decreased volume of the thorax causes a positive pressure within the thorax which in turn causes exhalation of the lung lobes.
  • [0049]
    In contrast to the healthy respiratory system of FIG. 1, FIG. 2 illustrates a respiratory system suffering from COPD. Here it may be seen that the lung lobes 52, 54, 56, 58, and 60 are enlarged and that the diaphragm 26 is not arched but substantially straight. Hence, this individual is incapable of breathing normally by moving the diaphragm 28. Instead, in order to create the negative pressure in the thorax 22 required for breathing, this individual must move the chest wall outwardly to increase the volume of the thorax. This results in inefficient breathing causing these individuals to breathe rapidly with shallow breaths. It has been found that the apex portion 62 and 66 of the upper lung lobes 52 and 56, respectively, are most affected by COPD.
  • [0050]
    In accordance with this embodiment of the present invention, COPD treatment or evaluation is initiated by feeding a conduit or catheter 70 down the trachea 28, into a mainstream bronchus such as the right mainstem bronchus 32, and into an air passageway such as the bronchial branch 42 or the bronchial sub-branch 50. An air passageway obstruction device embodying the present invention is then advanced down an internal lumen 71 of the catheter 70 for deployment in the air passageway. Once deployed, the obstruction device precludes inhaled air from entering the lung portion to be collapsed. In accordance with the present invention, it is preferable that the obstruction device take the form of a one-way valve. In addition to precluding inhaled air from entering the lung portion, the device further allows air within the lung portion to be exhaled. This results in more rapid collapse of the lung portion. However, obstruction devices which preclude both inhaled and exhaled air flow are contemplated as falling within the scope of the invention.
  • [0051]
    The catheter 70 is preferably formed of flexible material such as polyethylene. Also, the catheter 70 is preferably preformed with a bend 72 to assist the feeding of the catheter from the right mainstem bronchus 32 into the bronchial branch 42.
  • [0052]
    [0052]FIGS. 3 and 4 show an air passageway obstruction device 80 embodying the present invention. The device 80 includes a proximal end 82 and a distal end 84. The device 80 further includes a frame structure 86 including frame supports 88, 90, and 92.
  • [0053]
    Each of the frame supports has a shape to define a generally cylindrical center portion 94 and a pair of oppositely extending inwardly arcuate conical end portions 96 and 98. The frame structure further includes a plurality of fixation members 100, 102, and 104 which extend distally from the proximal end 82. The fixation members have the generally conical shape and terminate in fixation projections or anchors 106, 108, and 110 which extend radially outwardly.
  • [0054]
    Overlying and partially enclosing the frame structure 86 is a flexible membrane 112. The flexible membrane extends over the generally cylindrical and conical portions 94 and 98 defined by the frame structure. Hence, the flexible membrane is opened in the proximal direction.
  • [0055]
    The flexible membrane may be formed of silicone or polyurethane, for example. It may be secured to the frame structure in a manner known in the art such as by crimping, riveting, or adhesion.
  • [0056]
    The frame structure 86 and the device 80 are illustrated in FIGS. 3 and 4 as the device would appear when fully deployed in an air passageway. The frame structure supports and frame structure fixation members are preferably formed of stainless steel or Nitinol or other suitable material which has memory of an original shape. The frame structure permits the device to be collapsed for advancement down the internal lumen 71 of the catheter 70 into the air passageway where the device is to be deployed. Once the point of deployment is reached, the device is expelled from the catheter to assume its original shape in the air passageway. In doing so, the generally cylindrical portion 94 contacts the inner wall of the air passageway and the fixation projections 106, 108, and 110 pierce the wall of the air passageway for fixing or anchoring the device 80 within the air passageway.
  • [0057]
    When the device 80 is deployed, the frame structure 86 and flexible membrane 112 form an obstructing structure or one-way valve. FIGS. 5 and 6 show the valve action of the device 80 when deployed in an air passageway, such as the bronchial branch 42.
  • [0058]
    As shown in FIG. 5, during inhalation, the flexible membrane is filled with air and expands outwardly to obstruct the air passageway 42. This precludes air from entering the lung portion being collapsed. However, as shown in FIG. 6, during expiration, the flexible membrane 112 deflects inwardly to only partially obstruct the air passageway 42. This enables air, which may be in the lung portion being collapsed, to be exhaled for more rapid collapse of the lung portion. FIG. 7 is another view showing the device 80 during expiration with a portion 114 of the membrane 112 deflected inwardly.
  • [0059]
    [0059]FIGS. 8 and 9 illustrate a manner in which the device 80 may be removed from the air passageway 42 in accordance with one embodiment of the present invention. As previously mentioned, it may be desired to remove the device 80 if it is only used for evaluating the effectiveness of collapsing a lung portion or if it is found the more effective treatment may be had with the collapse of other lung portions.
  • [0060]
    The device 80 is shown in FIG. 8 in a fully deployed state. The catheter 70 having the internal lumen 71 is advanced to the proximal end of the device 80. In FIG. 8 it may be noted that the fixation members 102 and 104 define a larger conical radius than the frame supports 88 and 90. Hence, when the proximal end of the device is engaged by a retractor and the catheter 70 is moved distally as shown in FIG. 9, the internal lumen of the catheter engages the fixation members 102 and 104 before it engages the frame supports 88 and 90. This causes the fixation projections to first disengage the inner wall of the air passageway 42. With the device now free of the air passageway side wall, the retractor may be used to pull the device into the internal lumen 71 of the catheter 70 causing the support structure and thus the device to collapse. The collapsed device may now fully enter the internal lumen of the catheter for removal.
  • [0061]
    FIGS. 10-12 show another embodiment of the present invention for removing the device 80 from the air passageway 42. Here, the catheter 70 is fed down a bronchoscope 118 to the device 80. The retractor takes the form of a forceps 120.
  • [0062]
    In FIG. 10 it may be seen that the forceps has just engaged the proximal end 82 of the device 80. In FIG. 11 the forceps 120 is held stationary while the catheter 70 is advanced distally so that the internal lumen 71 of the catheter 70 engages the fixation members 102 and 104. Further advancement of the catheter 70 as seen in FIG. 12 deflects the fixation projections 110 and 108 inwardly away from the inner wall of the air passageway 42. Now, the forceps may be used to pull the device 80 into the internal lumen 71 of the catheter 70 for removal of the device 80 from the air passageway 42.
  • [0063]
    [0063]FIGS. 13 and 14 show another removable air passageway obstruction device 130 and a method of removing it from an air passageway in accordance with the present invention. The device 130 is shown in FIG. 13 deployed in the air passageway 42 and the catheter 70 is in ready position to remove the device 130 from the air passageway 42.
  • [0064]
    The device 130 is of similar configuration to the device 80 previously described. Here however, the fixation members 136 and 138 are extensions of the frame supports 132 and 134, respectively. To that end, it will be noted in FIG. 13 that the frame supports 132 and 134 cross at a pivot point 140 at the distal end 142 of the device 130. They extend distally and then are turned back at an acute angle to terminate at fixation or anchor ends 146 and 148. When the device is deployed as shown in FIG. 13, the cylindrical portions of the support frame engage the inner wall of the air passageway 42 and the fixation points 146 and 148 project into the inner wall of the air passageway 42 to maintain the device in a fixed position. The flexible membrane 150 extends from the dashed line 152 to the pivot or crossing point 140 of the frame supports 132 and 134 to form a one-way valve.
  • [0065]
    When the device is to be removed, the frame structure of the device 130 is held stationary by a retractor within the catheter 70 and the catheter is advanced distally. When the catheter 70 engages the frame supports 132 and 134, the frame supports are deflected inwardly from their dashed line positions to their solid line positions. This also causes the fixation members 136 and 138 to be deflected inwardly from their dashed line positions to their solid line positions in the direction of arrows 154. These actions disengage the device 130 from the inner wall of the air passageway 42. Now, the retractor may pull the device into the internal lumen 71 of the catheter 70 for removal of the device 130 from the air passageway 42.
  • [0066]
    FIGS. 15-17 show a still further removable air passageway obstruction device 160 embodying the present invention. As shown in the initial collapsed state in FIG. 15, the device 160 includes a plurality of frame supports 162, 164, 166, and 168. The frame supports extend between a proximal ring 170 and a distal ring 172. The device 160 is preferably laser cut from a sheet of Nitinol.
  • [0067]
    Since each of the frame supports are identical, only frame support 164 will be described herein. As will be noted, the support 164 includes a bend point 174 with a relatively long section 176 extending distally from the bend point 174 and a relatively short section 178 extending proximally from the bend point 174. The short section 178 includes a fixation projection or anchor 180 extending slightly distally from the bend point 174.
  • [0068]
    [0068]FIGS. 16 and 17 show the device 160 in its deployed configuration. When the device is deployed, it is advanced down a catheter to its deployment site in its collapsed state as shown in FIG. 15. When the deployment site is reached, the device 160 is held outside of the catheter and the rings 170 and 172 are pulled toward each other. This causes the device to bend at the bend points of the frame supports. This forms fixation projections 180, 182, and 184 extending into the inner wall of the air passageway to fix the device in position.
  • [0069]
    The relatively long sections of the frame supports are covered with a flexible membrane 186 as shown in FIGS. 16 and 17 to form a one-way valve. The valve functions as previously described to obstruct inhaled air flow but to permit exhaled air flow.
  • [0070]
    FIGS. 18-20 illustrate a manner of removing the device 160 from an air passageway. Once again a catheter 70 is advanced down a bronchoscope 118 to the device 160. Next, a retractor including a forceps 120 and pin 190 are advanced to the device. The pin 190, carrying a larger diameter disk 192, extends into the device as the forceps 120 grasps the proximal ring 170 of the device 160. The pin 190 continues to advance until the disk 192 engages the distal ring 172 of the device 160 as shown in FIG. 19. Then, while the forceps 120 holds the proximal ring 170, the pin 190 and disk 192 are advanced distally carrying the distal ring 172 distally. This causes the device 160 to straighten and collapse as shown in FIG. 20. Now, the forceps 120, pin 190, and the device 160 may be pulled into the internal lumen 71 of the catheter 70 for removal of the device. As will be appreciated by those skilled in the art, the foregoing steps may be reversed for deploying the device 160.
  • [0071]
    While particular embodiments of the present invention have been shown and described, modifications may be made, and it is therefore intended in the appended claims to cover all such changes and modifications which fall within the true spirit and scope of the invention.

Claims (32)

    What is claimed is:
  1. 1. A device for reducing the size of a lung comprising an obstructing structure dimensioned for insertion into an air passageway communicating with a portion of the lung to be reduced in size, the obstructing structure having an outer dimension which is so dimensioned when deployed in the air passageway to preclude air from flowing into the lung portion to collapse the portion of the lung for reducing the size of the lung, the obstructing structure being collapsible to permit removal of the obstruction device from the air passageway.
  2. 2. The device of claim 1 wherein the obstructing structure forms a one-way valve.
  3. 3. The device of claim 1 further including at least one anchor that anchors the device within the air passageway when the device is deployed and wherein the at least one anchor is releasable during collapse of the obstructing structure and removal of the device from the air passageway.
  4. 4. The device of claim 1 wherein the obstructing structure includes a collapsible frame and a flexible membrane overlying the collapsible frame.
  5. 5. The device of claim 4 wherein the flexible membrane has an opened proximal end and a closed distal end.
  6. 6. The device of claim 5 wherein the flexible membrane inflates to inhaled air to preclude air from flowing into the lung portion and at least partially deflates to exhaled air to permit air to flow from the lung portion.
  7. 7. The device of claim 4 wherein the collapsible frame includes at least one anchor that anchors the device within the air passageway when deployed and wherein the at least one anchor is releasable during collapse of the collapsible frame and removal of the device from the air passageway.
  8. 8. An assembly comprising:
    a device for reducing the size of a lung, the device being dimensioned for insertion into an air passageway communicating with a portion of the lung to be reduced in size, the device having an outer dimension which is so dimensioned when deployed in the air passageway to preclude air from flowing into the lung portion to collapse the portion of the lung for reducing the size of the lung;
    a catheter having an internal lumen and being configured to be passed down a trachea, into the air passageway; and
    a retractor dimensioned to be passed down the internal lumen of the catheter, seizing the device, and pulling the obstruction device proximally into the internal lumen to remove the device from the air passageway,
    the device being collapsible after having been deployed to permit the device to be pulled proximally into the internal lumen of the catheter by the retractor.
  9. 9. The assembly of claim 8 wherein the device is collapsible by the catheter as the device is pulled into the internal lumen of the catheter by the retractor.
  10. 10. The assembly of claim 8 wherein the retractor includes collapsing means for collapsing the device before pulling the device into the internal lumen of the catheter.
  11. 11. The assembly of claim 8 wherein the device is a one-way valve.
  12. 12. The assembly of claim 8 wherein the device further includes at least one anchor that anchors the device within the air passageway when the device is deployed and wherein the at least one anchor is releasable as the device is pulled proximally into the internal lumen of the catheter and collapsed for removal from the air passageway.
  13. 13. The assembly of claim 8 wherein the device includes a collapsible frame and a flexible membrane overlying the collapsible frame.
  14. 14. The assembly of claim 13 wherein the flexible membrane has an opened proximal end and a closed distal end.
  15. 15. The assembly of claim 14 wherein the flexible membrane inflates to inhaled air to preclude air from flowing into the lung portion and at least partially deflates to exhaled air to permit air to flow from the lung portion.
  16. 16. The assembly of claim 13 wherein the collapsible frame includes at least one anchor that anchors the device within the air passageway when deployed and wherein the at least one anchor is releasable during collapse of the collapsible frame and removal of the device from the air passageway.
  17. 17. A method of removing a deployed air passageway obstruction device from an air passageway in which the device is deployed, the method including the steps of:
    passing a catheter, having an internal lumen, down a trachea and into the air passageway;
    advancing a retractor down the internal lumen of the catheter to the device;
    seizing the device with the retractor;
    collapsing the device to free the device from deployment in the air passageway; and
    pulling the device with the retractor proximally into the internal lumen of the catheter.
  18. 18. The method of claim 17 wherein the collapsing step is performed as the device is pulled into the internal lumen of the catheter.
  19. 19. The method of claim 18 wherein the device is collapsed by the catheter.
  20. 20. The method of claim 19 wherein the device is collapsed by the internal lumen of the catheter.
  21. 21. The method of claim 17 wherein the device is collapsed prior to being pulled into the internal lumen of the catheter.
  22. 22. The method of claim 21 wherein the device is collapsed by the retractor.
  23. 23. The method of claim 17 wherein the device includes at least one anchor for fixing the device in the air passageway when deployed and wherein the collapsing step includes the step of releasing the at least one anchor from the air passageway.
  24. 24. An air passageway obstruction device comprising:
    a frame structure; and
    a flexible membrane overlying the frame structure,
    the frame structure being collapsible upon advancement of the device into the air passageway, expandable into a rigid structure upon deployment in the air passageway whereby the flexible membrane obstructs inhaled air flow into a lung portion communicating with the air passageway, and recollapsible upon removal from the air passageway.
  25. 25. The device of claim 24 wherein the frame structure and flexible membrane form a one-way valve.
  26. 26. The device of claim 25 wherein the flexible membrane inflates to inhaled air to obstruct the air passageway and at least partially deflates to exhaled air to at least partially unobstruct the air passageway.
  27. 27. The device of claim 24 wherein the frame structure includes at least one anchor that engages and fixes the device in the air passageway upon deployment.
  28. 28. The device of claim 27 wherein the at least one anchor is releasable from engagement with the air passageway upon recollapse of the frame structure.
  29. 29. An air passageway obstruction device comprising:
    frame means for forming a support structure; and
    flexible membrane means overlying the support structure,
    the frame means being expandable to an expanded state within an air passageway to position the membrane means for obstructing air flow within the air passageway and being collapsible for removal of the device from the air passageway.
  30. 30. The device of claim 29 wherein the frame means and flexible membrane means form a one-way valve when the frame means is in the expanded state.
  31. 31. The device of claim 29 wherein the frame means further includes anchor means for fixing the device in the air passageway when the frame means is in the expanded state.
  32. 32. The device of claim 31 wherein the anchor means releases the device from the air passageway when the frame means collapses for removal of the device from the air passageway.
US09951105 2001-09-11 2001-09-11 Removable lung reduction devices, systems, and methods Abandoned US20030050648A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US09951105 US20030050648A1 (en) 2001-09-11 2001-09-11 Removable lung reduction devices, systems, and methods

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US09951105 US20030050648A1 (en) 2001-09-11 2001-09-11 Removable lung reduction devices, systems, and methods
ES02759335T ES2318034T3 (en) 2001-09-11 2002-08-09 Removable devices and systems for reducing lung cancer.
EP20080022468 EP2078502A3 (en) 2001-09-11 2002-08-09 Removable lung reduction devices systems, and methods
DE2002630638 DE60230638D1 (en) 2001-09-11 2002-08-09 lung reduction devices and removable systems
CA 2459702 CA2459702C (en) 2001-09-11 2002-08-09 Removable lung reduction devices, systems, and methods
EP20020759335 EP1424970B1 (en) 2001-09-11 2002-08-09 Removable lung reduction devices and systems
PCT/US2002/025555 WO2003022124A3 (en) 2001-09-11 2002-08-09 Removable lung reduction devices, systems, and methods
JP2003526258A JP4291144B2 (en) 2001-09-11 2002-08-09 Detachable lung volume reduction device and system and method
US10847554 US20040206349A1 (en) 2001-09-11 2004-05-17 Removable lung reduction devices, systems, and methods
US10847427 US20040211412A1 (en) 2001-09-11 2004-05-17 Removable lung reduction devices, systems, and method
US10848571 US20050033310A1 (en) 2001-09-11 2004-05-17 Intra-bronchial valve devices
US10848041 US20040243140A1 (en) 2001-09-11 2004-05-18 Collapsible intra-bronchial valve devices
US12428287 US7757692B2 (en) 2001-09-11 2009-04-22 Removable lung reduction devices, systems, and methods
US12828629 US8414655B2 (en) 2001-09-11 2010-07-01 Removable lung reduction devices, systems, and methods
US13787052 US8974484B2 (en) 2001-09-11 2013-03-06 Removable lung reduction devices, systems, and methods
US14640348 US20160030049A1 (en) 2001-09-11 2015-03-06 Removable lung reduction devices, systems, and methods

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US10847554 Division US20040206349A1 (en) 2001-09-11 2004-05-17 Removable lung reduction devices, systems, and methods
US10847427 Division US20040211412A1 (en) 2001-09-11 2004-05-17 Removable lung reduction devices, systems, and method
US10848571 Continuation US20050033310A1 (en) 2001-09-11 2004-05-17 Intra-bronchial valve devices
US10848041 Division US20040243140A1 (en) 2001-09-11 2004-05-18 Collapsible intra-bronchial valve devices

Publications (1)

Publication Number Publication Date
US20030050648A1 true true US20030050648A1 (en) 2003-03-13

Family

ID=25491272

Family Applications (9)

Application Number Title Priority Date Filing Date
US09951105 Abandoned US20030050648A1 (en) 2001-09-11 2001-09-11 Removable lung reduction devices, systems, and methods
US10847427 Abandoned US20040211412A1 (en) 2001-09-11 2004-05-17 Removable lung reduction devices, systems, and method
US10848571 Abandoned US20050033310A1 (en) 2001-09-11 2004-05-17 Intra-bronchial valve devices
US10847554 Abandoned US20040206349A1 (en) 2001-09-11 2004-05-17 Removable lung reduction devices, systems, and methods
US10848041 Abandoned US20040243140A1 (en) 2001-09-11 2004-05-18 Collapsible intra-bronchial valve devices
US12428287 Active US7757692B2 (en) 2001-09-11 2009-04-22 Removable lung reduction devices, systems, and methods
US12828629 Active 2021-11-12 US8414655B2 (en) 2001-09-11 2010-07-01 Removable lung reduction devices, systems, and methods
US13787052 Active US8974484B2 (en) 2001-09-11 2013-03-06 Removable lung reduction devices, systems, and methods
US14640348 Abandoned US20160030049A1 (en) 2001-09-11 2015-03-06 Removable lung reduction devices, systems, and methods

Family Applications After (8)

Application Number Title Priority Date Filing Date
US10847427 Abandoned US20040211412A1 (en) 2001-09-11 2004-05-17 Removable lung reduction devices, systems, and method
US10848571 Abandoned US20050033310A1 (en) 2001-09-11 2004-05-17 Intra-bronchial valve devices
US10847554 Abandoned US20040206349A1 (en) 2001-09-11 2004-05-17 Removable lung reduction devices, systems, and methods
US10848041 Abandoned US20040243140A1 (en) 2001-09-11 2004-05-18 Collapsible intra-bronchial valve devices
US12428287 Active US7757692B2 (en) 2001-09-11 2009-04-22 Removable lung reduction devices, systems, and methods
US12828629 Active 2021-11-12 US8414655B2 (en) 2001-09-11 2010-07-01 Removable lung reduction devices, systems, and methods
US13787052 Active US8974484B2 (en) 2001-09-11 2013-03-06 Removable lung reduction devices, systems, and methods
US14640348 Abandoned US20160030049A1 (en) 2001-09-11 2015-03-06 Removable lung reduction devices, systems, and methods

Country Status (7)

Country Link
US (9) US20030050648A1 (en)
EP (2) EP1424970B1 (en)
JP (1) JP4291144B2 (en)
CA (1) CA2459702C (en)
DE (1) DE60230638D1 (en)
ES (1) ES2318034T3 (en)
WO (1) WO2003022124A3 (en)

Cited By (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020095209A1 (en) * 1997-09-16 2002-07-18 Gholam-Reza Zadno-Azizi Body fluid flow control device
US20020112729A1 (en) * 2001-02-21 2002-08-22 Spiration, Inc. Intra-bronchial obstructing device that controls biological interaction with the patient
US20030070683A1 (en) * 2000-03-04 2003-04-17 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US20030070682A1 (en) * 2001-10-11 2003-04-17 Wilson Peter M. Bronchial flow control devices and methods of use
US20030158515A1 (en) * 2002-02-21 2003-08-21 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US20030183235A1 (en) * 2001-10-25 2003-10-02 Spiration, Inc. Bronchial obstruction device deployment system and method
US20030195385A1 (en) * 2002-04-16 2003-10-16 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20030212412A1 (en) * 2002-05-09 2003-11-13 Spiration, Inc. Intra-bronchial obstructing device that permits mucus transport
US20030216769A1 (en) * 2002-05-17 2003-11-20 Dillard David H. Removable anchored lung volume reduction devices and methods
US20040010209A1 (en) * 2002-07-15 2004-01-15 Spiration, Inc. Device and method for measuring the diameter of an air passageway
US6679264B1 (en) 2000-03-04 2004-01-20 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US20040039250A1 (en) * 2002-05-28 2004-02-26 David Tholfsen Guidewire delivery of implantable bronchial isolation devices in accordance with lung treatment
US20040055606A1 (en) * 2001-03-02 2004-03-25 Emphasys Medical, Inc. Bronchial flow control devices with membrane seal
US20040059263A1 (en) * 2002-09-24 2004-03-25 Spiration, Inc. Device and method for measuring the diameter of an air passageway
US20040060563A1 (en) * 2001-03-02 2004-04-01 Alan Rapacki Bronchial flow control devices and methods of use
US6722360B2 (en) 2000-06-16 2004-04-20 Rajiv Doshi Methods and devices for improving breathing in patients with pulmonary disease
US20040078054A1 (en) * 1998-06-05 2004-04-22 Broncus Technologies, Inc. Method for lung volume reduction
US20040074491A1 (en) * 2001-03-02 2004-04-22 Michael Hendricksen Delivery methods and devices for implantable bronchial isolation devices
US20040148035A1 (en) * 2002-11-27 2004-07-29 Michael Barrett Delivery methods and devices for implantable bronchial isolation devices
US20040200484A1 (en) * 2003-04-08 2004-10-14 Springmeyer Steven C. Bronchoscopic lung volume reduction method
US20040210248A1 (en) * 2003-03-12 2004-10-21 Spiration, Inc. Apparatus, method and assembly for delivery of intra-bronchial devices
US20040206349A1 (en) * 2001-09-11 2004-10-21 Alferness Clifton A. Removable lung reduction devices, systems, and methods
US20040225254A1 (en) * 2003-05-07 2004-11-11 Don Tanaka Localized pleurodesis chemical delivery
US20040243393A1 (en) * 2003-05-29 2004-12-02 Microsoft Corporation Semantic object synchronous understanding implemented with speech application language tags
US20040237966A1 (en) * 2003-05-29 2004-12-02 Don Tanaka Methods and devices to assist pulmonary decompression
US20040244803A1 (en) * 2003-06-05 2004-12-09 Don Tanaka Intra-thoracic collateral ventilation bypass system
US20050025816A1 (en) * 2003-07-15 2005-02-03 Don Tanaka Methods and devices to accelerate wound healing in thoracic anastomosis applications
US20050137714A1 (en) * 2003-08-08 2005-06-23 Gonzalez Hugo X. Bronchoscopic repair of air leaks in a lung
US20050178389A1 (en) * 2004-01-27 2005-08-18 Shaw David P. Disease indications for selective endobronchial lung region isolation
US20050196344A1 (en) * 2004-02-27 2005-09-08 Mccutcheon John Methods and devices for blocking flow through collateral pathways in the lung
US20050288549A1 (en) * 2004-06-14 2005-12-29 Pneumrx, Inc. Guided access to lung tissues
US20050288684A1 (en) * 2004-06-16 2005-12-29 Aronson Nathan A Method of reducing collateral flow in a portion of a lung
US20060004305A1 (en) * 2002-11-27 2006-01-05 George Robert M Delivery methods and devices for implantable bronchial isolation devices
US20060009801A1 (en) * 2004-07-08 2006-01-12 Mcgurk Erin Pleural effusion treatment device, method and material
US20060020347A1 (en) * 2004-03-08 2006-01-26 Michael Barrett Implanted bronchial isolation devices and methods
US20060025815A1 (en) * 2004-07-08 2006-02-02 Mcgurk Erin Lung device with sealing features
US20060030863A1 (en) * 2004-07-21 2006-02-09 Fields Antony J Implanted bronchial isolation device delivery devices and methods
US20060107961A1 (en) * 2004-11-19 2006-05-25 Don Tanaka Localized pleurodesis evacuation device
US20060107956A1 (en) * 2004-11-19 2006-05-25 Hendricksen Michael J Bronchial flow control devices and methods of use
US20060118126A1 (en) * 2004-11-19 2006-06-08 Don Tanaka Methods and devices for controlling collateral ventilation
US20060118125A1 (en) * 2004-11-19 2006-06-08 Don Tanaka Pulmonary drug delivery
US20060124126A1 (en) * 2004-12-10 2006-06-15 Don Tanaka Collateral ventilation device with chest tube/evacuation features
US20060144398A1 (en) * 2004-12-08 2006-07-06 Rajiv Doshi Respiratory devices
US20060167416A1 (en) * 2004-11-23 2006-07-27 Mark Mathis Steerable device for accessing a target site and methods
US20060206147A1 (en) * 2002-02-21 2006-09-14 Devore Lauri J Intra-bronchial obstruction device that provides a medicant intra-bronchially to the patient
US20060235432A1 (en) * 2002-02-21 2006-10-19 Devore Lauri J Intra-bronchial obstructing device that controls biological interaction with the patient
US20060283462A1 (en) * 2002-03-08 2006-12-21 Fields Antony J Methods and devices for inducing collapse in lung regions fed by collateral pathways
US20070051372A1 (en) * 2005-08-23 2007-03-08 Don Tanaka Collateral ventilation bypass system with retention features
US20070163598A1 (en) * 2006-01-17 2007-07-19 Asia Chang Variable resistance pulmonary ventilation bypass valve
US20070221230A1 (en) * 2006-03-13 2007-09-27 David Thompson Minimally invasive lung volume reduction device and method
US20070232992A1 (en) * 2006-03-31 2007-10-04 James Kutsko Articulable anchor
US20070235846A1 (en) * 2006-04-01 2007-10-11 Stats Chippac Ltd. Integrated circuit package system with net spacer
US20070270776A1 (en) * 2003-06-03 2007-11-22 Respira, Inc. Lung reduction system
US20070283962A1 (en) * 2006-06-07 2007-12-13 Ventus Medical, Inc. Layered nasal devices
US20080052727A1 (en) * 2006-08-22 2008-02-28 International Business Machines Corporation Data processing system using matching engine and routing switch
US20080072914A1 (en) * 2006-08-25 2008-03-27 Hendricksen Michael J Bronchial Isolation Devices for Placement in Short Lumens
US20080119866A1 (en) * 2002-03-20 2008-05-22 Alferness Clifton A Removable anchored lung volume reduction devices and methods
US20080142018A1 (en) * 2006-11-16 2008-06-19 Ventus Medical, Inc. Nasal device applicators
US20080221470A1 (en) * 2007-03-07 2008-09-11 Elliot Sather Respiratory sensor adapters for nasal devices
US20080281433A1 (en) * 2007-05-11 2008-11-13 Portaero, Inc. Methods and devices to create a chemically and/or mechanically localized pleurodesis
US20080281151A1 (en) * 2007-05-11 2008-11-13 Portaero, Inc. Pulmonary pleural stabilizer
US20080287878A1 (en) * 2007-05-15 2008-11-20 Portaero, Inc. Pulmonary visceral pleura anastomosis reinforcement
US20080283065A1 (en) * 2007-05-15 2008-11-20 Portaero, Inc. Methods and devices to maintain patency of a lumen in parenchymal tissue of the lung
US20080295829A1 (en) * 2007-05-30 2008-12-04 Portaero, Inc. Bridge element for lung implant
US20090050144A1 (en) * 2004-12-08 2009-02-26 Ryan Kendall Pierce Adhesive nasal respiratory devices
US20090099530A1 (en) * 2007-10-12 2009-04-16 Martin Neal Adams Valve loader method, system, and apparatus
US20090145441A1 (en) * 2007-12-06 2009-06-11 Rajiv Doshi Delayed resistance nasal devices and methods of use
US20090145788A1 (en) * 2007-12-05 2009-06-11 Rajiv Doshi Packaging and dispensing nasal devices
US20090194109A1 (en) * 2008-02-01 2009-08-06 Rajiv Doshi Cpap interface and backup devices
US20090205644A1 (en) * 2008-02-19 2009-08-20 Portaero, Inc. Pneumostoma management system for treatment of chronic obstructive pulmonary disease
US20090205641A1 (en) * 2008-02-19 2009-08-20 Portaero, Inc. Pneumostoma management device and method for treatment of chronic obstructive pulmonary disease
US20090292262A1 (en) * 2007-10-12 2009-11-26 Martin Neal Adams Valve loader method, system, and apparatus
US20090308398A1 (en) * 2008-06-16 2009-12-17 Arthur Ferdinand Adjustable resistance nasal devices
US20100170507A1 (en) * 2009-01-08 2010-07-08 Portaero, Inc. Pneumostoma management device with integrated patency sensor and method
US20100204707A1 (en) * 2009-02-11 2010-08-12 Portaero, Inc. Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease
US7789083B2 (en) 2003-05-20 2010-09-07 Portaero, Inc. Intra/extra thoracic system for ameliorating a symptom of chronic obstructive pulmonary disease
US7806120B2 (en) 2004-12-08 2010-10-05 Ventus Medical, Inc. Nasal respiratory devices for positive end-expiratory pressure
US20100286544A1 (en) * 2008-02-19 2010-11-11 Portaero, Inc. Methods and devices for assessment of pneumostoma function
US20100305715A1 (en) * 2009-05-18 2010-12-02 Pneumrx, Inc. Cross-Sectional Modification During Deployment of an Elongate Lung Volume Reduction Device
US7856979B2 (en) 2006-05-23 2010-12-28 Ventus Medical, Inc. Nasal respiratory devices
US20110017207A1 (en) * 2001-03-02 2011-01-27 Pulmonx Corporation Bronchial flow control devices with membrane seal
US7931641B2 (en) 2007-05-11 2011-04-26 Portaero, Inc. Visceral pleura ring connector
US20110108041A1 (en) * 2009-11-06 2011-05-12 Elliot Sather Nasal devices having a safe failure mode and remotely activatable
US20110203598A1 (en) * 2006-06-07 2011-08-25 Favet Michael L Nasal devices including layered nasal devices and delayed resistance adapters for use with nasal devices
US20110226238A1 (en) * 2000-03-04 2011-09-22 Pulmonx Corporation Implanted bronchial isolation devices and methods
US8062315B2 (en) * 2007-05-17 2011-11-22 Portaero, Inc. Variable parietal/visceral pleural coupling
CN102580171A (en) * 2012-01-30 2012-07-18 先健科技(深圳)有限公司 Bronchus flap and manufacturing method thereof
US8632605B2 (en) 2008-09-12 2014-01-21 Pneumrx, Inc. Elongated lung volume reduction devices, methods, and systems
CN103750920A (en) * 2013-12-31 2014-04-30 先健科技(深圳)有限公司 Unidirectional flap
US8740921B2 (en) 2006-03-13 2014-06-03 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US8795241B2 (en) 2011-05-13 2014-08-05 Spiration, Inc. Deployment catheter
US8876791B2 (en) 2005-02-25 2014-11-04 Pulmonx Corporation Collateral pathway treatment using agent entrained by aspiration flow current
US8875711B2 (en) 2010-05-27 2014-11-04 Theravent, Inc. Layered nasal respiratory devices
US9211181B2 (en) 2004-11-19 2015-12-15 Pulmonx Corporation Implant loading device and system
US9402633B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Torque alleviating intra-airway lung volume reduction compressive implant structures
US9833354B2 (en) 2004-12-08 2017-12-05 Theravent, Inc. Nasal respiratory devices
WO2018067735A1 (en) * 2016-10-05 2018-04-12 Sri Radhakrishnan High resistance implanted bronchial isolation devices and methods

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060135947A1 (en) * 2000-10-27 2006-06-22 Pulmonx Occlusal stent and methods for its use
US8496006B2 (en) 2005-01-20 2013-07-30 Pulmonx Corporation Methods and devices for passive residual lung volume reduction and functional lung volume expansion
US8628564B2 (en) 2004-05-25 2014-01-14 Covidien Lp Methods and apparatus for luminal stenting
US7451765B2 (en) 2004-11-18 2008-11-18 Mark Adler Intra-bronchial apparatus for aspiration and insufflation of lung regions distal to placement or cross communication and deployment and placement system therefor
US8147534B2 (en) 2005-05-25 2012-04-03 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
US8267985B2 (en) 2005-05-25 2012-09-18 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
US8342182B2 (en) 2006-08-28 2013-01-01 Pulmonx Corporation Functional assessment and treatment catheters and methods for their use in the lung
DE102006050385A1 (en) * 2006-10-05 2008-04-10 pfm Produkte für die Medizin AG Implantable mechanism for use in human and/or animal body for e.g. closing atrium septum defect, has partial piece that is folded back on another partial piece from primary form into secondary form of carrying structure
US20080228137A1 (en) 2007-03-12 2008-09-18 Pulmonx Methods and devices for passive residual lung volume reduction and functional lung volume expansion
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
WO2009134876A1 (en) 2008-04-29 2009-11-05 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US9675482B2 (en) 2008-05-13 2017-06-13 Covidien Lp Braid implant delivery systems
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
EP2323720A4 (en) * 2008-09-09 2013-04-10 Pulmonx Corp Systems and methods for inhibiting secretion flow into a functional assessment catheter
FR2944201B1 (en) * 2009-04-14 2011-06-10 Novatech Sa bronchial plug valve has
US8425455B2 (en) 2010-03-30 2013-04-23 Angiodynamics, Inc. Bronchial catheter and method of use
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
US9155647B2 (en) 2012-07-18 2015-10-13 Covidien Lp Methods and apparatus for luminal stenting
US9345564B2 (en) 2013-03-15 2016-05-24 Cook Medical Technologies Llc Removable vena cava filter having primary and secondary struts
US20150351776A1 (en) * 2014-06-10 2015-12-10 Ethicon Endo-Surgery, Inc. Bronchus Sealants and Methods of Sealing Bronchial Tubes
GB201714746D0 (en) 2015-03-24 2017-10-25 Spiration Inc D/B/A Olympus Respiratory America Airway stent
US20180049693A1 (en) * 2016-08-17 2018-02-22 Covidien Lp Induced atelectasis and pulmonary consolidation systems and methods

Citations (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2832078A (en) * 1956-10-17 1958-04-29 Battelle Memorial Institute Heart valve
US2981254A (en) * 1957-11-12 1961-04-25 Edwin G Vanderbilt Apparatus for the gas deflation of an animal's stomach
US3320972A (en) * 1964-04-16 1967-05-23 Roy F High Prosthetic tricuspid valve and method of and device for fabricating same
US3445916A (en) * 1967-04-19 1969-05-27 Rudolf R Schulte Method for making an anatomical check valve
US3472230A (en) * 1966-12-19 1969-10-14 Fogarty T J Umbrella catheter
US3617060A (en) * 1967-04-10 1971-11-02 Warren Iezzi Pneumothorox-inducing hunting arrow
US3657744A (en) * 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US3671979A (en) * 1969-09-23 1972-06-27 Univ Utah Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve
US3757783A (en) * 1971-09-24 1973-09-11 Sherwood Medical Ind Inc Suction drainage apparatus
US3760808A (en) * 1969-12-01 1973-09-25 K Bleuer Tampon applicator assembly
US3788327A (en) * 1971-03-30 1974-01-29 H Donowitz Surgical implant device
US4014318A (en) * 1973-08-20 1977-03-29 Dockum James M Circulatory assist device and system
US4056854A (en) * 1976-09-28 1977-11-08 The United States Of America As Represented By The Department Of Health, Education And Welfare Aortic heart valve catheter
US4084268A (en) * 1976-04-22 1978-04-18 Shiley Laboratories, Incorporated Prosthetic tissue heart valve
US4086665A (en) * 1976-12-16 1978-05-02 Thermo Electron Corporation Artificial blood conduit
US4212463A (en) * 1978-02-17 1980-07-15 Pratt Enoch B Humane bleeder arrow
US4218782A (en) * 1977-05-25 1980-08-26 Biocoating Anpartsselskab Heart valve prosthesis and method for the production thereof
US4222126A (en) * 1978-12-14 1980-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health, Education & Welfare Unitized three leaflet heart valve
US4250873A (en) * 1977-04-26 1981-02-17 Richard Wolf Gmbh Endoscopes
US4302854A (en) * 1980-06-04 1981-12-01 Runge Thomas M Electrically activated ferromagnetic/diamagnetic vascular shunt for left ventricular assist
US4339831A (en) * 1981-03-27 1982-07-20 Medtronic, Inc. Dynamic annulus heart valve and reconstruction ring
US4619246A (en) * 1984-05-23 1986-10-28 William Cook, Europe A/S Collapsible filter basket
US4681110A (en) * 1985-12-02 1987-07-21 Wiktor Dominik M Catheter arrangement having a blood vessel liner, and method of using it
US4710192A (en) * 1985-12-30 1987-12-01 Liotta Domingo S Diaphragm and method for occlusion of the descending thoracic aorta
US4732152A (en) * 1984-12-05 1988-03-22 Medinvent S.A. Device for implantation and a method of implantation in a vessel using such device
US4759758A (en) * 1984-12-07 1988-07-26 Shlomo Gabbay Prosthetic heart valve
US4795449A (en) * 1986-08-04 1989-01-03 Hollister Incorporated Female urinary incontinence device
US4808183A (en) * 1980-06-03 1989-02-28 University Of Iowa Research Foundation Voice button prosthesis and method for installing same
US4819664A (en) * 1984-11-15 1989-04-11 Stefano Nazari Device for selective bronchial intubation and separate lung ventilation, particularly during anesthesia, intensive therapy and reanimation
US4830003A (en) * 1988-06-17 1989-05-16 Wolff Rodney G Compressive stent and delivery system
US4832680A (en) * 1986-07-03 1989-05-23 C.R. Bard, Inc. Apparatus for hypodermically implanting a genitourinary prosthesis
US4846836A (en) * 1988-10-03 1989-07-11 Reich Jonathan D Artificial lower gastrointestinal valve
US4850999A (en) * 1980-05-24 1989-07-25 Institute Fur Textil-Und Faserforschung Of Stuttgart Flexible hollow organ
US4852568A (en) * 1987-02-17 1989-08-01 Kensey Nash Corporation Method and apparatus for sealing an opening in tissue of a living being
US4877025A (en) * 1988-10-06 1989-10-31 Hanson Donald W Tracheostomy tube valve apparatus
US4934999A (en) * 1987-07-28 1990-06-19 Paul Bader Closure for a male urethra
US4968294A (en) * 1989-02-09 1990-11-06 Salama Fouad A Urinary control valve and method of using same
US5061274A (en) * 1989-12-04 1991-10-29 Kensey Nash Corporation Plug device for sealing openings and method of use
US5116360A (en) * 1990-12-27 1992-05-26 Corvita Corporation Mesh composite graft
US5116564A (en) * 1988-10-11 1992-05-26 Josef Jansen Method of producing a closing member having flexible closing elements, especially a heart valve
US5123919A (en) * 1991-11-21 1992-06-23 Carbomedics, Inc. Combined prosthetic aortic heart valve and vascular graft
US5151105A (en) * 1991-10-07 1992-09-29 Kwan Gett Clifford Collapsible vessel sleeve implant
US5158548A (en) * 1990-04-25 1992-10-27 Advanced Cardiovascular Systems, Inc. Method and system for stent delivery
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5283063A (en) * 1992-01-31 1994-02-01 Eagle Vision Punctum plug method and apparatus
US5304199A (en) * 1993-01-04 1994-04-19 Gene E. Myers Enterprises, Inc. Apparatus for arterial total occlusion plaque separation
US5306234A (en) * 1993-03-23 1994-04-26 Johnson W Dudley Method for closing an atrial appendage
US5314473A (en) * 1989-07-20 1994-05-24 Godin Norman J Prosthesis for preventing gastric reflux into the esophagus
US5352240A (en) * 1989-05-31 1994-10-04 Promedica International, Inc. Human heart valve replacement with porcine pulmonary valve
US5358518A (en) * 1991-06-25 1994-10-25 Sante Camilli Artificial venous valve
US5366478A (en) * 1993-07-27 1994-11-22 Ethicon, Inc. Endoscopic surgical sealing device
US5382261A (en) * 1992-09-01 1995-01-17 Expandable Grafts Partnership Method and apparatus for occluding vessels
US5392775A (en) * 1994-03-22 1995-02-28 Adkins, Jr.; Claude N. Duckbill valve for a tracheostomy tube that permits speech
US5409019A (en) * 1992-10-30 1995-04-25 Wilk; Peter J. Coronary artery by-pass method
US5411507A (en) * 1993-01-08 1995-05-02 Richard Wolf Gmbh Instrument for implanting and extracting stents
US5411552A (en) * 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis
US5453090A (en) * 1994-03-01 1995-09-26 Cordis Corporation Method of stent delivery through an elongate softenable sheath
US5507754A (en) * 1993-08-20 1996-04-16 United States Surgical Corporation Apparatus and method for applying and adjusting an anchoring device
US5509900A (en) * 1992-03-02 1996-04-23 Kirkman; Thomas R. Apparatus and method for retaining a catheter in a blood vessel in a fixed position
US5603698A (en) * 1993-04-13 1997-02-18 Boston Scientific Corporation Prosthesis delivery system
US5803078A (en) * 1994-05-06 1998-09-08 Brauner; Mark E. Methods and apparatus for intrapulmonary therapy and drug administration
US5833694A (en) * 1995-05-25 1998-11-10 Medtronic, Inc. Stent assembly and method of use
US5925063A (en) * 1997-09-26 1999-07-20 Khosravi; Farhad Coiled sheet valve, filter or occlusive device and methods of use
US5954636A (en) * 1997-07-15 1999-09-21 Schwartz; Roy E. Pediatric endotracheal tube with bronchial blocker and method for selectively blocking respiratory airflow to a pediatric patient's lung
US6010525A (en) * 1997-08-01 2000-01-04 Peter M. Bonutti Method and apparatus for securing a suture
US6132458A (en) * 1998-05-15 2000-10-17 American Medical Systems, Inc. Method and device for loading a stent
US6149664A (en) * 1998-08-27 2000-11-21 Micrus Corporation Shape memory pusher introducer for vasoocclusive devices
US6165179A (en) * 1995-05-23 2000-12-26 Boston Scientific Corporation Vena cava delivery system
US6203551B1 (en) * 1999-10-04 2001-03-20 Advanced Cardiovascular Systems, Inc. Chamber for applying therapeutic substances to an implant device
US20010010017A1 (en) * 1996-12-31 2001-07-26 Brice Letac Alve prosthesis for implantation in body channels
US6267775B1 (en) * 1997-03-21 2001-07-31 Schneider (Usa) Inc. Self-expanding medical device for centering radioactive treatment sources in body vessels
US6283334B1 (en) * 1999-08-30 2001-09-04 Kimberly-Clark Worldwide, Inc. Personal dispensing system
US6293951B1 (en) * 1999-08-24 2001-09-25 Spiration, Inc. Lung reduction device, system, and method
US20010037808A1 (en) * 2000-03-04 2001-11-08 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US20020052626A1 (en) * 1997-11-07 2002-05-02 Paul Gilson Embolic protection system
US6425916B1 (en) * 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
US20020112729A1 (en) * 2001-02-21 2002-08-22 Spiration, Inc. Intra-bronchial obstructing device that controls biological interaction with the patient
US6447530B1 (en) * 1996-11-27 2002-09-10 Scimed Life Systems, Inc. Atraumatic anchoring and disengagement mechanism for permanent implant device
US20030018922A1 (en) * 2001-07-18 2003-01-23 Litwin Louis Robert Method and system for providing emergency shutdown of a malfunctioning device
US20030019385A1 (en) * 1997-01-27 2003-01-30 Leasure John D. Subsonic cartridge for gas-operated automatic and semiautomatic weapons
US6527761B1 (en) * 2000-10-27 2003-03-04 Pulmonx, Inc. Methods and devices for obstructing and aspirating lung tissue segments
US6558429B2 (en) * 1997-12-09 2003-05-06 Reflux Corporation Perorally insertable gastroesophageal anti-reflux valve prosthesis and tool for implantation thereof
US20030167065A1 (en) * 2002-03-01 2003-09-04 Arvik Enterprises, Llc Blood vessel occlusion device
US20030181922A1 (en) * 2002-03-20 2003-09-25 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20030183235A1 (en) * 2001-10-25 2003-10-02 Spiration, Inc. Bronchial obstruction device deployment system and method
US20030212412A1 (en) * 2002-05-09 2003-11-13 Spiration, Inc. Intra-bronchial obstructing device that permits mucus transport
US20030216769A1 (en) * 2002-05-17 2003-11-20 Dillard David H. Removable anchored lung volume reduction devices and methods
US20040173282A1 (en) * 2001-07-02 2004-09-09 Thomas Laetgaard Inflating unit with sealing facilities for a tyre filled with air
US20040206349A1 (en) * 2001-09-11 2004-10-21 Alferness Clifton A. Removable lung reduction devices, systems, and methods
US20040210248A1 (en) * 2003-03-12 2004-10-21 Spiration, Inc. Apparatus, method and assembly for delivery of intra-bronchial devices
US6860847B2 (en) * 2001-07-10 2005-03-01 Spiration, Inc. Constriction device viewable under X ray fluoroscopy
US6904909B2 (en) * 2000-03-04 2005-06-14 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures

Family Cites Families (432)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US538518A (en) * 1895-04-30 houseman
US2115298A (en) 1937-04-16 1938-04-26 Roderick F Brown Suction tonsillectome
US2479805A (en) 1946-08-15 1949-08-23 Toledo Engineering Company Inc Method of and apparatus for feeding batch materials
US2728225A (en) 1953-03-12 1955-12-27 Herbert E Skibitzke Thermal flowmeter
US3370305A (en) 1965-05-28 1968-02-27 Goott Bernard Heart valve with magnetic hinge means
US3540431A (en) * 1968-04-04 1970-11-17 Kazi Mobin Uddin Collapsible filter for fluid flowing in closed passageway
US3683913A (en) 1970-10-05 1972-08-15 Deknatel Inc Underwater drainage apparatus with air flow meters
US3874388A (en) * 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
US3889657A (en) 1974-02-12 1975-06-17 Gomco Surgical Mfg Co Uterine aspirating curette
US3962917A (en) 1974-07-03 1976-06-15 Minato Medical Science Co., Ltd. Respirometer having thermosensitive elements on both sides of a hot wire
USRE31040E (en) 1975-04-24 1982-09-28 St. Jude Medical, Inc. Heart valve prosthesis
JPS6010740Y2 (en) 1976-08-12 1985-04-11
US4040428A (en) 1976-08-30 1977-08-09 The Aro Corporation Control valves for tracheotomy patient or laryngeal prosthesis
US4205282A (en) 1978-08-21 1980-05-27 Westinghouse Electric Corp. Phase shifting circuit element
US4267839A (en) 1979-09-12 1981-05-19 Repromed, Inc. Surgical instrument for use in reversible sterilization or permanent occlusion procedures
US4301810A (en) 1980-02-29 1981-11-24 City Of Hope National Medical Center Ventilatory muscle training apparatus
US4393879A (en) 1980-04-11 1983-07-19 Milex Products, Inc. Tissue-collecting apparatus
CA1178866A (en) 1980-06-06 1984-12-04 Davol Inc. Chest drainage apparatus
US4483200A (en) 1981-01-19 1984-11-20 Anima Corporation Thermal pulse flowmeter
US4403616A (en) 1981-06-09 1983-09-13 K-Med, Inc. Expiratory breathing exercise device
US4402445A (en) 1981-10-09 1983-09-06 United States Surgical Corporation Surgical fastener and means for applying same
US4533137A (en) 1982-01-19 1985-08-06 Healthscan Inc. Pulmonary training method
JPS58163332U (en) 1982-04-27 1983-10-31
US4456016A (en) 1982-07-01 1984-06-26 Trutek Research, Inc. Inhalation valve
US4569674A (en) 1982-08-03 1986-02-11 Stryker Corporation Continuous vacuum wound drainage system
US4888015A (en) 1982-08-20 1989-12-19 Domino Rudolph S Method of replacing an eye lens
US4727873A (en) * 1984-04-17 1988-03-01 Mobin Uddin Kazi Embolus trap
US4654029A (en) 1982-12-13 1987-03-31 Howmedica, Inc. Electronic drainage system
FR2538705B1 (en) 1982-12-29 1987-12-31 Vincent Michel An apparatus for medical exsufflation of pneumothorax
US4512338A (en) 1983-01-25 1985-04-23 Balko Alexander B Process for restoring patency to body vessels
US5669936A (en) 1983-12-09 1997-09-23 Endovascular Technologies, Inc. Endovascular grafting system and method for use therewith
US4601465A (en) 1984-03-22 1986-07-22 Roy Jean Yves Device for stimulating the human respiratory system
US4583541A (en) 1984-05-07 1986-04-22 Barry Joseph P Sternal stabilization device
US5135531A (en) 1984-05-14 1992-08-04 Surgical Systems & Instruments, Inc. Guided atherectomy system
US4610256B1 (en) 1984-09-25 1988-06-21
US4685908A (en) 1984-10-18 1987-08-11 Bioresearch Ithaca Inc. Device for detecting increased pressure in pleural cavity
US4684363A (en) 1984-10-31 1987-08-04 American Hospital Supply Corporation Rapidly inflatable balloon catheter and method
US4599995A (en) * 1984-11-07 1986-07-15 Dane John A Linear collector for a parabolic reflector
US4577631A (en) * 1984-11-16 1986-03-25 Kreamer Jeffry W Aneurysm repair apparatus and method
US4582058A (en) 1984-11-26 1986-04-15 Bivona, Inc. Tracheostoma valves
US4881939A (en) 1985-02-19 1989-11-21 The Johns Hopkins University Implantable helical cuff
US4654027A (en) 1985-10-30 1987-03-31 Dragan William B Vascular dilating device
FR2596978A1 (en) 1986-04-10 1987-10-16 Peters A bone fixation plate, provided with suture son
ES1001021U (en) 1986-09-02 1988-04-16 Moriones Elosegui Ignacio mechanical valve prosthesis for use in cardiac surgery
US4745925A (en) 1986-10-06 1988-05-24 Dietz Henry G Optoelectronic inhalation sensor for monitoring inhalation and for inhalation therapy
US5300050A (en) 1986-10-07 1994-04-05 Deknatel Technology Corporation Drainage device
JPH0318528B2 (en) 1987-02-26 1991-03-12 Matsutani Seisakusho
US4988342A (en) 1987-03-02 1991-01-29 Atrium Medical Corporation Improved fluid recovery system
FR2612597B1 (en) 1987-03-20 1989-06-23 Colon Jean Valve has at least one tilting flap with respect to elastic pivots
US4794928A (en) * 1987-06-10 1989-01-03 Kletschka Harold D Angioplasty device and method of using the same
US4759449A (en) * 1987-08-10 1988-07-26 Gold Kenneth S Interlocking expandable bookrack
US4852552A (en) 1987-09-03 1989-08-01 Pilling Co. Sternal retractor
US4936823A (en) 1988-05-04 1990-06-26 Triangle Research And Development Corp. Transendoscopic implant capsule
US5002772A (en) 1988-05-31 1991-03-26 Pfizer Inc. Gastric retention system for controlled drug release
US4870975A (en) 1988-07-05 1989-10-03 Scott Cronk Suction canister assembly for the collection of body fluids and tissue specimens
US5556376A (en) 1988-07-22 1996-09-17 Yoon; Inbae Multifunctional devices having loop configured portions and collection systems for endoscopic surgical procedures and methods thereof
US4920978A (en) 1988-08-31 1990-05-01 Triangle Research And Development Corporation Method and apparatus for the endoscopic treatment of deep tumors using RF hyperthermia
JP2710355B2 (en) * 1988-09-20 1998-02-10 日本ゼオン株式会社 The medical valve device
GB8822492D0 (en) 1988-09-24 1988-10-26 Considine J Apparatus for removing tumours from hollow organs of body
US4984581A (en) 1988-10-12 1991-01-15 Flexmedics Corporation Flexible guide having two-way shape memory alloy
EP0372148A1 (en) 1988-12-09 1990-06-13 Erik Folke Norell Lung exercising device
US5800339A (en) 1989-02-09 1998-09-01 Opticon Medical Inc. Urinary control valve
US5186711A (en) 1989-03-07 1993-02-16 Albert Einstein College Of Medicine Of Yeshiva University Hemostasis apparatus and method
US5135488A (en) 1989-03-17 1992-08-04 Merit Medical Systems, Inc. System and method for monitoring, displaying and recording balloon catheter inflation data
US5111823A (en) 1989-04-20 1992-05-12 National Fertility Institute Apparatus and method for generating echographic images
EP0474748B1 (en) * 1989-05-31 1995-01-25 Baxter International Inc. Biological valvular prosthesis
US4979505A (en) 1989-06-06 1990-12-25 Cox Everard F Tracheal tube
US5562608A (en) 1989-08-28 1996-10-08 Biopulmonics, Inc. Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation
US5019086A (en) 1989-09-12 1991-05-28 Neward Theodore C Manipulable vacuum extractor for childbirth and method of using the same
US4995872A (en) 1989-10-04 1991-02-26 Ferrara Janice J Expandable catheter and bridge device
US5033312A (en) 1989-11-06 1991-07-23 Bicore Monitoring Systems Gas flow meter housing
US5797907A (en) 1989-11-06 1998-08-25 Mectra Labs, Inc. Electrocautery cutter
US5038621A (en) 1989-11-06 1991-08-13 Bicore Monitoring Systems Variable area obstruction gas flow meter
US5174283A (en) 1989-11-08 1992-12-29 Parker Jeffrey D Blind orolaryngeal and oroesophageal guiding and aiming device
US5516336A (en) 1990-02-07 1996-05-14 Advanced Cardiovascular Systems, Inc. Readily exchangeable perfusion dilatation catheter
US5514153A (en) 1990-03-02 1996-05-07 General Surgical Innovations, Inc. Method of dissecting tissue layers
US5127412A (en) 1990-03-14 1992-07-07 Cosmetto Aristodeme J Skin tensioning
US5593413A (en) 1990-05-14 1997-01-14 Medisys Technologies, Inc. Device for assisting childbirth
DK124690D0 (en) 1990-05-18 1990-05-18 Henning Rud Andersen Klapprotes for implantation in the body for replacement of the natural folding and catheter for use in the implantation of such a prosthesis flap
US5078739A (en) 1990-07-20 1992-01-07 Janus Biomedical, Inc. Bileaflet heart valve with external leaflets
RU1767723C (en) 1990-08-14 1995-01-27 Кирово-Чепецкий химический комбинат Artificial heart valve
US5092781A (en) 1990-11-08 1992-03-03 Amp Incorporated Electrical connector using shape memory alloy coil springs
EP0513309A1 (en) 1990-12-11 1992-11-19 JOHNSON & JOHNSON PROFESSIONAL PRODUCTS LIMITED Hot wire anemometer
US5059208A (en) 1991-02-04 1991-10-22 Helix Medical, Inc. Adjustable tracheostoma valve
US5224238A (en) 1991-04-18 1993-07-06 Ryobi Motor Products Corp. Horizontal canister vacuum
US5226429A (en) 1991-06-20 1993-07-13 Inamed Development Co. Laparoscopic gastric band and method
US5147369A (en) 1991-07-01 1992-09-15 Wagner Michael A Forceps and method for nuclear fragment removal
US5171299A (en) 1991-08-02 1992-12-15 Baxter International Inc. Balloon catheter inflation pressure and diameter display apparatus and method
US5163944A (en) 1991-08-09 1992-11-17 Neward Theodore C Obstetrical vacuum extractor
US5207702A (en) 1991-08-14 1993-05-04 Pearl Michael L Method and apparatus for handling hygroscopic dilators
US5662713A (en) 1991-10-09 1997-09-02 Boston Scientific Corporation Medical stents for body lumens exhibiting peristaltic motion
US5876445A (en) * 1991-10-09 1999-03-02 Boston Scientific Corporation Medical stents for body lumens exhibiting peristaltic motion
US5197485A (en) 1991-10-15 1993-03-30 Pilling Co. Method and apparatus for sampling aortic plaque
US5741271A (en) 1991-11-05 1998-04-21 Nakao; Naomi L. Surgical retrieval assembly and associated method
US5643317A (en) 1992-11-25 1997-07-01 William Cook Europe S.A. Closure prosthesis for transcatheter placement
US5197963A (en) 1991-12-02 1993-03-30 Everest Medical Corporation Electrosurgical instrument with extendable sheath for irrigation and aspiration
WO1993010845A1 (en) 1991-12-05 1993-06-10 Luigi Gigante Valve operated catheter for urinary incontinence and retention
US5391205A (en) 1991-12-17 1995-02-21 Knight; Roy F. Tracheoesophageal voice prosthesis
US5626605A (en) 1991-12-30 1997-05-06 Scimed Life Systems, Inc. Thrombosis filter
US5275169A (en) 1992-01-15 1994-01-04 Innovation Associates Apparatus and method for determining physiologic characteristics of body lumens
JP3393383B2 (en) * 1992-01-21 2003-04-07 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ Septal defect closure device
US5255687A (en) 1992-01-21 1993-10-26 Mckenna Charles L Zero dead space respiratory exercise valve
US5409444A (en) 1992-03-04 1995-04-25 Kensey Nash Corporation Method and apparatus to reduce injury to the vascular system
US5421325A (en) 1992-04-30 1995-06-06 Cinberg; James Z. Endotracheal tube assembly and related method
FR2693961B1 (en) * 1992-07-21 1994-10-07 Valeo Vision Device of a movable portion for adjusting the orientation of a vehicle headlight, and the device mounting method.
US5342298A (en) 1992-07-31 1994-08-30 Advanced Cardiovascular Systems, Inc. Automated fluid pressure control system
FR2696092B1 (en) * 1992-09-28 1994-12-30 Lefebvre Jean Marie Kit for medical use consisting of a filter and its implementation device in the vessel.
US5356412A (en) 1992-10-09 1994-10-18 United States Surgical Corporation Sternum buckle with rotational engagement and method of closure
EP0596145B1 (en) * 1992-10-31 1996-05-08 Schneider (Europe) Ag Disposition for implanting a self-expanding endoprothesis
DE59200548D1 (en) 1992-12-16 1994-10-27 Schneider Europ Ag A device for implanting a self-expanding endoprosthesis.
US5366475A (en) 1992-12-21 1994-11-22 Shatzu Health Products, Inc. Tragus acupressure clip
WO1994015549A1 (en) 1992-12-30 1994-07-21 Schneider (Usa) Inc. Apparatus for deploying body implantable stents
JPH06230457A (en) 1993-02-01 1994-08-19 Konica Corp Camera
JPH0819544B2 (en) 1993-02-05 1996-02-28 協和電線株式会社 Electronic component lead steel wire and a manufacturing method thereof
US5797960A (en) 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
WO1994026175A1 (en) 1993-05-06 1994-11-24 Vitaphore Corporation Embolization device
EP0626153A1 (en) 1993-05-28 1994-11-30 Medical Shape Memory, Ltd. Ni-Ti medical stent
US5486154A (en) * 1993-06-08 1996-01-23 Kelleher; Brian S. Endoscope
US5423830A (en) 1993-07-07 1995-06-13 Schneebaum; Cary W. Polyp retrieval method and associated instrument assembly
JP2958219B2 (en) * 1993-08-20 1999-10-06 住友ベークライト株式会社 Endoscopic ligation kit
WO1995008945A3 (en) 1993-09-20 1995-04-20 Boston Scient Corp Multiple biopsy sampling device
US5383470A (en) 1993-09-20 1995-01-24 Steve Novak Portable spirometer
US5542594A (en) * 1993-10-06 1996-08-06 United States Surgical Corporation Surgical stapling apparatus with biocompatible surgical fabric
US5456689A (en) 1993-10-13 1995-10-10 Arnold J. Kresch Method and device for tissue resection
DE4336899C1 (en) 1993-10-28 1994-12-01 Novacor Gmbh Double-leaf heart valve prosthesis
US5957672A (en) 1993-11-10 1999-09-28 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Blood pump bearing system
US5490860A (en) 1993-12-08 1996-02-13 Sofamor Danek Properties, Inc. Portable power cutting tool
US5415658A (en) 1993-12-14 1995-05-16 Pioneer Laboratories, Inc. Surgical cable loop connector
US5415660A (en) 1994-01-07 1995-05-16 Regents Of The University Of Minnesota Implantable limb lengthening nail driven by a shape memory alloy
US5772583A (en) 1994-01-21 1998-06-30 Wright; John T. M. Sternal retractor with attachments for mitral & tricuspid valve repair
US5499625A (en) 1994-01-27 1996-03-19 The Kendall Company Esophageal-tracheal double lumen airway
US5398844A (en) * 1994-01-31 1995-03-21 Boston Scientific Corporation Multiple ligating band dispenser
US5871453A (en) 1994-02-08 1999-02-16 Boston Scientific Corporation Moveable sample tube multiple biopsy sampling device
US5503638A (en) 1994-02-10 1996-04-02 Bio-Vascular, Inc. Soft tissue stapling buttress
US5411016A (en) 1994-02-22 1995-05-02 Scimed Life Systems, Inc. Intravascular balloon catheter for use in combination with an angioscope
US5499995C1 (en) * 1994-05-25 2002-03-12 Paul S Teirstein Body passageway closure apparatus and method of use
US5824041A (en) 1994-06-08 1998-10-20 Medtronic, Inc. Apparatus and methods for placement and repositioning of intraluminal prostheses
US5683451A (en) 1994-06-08 1997-11-04 Cardiovascular Concepts, Inc. Apparatus and methods for deployment release of intraluminal prostheses
US5417226A (en) * 1994-06-09 1995-05-23 Juma; Saad Female anti-incontinence device
US5642730A (en) 1994-06-17 1997-07-01 Trudell Medical Limited Catheter system for delivery of aerosolized medicine for use with pressurized propellant canister
US6056744A (en) 1994-06-24 2000-05-02 Conway Stuart Medical, Inc. Sphincter treatment apparatus
US6062575A (en) 1994-07-27 2000-05-16 Mednext, Inc. Tool shaft coupler
US5549626A (en) 1994-12-23 1996-08-27 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Vena caval filter
US5755770A (en) * 1995-01-31 1998-05-26 Boston Scientific Corporatiion Endovascular aortic graft
US5575293A (en) 1995-02-06 1996-11-19 Promex, Inc. Apparatus for collecting and staging tissue
US6083141A (en) 1995-02-10 2000-07-04 Hougen; Everett D. Portable respiratory exercise apparatus and method for using the same
US5647857A (en) 1995-03-16 1997-07-15 Endotex Interventional Systems, Inc. Protective intraluminal sheath
US5662622A (en) 1995-04-04 1997-09-02 Cordis Corporation Intravascular catheter
US5693089A (en) 1995-04-12 1997-12-02 Inoue; Kanji Method of collapsing an implantable appliance
US5634893A (en) 1995-04-24 1997-06-03 Haemonetics Corporation Autotransfusion apparatus
US5752522A (en) 1995-05-04 1998-05-19 Cardiovascular Concepts, Inc. Lesion diameter measurement catheter and method
DE29507519U1 (en) 1995-05-05 1995-08-10 Angiomed Ag Endosphincter and set for releasably sealing the urethra
US6312407B1 (en) 1995-06-05 2001-11-06 Medtronic Percusurge, Inc. Occlusion of a vessel
US5704910A (en) 1995-06-05 1998-01-06 Nephros Therapeutics, Inc. Implantable device and use therefor
US5645565A (en) * 1995-06-13 1997-07-08 Ethicon Endo-Surgery, Inc. Surgical plug
JPH11508791A (en) 1995-07-03 1999-08-03 フレーター・ダーク・エイ Apparatus for attaching a support member to a tissue stapler
US5766134A (en) 1995-07-18 1998-06-16 Atrion Medical Products, Inc. Autogenous bone specimen collector
US5810855A (en) 1995-07-21 1998-09-22 Gore Enterprise Holdings, Inc. Endoscopic device and method for reinforcing surgical staples
US5702409A (en) 1995-07-21 1997-12-30 W. L. Gore & Associates, Inc. Device and method for reinforcing surgical staples
US5697968A (en) 1995-08-10 1997-12-16 Aeroquip Corporation Check valve for intraluminal graft
US5660175A (en) 1995-08-21 1997-08-26 Dayal; Bimal Endotracheal device
US5817034A (en) 1995-09-08 1998-10-06 United States Surgical Corporation Apparatus and method for removing tissue
US5702418A (en) 1995-09-12 1997-12-30 Boston Scientific Corporation Stent delivery system
JPH11513577A (en) * 1995-10-13 1999-11-24 トランスバスキュラー インコーポレイテッド Apparatus for tissue between transluminal intervention, the system and method
US6638293B1 (en) 1996-02-02 2003-10-28 Transvascular, Inc. Methods and apparatus for blocking flow through blood vessels
US6146384A (en) 1995-10-13 2000-11-14 Sdgi Holdings, Inc. Orthopedic fixation device and method of implantation
WO1997024988A1 (en) 1996-01-11 1997-07-17 Symbiosis Corporation Flexible microsurgical instruments incorporating a sheath having tactile and visual position indicators
DE69716779D1 (en) 1996-01-30 2002-12-05 Medtronic Inc Products and methods for production of dilators
US5763979A (en) 1996-02-29 1998-06-09 The United States Of America As Represented By The Secretary Of The Navy Actuation system for the control of multiple shape memory alloy elements
US6258083B1 (en) 1996-03-29 2001-07-10 Eclipse Surgical Technologies, Inc. Viewing surgical scope for minimally invasive procedures
WO1997042871A1 (en) 1996-05-10 1997-11-20 Cardiovascular Concepts, Inc. Lesion diameter measurement catheter and method
US5980545A (en) 1996-05-13 1999-11-09 United States Surgical Corporation Coring device and method
US6152909A (en) 1996-05-20 2000-11-28 Percusurge, Inc. Aspiration system and method
US20050245894A1 (en) 1996-05-20 2005-11-03 Medtronic Vascular, Inc. Methods and apparatuses for drug delivery to an intravascular occlusion
US6958059B2 (en) 1996-05-20 2005-10-25 Medtronic Ave, Inc. Methods and apparatuses for drug delivery to an intravascular occlusion
US6325777B1 (en) 1996-05-20 2001-12-04 Medtronic Percusurge, Inc. Low profile catheter valve and inflation adaptor
US6050972A (en) 1996-05-20 2000-04-18 Percusurge, Inc. Guidewire inflation system
WO1997044085A3 (en) 1996-05-20 1998-09-17 Percusurge Inc Low profile catheter valve
DE69719237D1 (en) * 1996-05-23 2003-04-03 Samsung Electronics Co Ltd Flexible, self-expanding stent and method for its production
KR20000016341A (en) 1996-06-05 2000-03-25 클래스 빌헬름슨 Biocompatible glue
KR980000327U (en) * 1996-06-13 1998-03-30 이정행 Nine earrings earrings mounting hole molding
US5797920A (en) 1996-06-14 1998-08-25 Beth Israel Deaconess Medical Center Catheter apparatus and method using a shape-memory alloy cuff for creating a bypass graft in-vivo
US5855601A (en) * 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
FR2750315B1 (en) 1996-06-26 1998-12-18 Novatech Inc Prothese intralaryngeal
WO1998000840A1 (en) 1996-06-28 1998-01-08 Samsung Electronics Co., Ltd. Thin film magnetic head tip and manufacturing method therefor
US6123663A (en) 1996-07-04 2000-09-26 Rebuffat; Carlo Surgical appliance for the treatment of pulmonary emphysema
US6077295A (en) 1996-07-15 2000-06-20 Advanced Cardiovascular Systems, Inc. Self-expanding stent delivery system
US5916819A (en) * 1996-07-17 1999-06-29 Micron Technology, Inc. Planarization fluid composition chelating agents and planarization method using same
US5669933A (en) 1996-07-17 1997-09-23 Nitinol Medical Technologies, Inc. Removable embolus blood clot filter
US20020077564A1 (en) 1996-07-29 2002-06-20 Farallon Medsystems, Inc. Thermography catheter
US6102885A (en) 1996-08-08 2000-08-15 Bass; Lawrence S. Device for suction-assisted lipectomy and method of using same
US5830217A (en) 1996-08-09 1998-11-03 Thomas J. Fogarty Soluble fixation device and method for stent delivery catheters
US5782916A (en) * 1996-08-13 1998-07-21 Galt Laboratories, Inc. Device for maintaining urinary continence
US5810806A (en) 1996-08-29 1998-09-22 Ethicon Endo-Surgery Methods and devices for collection of soft tissue
US5725519A (en) * 1996-09-30 1998-03-10 Medtronic Instent Israel Ltd. Stent loading device for a balloon catheter
US5702343A (en) 1996-10-02 1997-12-30 Acorn Medical, Inc. Cardiac reinforcement device
US5895387A (en) 1996-10-09 1999-04-20 Romulo Guerrero Method of craniofacial bone distraction
US5752965A (en) * 1996-10-21 1998-05-19 Bio-Vascular, Inc. Apparatus and method for producing a reinforced surgical fastener suture line
US5769892A (en) 1996-10-22 1998-06-23 Mitroflow International Inc. Surgical stapler sleeve for reinforcing staple lines
US5893867A (en) 1996-11-06 1999-04-13 Percusurge, Inc. Stent positioning apparatus and method
US6102926A (en) 1996-12-02 2000-08-15 Angiotrax, Inc. Apparatus for percutaneously performing myocardial revascularization having means for sensing tissue parameters and methods of use
US5779649A (en) 1996-12-17 1998-07-14 Pabban Development, Inc. Surgical suction wand with filter
NL1004827C2 (en) 1996-12-18 1998-06-19 Surgical Innovations Vof Device for the regulation of the circulatory system.
US5810809A (en) 1997-01-13 1998-09-22 Enhanced Orthopaedic Technologies, Inc. Arthroscopic shaver incorporating electrocautery
US5989234A (en) 1997-01-14 1999-11-23 Deknatel Technology Corporation Device and system for draining a body cavity and methods related thereto
US5782896A (en) 1997-01-29 1998-07-21 Light Sciences Limited Partnership Use of a shape memory alloy to modify the disposition of a device within an implantable medical probe
US5919224A (en) 1997-02-12 1999-07-06 Schneider (Usa) Inc Medical device having a constricted region for occluding fluid flow in a body lumen
US6508825B1 (en) 1997-02-28 2003-01-21 Lumend, Inc. Apparatus for treating vascular occlusions
WO1998038929A1 (en) 1997-03-06 1998-09-11 Percusurge, Inc. Intravascular aspiration system
US5817101A (en) 1997-03-13 1998-10-06 Schneider (Usa) Inc Fluid actuated stent delivery system
US5851232A (en) 1997-03-15 1998-12-22 Lois; William A. Venous stent
JPH10262046A (en) * 1997-03-17 1998-09-29 Fujitsu Ltd Ubr connection route decision system
US6273907B1 (en) 1997-04-07 2001-08-14 Broncus Technologies, Inc. Bronchial stenter
US6488673B1 (en) 1997-04-07 2002-12-03 Broncus Technologies, Inc. Method of increasing gas exchange of a lung
US6283988B1 (en) 1997-04-07 2001-09-04 Broncus Technologies, Inc. Bronchial stenter having expandable electrodes
US6200333B1 (en) * 1997-04-07 2001-03-13 Broncus Technologies, Inc. Bronchial stenter
US6634363B1 (en) 1997-04-07 2003-10-21 Broncus Technologies, Inc. Methods of treating lungs having reversible obstructive pulmonary disease
US6083255A (en) 1997-04-07 2000-07-04 Broncus Technologies, Inc. Bronchial stenter
US6411852B1 (en) 1997-04-07 2002-06-25 Broncus Technologies, Inc. Modification of airways by application of energy
GB2324729B (en) 1997-04-30 2002-01-02 Bradford Hospitals Nhs Trust Lung treatment device
US5957949A (en) 1997-05-01 1999-09-28 World Medical Manufacturing Corp. Percutaneous placement valve stent
US6162245A (en) 1997-05-07 2000-12-19 Iowa-India Investments Company Limited Stent valve and stent graft
US5855597A (en) * 1997-05-07 1999-01-05 Iowa-India Investments Co. Limited Stent valve and stent graft for percutaneous surgery
US6245102B1 (en) * 1997-05-07 2001-06-12 Iowa-India Investments Company Ltd. Stent, stent graft and stent valve
US5976158A (en) 1997-06-02 1999-11-02 Boston Scientific Corporation Method of using a textured ligating band
US6007575A (en) 1997-06-06 1999-12-28 Samuels; Shaun Laurence Wilkie Inflatable intraluminal stent and method for affixing same within the human body
US5957919A (en) 1997-07-02 1999-09-28 Laufer; Michael D. Bleb reducer
US5876434A (en) 1997-07-13 1999-03-02 Litana Ltd. Implantable medical devices of shape memory alloy
US6626903B2 (en) 1997-07-24 2003-09-30 Rex Medical, L.P. Surgical biopsy device
US5984965A (en) 1997-08-28 1999-11-16 Urosurge, Inc. Anti-reflux reinforced stent
US5954766A (en) 1997-09-16 1999-09-21 Zadno-Azizi; Gholam-Reza Body fluid flow control device
US6322522B1 (en) 1997-09-22 2001-11-27 Zimmon Science Corp. Apparatus for separable external serial collection, storage and processing of biopsy specimens
US6016800A (en) 1997-10-24 2000-01-25 Century; Theodore J. Intrapulmonary aerosolizer
US20030009012A1 (en) 1998-12-30 2003-01-09 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
JP2001521790A (en) * 1997-11-03 2001-11-13 カーディオ・テクノロジーズ・インコーポレーテッド Method and apparatus for assisting the blood pumping function of the heart
US5976174A (en) 1997-12-15 1999-11-02 Ruiz; Carlos E. Medical hole closure device and methods of use
US5957978A (en) 1997-12-22 1999-09-28 Hansa Medical Products, Inc. Valved fenestrated tracheotomy tube
FR2773702B1 (en) 1998-01-16 2000-04-07 Johnson & Johnson Internationa Compression device for haemostasis of an organ such as the liver
US5944738A (en) 1998-02-06 1999-08-31 Aga Medical Corporation Percutaneous catheter directed constricting occlusion device
US7879022B2 (en) 1998-02-06 2011-02-01 Medrad, Inc. Rapid exchange fluid jet thrombectomy device and method
US20010016704A1 (en) 1998-02-19 2001-08-23 Gholam Reza Zadno-Azizi Low profile fluid delivery and sealing system for a catheter
US6544192B2 (en) 1998-02-25 2003-04-08 Respironics, Inc. Patient monitor and method of using same
US6454727B1 (en) 1998-03-03 2002-09-24 Senorx, Inc. Tissue acquisition system and method of use
DE59812219D1 (en) * 1998-03-04 2004-12-09 Schneider Europ Gmbh Buelach Apparatus for introducing a stent into a catheter shaft
US6099551A (en) 1998-03-12 2000-08-08 Shelhigh, Inc. Pericardial strip and stapler assembly for dividing and sealing visceral tissues and method of use thereof
US5925060A (en) * 1998-03-13 1999-07-20 B. Braun Celsa Covered self-expanding vascular occlusion device
US6911028B2 (en) 1998-10-28 2005-06-28 John H. Shadduck Medical instrument working end and method for endoluminal treatments
US5972009A (en) 1998-04-07 1999-10-26 Boston Scientific Corporation Ligating band with rounded edges and method of use of same
US6009614A (en) * 1998-04-21 2000-01-04 Advanced Cardiovascular Systems, Inc. Stent crimping tool and method of use
US6510848B1 (en) * 1998-04-22 2003-01-28 Mallinckrodt, Inc. Disposable active humidifier for the mechanical ventilation of a patient
US6141855A (en) 1998-04-28 2000-11-07 Advanced Cardiovascular Systems, Inc. Stent crimping tool and method of use
US6003517A (en) 1998-04-30 1999-12-21 Ethicon Endo-Surgery, Inc. Method for using an electrosurgical device on lung tissue
US5974652A (en) * 1998-05-05 1999-11-02 Advanced Cardiovascular Systems, Inc. Method and apparatus for uniformly crimping a stent onto a catheter
US6493589B1 (en) 1998-05-07 2002-12-10 Medtronic, Inc. Methods and apparatus for treatment of pulmonary conditions
US6327505B1 (en) 1998-05-07 2001-12-04 Medtronic, Inc. Method and apparatus for rf intraluminal reduction and occlusion
US6024759A (en) 1998-05-08 2000-02-15 Walter Lorenz Surgical, Inc. Method and apparatus for performing pectus excavatum repair
US6174323B1 (en) * 1998-06-05 2001-01-16 Broncus Technologies, Inc. Method and assembly for lung volume reduction
US6599311B1 (en) 1998-06-05 2003-07-29 Broncus Technologies, Inc. Method and assembly for lung volume reduction
US6086543A (en) 1998-06-24 2000-07-11 Rubicor Medical, Inc. Fine needle and core biopsy devices and methods
US6077214A (en) 1998-07-29 2000-06-20 Myocor, Inc. Stress reduction apparatus and method
WO2000010622A1 (en) 1998-08-20 2000-03-02 Cook Incorporated Coated implantable medical device
US6210338B1 (en) 1998-08-21 2001-04-03 Aga Medical Corp. Sizing catheter for measuring cardiovascular structures
US6241678B1 (en) 1998-08-21 2001-06-05 Aga Medical Corporation Sizing catheter for measuring septal defects
US6264700B1 (en) 1998-08-27 2001-07-24 Endonetics, Inc. Prosthetic gastroesophageal valve
WO2000012011A1 (en) 1998-08-27 2000-03-09 Shoshan Hendler Apparatus and method for acquisition and retrieval of resected biological specimens
US6331183B1 (en) * 1998-09-24 2001-12-18 Scimed Life Systems, Inc. Basket filter
US6342062B1 (en) * 1998-09-24 2002-01-29 Scimed Life Systems, Inc. Retrieval devices for vena cava filter
US6096027A (en) 1998-09-30 2000-08-01 Impra, Inc., A Subsidiary Of C.R. Bard, Inc. Bag enclosed stent loading apparatus
US6544215B1 (en) 1998-10-02 2003-04-08 Scimed Life Systems, Inc. Steerable device for introducing diagnostic and therapeutic apparatus into the body
US6270527B1 (en) 1998-10-16 2001-08-07 Sulzer Carbomedics Inc. Elastic valve with partially exposed stent
RU2140211C1 (en) 1998-10-28 1999-10-27 Российская медицинская академия последипломного образования Министерства здравоохранения Российской Федерации Method of surgical treatment of patients with pathology of respiratory organs complicated with pulmonary hemorrhages
US6454754B1 (en) 1998-10-29 2002-09-24 Steven R. Frank Respiratory infection treatment device
US6152144A (en) * 1998-11-06 2000-11-28 Appriva Medical, Inc. Method and device for left atrial appendage occlusion
US6020380A (en) * 1998-11-25 2000-02-01 Tap Holdings Inc. Method of treating chronic obstructive pulmonary disease
US6051022A (en) * 1998-12-30 2000-04-18 St. Jude Medical, Inc. Bileaflet valve having non-parallel pivot axes
CA2358521C (en) 1999-01-26 2009-12-29 Edwards Lifesciences Corporation Flexible heart valve
ES2201578T3 (en) 1999-02-01 2004-03-16 Adeva Medical Gesellschaft Fur Entwicklung Und Vertrieb Von Medizinischen Implantat-Artikeln Mbh Valve for a traquostoma.
US6296639B1 (en) 1999-02-12 2001-10-02 Novacept Apparatuses and methods for interstitial tissue removal
US6090041A (en) 1999-02-16 2000-07-18 Regents Of The University Of California vacuum actuated surgical retractor and methods
FR2789889B1 (en) 1999-02-18 2001-04-27 Tokendo Sarl semi-rigid tubular STENT delivery system
US6368338B1 (en) * 1999-03-05 2002-04-09 Board Of Regents, The University Of Texas Occlusion method and apparatus
US6090035A (en) 1999-03-19 2000-07-18 Isostent, Inc. Stent loading assembly for a self-expanding stent
US6231589B1 (en) * 1999-03-22 2001-05-15 Microvena Corporation Body vessel filter
US6146357A (en) 1999-05-07 2000-11-14 Embol-X, Inc. Balloon occlusion diameter and pressure measuring devices and methods of use
US6206918B1 (en) * 1999-05-12 2001-03-27 Sulzer Carbomedics Inc. Heart valve prosthesis having a pivot design for improving flow characteristics
US6241758B1 (en) 1999-05-28 2001-06-05 Advanced Cardiovascular Systems, Inc. Self-expanding stent delivery system and method of use
US6168617B1 (en) 1999-06-14 2001-01-02 Scimed Life Systems, Inc. Stent delivery system
CA2377559A1 (en) 1999-06-18 2000-12-28 Powerlung,Inc Pulmonary exercise device
US6146388A (en) 1999-06-21 2000-11-14 Surgical Concepts, Inc. Rocking apparatus for manipulating element in the eye
US6234996B1 (en) * 1999-06-23 2001-05-22 Percusurge, Inc. Integrated inflation/deflation device and method
US6997951B2 (en) 1999-06-30 2006-02-14 Edwards Lifesciences Ag Method and device for treatment of mitral insufficiency
US6287290B1 (en) 1999-07-02 2001-09-11 Pulmonx Methods, systems, and kits for lung volume reduction
CA2375538A1 (en) 1999-07-07 2001-01-18 Astrazeneca Ab Closure device for a medical container
US6241654B1 (en) * 1999-07-07 2001-06-05 Acorn Cardiovasculr, Inc. Cardiac reinforcement devices and methods
US6174331B1 (en) 1999-07-19 2001-01-16 Sulzer Carbomedics Inc. Heart valve leaflet with reinforced free margin
US20050137611A1 (en) 2001-09-04 2005-06-23 Broncus Technologies, Inc. Methods and devices for maintaining surgically created channels in a body organ
US6709427B1 (en) 1999-08-05 2004-03-23 Kensey Nash Corporation Systems and methods for delivering agents into targeted tissue of a living being
DE60008072D1 (en) 1999-08-05 2004-03-11 Broncus Tech Inc Methods and devices for production of collateral channels in the lungs
US6749606B2 (en) * 1999-08-05 2004-06-15 Thomas Keast Devices for creating collateral channels
US6712812B2 (en) * 1999-08-05 2004-03-30 Broncus Technologies, Inc. Devices for creating collateral channels
US8257428B2 (en) 1999-08-09 2012-09-04 Cardiokinetix, Inc. System for improving cardiac function
US7862500B2 (en) 2002-08-01 2011-01-04 Cardiokinetix, Inc. Multiple partitioning devices for heart treatment
WO2001012104A1 (en) 1999-08-13 2001-02-22 Percusurge, Inc. Occlusion of a vessel
US6610043B1 (en) 1999-08-23 2003-08-26 Bistech, Inc. Tissue volume reduction
US6416554B1 (en) 1999-08-24 2002-07-09 Spiration, Inc. Lung reduction apparatus and method
EP1078601B1 (en) 1999-08-24 2006-10-04 Spiration, Inc. Kit for lung volume reduction
US7037275B1 (en) 1999-08-31 2006-05-02 The University Of Western Australia Methods and devices for obtaining samples from hollow viscera
US6280398B1 (en) 1999-10-18 2001-08-28 Ethicon Endo-Surgery Methods and devices for collection of soft tissue
US6402754B1 (en) * 1999-10-20 2002-06-11 Spiration, Inc. Apparatus for expanding the thorax
US6398775B1 (en) * 1999-10-21 2002-06-04 Pulmonx Apparatus and method for isolated lung access
US6440164B1 (en) * 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
US6551303B1 (en) 1999-10-27 2003-04-22 Atritech, Inc. Barrier device for ostium of left atrial appendage
US6689150B1 (en) * 1999-10-27 2004-02-10 Atritech, Inc. Filter apparatus for ostium of left atrial appendage
US6383198B1 (en) 1999-12-07 2002-05-07 Scimed Life System, Inc. Flexible vacuum grabber for holding lesions
WO2001045590A3 (en) 1999-12-23 2002-03-07 Percusurge Inc Strut design for an occlusion device
US6510846B1 (en) * 1999-12-23 2003-01-28 O'rourke Sam Sealed back pressure breathing device
US6277083B1 (en) 1999-12-27 2001-08-21 Neothermia Corporation Minimally invasive intact recovery of tissue
US6471979B2 (en) 1999-12-29 2002-10-29 Estrogen Vascular Technology, Llc Apparatus and method for delivering compounds to a living organism
US6458153B1 (en) * 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
NL1014095C2 (en) 2000-01-17 2001-07-18 Cornelis Hendrikus Anna Witten Implant valve for implantation in a blood vessel.
JP5000826B2 (en) 2000-01-24 2012-08-15 バイオコンパテイブルズ・ユーケイ・リミテツド The coated implant
CA2840468C (en) 2000-01-31 2016-07-26 Cook Biotech Incorporated Stent valves and uses of same
JP2004507444A (en) 2000-01-31 2004-03-11 ジェネーラ コーポレーション Mucin synthesis inhibitors
US6458076B1 (en) 2000-02-01 2002-10-01 5 Star Medical Multi-lumen medical device
WO2001056512A1 (en) * 2000-02-02 2001-08-09 Snyders Robert V Artificial heart valve
US6399366B1 (en) 2000-02-07 2002-06-04 Eric Seagren Method and apparatus for composting organic waste together with its packaging cartons, boxes or crates on site
US6540767B1 (en) * 2000-02-08 2003-04-01 Scimed Life Systems, Inc. Recoilable thrombosis filtering device and method
US6600307B2 (en) 2000-03-02 2003-07-29 Sarnoff Corporation Method and apparatus for measuring true transmitted power using a broadband dual directional coupler
US7011094B2 (en) * 2001-03-02 2006-03-14 Emphasys Medical, Inc. Bronchial flow control devices and methods of use
US6770070B1 (en) 2000-03-17 2004-08-03 Rita Medical Systems, Inc. Lung treatment apparatus and method
US6328689B1 (en) 2000-03-23 2001-12-11 Spiration, Inc., Lung constriction apparatus and method
WO2001074271A1 (en) 2000-03-31 2001-10-11 Broncus Technologies, Inc. Lung elastic recoil restoring/compression device
US6514290B1 (en) * 2000-03-31 2003-02-04 Broncus Technologies, Inc. Lung elastic recoil restoring or tissue compressing device and method
JP3793090B2 (en) * 2000-05-18 2006-07-05 エンファシス・メディカル・インコーポレイテッド Bronchopulmonary closure device
US6722360B2 (en) * 2000-06-16 2004-04-20 Rajiv Doshi Methods and devices for improving breathing in patients with pulmonary disease
US6695878B2 (en) 2000-06-26 2004-02-24 Rex Medical, L.P. Vascular device for valve leaflet apposition
WO2002005884A8 (en) 2000-07-19 2002-03-28 Univ Florida Method for treating chronic obstructive pulmonary disorder
US6485436B1 (en) 2000-08-10 2002-11-26 Csaba Truckai Pressure-assisted biopsy needle apparatus and technique
DE60114640T2 (en) * 2000-08-17 2006-07-20 Eli Lilly And Co., Indianapolis Antithrombotic agents
EP1355611A2 (en) 2000-09-11 2003-10-29 Closure Medical Corporation Bronchial occlusion method and apparatus
US6945989B1 (en) 2000-09-18 2005-09-20 Endotex Interventional Systems, Inc. Apparatus for delivering endoluminal prostheses and methods of making and using them
US20020072730A1 (en) 2000-10-12 2002-06-13 Mcgill Scott A. Methods and apparatus for protecting the proximal end of a medical device
US6540694B1 (en) 2000-10-16 2003-04-01 Sanarus Medical, Inc. Device for biopsy tumors
DE60025049T2 (en) 2000-10-17 2006-08-03 Asthmatx, Inc., Mountain View Modification of air for by exercise of power
US7077851B2 (en) 2000-10-17 2006-07-18 Aesculap Ag & Co. Kg Aneurysm clip
US6585639B1 (en) 2000-10-27 2003-07-01 Pulmonx Sheath and method for reconfiguring lung viewing scope
JP4064243B2 (en) 2000-11-06 2008-03-19 スルーズ サージカル システムズ、インク Tissue biopsy apparatus
US6840952B2 (en) 2000-12-07 2005-01-11 Mark B. Saker Tissue tract sealing device
US20040093075A1 (en) 2000-12-15 2004-05-13 Titus Kuehne Stent with valve and method of use thereof
US6620095B2 (en) 2000-12-22 2003-09-16 Syde A. Taheri Cradle-assisted myocardial repair and treatment
WO2002056794A3 (en) 2001-01-18 2002-11-07 Brigham & Womens Hospital Prosthetic device for respiratory patients
US6494884B2 (en) 2001-02-09 2002-12-17 Concentric Medical, Inc. Methods and devices for delivering occlusion elements
US7175644B2 (en) 2001-02-14 2007-02-13 Broncus Technologies, Inc. Devices and methods for maintaining collateral channels in tissue
US6666862B2 (en) 2001-03-01 2003-12-23 Cardiac Pacemakers, Inc. Radio frequency ablation system and method linking energy delivery with fluid flow
US6503272B2 (en) * 2001-03-21 2003-01-07 Cordis Corporation Stent-based venous valves
US6958076B2 (en) * 2001-04-16 2005-10-25 Biomedical Research Associates Inc. Implantable venous valve
US6638285B2 (en) 2001-04-16 2003-10-28 Shlomo Gabbay Biological tissue strip and system and method to seal tissue
KR100393548B1 (en) * 2001-06-05 2003-08-02 주식회사 엠아이텍 Stent
US6716239B2 (en) 2001-07-03 2004-04-06 Scimed Life Systems, Inc. ePTFE graft with axial elongation properties
US6491706B1 (en) 2001-07-10 2002-12-10 Spiration, Inc. Constriction device including fixation structure
JP4602602B2 (en) * 2001-07-19 2010-12-22 オリンパス株式会社 Medical instruments
US20030018327A1 (en) * 2001-07-20 2003-01-23 Csaba Truckai Systems and techniques for lung volume reduction
JP4252448B2 (en) 2001-07-26 2009-04-08 フィリップス、バン エル.PHILLIPS,Van,L. Socket insert having a bladder system
US6743259B2 (en) * 2001-08-03 2004-06-01 Core Medical, Inc. Lung assist apparatus and methods for use
US6902540B2 (en) 2001-08-22 2005-06-07 Gerald Dorros Apparatus and methods for treating stroke and controlling cerebral flow characteristics
US6589240B2 (en) 2001-08-28 2003-07-08 Rex Medical, L.P. Tissue biopsy apparatus with collapsible cutter
JP4301945B2 (en) * 2001-09-10 2009-07-22 パルモンクス Method and apparatus for intrabronchial diagnosis
US20030055331A1 (en) * 2001-09-11 2003-03-20 Pulmonx Methods of endobronchial diagnosis using imaging
US6632239B2 (en) 2001-10-02 2003-10-14 Spiration, Inc. Constriction device including reinforced suture holes
US20040089306A1 (en) 2002-05-28 2004-05-13 Ronald Hundertmark Devices and methods for removing bronchial isolation devices implanted in the lung
JP4446739B2 (en) * 2001-10-11 2010-04-07 パルモンクス・コーポレイションPulmonx Corporation Using bronchial flow control device and the device
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
US20030083730A1 (en) 2001-10-25 2003-05-01 Scimed Life Systems, Inc. Loading cartridge for self-expanding stent
US6682250B2 (en) * 2001-11-07 2004-01-27 Lockheed Martin Corporation Position-adjustable fastening apparatus and method
WO2003041779A9 (en) 2001-11-14 2004-03-11 Emphasys Medical Inc Active pump bronchial implant and methods of use thereof
CA2365752A1 (en) 2001-12-20 2003-06-20 Pierre Coll Data communication apparatus with distributed traffic protection switching system
US6695791B2 (en) 2002-01-04 2004-02-24 Spiration, Inc. System and method for capturing body tissue samples
US20030154988A1 (en) * 2002-02-21 2003-08-21 Spiration, Inc. Intra-bronchial device that provides a medicant intra-bronchially to the patient
US6929637B2 (en) 2002-02-21 2005-08-16 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US20060235432A1 (en) 2002-02-21 2006-10-19 Devore Lauri J Intra-bronchial obstructing device that controls biological interaction with the patient
EP1482863A1 (en) 2002-03-08 2004-12-08 Emphasys Medical, Inc. Methods and devices for inducing collapse in lung regions fed by collateral pathways
US20030181356A1 (en) 2002-03-11 2003-09-25 Edward Ingenito Compositions and methods for treating emphysema
EP1487357B1 (en) 2002-03-15 2011-11-23 W.L. Gore & Associates, Inc. Coupling system useful in placement of implants
WO2003079944A1 (en) 2002-03-20 2003-10-02 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20030181890A1 (en) 2002-03-22 2003-09-25 Schulze Dale R. Medical device that removably attaches to a bodily organ
US20030195385A1 (en) 2002-04-16 2003-10-16 Spiration, Inc. Removable anchored lung volume reduction devices and methods
WO2003088820A3 (en) 2002-04-19 2004-12-29 Broncus Tech Inc Devices for maintaining surgically created openings
US7207946B2 (en) 2002-05-09 2007-04-24 Spiration, Inc. Automated provision of information related to air evacuation from a chest cavity
US6852108B2 (en) 2002-05-14 2005-02-08 Spiration, Inc. Apparatus and method for resecting and removing selected body tissue from a site inside a patient
US20030225445A1 (en) 2002-05-14 2003-12-04 Derus Patricia M. Surgical stent delivery devices and methods
EP1509176B1 (en) 2002-05-23 2006-08-23 Otto Bock HealthCare, LP Pulsating pressure chamber in a prosthetic limb
US7422584B2 (en) 2002-07-05 2008-09-09 Broncus Technologies, Inc. Extrapleural airway device and method
US20040010209A1 (en) 2002-07-15 2004-01-15 Spiration, Inc. Device and method for measuring the diameter of an air passageway
DE60323502D1 (en) 2002-07-26 2008-10-23 Emphasys Medical Inc Bronchial flow device with a membrane seal
US7086398B2 (en) 2002-07-31 2006-08-08 Cordis Corporation Long term oxygen therapy system
US6886558B2 (en) 2002-08-28 2005-05-03 Cordis Corporation Collateral ventilation bypass trap system
US20040059263A1 (en) 2002-09-24 2004-03-25 Spiration, Inc. Device and method for measuring the diameter of an air passageway
US6849084B2 (en) 2002-12-31 2005-02-01 Intek Technology L.L.C. Stent delivery system
US20040143283A1 (en) 2003-01-17 2004-07-22 Mcgill Scott Inflation adaptor and method of use
US7637934B2 (en) 2003-03-31 2009-12-29 Merit Medical Systems, Inc. Medical appliance optical delivery and deployment apparatus and method
US7100616B2 (en) 2003-04-08 2006-09-05 Spiration, Inc. Bronchoscopic lung volume reduction method
US7530995B2 (en) 2003-04-17 2009-05-12 3F Therapeutics, Inc. Device for reduction of pressure effects of cardiac tricuspid valve regurgitation
EP1472996B1 (en) * 2003-04-30 2009-09-30 Medtronic Vascular, Inc. Percutaneously delivered temporary valve
US7252086B2 (en) 2003-06-03 2007-08-07 Cordis Corporation Lung reduction system
EP1524850A1 (en) * 2003-07-30 2005-04-20 Sony International (Europe) GmbH Projection arrangement and electronic customer device
US7533671B2 (en) 2003-08-08 2009-05-19 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US20050080434A1 (en) 2003-10-08 2005-04-14 Cedars-Sinai Medical Center Laparoscopic retractable dissector and suture and needle passer
US8057533B2 (en) 2003-10-29 2011-11-15 Boston Scientific Scimed, Inc. Apparatus with visual marker for guiding deployment of implantable prosthesis
US7273469B1 (en) 2003-12-31 2007-09-25 Advanced Cardiovascular Systems, Inc. Modified needle catheter for directional orientation delivery
US7704268B2 (en) 2004-05-07 2010-04-27 Nmt Medical, Inc. Closure device with hinges
US8317859B2 (en) 2004-06-28 2012-11-27 J.W. Medical Systems Ltd. Devices and methods for controlling expandable prostheses during deployment
WO2006034166A3 (en) 2004-09-17 2009-04-09 Cordis Neurovascular Inc Thin film metallic devices for plugging aneurysms or vessels
US6951571B1 (en) * 2004-09-30 2005-10-04 Rohit Srivastava Valve implanting device
DE602004010276D1 (en) 2004-11-10 2008-01-03 Creganna Technologies Ltd Einführkatheteranordnung for stents
CA2587909C (en) 2004-11-16 2016-01-05 Robert L. Barry Device and method for lung treatment
US20060241745A1 (en) 2005-04-21 2006-10-26 Solem Jan O Blood flow controlling apparatus
EP1895951A1 (en) 2005-05-13 2008-03-12 Alveolus Inc. Delivery device allowing visual inspection of an intravascular site
US7736320B2 (en) 2005-05-25 2010-06-15 Sierra Medical Technology, Inc. Self-condensing pH sensor and catheter apparatus
US7453015B2 (en) 2005-08-02 2008-11-18 Shell Oil Company Process for the preparation of alkylene glycols
US7842010B2 (en) 2005-12-05 2010-11-30 Medrad, Inc. Pneumatically-operated thrombectomy catheter deployment system
US8136526B2 (en) 2006-03-08 2012-03-20 Pulmonx Corporation Methods and devices to induce controlled atelectasis and hypoxic pulmonary vasoconstriction
US20070209204A1 (en) 2006-03-09 2007-09-13 Chase Daniel J Hose Assembly Process, Device, and Product-by-Process
US8157837B2 (en) 2006-03-13 2012-04-17 Pneumrx, Inc. Minimally invasive lung volume reduction device and method
US7691151B2 (en) 2006-03-31 2010-04-06 Spiration, Inc. Articulable Anchor
US20090188508A1 (en) 2007-09-14 2009-07-30 Smith Jr A James Disposable medical mouthpiece appliance
CN101868199B (en) 2007-10-12 2016-04-06 斯波瑞申有限公司 Valve loader methods, systems, and devices
US8043301B2 (en) 2007-10-12 2011-10-25 Spiration, Inc. Valve loader method, system, and apparatus
WO2009135070A1 (en) 2008-05-01 2009-11-05 Spiration, Inc. Direct lung sensor systems, methods, and apparatuses
EP2330985A4 (en) 2008-09-04 2015-11-18 Curaseal Inc Inflatable devices for enteric fistula treatment
WO2010040009A1 (en) 2008-10-01 2010-04-08 Cardiaq Valve Technologies, Inc. Delivery system for vascular implant
CN106333749A (en) 2011-05-13 2017-01-18 斯波瑞申有限公司 Unfolded catheter
US8795241B2 (en) 2011-05-13 2014-08-05 Spiration, Inc. Deployment catheter

Patent Citations (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2832078A (en) * 1956-10-17 1958-04-29 Battelle Memorial Institute Heart valve
US2981254A (en) * 1957-11-12 1961-04-25 Edwin G Vanderbilt Apparatus for the gas deflation of an animal's stomach
US3320972A (en) * 1964-04-16 1967-05-23 Roy F High Prosthetic tricuspid valve and method of and device for fabricating same
US3472230A (en) * 1966-12-19 1969-10-14 Fogarty T J Umbrella catheter
US3617060A (en) * 1967-04-10 1971-11-02 Warren Iezzi Pneumothorox-inducing hunting arrow
US3445916A (en) * 1967-04-19 1969-05-27 Rudolf R Schulte Method for making an anatomical check valve
US3671979A (en) * 1969-09-23 1972-06-27 Univ Utah Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve
US3760808A (en) * 1969-12-01 1973-09-25 K Bleuer Tampon applicator assembly
US3657744A (en) * 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US3788327A (en) * 1971-03-30 1974-01-29 H Donowitz Surgical implant device
US3757783A (en) * 1971-09-24 1973-09-11 Sherwood Medical Ind Inc Suction drainage apparatus
US4014318A (en) * 1973-08-20 1977-03-29 Dockum James M Circulatory assist device and system
US4084268A (en) * 1976-04-22 1978-04-18 Shiley Laboratories, Incorporated Prosthetic tissue heart valve
US4056854A (en) * 1976-09-28 1977-11-08 The United States Of America As Represented By The Department Of Health, Education And Welfare Aortic heart valve catheter
US4086665A (en) * 1976-12-16 1978-05-02 Thermo Electron Corporation Artificial blood conduit
US4250873A (en) * 1977-04-26 1981-02-17 Richard Wolf Gmbh Endoscopes
US4218782A (en) * 1977-05-25 1980-08-26 Biocoating Anpartsselskab Heart valve prosthesis and method for the production thereof
US4212463A (en) * 1978-02-17 1980-07-15 Pratt Enoch B Humane bleeder arrow
US4222126A (en) * 1978-12-14 1980-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health, Education & Welfare Unitized three leaflet heart valve
US4850999A (en) * 1980-05-24 1989-07-25 Institute Fur Textil-Und Faserforschung Of Stuttgart Flexible hollow organ
US4808183A (en) * 1980-06-03 1989-02-28 University Of Iowa Research Foundation Voice button prosthesis and method for installing same
US4302854A (en) * 1980-06-04 1981-12-01 Runge Thomas M Electrically activated ferromagnetic/diamagnetic vascular shunt for left ventricular assist
US4339831A (en) * 1981-03-27 1982-07-20 Medtronic, Inc. Dynamic annulus heart valve and reconstruction ring
US4619246A (en) * 1984-05-23 1986-10-28 William Cook, Europe A/S Collapsible filter basket
US4819664A (en) * 1984-11-15 1989-04-11 Stefano Nazari Device for selective bronchial intubation and separate lung ventilation, particularly during anesthesia, intensive therapy and reanimation
US4732152A (en) * 1984-12-05 1988-03-22 Medinvent S.A. Device for implantation and a method of implantation in a vessel using such device
US4759758A (en) * 1984-12-07 1988-07-26 Shlomo Gabbay Prosthetic heart valve
US4681110A (en) * 1985-12-02 1987-07-21 Wiktor Dominik M Catheter arrangement having a blood vessel liner, and method of using it
US4710192A (en) * 1985-12-30 1987-12-01 Liotta Domingo S Diaphragm and method for occlusion of the descending thoracic aorta
US4832680A (en) * 1986-07-03 1989-05-23 C.R. Bard, Inc. Apparatus for hypodermically implanting a genitourinary prosthesis
US4795449A (en) * 1986-08-04 1989-01-03 Hollister Incorporated Female urinary incontinence device
US4852568A (en) * 1987-02-17 1989-08-01 Kensey Nash Corporation Method and apparatus for sealing an opening in tissue of a living being
US4934999A (en) * 1987-07-28 1990-06-19 Paul Bader Closure for a male urethra
US4830003A (en) * 1988-06-17 1989-05-16 Wolff Rodney G Compressive stent and delivery system
US4846836A (en) * 1988-10-03 1989-07-11 Reich Jonathan D Artificial lower gastrointestinal valve
US4877025A (en) * 1988-10-06 1989-10-31 Hanson Donald W Tracheostomy tube valve apparatus
US5116564A (en) * 1988-10-11 1992-05-26 Josef Jansen Method of producing a closing member having flexible closing elements, especially a heart valve
US4968294A (en) * 1989-02-09 1990-11-06 Salama Fouad A Urinary control valve and method of using same
US5352240A (en) * 1989-05-31 1994-10-04 Promedica International, Inc. Human heart valve replacement with porcine pulmonary valve
US5314473A (en) * 1989-07-20 1994-05-24 Godin Norman J Prosthesis for preventing gastric reflux into the esophagus
US5061274A (en) * 1989-12-04 1991-10-29 Kensey Nash Corporation Plug device for sealing openings and method of use
US5158548A (en) * 1990-04-25 1992-10-27 Advanced Cardiovascular Systems, Inc. Method and system for stent delivery
US5411552A (en) * 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis
US5116360A (en) * 1990-12-27 1992-05-26 Corvita Corporation Mesh composite graft
US5358518A (en) * 1991-06-25 1994-10-25 Sante Camilli Artificial venous valve
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5151105A (en) * 1991-10-07 1992-09-29 Kwan Gett Clifford Collapsible vessel sleeve implant
US5123919A (en) * 1991-11-21 1992-06-23 Carbomedics, Inc. Combined prosthetic aortic heart valve and vascular graft
US5283063A (en) * 1992-01-31 1994-02-01 Eagle Vision Punctum plug method and apparatus
US5509900A (en) * 1992-03-02 1996-04-23 Kirkman; Thomas R. Apparatus and method for retaining a catheter in a blood vessel in a fixed position
US5382261A (en) * 1992-09-01 1995-01-17 Expandable Grafts Partnership Method and apparatus for occluding vessels
US5409019A (en) * 1992-10-30 1995-04-25 Wilk; Peter J. Coronary artery by-pass method
US5304199A (en) * 1993-01-04 1994-04-19 Gene E. Myers Enterprises, Inc. Apparatus for arterial total occlusion plaque separation
US5411507A (en) * 1993-01-08 1995-05-02 Richard Wolf Gmbh Instrument for implanting and extracting stents
US5306234A (en) * 1993-03-23 1994-04-26 Johnson W Dudley Method for closing an atrial appendage
US5603698A (en) * 1993-04-13 1997-02-18 Boston Scientific Corporation Prosthesis delivery system
US5366478A (en) * 1993-07-27 1994-11-22 Ethicon, Inc. Endoscopic surgical sealing device
US5507754A (en) * 1993-08-20 1996-04-16 United States Surgical Corporation Apparatus and method for applying and adjusting an anchoring device
US5453090A (en) * 1994-03-01 1995-09-26 Cordis Corporation Method of stent delivery through an elongate softenable sheath
US5392775A (en) * 1994-03-22 1995-02-28 Adkins, Jr.; Claude N. Duckbill valve for a tracheostomy tube that permits speech
US5803078A (en) * 1994-05-06 1998-09-08 Brauner; Mark E. Methods and apparatus for intrapulmonary therapy and drug administration
US6165179A (en) * 1995-05-23 2000-12-26 Boston Scientific Corporation Vena cava delivery system
US5833694A (en) * 1995-05-25 1998-11-10 Medtronic, Inc. Stent assembly and method of use
US6447530B1 (en) * 1996-11-27 2002-09-10 Scimed Life Systems, Inc. Atraumatic anchoring and disengagement mechanism for permanent implant device
US20010010017A1 (en) * 1996-12-31 2001-07-26 Brice Letac Alve prosthesis for implantation in body channels
US20030019385A1 (en) * 1997-01-27 2003-01-30 Leasure John D. Subsonic cartridge for gas-operated automatic and semiautomatic weapons
US6267775B1 (en) * 1997-03-21 2001-07-31 Schneider (Usa) Inc. Self-expanding medical device for centering radioactive treatment sources in body vessels
US5954636A (en) * 1997-07-15 1999-09-21 Schwartz; Roy E. Pediatric endotracheal tube with bronchial blocker and method for selectively blocking respiratory airflow to a pediatric patient's lung
US6010525A (en) * 1997-08-01 2000-01-04 Peter M. Bonutti Method and apparatus for securing a suture
US5925063A (en) * 1997-09-26 1999-07-20 Khosravi; Farhad Coiled sheet valve, filter or occlusive device and methods of use
US20020052626A1 (en) * 1997-11-07 2002-05-02 Paul Gilson Embolic protection system
US6558429B2 (en) * 1997-12-09 2003-05-06 Reflux Corporation Perorally insertable gastroesophageal anti-reflux valve prosthesis and tool for implantation thereof
US6132458A (en) * 1998-05-15 2000-10-17 American Medical Systems, Inc. Method and device for loading a stent
US6471718B1 (en) * 1998-05-15 2002-10-29 American Medical Systems, Inc. Method and device for loading a stent
US6149664A (en) * 1998-08-27 2000-11-21 Micrus Corporation Shape memory pusher introducer for vasoocclusive devices
US6425916B1 (en) * 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
US6293951B1 (en) * 1999-08-24 2001-09-25 Spiration, Inc. Lung reduction device, system, and method
US6283334B1 (en) * 1999-08-30 2001-09-04 Kimberly-Clark Worldwide, Inc. Personal dispensing system
US6203551B1 (en) * 1999-10-04 2001-03-20 Advanced Cardiovascular Systems, Inc. Chamber for applying therapeutic substances to an implant device
US6694979B2 (en) * 2000-03-04 2004-02-24 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US20010037808A1 (en) * 2000-03-04 2001-11-08 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US6904909B2 (en) * 2000-03-04 2005-06-14 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US6527761B1 (en) * 2000-10-27 2003-03-04 Pulmonx, Inc. Methods and devices for obstructing and aspirating lung tissue segments
US20020112729A1 (en) * 2001-02-21 2002-08-22 Spiration, Inc. Intra-bronchial obstructing device that controls biological interaction with the patient
US20040173282A1 (en) * 2001-07-02 2004-09-09 Thomas Laetgaard Inflating unit with sealing facilities for a tyre filled with air
US6860847B2 (en) * 2001-07-10 2005-03-01 Spiration, Inc. Constriction device viewable under X ray fluoroscopy
US20030018922A1 (en) * 2001-07-18 2003-01-23 Litwin Louis Robert Method and system for providing emergency shutdown of a malfunctioning device
US20040206349A1 (en) * 2001-09-11 2004-10-21 Alferness Clifton A. Removable lung reduction devices, systems, and methods
US20050033310A1 (en) * 2001-09-11 2005-02-10 Alferness Clifton A. Intra-bronchial valve devices
US20040243140A1 (en) * 2001-09-11 2004-12-02 Alferness Clifton A. Collapsible intra-bronchial valve devices
US20040211412A1 (en) * 2001-09-11 2004-10-28 Alferness Clifton A. Removable lung reduction devices, systems, and method
US20030183235A1 (en) * 2001-10-25 2003-10-02 Spiration, Inc. Bronchial obstruction device deployment system and method
US20030167065A1 (en) * 2002-03-01 2003-09-04 Arvik Enterprises, Llc Blood vessel occlusion device
US20030181922A1 (en) * 2002-03-20 2003-09-25 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20030212412A1 (en) * 2002-05-09 2003-11-13 Spiration, Inc. Intra-bronchial obstructing device that permits mucus transport
US20040167636A1 (en) * 2002-05-17 2004-08-26 Dillard David H. Methods of achieving lung volume reduction with removable anchored devices
US20050033344A1 (en) * 2002-05-17 2005-02-10 Dillard David H. One-way valve devices for anchored implantation in a lung
US20030216769A1 (en) * 2002-05-17 2003-11-20 Dillard David H. Removable anchored lung volume reduction devices and methods
US20040210248A1 (en) * 2003-03-12 2004-10-21 Spiration, Inc. Apparatus, method and assembly for delivery of intra-bronchial devices

Cited By (276)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030199972A1 (en) * 1997-09-16 2003-10-23 Gholam-Reza Zadno-Azizi Body fluid flow control device
US20030212452A1 (en) * 1997-09-16 2003-11-13 Gholam-Reza Zadno-Azizi Body fluid flow control device
US20020095209A1 (en) * 1997-09-16 2002-07-18 Gholam-Reza Zadno-Azizi Body fluid flow control device
US20040078054A1 (en) * 1998-06-05 2004-04-22 Broncus Technologies, Inc. Method for lung volume reduction
US6997189B2 (en) 1998-06-05 2006-02-14 Broncus Technologies, Inc. Method for lung volume reduction
US7662181B2 (en) 2000-03-04 2010-02-16 Pulmonx Corporation Methods and devices for use in performing pulmonary procedures
US20040134487A1 (en) * 2000-03-04 2004-07-15 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US20060174870A1 (en) * 2000-03-04 2006-08-10 Deem Mark E Methods and devices for use in performing pulmonary procedures
US20050051163A1 (en) * 2000-03-04 2005-03-10 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US20030070683A1 (en) * 2000-03-04 2003-04-17 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US20110226238A1 (en) * 2000-03-04 2011-09-22 Pulmonx Corporation Implanted bronchial isolation devices and methods
US6679264B1 (en) 2000-03-04 2004-01-20 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US8357139B2 (en) 2000-03-04 2013-01-22 Pulmonx Corporation Methods and devices for use in performing pulmonary procedures
US8474460B2 (en) 2000-03-04 2013-07-02 Pulmonx Corporation Implanted bronchial isolation devices and methods
US7334581B2 (en) 2000-06-16 2008-02-26 Ventus Medical, Inc. Methods and devices for improving breathing in patients with pulmonary disease
US20060032497A1 (en) * 2000-06-16 2006-02-16 Rajiv Doshi Methods and devices for improving breathing in patients with pulmonary disease
US6722360B2 (en) 2000-06-16 2004-04-20 Rajiv Doshi Methods and devices for improving breathing in patients with pulmonary disease
US20040194779A1 (en) * 2000-06-16 2004-10-07 Rajiv Doshi Methods and devices for improving breathing in patients with pulmonary disease
US20020112729A1 (en) * 2001-02-21 2002-08-22 Spiration, Inc. Intra-bronchial obstructing device that controls biological interaction with the patient
US20040055606A1 (en) * 2001-03-02 2004-03-25 Emphasys Medical, Inc. Bronchial flow control devices with membrane seal
US20040074491A1 (en) * 2001-03-02 2004-04-22 Michael Hendricksen Delivery methods and devices for implantable bronchial isolation devices
US20110017207A1 (en) * 2001-03-02 2011-01-27 Pulmonx Corporation Bronchial flow control devices with membrane seal
US20040060563A1 (en) * 2001-03-02 2004-04-01 Alan Rapacki Bronchial flow control devices and methods of use
US7798147B2 (en) 2001-03-02 2010-09-21 Pulmonx Corporation Bronchial flow control devices with membrane seal
US8251067B2 (en) 2001-03-02 2012-08-28 Pulmonx Corporation Bronchial flow control devices with membrane seal
US8414655B2 (en) 2001-09-11 2013-04-09 Spiration, Inc. Removable lung reduction devices, systems, and methods
US20090205667A1 (en) * 2001-09-11 2009-08-20 Spiration, Inc. Removable lung reduction devices, systems, and methods
US20040206349A1 (en) * 2001-09-11 2004-10-21 Alferness Clifton A. Removable lung reduction devices, systems, and methods
US20040211412A1 (en) * 2001-09-11 2004-10-28 Alferness Clifton A. Removable lung reduction devices, systems, and method
US7757692B2 (en) 2001-09-11 2010-07-20 Spiration, Inc. Removable lung reduction devices, systems, and methods
US20040243140A1 (en) * 2001-09-11 2004-12-02 Alferness Clifton A. Collapsible intra-bronchial valve devices
US8974484B2 (en) 2001-09-11 2015-03-10 Spiration, Inc. Removable lung reduction devices, systems, and methods
US20110054632A1 (en) * 2001-09-11 2011-03-03 Spiration, Inc. Removable lung reduction devices, systems, and methods
US20050033310A1 (en) * 2001-09-11 2005-02-10 Alferness Clifton A. Intra-bronchial valve devices
US20110130834A1 (en) * 2001-10-11 2011-06-02 Pulmonx Corporation Bronchial flow control devices and methods of use
US7854228B2 (en) 2001-10-11 2010-12-21 Pulmonx Corporation Bronchial flow control devices and methods of use
US20050145253A1 (en) * 2001-10-11 2005-07-07 Emphasys Medical, Inc., A Delaware Corporation Bronchial flow control devices and methods of use
US20030070682A1 (en) * 2001-10-11 2003-04-17 Wilson Peter M. Bronchial flow control devices and methods of use
US20050166925A1 (en) * 2001-10-11 2005-08-04 Emphasys Medical, Inc., A California Corporation Bronchial flow control devices and methods of use
US7896887B2 (en) 2001-10-25 2011-03-01 Spiration, Inc. Apparatus and method for deployment of a bronchial obstruction device
US20030183235A1 (en) * 2001-10-25 2003-10-02 Spiration, Inc. Bronchial obstruction device deployment system and method
US20070185531A1 (en) * 2001-10-25 2007-08-09 Spiration, Inc. Apparatus and method for deployment of a bronchial obstruction device
US8986336B2 (en) 2001-10-25 2015-03-24 Spiration, Inc. Apparatus and method for deployment of a bronchial obstruction device
US20060074382A1 (en) * 2002-02-21 2006-04-06 Gonzalez Hugo X Device and method for intra-bronchial provision of a therapeutic agent
US7942931B2 (en) 2002-02-21 2011-05-17 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US20060206147A1 (en) * 2002-02-21 2006-09-14 Devore Lauri J Intra-bronchial obstruction device that provides a medicant intra-bronchially to the patient
US20060200076A1 (en) * 2002-02-21 2006-09-07 Gonzalez Hugo X Device and method for intra-bronchial provision of a therapeutic agent
US20030158515A1 (en) * 2002-02-21 2003-08-21 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US20060235432A1 (en) * 2002-02-21 2006-10-19 Devore Lauri J Intra-bronchial obstructing device that controls biological interaction with the patient
US20060283462A1 (en) * 2002-03-08 2006-12-21 Fields Antony J Methods and devices for inducing collapse in lung regions fed by collateral pathways
US20080249503A1 (en) * 2002-03-08 2008-10-09 Fields Antony J Methods and devices for lung treatment
US20080119866A1 (en) * 2002-03-20 2008-05-22 Alferness Clifton A Removable anchored lung volume reduction devices and methods
US8177805B2 (en) 2002-03-20 2012-05-15 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US8603127B2 (en) 2002-03-20 2013-12-10 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US8021385B2 (en) 2002-03-20 2011-09-20 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US8926647B2 (en) 2002-03-20 2015-01-06 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20030195385A1 (en) * 2002-04-16 2003-10-16 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20060235467A1 (en) * 2002-04-16 2006-10-19 Devore Lauri J Removable anchored lung volume reduction device and methods
US20030212412A1 (en) * 2002-05-09 2003-11-13 Spiration, Inc. Intra-bronchial obstructing device that permits mucus transport
US8956319B2 (en) 2002-05-17 2015-02-17 Spiration, Inc. One-way valve devices for anchored implantation in a lung
US8257381B2 (en) 2002-05-17 2012-09-04 Spiration, Inc. One-way valve devices for anchored implantation in a lung
US7842061B2 (en) 2002-05-17 2010-11-30 Spiration, Inc. Methods of achieving lung volume reduction with removable anchored devices
US20030216769A1 (en) * 2002-05-17 2003-11-20 Dillard David H. Removable anchored lung volume reduction devices and methods
US7875048B2 (en) 2002-05-17 2011-01-25 Spiration, Inc. One-way valve devices for anchored implantation in a lung
US20040143282A1 (en) * 2002-05-17 2004-07-22 Dillard David H. Methods of achieving lung volume reduction with removable anchored devices
US20110079221A1 (en) * 2002-05-17 2011-04-07 Spiration, Inc. One-way valve devices for anchored implantation in a lung
US20050033344A1 (en) * 2002-05-17 2005-02-10 Dillard David H. One-way valve devices for anchored implantation in a lung
US20040089306A1 (en) * 2002-05-28 2004-05-13 Ronald Hundertmark Devices and methods for removing bronchial isolation devices implanted in the lung
US20040039250A1 (en) * 2002-05-28 2004-02-26 David Tholfsen Guidewire delivery of implantable bronchial isolation devices in accordance with lung treatment
US20050066974A1 (en) * 2002-05-28 2005-03-31 Antony Fields Modification of lung region flow dynamics using flow control devices implanted in bronchial wall channels
US20040010209A1 (en) * 2002-07-15 2004-01-15 Spiration, Inc. Device and method for measuring the diameter of an air passageway
US20060076023A1 (en) * 2002-07-26 2006-04-13 Emphasys Medical, Inc., A Delaware Corporation Bronchial flow control devices and methods of use
US20060155217A1 (en) * 2002-09-24 2006-07-13 Devore Lauri J Device and method for measuring the diameter of an air passageway
US20040059263A1 (en) * 2002-09-24 2004-03-25 Spiration, Inc. Device and method for measuring the diameter of an air passageway
US20110092767A1 (en) * 2002-11-27 2011-04-21 Pulmonx Corporation Delivery methods and devices for implantable bronchial isolation devices
US7717115B2 (en) 2002-11-27 2010-05-18 Pulmonx Corporation Delivery methods and devices for implantable bronchial isolation devices
US7814912B2 (en) 2002-11-27 2010-10-19 Pulmonx Corporation Delivery methods and devices for implantable bronchial isolation devices
US20060004305A1 (en) * 2002-11-27 2006-01-05 George Robert M Delivery methods and devices for implantable bronchial isolation devices
US20040148035A1 (en) * 2002-11-27 2004-07-29 Michael Barrett Delivery methods and devices for implantable bronchial isolation devices
US20040210248A1 (en) * 2003-03-12 2004-10-21 Spiration, Inc. Apparatus, method and assembly for delivery of intra-bronchial devices
US8079368B2 (en) 2003-04-08 2011-12-20 Spiration, Inc. Bronchoscopic lung volume reduction method
US20100256714A1 (en) * 2003-04-08 2010-10-07 Springmeyer Steven C Bronchoscopic lung volume reduction method
US20060249164A1 (en) * 2003-04-08 2006-11-09 Springmeyer Steven C Bronchoscopic lung volume reduction method
US20040200484A1 (en) * 2003-04-08 2004-10-14 Springmeyer Steven C. Bronchoscopic lung volume reduction method
US8667973B2 (en) 2003-04-08 2014-03-11 Spiration, Inc. Bronchoscopic lung volume reduction method
US8029492B2 (en) 2003-05-07 2011-10-04 Portaero, Inc. Method for treating chronic obstructive pulmonary disease
US20080188809A1 (en) * 2003-05-07 2008-08-07 Portaero, Inc. Device and method for creating a localized pleurodesis and treating a lung through the localized pleurodesis
US7811274B2 (en) 2003-05-07 2010-10-12 Portaero, Inc. Method for treating chronic obstructive pulmonary disease
US20040225254A1 (en) * 2003-05-07 2004-11-11 Don Tanaka Localized pleurodesis chemical delivery
US7828789B2 (en) 2003-05-07 2010-11-09 Portaero, Inc. Device and method for creating a localized pleurodesis and treating a lung through the localized pleurodesis
US7789083B2 (en) 2003-05-20 2010-09-07 Portaero, Inc. Intra/extra thoracic system for ameliorating a symptom of chronic obstructive pulmonary disease
US20040237966A1 (en) * 2003-05-29 2004-12-02 Don Tanaka Methods and devices to assist pulmonary decompression
US20040243393A1 (en) * 2003-05-29 2004-12-02 Microsoft Corporation Semantic object synchronous understanding implemented with speech application language tags
US7896008B2 (en) 2003-06-03 2011-03-01 Portaero, Inc. Lung reduction system
US20070270776A1 (en) * 2003-06-03 2007-11-22 Respira, Inc. Lung reduction system
US20040244803A1 (en) * 2003-06-05 2004-12-09 Don Tanaka Intra-thoracic collateral ventilation bypass system
US7753052B2 (en) 2003-06-05 2010-07-13 Portaero, Inc. Intra-thoracic collateral ventilation bypass system
US20100129420A1 (en) * 2003-07-15 2010-05-27 Portaero, Inc. Methods and devices to accelerate wound healing in thoracic anastomosis applications
US7682332B2 (en) 2003-07-15 2010-03-23 Portaero, Inc. Methods to accelerate wound healing in thoracic anastomosis applications
US20050025816A1 (en) * 2003-07-15 2005-02-03 Don Tanaka Methods and devices to accelerate wound healing in thoracic anastomosis applications
US8323230B2 (en) 2003-07-15 2012-12-04 Portaero, Inc. Methods and devices to accelerate wound healing in thoracic anastomosis applications
US20090182369A1 (en) * 2003-08-08 2009-07-16 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US20110208228A1 (en) * 2003-08-08 2011-08-25 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US20050137714A1 (en) * 2003-08-08 2005-06-23 Gonzalez Hugo X. Bronchoscopic repair of air leaks in a lung
US9622752B2 (en) 2003-08-08 2017-04-18 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US8974527B2 (en) 2003-08-08 2015-03-10 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US8444690B2 (en) 2003-08-08 2013-05-21 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US7887585B2 (en) 2003-08-08 2011-02-15 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US20050178389A1 (en) * 2004-01-27 2005-08-18 Shaw David P. Disease indications for selective endobronchial lung region isolation
US20090255537A1 (en) * 2004-01-27 2009-10-15 Pulmonx Disease indications for selective endobronchial lung region isolation
US8206684B2 (en) 2004-02-27 2012-06-26 Pulmonx Corporation Methods and devices for blocking flow through collateral pathways in the lung
US20050196344A1 (en) * 2004-02-27 2005-09-08 Mccutcheon John Methods and devices for blocking flow through collateral pathways in the lung
US20060020347A1 (en) * 2004-03-08 2006-01-26 Michael Barrett Implanted bronchial isolation devices and methods
US7775968B2 (en) 2004-06-14 2010-08-17 Pneumrx, Inc. Guided access to lung tissues
US20050288549A1 (en) * 2004-06-14 2005-12-29 Pneumrx, Inc. Guided access to lung tissues
US7670282B2 (en) 2004-06-14 2010-03-02 Pneumrx, Inc. Lung access device
US20050288684A1 (en) * 2004-06-16 2005-12-29 Aronson Nathan A Method of reducing collateral flow in a portion of a lung
US7766891B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Lung device with sealing features
US20060025815A1 (en) * 2004-07-08 2006-02-02 Mcgurk Erin Lung device with sealing features
US20060009801A1 (en) * 2004-07-08 2006-01-12 Mcgurk Erin Pleural effusion treatment device, method and material
US7766938B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Pleural effusion treatment device, method and material
US20060030863A1 (en) * 2004-07-21 2006-02-09 Fields Antony J Implanted bronchial isolation device delivery devices and methods
US20060118126A1 (en) * 2004-11-19 2006-06-08 Don Tanaka Methods and devices for controlling collateral ventilation
US20060118125A1 (en) * 2004-11-19 2006-06-08 Don Tanaka Pulmonary drug delivery
US20060107956A1 (en) * 2004-11-19 2006-05-25 Hendricksen Michael J Bronchial flow control devices and methods of use
US9211181B2 (en) 2004-11-19 2015-12-15 Pulmonx Corporation Implant loading device and system
US20060107961A1 (en) * 2004-11-19 2006-05-25 Don Tanaka Localized pleurodesis evacuation device
US8220460B2 (en) 2004-11-19 2012-07-17 Portaero, Inc. Evacuation device and method for creating a localized pleurodesis
US7771472B2 (en) 2004-11-19 2010-08-10 Pulmonx Corporation Bronchial flow control devices and methods of use
US8388682B2 (en) 2004-11-19 2013-03-05 Pulmonx Corporation Bronchial flow control devices and methods of use
US9872755B2 (en) 2004-11-19 2018-01-23 Pulmonx Corporation Implant loading device and system
US9125639B2 (en) 2004-11-23 2015-09-08 Pneumrx, Inc. Steerable device for accessing a target site and methods
US20060167416A1 (en) * 2004-11-23 2006-07-27 Mark Mathis Steerable device for accessing a target site and methods
US7735492B2 (en) 2004-12-08 2010-06-15 Ventus Medical, Inc. Nasal respiratory devices
US8365736B2 (en) 2004-12-08 2013-02-05 Ventus Medical, Inc. Nasal devices with respiratory gas source
US7806120B2 (en) 2004-12-08 2010-10-05 Ventus Medical, Inc. Nasal respiratory devices for positive end-expiratory pressure
US20110056499A1 (en) * 2004-12-08 2011-03-10 Rajiv Doshi Sealing nasal devices for use while sleeping
US20060144398A1 (en) * 2004-12-08 2006-07-06 Rajiv Doshi Respiratory devices
US8235046B2 (en) 2004-12-08 2012-08-07 Ventus Medical, Inc. Nasal devices for use while sleeping
US20100147308A1 (en) * 2004-12-08 2010-06-17 Rajiv Doshi Respiratory devices
US20100326447A1 (en) * 2004-12-08 2010-12-30 Bryan Loomas Nasal respiratory devices for positive end-expiratory pressure
US8302606B2 (en) 2004-12-08 2012-11-06 Ventus Medical, Inc. Methods of treating a sleeping subject
US8302607B2 (en) 2004-12-08 2012-11-06 Ventus Medical, Inc. Adhesive nasal respiratory devices
US7992564B2 (en) 2004-12-08 2011-08-09 Ventus Medical, Inc. Respiratory devices
US7798148B2 (en) 2004-12-08 2010-09-21 Ventus Medical, Inc. Respiratory devices
US9238113B2 (en) 2004-12-08 2016-01-19 Theravent, Inc. Nasal respiratory devices for positive end-expiratory pressure
US20060150979A1 (en) * 2004-12-08 2006-07-13 Ventus Medical, Inc. Nasal respiratory devices
US20060150978A1 (en) * 2004-12-08 2006-07-13 Ventus Medical, Inc. Methods of treating respiratory disorders
US20090050144A1 (en) * 2004-12-08 2009-02-26 Ryan Kendall Pierce Adhesive nasal respiratory devices
US8291909B2 (en) 2004-12-08 2012-10-23 Ventus Medical, Inc. Methods of treating a disorder by inhibiting expiration
US20110005520A1 (en) * 2004-12-08 2011-01-13 Rajiv Doshi Quiet nasal respiratory devices
US8061357B2 (en) 2004-12-08 2011-11-22 Ventus Medical, Inc. Adhesive nasal respiratory devices
US20110005529A1 (en) * 2004-12-08 2011-01-13 Rajiv Doshi Methods of treating a sleeping subject
US7735491B2 (en) 2004-12-08 2010-06-15 Ventus Medical, Inc. Methods of treating respiratory disorders
US20110005530A1 (en) * 2004-12-08 2011-01-13 Rajiv Doshi Methods of treating a disorder by inhibiting expiration
US9833354B2 (en) 2004-12-08 2017-12-05 Theravent, Inc. Nasal respiratory devices
US20110005528A1 (en) * 2004-12-08 2011-01-13 Rajiv Doshi Nasal devices with respiratory gas source
US8215308B2 (en) 2004-12-08 2012-07-10 Ventus Medical, Inc. Sealing nasal devices for use while sleeping
US20110067708A1 (en) * 2004-12-08 2011-03-24 Rajiv Doshi Nasal devices for use while sleeping
US20060124126A1 (en) * 2004-12-10 2006-06-15 Don Tanaka Collateral ventilation device with chest tube/evacuation features
US7824366B2 (en) 2004-12-10 2010-11-02 Portaero, Inc. Collateral ventilation device with chest tube/evacuation features and method
US8876791B2 (en) 2005-02-25 2014-11-04 Pulmonx Corporation Collateral pathway treatment using agent entrained by aspiration flow current
US20070051372A1 (en) * 2005-08-23 2007-03-08 Don Tanaka Collateral ventilation bypass system with retention features
US8104474B2 (en) 2005-08-23 2012-01-31 Portaero, Inc. Collateral ventilation bypass system with retention features
US7726305B2 (en) 2006-01-17 2010-06-01 Portaero, Inc. Variable resistance pulmonary ventilation bypass valve
US7686013B2 (en) 2006-01-17 2010-03-30 Portaero, Inc. Variable resistance pulmonary ventilation bypass valve
US20070163598A1 (en) * 2006-01-17 2007-07-19 Asia Chang Variable resistance pulmonary ventilation bypass valve
US8888800B2 (en) 2006-03-13 2014-11-18 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US8740921B2 (en) 2006-03-13 2014-06-03 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US8282660B2 (en) 2006-03-13 2012-10-09 Pneumrx, Inc. Minimally invasive lung volume reduction devices, methods, and systems
US20090076622A1 (en) * 2006-03-13 2009-03-19 Pneumrx, Inc. Delivery of Minimally Invasive Lung Volume Reduction Devices
US8142455B2 (en) 2006-03-13 2012-03-27 Pneumrx, Inc. Delivery of minimally invasive lung volume reduction devices
US9402632B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US9402633B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Torque alleviating intra-airway lung volume reduction compressive implant structures
US9782558B2 (en) 2006-03-13 2017-10-10 Pneumrx, Inc. Minimally invasive lung volume reduction devices, methods, and systems
US8932310B2 (en) 2006-03-13 2015-01-13 Pneumrx, Inc. Minimally invasive lung volume reduction devices, methods, and systems
US9474533B2 (en) 2006-03-13 2016-10-25 Pneumrx, Inc. Cross-sectional modification during deployment of an elongate lung volume reduction device
US20070221230A1 (en) * 2006-03-13 2007-09-27 David Thompson Minimally invasive lung volume reduction device and method
US9402971B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Minimally invasive lung volume reduction devices, methods, and systems
US8157837B2 (en) 2006-03-13 2012-04-17 Pneumrx, Inc. Minimally invasive lung volume reduction device and method
US8157823B2 (en) 2006-03-13 2012-04-17 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US8668707B2 (en) 2006-03-13 2014-03-11 Pneumrx, Inc. Minimally invasive lung volume reduction devices, methods, and systems
US8454708B2 (en) 2006-03-31 2013-06-04 Spiration, Inc. Articulable anchor
US9198669B2 (en) 2006-03-31 2015-12-01 Spiration, Inc. Articulable anchor
US7691151B2 (en) 2006-03-31 2010-04-06 Spiration, Inc. Articulable Anchor
US8647392B2 (en) 2006-03-31 2014-02-11 Spiration, Inc. Articulable anchor
US20100262071A1 (en) * 2006-03-31 2010-10-14 James Kutsko Articulable anchor
US20070232992A1 (en) * 2006-03-31 2007-10-04 James Kutsko Articulable anchor
US20070235846A1 (en) * 2006-04-01 2007-10-11 Stats Chippac Ltd. Integrated circuit package system with net spacer
US7856979B2 (en) 2006-05-23 2010-12-28 Ventus Medical, Inc. Nasal respiratory devices
US20110067709A1 (en) * 2006-05-23 2011-03-24 Rajiv Doshi Nasal respiratory devices
US7987852B2 (en) 2006-06-07 2011-08-02 Ventus Medical, Inc. Nasal devices
US20090188493A1 (en) * 2006-06-07 2009-07-30 Rajiv Doshi Nasal devices
US20080041373A1 (en) * 2006-06-07 2008-02-21 Ventus Medical, Inc. Nasal devices
US20110203598A1 (en) * 2006-06-07 2011-08-25 Favet Michael L Nasal devices including layered nasal devices and delayed resistance adapters for use with nasal devices
US20070283962A1 (en) * 2006-06-07 2007-12-13 Ventus Medical, Inc. Layered nasal devices
US8985116B2 (en) 2006-06-07 2015-03-24 Theravent, Inc. Layered nasal devices
US20080052727A1 (en) * 2006-08-22 2008-02-28 International Business Machines Corporation Data processing system using matching engine and routing switch
US8635365B2 (en) * 2006-08-22 2014-01-21 International Business Machines Corporation Data processing system using matching engine and routing switch
US20080072914A1 (en) * 2006-08-25 2008-03-27 Hendricksen Michael J Bronchial Isolation Devices for Placement in Short Lumens
US20080142018A1 (en) * 2006-11-16 2008-06-19 Ventus Medical, Inc. Nasal device applicators
US8240309B2 (en) 2006-11-16 2012-08-14 Ventus Medical, Inc. Adjustable nasal devices
US20080178874A1 (en) * 2006-11-16 2008-07-31 Ventus Medical, Inc. Adjustable nasal devices
US20080221470A1 (en) * 2007-03-07 2008-09-11 Elliot Sather Respiratory sensor adapters for nasal devices
US8163034B2 (en) 2007-05-11 2012-04-24 Portaero, Inc. Methods and devices to create a chemically and/or mechanically localized pleurodesis
US7931641B2 (en) 2007-05-11 2011-04-26 Portaero, Inc. Visceral pleura ring connector
US20080281151A1 (en) * 2007-05-11 2008-11-13 Portaero, Inc. Pulmonary pleural stabilizer
US20080281433A1 (en) * 2007-05-11 2008-11-13 Portaero, Inc. Methods and devices to create a chemically and/or mechanically localized pleurodesis
US20080287878A1 (en) * 2007-05-15 2008-11-20 Portaero, Inc. Pulmonary visceral pleura anastomosis reinforcement
US20100147295A1 (en) * 2007-05-15 2010-06-17 Portaero, Inc. Devices and methods to create and maintain the patency of an opening relative to parenchymal tissue of the lung
US20080283065A1 (en) * 2007-05-15 2008-11-20 Portaero, Inc. Methods and devices to maintain patency of a lumen in parenchymal tissue of the lung
US20100147294A1 (en) * 2007-05-15 2010-06-17 Portaero, Inc. Devices and methods to maintain the patency of an opening relative to parenchymal tissue of the lung
US8062315B2 (en) * 2007-05-17 2011-11-22 Portaero, Inc. Variable parietal/visceral pleural coupling
US20080295829A1 (en) * 2007-05-30 2008-12-04 Portaero, Inc. Bridge element for lung implant
US9326873B2 (en) 2007-10-12 2016-05-03 Spiration, Inc. Valve loader method, system, and apparatus
US20090292262A1 (en) * 2007-10-12 2009-11-26 Martin Neal Adams Valve loader method, system, and apparatus
US20090099530A1 (en) * 2007-10-12 2009-04-16 Martin Neal Adams Valve loader method, system, and apparatus
US8043301B2 (en) 2007-10-12 2011-10-25 Spiration, Inc. Valve loader method, system, and apparatus
US8136230B2 (en) 2007-10-12 2012-03-20 Spiration, Inc. Valve loader method, system, and apparatus
US8281557B2 (en) 2007-12-05 2012-10-09 Ventus Medical, Inc. Method of packaging and dispensing nasal devices
US8020700B2 (en) 2007-12-05 2011-09-20 Ventus Medical, Inc. Packaging and dispensing nasal devices
US20090145788A1 (en) * 2007-12-05 2009-06-11 Rajiv Doshi Packaging and dispensing nasal devices
US20090145441A1 (en) * 2007-12-06 2009-06-11 Rajiv Doshi Delayed resistance nasal devices and methods of use
US20090194109A1 (en) * 2008-02-01 2009-08-06 Rajiv Doshi Cpap interface and backup devices
US8347880B2 (en) 2008-02-19 2013-01-08 Potaero, Inc. Pneumostoma management system with secretion management features for treatment of chronic obstructive pulmonary disease
US8365722B2 (en) 2008-02-19 2013-02-05 Portaero, Inc. Multi-layer pneumostoma management system and methods for treatment of chronic obstructive pulmonary disease
US20090205644A1 (en) * 2008-02-19 2009-08-20 Portaero, Inc. Pneumostoma management system for treatment of chronic obstructive pulmonary disease
US8430094B2 (en) 2008-02-19 2013-04-30 Portaero, Inc. Flexible pneumostoma management system and methods for treatment of chronic obstructive pulmonary disease
US8252003B2 (en) 2008-02-19 2012-08-28 Portaero, Inc. Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease
US20090205641A1 (en) * 2008-02-19 2009-08-20 Portaero, Inc. Pneumostoma management device and method for treatment of chronic obstructive pulmonary disease
US8453637B2 (en) 2008-02-19 2013-06-04 Portaero, Inc. Pneumostoma management system for treatment of chronic obstructive pulmonary disease
US8453638B2 (en) 2008-02-19 2013-06-04 Portaero, Inc. One-piece pneumostoma management system and methods for treatment of chronic obstructive pulmonary disease
US8464708B2 (en) 2008-02-19 2013-06-18 Portaero, Inc. Pneumostoma management system having a cosmetic and/or protective cover
US8231581B2 (en) 2008-02-19 2012-07-31 Portaero, Inc. Enhanced pneumostoma management device and methods for treatment of chronic obstructive pulmonary disease
US8474449B2 (en) 2008-02-19 2013-07-02 Portaero, Inc. Variable length pneumostoma management system for treatment of chronic obstructive pulmonary disease
US8475389B2 (en) 2008-02-19 2013-07-02 Portaero, Inc. Methods and devices for assessment of pneumostoma function
US8491602B2 (en) 2008-02-19 2013-07-23 Portaero, Inc. Single-phase surgical procedure for creating a pneumostoma to treat chronic obstructive pulmonary disease
US8506577B2 (en) 2008-02-19 2013-08-13 Portaero, Inc. Two-phase surgical procedure for creating a pneumostoma to treat chronic obstructive pulmonary disease
US20090205651A1 (en) * 2008-02-19 2009-08-20 Portaero, Inc. One-piece pneumostoma management system and methods for treatment of chronic obstructive pulmonary disease
US8348906B2 (en) 2008-02-19 2013-01-08 Portaero, Inc. Aspirator for pneumostoma management
US20090205648A1 (en) * 2008-02-19 2009-08-20 Portaero, Inc. Pneumostoma management system with secretion management features for treatment of chronic obstructive pulmonary disease
US20090205643A1 (en) * 2008-02-19 2009-08-20 Portaero, Inc. Accelerated two-phase surgical procedure for creating a pneumostoma to treat chronic obstructive pulmonary disease
US20090205650A1 (en) * 2008-02-19 2009-08-20 Portaero, Inc. Variable length pneumostoma management system for treatment of chronic obstructive pulmonary disease
US20090209936A1 (en) * 2008-02-19 2009-08-20 Portaero, Inc. Aspirator and method for pneumostoma management
US20090205649A1 (en) * 2008-02-19 2009-08-20 Portaero, Inc. Multi-layer pneumostoma management system and methods for treatment of chronic obstructive pulmonary disease
US20090209856A1 (en) * 2008-02-19 2009-08-20 Portaero, Inc. Two-phase surgical procedure for creating a pneumostoma to treat chronic obstructive pulmonary disease
US20090205646A1 (en) * 2008-02-19 2009-08-20 Portaero, Inc. Flexible pneumostoma management system and methods for treatment of chronic obstructive pulmonary disease
US8336540B2 (en) 2008-02-19 2012-12-25 Portaero, Inc. Pneumostoma management device and method for treatment of chronic obstructive pulmonary disease
US8021320B2 (en) 2008-02-19 2011-09-20 Portaero, Inc. Self-sealing device and method for delivery of a therapeutic agent through a pneumostoma
US20090205645A1 (en) * 2008-02-19 2009-08-20 Portaero, Inc. Pneumostoma management method for the treatment of chronic obstructive pulmonary disease
US20090209909A1 (en) * 2008-02-19 2009-08-20 Portaero, Inc. Percutaneous single-phase surgical procedure for creating a pneumostoma to treat chronic obstructive pulmonary disease
US20090209924A1 (en) * 2008-02-19 2009-08-20 Portaero, Inc. Enhanced pneumostoma management device and methods for treatment of chronic obstructive pulmonary disease
US20110118669A1 (en) * 2008-02-19 2011-05-19 Portaero, Inc. Enhanced pneumostoma management device and methods for treatment of chronic obstructive pulmonary disease
US7927324B2 (en) 2008-02-19 2011-04-19 Portaero, Inc. Aspirator and method for pneumostoma management
US20090205665A1 (en) * 2008-02-19 2009-08-20 Portaero, Inc. Methods and devices for follow-up care and treatment of a pneumostoma
US20100286544A1 (en) * 2008-02-19 2010-11-11 Portaero, Inc. Methods and devices for assessment of pneumostoma function
US7909803B2 (en) 2008-02-19 2011-03-22 Portaero, Inc. Enhanced pneumostoma management device and methods for treatment of chronic obstructive pulmonary disease
US20090209971A1 (en) * 2008-02-19 2009-08-20 Portaero, Inc. Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease
US20090308398A1 (en) * 2008-06-16 2009-12-17 Arthur Ferdinand Adjustable resistance nasal devices
US9192403B2 (en) 2008-09-12 2015-11-24 Pneumrx, Inc. Elongated lung volume reduction devices, methods, and systems
US9173669B2 (en) 2008-09-12 2015-11-03 Pneumrx, Inc. Enhanced efficacy lung volume reduction devices, methods, and systems
US8632605B2 (en) 2008-09-12 2014-01-21 Pneumrx, Inc. Elongated lung volume reduction devices, methods, and systems
US8347881B2 (en) 2009-01-08 2013-01-08 Portaero, Inc. Pneumostoma management device with integrated patency sensor and method
US20100170507A1 (en) * 2009-01-08 2010-07-08 Portaero, Inc. Pneumostoma management device with integrated patency sensor and method
US8518053B2 (en) 2009-02-11 2013-08-27 Portaero, Inc. Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease
US20100204707A1 (en) * 2009-02-11 2010-08-12 Portaero, Inc. Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease
WO2010118056A1 (en) 2009-04-10 2010-10-14 Spiration, Inc. Valve loader method, system, and apparatus
EP2954874A2 (en) 2009-04-10 2015-12-16 Spiration Inc. Deployment catheter with marker bands
US8721734B2 (en) 2009-05-18 2014-05-13 Pneumrx, Inc. Cross-sectional modification during deployment of an elongate lung volume reduction device
US20100305715A1 (en) * 2009-05-18 2010-12-02 Pneumrx, Inc. Cross-Sectional Modification During Deployment of an Elongate Lung Volume Reduction Device
US20110108041A1 (en) * 2009-11-06 2011-05-12 Elliot Sather Nasal devices having a safe failure mode and remotely activatable
US8875711B2 (en) 2010-05-27 2014-11-04 Theravent, Inc. Layered nasal respiratory devices
US8795241B2 (en) 2011-05-13 2014-08-05 Spiration, Inc. Deployment catheter
CN102580171A (en) * 2012-01-30 2012-07-18 先健科技(深圳)有限公司 Bronchus flap and manufacturing method thereof
CN103750920A (en) * 2013-12-31 2014-04-30 先健科技(深圳)有限公司 Unidirectional flap
WO2018067735A1 (en) * 2016-10-05 2018-04-12 Sri Radhakrishnan High resistance implanted bronchial isolation devices and methods

Also Published As

Publication number Publication date Type
US7757692B2 (en) 2010-07-20 grant
WO2003022124A2 (en) 2003-03-20 application
JP2005503852A (en) 2005-02-10 application
EP2078502A3 (en) 2009-08-26 application
EP2078502A2 (en) 2009-07-15 application
DE60230638D1 (en) 2009-02-12 grant
US20110054632A1 (en) 2011-03-03 application
CA2459702A1 (en) 2003-03-20 application
EP1424970A2 (en) 2004-06-09 application
US20160030049A1 (en) 2016-02-04 application
US20090205667A1 (en) 2009-08-20 application
WO2003022124A3 (en) 2003-08-21 application
US20040211412A1 (en) 2004-10-28 application
CA2459702C (en) 2012-05-08 grant
EP1424970B1 (en) 2008-12-31 grant
US20040206349A1 (en) 2004-10-21 application
US8414655B2 (en) 2013-04-09 grant
US20130345737A1 (en) 2013-12-26 application
JP4291144B2 (en) 2009-07-08 grant
EP1424970A4 (en) 2007-02-28 application
US20040243140A1 (en) 2004-12-02 application
ES2318034T3 (en) 2009-05-01 grant
US20050033310A1 (en) 2005-02-10 application
US8974484B2 (en) 2015-03-10 grant

Similar Documents

Publication Publication Date Title
US7582104B2 (en) Daisy design for occlusion device
US6840243B2 (en) Methods and devices for use in performing pulmonary procedures
US6436088B2 (en) Method and apparatus for closing a subcutaneous tissue opening
US6635068B1 (en) Occlusion, anchoring, tensioning and flow direction apparatus and methods for use
US5499995A (en) Body passageway closure apparatus and method of use
US20050177182A1 (en) System and method for delivering a left atrial appendage containment device
US7771472B2 (en) Bronchial flow control devices and methods of use
US20090093670A1 (en) Treating Dysfunctional Cardiac Tissue
US20080281433A1 (en) Methods and devices to create a chemically and/or mechanically localized pleurodesis
US7100616B2 (en) Bronchoscopic lung volume reduction method
US6616684B1 (en) Endovascular splinting devices and methods
US7412977B2 (en) Methods and devices for inducing collapse in lung regions fed by collateral pathways
US6904909B2 (en) Methods and devices for use in performing pulmonary procedures
US20030070676A1 (en) Conduits having distal cage structure for maintaining collateral channels in tissue and related methods
US20050234509A1 (en) Center joints for PFO occluders
US20050022809A1 (en) Methods, systems and devices for desufflating a lung area
US20040211434A1 (en) Extrapleural airway device and method
US6174323B1 (en) Method and assembly for lung volume reduction
US7533671B2 (en) Bronchoscopic repair of air leaks in a lung
US6527761B1 (en) Methods and devices for obstructing and aspirating lung tissue segments
US5769870A (en) Perfusion device for maintaining blood flow in a vessel while isolating an anastomosis
US20090241964A1 (en) Methods and devices for passive residual lung volume reduction and functional lung volume expansion
US7766895B2 (en) Methods, systems, and kits for lung volume reduction
US20020082467A1 (en) Prosthetic graft device with ventricular apex attachment apparatus
US7112225B2 (en) Lung assist apparatus and methods for use

Legal Events

Date Code Title Description
AS Assignment

Owner name: SPIRATION, INC., WASHINGTON

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ALFERNESS, CLIFTON A.;GONZALEZ, HUGO X.;DILLARD, DAVID H.;REEL/FRAME:012171/0164;SIGNING DATES FROM 20010829 TO 20010907