PE20060335A1 - Prolina cci-779, su produccion y sintesis enzimatica de dos etapas de prolina cci-779 y cci-779 - Google Patents
Prolina cci-779, su produccion y sintesis enzimatica de dos etapas de prolina cci-779 y cci-779Info
- Publication number
- PE20060335A1 PE20060335A1 PE2005000408A PE2005000408A PE20060335A1 PE 20060335 A1 PE20060335 A1 PE 20060335A1 PE 2005000408 A PE2005000408 A PE 2005000408A PE 2005000408 A PE2005000408 A PE 2005000408A PE 20060335 A1 PE20060335 A1 PE 20060335A1
- Authority
- PE
- Peru
- Prior art keywords
- cci
- prolina
- rapamycin
- stages
- production
- Prior art date
Links
- 229960000235 temsirolimus Drugs 0.000 title abstract 6
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 title abstract 5
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Chemical compound OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 title 2
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 4
- 229960002930 sirolimus Drugs 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 235000019260 propionic acid Nutrition 0.000 abstract 2
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 abstract 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 abstract 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 1
- GHMWZRWCBLXYBX-UHFFFAOYSA-M sodium;4-chlorobenzoate Chemical compound [Na+].[O-]C(=O)C1=CC=C(Cl)C=C1 GHMWZRWCBLXYBX-UHFFFAOYSA-M 0.000 abstract 1
- 229920001567 vinyl ester resin Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
REFERIDA A UN COMPUESTO 42-ESTER DE PROLINA-RAPAMICINA CON ACIDO 2,2-BIS(HIDROXIMETIL)PROPIONICO (PROLINA-CCI-779) Y A UN METODO DE PREPARACION DE ESTE COMPUESTO O DE UN 42-ESTER DE RAPAMICINA, DONDE DICHO METODO COMPRENDE HACER REACCIONAR RAPAMICINA O PROLINA-RAPAMICINA (CCI-779 Y PROLINA-CCI-779), CON UN VINILESTER DE ACIDO 2,2-BIS(HIDROXIMETIL)PROPIONICO EN UN SOLVENTE ORGANICO ADECUADO EN PRESENCIA DE UNA CANTIDAD EFECTIVA DE LIPASA MICROBIANA SEGUIDO DE UNA DESPROTECCION. TAMBIEN ESTA REFERIDA A UNA COMPOSICION QUE COMPRENDE AL CCI-779 Y A UN PRODUCTO QUE COMPRENDE DICHA COMPOSICION
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56206904P | 2004-04-14 | 2004-04-14 | |
| US62359404P | 2004-10-29 | 2004-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060335A1 true PE20060335A1 (es) | 2006-05-25 |
Family
ID=34968422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000408A PE20060335A1 (es) | 2004-04-14 | 2005-04-13 | Prolina cci-779, su produccion y sintesis enzimatica de dos etapas de prolina cci-779 y cci-779 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7202256B2 (es) |
| EP (1) | EP1751168A1 (es) |
| JP (1) | JP2007532650A (es) |
| AR (1) | AR048603A1 (es) |
| AU (1) | AU2005233612A1 (es) |
| BR (1) | BRPI0509854A (es) |
| CA (1) | CA2564811A1 (es) |
| MX (1) | MXPA06011883A (es) |
| PA (1) | PA8630001A1 (es) |
| PE (1) | PE20060335A1 (es) |
| SV (1) | SV2005002082A (es) |
| TW (1) | TW200533673A (es) |
| WO (1) | WO2005100366A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1553940B1 (en) | 2002-07-30 | 2008-02-13 | Wyeth | Parenteral formulations containing a rapamycin hydroxyester |
| CN1942478A (zh) * | 2004-04-14 | 2007-04-04 | 惠氏公司 | 用于制备与二羧酸的纳巴霉素42－酯和fk－506 32－酯的方法，用于纳巴霉素配合物的前体和抗体 |
| EP1740710A1 (en) * | 2004-04-27 | 2007-01-10 | Wyeth | Labeling of rapamycin using rapamycin-specific methylases |
| PE20060642A1 (es) * | 2004-08-10 | 2006-08-01 | Wyeth Corp | Derivados de 42-ester de rapamicina con acido 2,2-bis(hidoximetil)propionico (cci-779) y metodos para su preparacion |
| US7538119B2 (en) * | 2005-11-04 | 2009-05-26 | Wyeth | 41-Methoxy isotope labeled rapamycin 42-ester |
| EP1957501A2 (en) | 2005-12-07 | 2008-08-20 | Wyeth a Corporation of the State of Delaware | Scalable process for the preparation of a rapamycin 42-ester from a rapamycin 42-ester boronate |
| PE20071067A1 (es) * | 2005-12-20 | 2007-11-26 | Wyeth Corp | Composiciones de rapamicina y cci-779 y metodo para su preparacion |
| US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
| US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
| US20080175887A1 (en) | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
| US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
| TW200845960A (en) * | 2007-04-05 | 2008-12-01 | Wyeth Corp | Wortmannin-rapalog conjugate and uses thereof |
| PE20091714A1 (es) * | 2008-04-11 | 2009-11-15 | Galaxy Biotech Llc | Combinacion del inhibidor hgf y el agonista pten |
| WO2010024898A2 (en) | 2008-08-29 | 2010-03-04 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
| WO2011051960A2 (en) | 2009-09-25 | 2011-05-05 | Cadila Healthcare Limited | Process for the preparation of rapamycin derivatives |
| WO2011151704A2 (en) | 2010-06-02 | 2011-12-08 | Fresenius Kabi Oncology Ltd. | Stable pharmaceutical compositions of rapamycin esters |
| CN102020662B (zh) | 2011-01-07 | 2013-02-13 | 天津市炜杰科技有限公司 | 一种驮瑞塞尔制备方法 |
| KR20140013000A (ko) * | 2011-04-01 | 2014-02-04 | 산도즈 아게 | C-42 위치에서 라파마이신의 위치선택적 아실화 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| CA2106034A1 (en) * | 1992-09-24 | 1994-03-25 | Ralph J. Russo | 21-norrapamycin |
| US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| GB9710962D0 (en) | 1997-05-28 | 1997-07-23 | Univ Cambridge Tech | Polyketides and their synthesis |
| TWI256395B (en) | 1999-09-29 | 2006-06-11 | Wyeth Corp | Regioselective synthesis of rapamycin derivatives |
| US6277983B1 (en) | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
| EP1553940B1 (en) | 2002-07-30 | 2008-02-13 | Wyeth | Parenteral formulations containing a rapamycin hydroxyester |
| WO2004026280A2 (en) | 2002-09-17 | 2004-04-01 | Wyeth | Granulate formulation of the rapamycin ester cci-779 |
| ES2287772T3 (es) | 2003-08-07 | 2007-12-16 | Wyeth | Sintesis regioselectiva de cci-779. |
-
2005
- 2005-04-12 WO PCT/US2005/012030 patent/WO2005100366A1/en not_active Application Discontinuation
- 2005-04-12 JP JP2007508408A patent/JP2007532650A/ja not_active Withdrawn
- 2005-04-12 CA CA002564811A patent/CA2564811A1/en not_active Abandoned
- 2005-04-12 EP EP05744572A patent/EP1751168A1/en not_active Withdrawn
- 2005-04-12 MX MXPA06011883A patent/MXPA06011883A/es active IP Right Grant
- 2005-04-12 AU AU2005233612A patent/AU2005233612A1/en not_active Withdrawn
- 2005-04-12 BR BRPI0509854-8A patent/BRPI0509854A/pt not_active IP Right Cessation
- 2005-04-12 US US11/103,779 patent/US7202256B2/en not_active Expired - Fee Related
- 2005-04-13 AR ARP050101448A patent/AR048603A1/es unknown
- 2005-04-13 PA PA20058630001A patent/PA8630001A1/es unknown
- 2005-04-13 TW TW094111636A patent/TW200533673A/zh unknown
- 2005-04-13 SV SV2005002082A patent/SV2005002082A/es not_active Application Discontinuation
- 2005-04-13 PE PE2005000408A patent/PE20060335A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06011883A (es) | 2006-12-14 |
| TW200533673A (en) | 2005-10-16 |
| EP1751168A1 (en) | 2007-02-14 |
| WO2005100366A1 (en) | 2005-10-27 |
| JP2007532650A (ja) | 2007-11-15 |
| BRPI0509854A (pt) | 2007-10-23 |
| US7202256B2 (en) | 2007-04-10 |
| AR048603A1 (es) | 2006-05-10 |
| PA8630001A1 (es) | 2006-06-02 |
| AU2005233612A1 (en) | 2005-10-27 |
| US20050234086A1 (en) | 2005-10-20 |
| CA2564811A1 (en) | 2005-10-27 |
| SV2005002082A (es) | 2005-12-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |