SV2005002082A - "prolina cci-779, produccion y usos de la misma, y síntesis enzimática de dos etapas de prolina cci-779 y cci-779" ref. am-101578salvo - Google Patents
"prolina cci-779, produccion y usos de la misma, y síntesis enzimática de dos etapas de prolina cci-779 y cci-779" ref. am-101578salvoInfo
- Publication number
- SV2005002082A SV2005002082A SV2005002082A SV2005002082A SV2005002082A SV 2005002082 A SV2005002082 A SV 2005002082A SV 2005002082 A SV2005002082 A SV 2005002082A SV 2005002082 A SV2005002082 A SV 2005002082A SV 2005002082 A SV2005002082 A SV 2005002082A
- Authority
- SV
- El Salvador
- Prior art keywords
- cci
- prolina
- same
- ref
- stages
- Prior art date
Links
- 229960000235 temsirolimus Drugs 0.000 title abstract 6
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Chemical compound OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 title 2
- 230000002255 enzymatic effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 230000021736 acetylation Effects 0.000 abstract 1
- 238000006640 acetylation reaction Methods 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical class O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 abstract 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 abstract 1
- 229960002930 sirolimus Drugs 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 229920001567 vinyl ester resin Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE DESCRIBEN METODOS PARA LA SINTESIS DE CCI-779 Y PROLINA-CCI-779, INCLUYENDO UN METODO QUE INVOLUCRA ACETILACION CATALIZADA POR LIPASA DE 42-HIDROXI DE RAPAMICINA CON UN VINILESTER DE ACIDO 2,2-BIS(HIDROXIMETIL)PROPIONICO EN UN SOLVENTE ORGANICO SEGUIDO POR DESPROTECCION. ASIMISMO SE PROVEEN PRODUCTOS QUE CONTIENEN PROLINA-CCI-779 Y USOS DE LA MISMA
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56206904P | 2004-04-14 | 2004-04-14 | |
| US62359404P | 2004-10-29 | 2004-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SV2005002082A true SV2005002082A (es) | 2005-12-13 |
Family
ID=34968422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SV2005002082A SV2005002082A (es) | 2004-04-14 | 2005-04-13 | "prolina cci-779, produccion y usos de la misma, y síntesis enzimática de dos etapas de prolina cci-779 y cci-779" ref. am-101578salvo |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7202256B2 (es) |
| EP (1) | EP1751168A1 (es) |
| JP (1) | JP2007532650A (es) |
| AR (1) | AR048603A1 (es) |
| AU (1) | AU2005233612A1 (es) |
| BR (1) | BRPI0509854A (es) |
| CA (1) | CA2564811A1 (es) |
| MX (1) | MXPA06011883A (es) |
| PA (1) | PA8630001A1 (es) |
| PE (1) | PE20060335A1 (es) |
| SV (1) | SV2005002082A (es) |
| TW (1) | TW200533673A (es) |
| WO (1) | WO2005100366A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0313024A (pt) | 2002-07-30 | 2005-07-12 | Wyeth Corp | Formulações parenterais contendo um hidroxiéster de rapamicina |
| US7445916B2 (en) * | 2004-04-14 | 2008-11-04 | Wyeth | Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies |
| JP2007534337A (ja) * | 2004-04-27 | 2007-11-29 | ワイス | ラパマイシン特異的メチラーゼを用いるラパマイシンの標識 |
| MX2007001676A (es) * | 2004-08-10 | 2007-04-12 | Wyeth Corp | Derivados de 42-ester de rapamicina con acido 2,2-bis(hidroximetil)propionico y metodos para hacer los mismos. |
| WO2007056175A2 (en) * | 2005-11-04 | 2007-05-18 | Wyeth | 41-methoxy isotope labeled rapamycin 42-ester |
| TW200804399A (en) * | 2005-12-07 | 2008-01-16 | Wyeth Corp | Scalable process for the preparation of a rapamycin 42-ester from a rapamycin 42-ester boronate |
| WO2007075621A1 (en) * | 2005-12-20 | 2007-07-05 | Wyeth | Control of cci-779 dosage form stability through control of drug substance impurities |
| US20080175887A1 (en) | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
| US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
| US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
| US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
| TW200845960A (en) * | 2007-04-05 | 2008-12-01 | Wyeth Corp | Wortmannin-rapalog conjugate and uses thereof |
| PE20091714A1 (es) * | 2008-04-11 | 2009-11-15 | Galaxy Biotech Llc | Combinacion del inhibidor hgf y el agonista pten |
| WO2010024898A2 (en) | 2008-08-29 | 2010-03-04 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
| WO2011051960A2 (en) | 2009-09-25 | 2011-05-05 | Cadila Healthcare Limited | Process for the preparation of rapamycin derivatives |
| WO2011151704A2 (en) | 2010-06-02 | 2011-12-08 | Fresenius Kabi Oncology Ltd. | Stable pharmaceutical compositions of rapamycin esters |
| CN102020662B (zh) * | 2011-01-07 | 2013-02-13 | 天津市炜杰科技有限公司 | 一种驮瑞塞尔制备方法 |
| RU2603261C2 (ru) * | 2011-04-01 | 2016-11-27 | Сандоз Аг | Региоселективное ацилирование рапамицина в положении с-42 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| CA2106034A1 (en) | 1992-09-24 | 1994-03-25 | Ralph J. Russo | 21-norrapamycin |
| US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| GB9710962D0 (en) | 1997-05-28 | 1997-07-23 | Univ Cambridge Tech | Polyketides and their synthesis |
| TWI256395B (en) | 1999-09-29 | 2006-06-11 | Wyeth Corp | Regioselective synthesis of rapamycin derivatives |
| US6277983B1 (en) | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
| BR0313024A (pt) | 2002-07-30 | 2005-07-12 | Wyeth Corp | Formulações parenterais contendo um hidroxiéster de rapamicina |
| RU2326654C2 (ru) | 2002-09-17 | 2008-06-20 | Уайт | Пероральные композиции |
| DK1658295T3 (da) | 2003-08-07 | 2007-09-24 | Wyeth Corp | Regioselektiv syntese af CCI-779 |
-
2005
- 2005-04-12 BR BRPI0509854-8A patent/BRPI0509854A/pt not_active IP Right Cessation
- 2005-04-12 AU AU2005233612A patent/AU2005233612A1/en not_active Withdrawn
- 2005-04-12 CA CA002564811A patent/CA2564811A1/en not_active Abandoned
- 2005-04-12 EP EP05744572A patent/EP1751168A1/en not_active Withdrawn
- 2005-04-12 JP JP2007508408A patent/JP2007532650A/ja not_active Withdrawn
- 2005-04-12 MX MXPA06011883A patent/MXPA06011883A/es active IP Right Grant
- 2005-04-12 US US11/103,779 patent/US7202256B2/en not_active Expired - Fee Related
- 2005-04-12 WO PCT/US2005/012030 patent/WO2005100366A1/en not_active Application Discontinuation
- 2005-04-13 PE PE2005000408A patent/PE20060335A1/es not_active Application Discontinuation
- 2005-04-13 AR ARP050101448A patent/AR048603A1/es unknown
- 2005-04-13 PA PA20058630001A patent/PA8630001A1/es unknown
- 2005-04-13 TW TW094111636A patent/TW200533673A/zh unknown
- 2005-04-13 SV SV2005002082A patent/SV2005002082A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US7202256B2 (en) | 2007-04-10 |
| AR048603A1 (es) | 2006-05-10 |
| EP1751168A1 (en) | 2007-02-14 |
| AU2005233612A1 (en) | 2005-10-27 |
| US20050234086A1 (en) | 2005-10-20 |
| PE20060335A1 (es) | 2006-05-25 |
| BRPI0509854A (pt) | 2007-10-23 |
| JP2007532650A (ja) | 2007-11-15 |
| CA2564811A1 (en) | 2005-10-27 |
| PA8630001A1 (es) | 2006-06-02 |
| TW200533673A (en) | 2005-10-16 |
| MXPA06011883A (es) | 2006-12-14 |
| WO2005100366A1 (en) | 2005-10-27 |
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| FD | Lapse |