PA8630001A1 - Prolina cci-779, produccion y usos de la misma, y sintesis enzimatica de dos etapas de prolina cci-779 y cci-779 - Google Patents

Prolina cci-779, produccion y usos de la misma, y sintesis enzimatica de dos etapas de prolina cci-779 y cci-779

Info

Publication number
PA8630001A1
PA8630001A1 PA20058630001A PA8630001A PA8630001A1 PA 8630001 A1 PA8630001 A1 PA 8630001A1 PA 20058630001 A PA20058630001 A PA 20058630001A PA 8630001 A PA8630001 A PA 8630001A PA 8630001 A1 PA8630001 A1 PA 8630001A1
Authority
PA
Panama
Prior art keywords
cci
prolina
same
stages
production
Prior art date
Application number
PA20058630001A
Other languages
English (en)
Inventor
Jianxin Gu
Mark E Ruppen
Panolil Raveendranath
Warren Chew
Chia-Chemg Shaw
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PA8630001A1 publication Critical patent/PA8630001A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE DESCRIBEN METODOS PARA LA SINTESIS DE CCI-799 Y PROLINA-CCI-779, INCLUYENDO UN METODO QUE INVOLUCRA ACETILACION CATALIZADA POR LIPASA DE 42-HIDROXI DE RAPAMICINA CON UN VINILESTER DE ACIDO 2,2-BIS(HIDROXIMETIL)PROPIONICO EN UN SOLVENTE ORGANICO SEGUIDO POR DESPROTECCION. ASIMISMO SE PROVEEN PRODUCTOS QUE CONTIENEN PROLINA-CCI-779 Y USO DE LA MISMA
PA20058630001A 2004-04-14 2005-04-13 Prolina cci-779, produccion y usos de la misma, y sintesis enzimatica de dos etapas de prolina cci-779 y cci-779 PA8630001A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56206904P 2004-04-14 2004-04-14
US62359404P 2004-10-29 2004-10-29

Publications (1)

Publication Number Publication Date
PA8630001A1 true PA8630001A1 (es) 2006-06-02

Family

ID=34968422

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20058630001A PA8630001A1 (es) 2004-04-14 2005-04-13 Prolina cci-779, produccion y usos de la misma, y sintesis enzimatica de dos etapas de prolina cci-779 y cci-779

Country Status (13)

Country Link
US (1) US7202256B2 (es)
EP (1) EP1751168A1 (es)
JP (1) JP2007532650A (es)
AR (1) AR048603A1 (es)
AU (1) AU2005233612A1 (es)
BR (1) BRPI0509854A (es)
CA (1) CA2564811A1 (es)
MX (1) MXPA06011883A (es)
PA (1) PA8630001A1 (es)
PE (1) PE20060335A1 (es)
SV (1) SV2005002082A (es)
TW (1) TW200533673A (es)
WO (1) WO2005100366A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE385795T1 (de) 2002-07-30 2008-03-15 Wyeth Corp Parenterale formulierungen mit einem rapamycin hydroxyester
DE602005010228D1 (de) * 2004-04-14 2008-11-20 Wyeth Corp Verfahren zur herstellung von rapamycin-42-estern und fk-506-32-estern mit dicarbonsäure, vorstufen für rapamycinkonjugate und antikörper
CN1946852A (zh) * 2004-04-27 2007-04-11 惠氏公司 利用雷帕霉素特异性甲基化酶标记雷帕霉素
JP2008517874A (ja) * 2004-08-10 2008-05-29 ワイス Ｃｃｉ−７７９誘導体及びそれらの作製法
WO2007056175A2 (en) * 2005-11-04 2007-05-18 Wyeth 41-methoxy isotope labeled rapamycin 42-ester
WO2007067560A2 (en) 2005-12-07 2007-06-14 Wyeth Scalable process for the preparation of a rapamycin 42-ester from a rapamycin 42-ester boronate
PE20071067A1 (es) * 2005-12-20 2007-11-26 Wyeth Corp Composiciones de rapamicina y cci-779 y metodo para su preparacion
US20080175887A1 (en) 2006-11-20 2008-07-24 Lixiao Wang Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8430055B2 (en) 2008-08-29 2013-04-30 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
TW200845960A (en) * 2007-04-05 2008-12-01 Wyeth Corp Wortmannin-rapalog conjugate and uses thereof
CL2009000844A1 (es) * 2008-04-11 2009-06-12 Galaxy Biotech Llc Metodo para tratar cancer en un paciente que comprende la administracion de un primer agente que es inhibidor de factor de crecimiento de hepatocito (hgf) en combinacion con un segundo agente que es agonista de pten.
EP2480557A2 (en) 2009-09-25 2012-08-01 Cadila Healthcare Limited Process for the preparation of rapamycin derivatives
AU2011260016B2 (en) 2010-06-02 2013-08-22 Fresenius Kabi Oncology Ltd. Stable pharmaceutical compositions of Rapamycin esters
CN102020662B (zh) 2011-01-07 2013-02-13 天津市炜杰科技有限公司 一种驮瑞塞尔制备方法
WO2012131019A1 (en) 2011-04-01 2012-10-04 Sandoz Ag Regioselective acylation of rapamycin at the c-42 position

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA737247B (en) 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
CA2106034A1 (en) 1992-09-24 1994-03-25 Ralph J. Russo 21-norrapamycin
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
GB9710962D0 (en) * 1997-05-28 1997-07-23 Univ Cambridge Tech Polyketides and their synthesis
TWI256395B (en) 1999-09-29 2006-06-11 Wyeth Corp Regioselective synthesis of rapamycin derivatives
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
ATE385795T1 (de) 2002-07-30 2008-03-15 Wyeth Corp Parenterale formulierungen mit einem rapamycin hydroxyester
ATE413163T1 (de) 2002-09-17 2008-11-15 Wyeth Corp Granulierte formulierung des rapamycinesters ccl- 779
CN1829722B (zh) 2003-08-07 2010-10-27 惠氏公司 区域选择性合成cci-779

Also Published As

Publication number Publication date
CA2564811A1 (en) 2005-10-27
WO2005100366A1 (en) 2005-10-27
US7202256B2 (en) 2007-04-10
JP2007532650A (ja) 2007-11-15
AU2005233612A1 (en) 2005-10-27
EP1751168A1 (en) 2007-02-14
AR048603A1 (es) 2006-05-10
TW200533673A (en) 2005-10-16
PE20060335A1 (es) 2006-05-25
US20050234086A1 (en) 2005-10-20
SV2005002082A (es) 2005-12-13
BRPI0509854A (pt) 2007-10-23
MXPA06011883A (es) 2006-12-14

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