DK1177178T3 - Heterocyclisk substituerede benzimidazoler, deres fremstilling og anvendelse - Google Patents
Heterocyclisk substituerede benzimidazoler, deres fremstilling og anvendelseInfo
- Publication number
- DK1177178T3 DK1177178T3 DK00927088T DK00927088T DK1177178T3 DK 1177178 T3 DK1177178 T3 DK 1177178T3 DK 00927088 T DK00927088 T DK 00927088T DK 00927088 T DK00927088 T DK 00927088T DK 1177178 T3 DK1177178 T3 DK 1177178T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- heterocyclic substituted
- substituted benzimidazoles
- benzimidazoles
- heterocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19920936A DE19920936A1 (de) | 1999-05-07 | 1999-05-07 | Heterozyklisch substituierte Benzimidazole, deren Herstellung und Anwendung |
PCT/EP2000/003813 WO2000068206A1 (de) | 1999-05-07 | 2000-04-27 | Heterozyklisch substituierte benzimidazole, deren herstellung und anwendung |
EP00927088A EP1177178B1 (de) | 1999-05-07 | 2000-04-27 | Heterozyklisch substituierte benzimidazole, deren herstellung und anwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1177178T3 true DK1177178T3 (da) | 2005-05-02 |
Family
ID=7907219
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00927088T DK1177178T3 (da) | 1999-05-07 | 2000-04-27 | Heterocyclisk substituerede benzimidazoler, deres fremstilling og anvendelse |
Country Status (27)
Country | Link |
---|---|
US (1) | US6696437B1 (pt) |
EP (1) | EP1177178B1 (pt) |
JP (1) | JP4004737B2 (pt) |
KR (1) | KR20010112477A (pt) |
CN (1) | CN1353695A (pt) |
AR (1) | AR029161A1 (pt) |
AT (1) | ATE286029T1 (pt) |
AU (1) | AU4558400A (pt) |
BG (1) | BG106035A (pt) |
BR (1) | BR0010342A (pt) |
CA (1) | CA2371645C (pt) |
CO (1) | CO5170517A1 (pt) |
DE (2) | DE19920936A1 (pt) |
DK (1) | DK1177178T3 (pt) |
ES (1) | ES2235869T3 (pt) |
HK (1) | HK1046281A1 (pt) |
HU (1) | HUP0202970A2 (pt) |
IL (1) | IL146147A0 (pt) |
MY (1) | MY122771A (pt) |
NO (1) | NO20015362D0 (pt) |
PL (1) | PL351558A1 (pt) |
PT (1) | PT1177178E (pt) |
SK (1) | SK15962001A3 (pt) |
TR (1) | TR200103221T2 (pt) |
UA (1) | UA68436C2 (pt) |
WO (1) | WO2000068206A1 (pt) |
ZA (1) | ZA200108609B (pt) |
Families Citing this family (78)
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ID28787A (id) | 1998-11-03 | 2001-07-05 | Basf Ag | 2-fenilbenzimidazol tersubstitusi, pembuatannya dan penggunaannya |
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WO2002072090A1 (en) | 2001-03-12 | 2002-09-19 | Avanir Pharmaceuticals | Benzimidazole compounds for modulating ige and inhibiting cellular proliferation |
WO2002101073A2 (en) * | 2001-06-13 | 2002-12-19 | Genesoft Pharmaceuticals, Inc. | Aryl-benzimidazole compounds having antiinfective activity |
US7642278B2 (en) | 2001-07-03 | 2010-01-05 | Novartis Vaccines And Diagnostics, Inc. | Indazole benzimidazole compounds |
WO2003004488A1 (en) | 2001-07-03 | 2003-01-16 | Chiron Corporation | Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors |
JP4656838B2 (ja) * | 2002-02-06 | 2011-03-23 | バーテックス ファーマシューティカルズ インコーポレイテッド | Gsk−3の阻害剤として有用なヘテロアリール化合物 |
DE10227668A1 (de) * | 2002-06-20 | 2004-01-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Arzneimittel zur Behandlung des systemic inflammatory response syndrome |
EP1527183B1 (de) | 2002-07-26 | 2008-08-20 | BASF Plant Science GmbH | Neue selektionsverfahren |
WO2004012736A1 (en) | 2002-08-02 | 2004-02-12 | Genesoft Pharmaceuticals, Inc. | Biaryl compounds having anti-infective activity |
AU2003257329C1 (en) | 2002-08-19 | 2010-07-22 | Lorus Therapeutics Inc. | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents |
TWI276631B (en) | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
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US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
TW202116778A (zh) | 2019-07-10 | 2021-05-01 | 美商斯布雷克薩二號公司 | 作為治療劑之細胞毒素之肽結合物 |
CN114302744A (zh) | 2019-07-10 | 2022-04-08 | 赛博克萨3公司 | 作为治疗剂的微管靶向剂的肽缀合物 |
AU2022206297A1 (en) | 2021-01-08 | 2023-08-03 | Cybrexa 2, Inc. | Process for preparing a conjugate linking moiety |
WO2022155172A1 (en) | 2021-01-13 | 2022-07-21 | Cybrexa 3, Inc. | Peptide conjugates of therapeutics |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA885929B (en) * | 1987-08-25 | 1989-04-26 | Oxi Gene Inc | Agents for use in tumor or cancer cell killing therapy |
AU714873B2 (en) * | 1995-08-02 | 2000-01-13 | Newcastle University Ventures Limited | Benzimidazole compounds |
JP4373497B2 (ja) * | 1996-06-19 | 2009-11-25 | ローン−プーラン・ロレ・リミテツド | 置換されたアザビシクロ化合物、ならびにtnfおよびサイクリックampホスホジエステラーゼ産生の阻害剤としてのそれらの使用 |
ID28787A (id) * | 1998-11-03 | 2001-07-05 | Basf Ag | 2-fenilbenzimidazol tersubstitusi, pembuatannya dan penggunaannya |
IL143102A0 (en) * | 1998-11-17 | 2002-04-21 | Basf Ag | 2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof |
SK285529B6 (sk) * | 1998-11-27 | 2007-03-01 | Basf Aktiengesellschaft | Substituované benzimidazoly, farmaceutická kompozícia s ich obsahom a ich použitie ako inhibítorov PARP |
-
1999
- 1999-05-07 DE DE19920936A patent/DE19920936A1/de not_active Withdrawn
-
2000
- 2000-04-27 US US09/959,632 patent/US6696437B1/en not_active Expired - Lifetime
- 2000-04-27 KR KR1020017014145A patent/KR20010112477A/ko not_active Application Discontinuation
- 2000-04-27 ES ES00927088T patent/ES2235869T3/es not_active Expired - Lifetime
- 2000-04-27 IL IL14614700A patent/IL146147A0/xx unknown
- 2000-04-27 AT AT00927088T patent/ATE286029T1/de active
- 2000-04-27 HU HU0202970A patent/HUP0202970A2/hu unknown
- 2000-04-27 CN CN00808364A patent/CN1353695A/zh active Pending
- 2000-04-27 AU AU45584/00A patent/AU4558400A/en not_active Abandoned
- 2000-04-27 BR BR0010342-0A patent/BR0010342A/pt not_active IP Right Cessation
- 2000-04-27 DK DK00927088T patent/DK1177178T3/da active
- 2000-04-27 SK SK1596-2001A patent/SK15962001A3/sk unknown
- 2000-04-27 TR TR2001/03221T patent/TR200103221T2/xx unknown
- 2000-04-27 EP EP00927088A patent/EP1177178B1/de not_active Expired - Lifetime
- 2000-04-27 CA CA002371645A patent/CA2371645C/en not_active Expired - Fee Related
- 2000-04-27 WO PCT/EP2000/003813 patent/WO2000068206A1/de not_active Application Discontinuation
- 2000-04-27 DE DE50009118T patent/DE50009118D1/de not_active Expired - Lifetime
- 2000-04-27 JP JP2000617186A patent/JP4004737B2/ja not_active Expired - Fee Related
- 2000-04-27 PT PT00927088T patent/PT1177178E/pt unknown
- 2000-04-27 UA UA2001128419A patent/UA68436C2/uk unknown
- 2000-04-27 PL PL00351558A patent/PL351558A1/xx not_active Application Discontinuation
- 2000-05-05 CO CO00032472A patent/CO5170517A1/es not_active Application Discontinuation
- 2000-05-05 MY MYPI20001934A patent/MY122771A/en unknown
- 2000-05-05 AR ARP000102178A patent/AR029161A1/es unknown
-
2001
- 2001-10-19 ZA ZA200108609A patent/ZA200108609B/en unknown
- 2001-10-22 BG BG106035A patent/BG106035A/xx unknown
- 2001-11-02 NO NO20015362A patent/NO20015362D0/no not_active Application Discontinuation
-
2002
- 2002-10-30 HK HK02107871.7A patent/HK1046281A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
TR200103221T2 (tr) | 2002-04-22 |
KR20010112477A (ko) | 2001-12-20 |
DE19920936A1 (de) | 2000-11-09 |
EP1177178A1 (de) | 2002-02-06 |
EP1177178B1 (de) | 2004-12-29 |
AR029161A1 (es) | 2003-06-18 |
US6696437B1 (en) | 2004-02-24 |
HUP0202970A2 (hu) | 2002-12-28 |
AU4558400A (en) | 2000-11-21 |
DE50009118D1 (de) | 2005-02-03 |
ES2235869T3 (es) | 2005-07-16 |
NO20015362L (no) | 2001-11-02 |
PL351558A1 (en) | 2003-05-05 |
JP4004737B2 (ja) | 2007-11-07 |
HK1046281A1 (zh) | 2003-01-03 |
JP2002544199A (ja) | 2002-12-24 |
NO20015362D0 (no) | 2001-11-02 |
CO5170517A1 (es) | 2002-06-27 |
PT1177178E (pt) | 2005-05-31 |
BR0010342A (pt) | 2002-05-28 |
CA2371645C (en) | 2007-04-17 |
MY122771A (en) | 2006-05-31 |
ZA200108609B (en) | 2002-10-21 |
IL146147A0 (en) | 2002-07-25 |
WO2000068206A1 (de) | 2000-11-16 |
BG106035A (en) | 2002-06-28 |
UA68436C2 (en) | 2004-08-16 |
SK15962001A3 (sk) | 2002-06-04 |
ATE286029T1 (de) | 2005-01-15 |
CN1353695A (zh) | 2002-06-12 |
CA2371645A1 (en) | 2000-11-16 |
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