DK1155139T3 - Fremgangsmåde til mikrobiel fremstilling af L-valin - Google Patents

Fremgangsmåde til mikrobiel fremstilling af L-valin

Info

Publication number
DK1155139T3
DK1155139T3 DK00906363T DK00906363T DK1155139T3 DK 1155139 T3 DK1155139 T3 DK 1155139T3 DK 00906363 T DK00906363 T DK 00906363T DK 00906363 T DK00906363 T DK 00906363T DK 1155139 T3 DK1155139 T3 DK 1155139T3
Authority
DK
Denmark
Prior art keywords
activity
valine
intensified
synthase
microorganism
Prior art date
Application number
DK00906363T
Other languages
English (en)
Other versions
DK1155139T4 (da
Inventor
Lothar Eggeling
Hermann Sahm
Original Assignee
Forschungszentrum Juelich Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7898429&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1155139(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Forschungszentrum Juelich Gmbh filed Critical Forschungszentrum Juelich Gmbh
Publication of DK1155139T3 publication Critical patent/DK1155139T3/da
Application granted granted Critical
Publication of DK1155139T4 publication Critical patent/DK1155139T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1014—Hydroxymethyl-, formyl-transferases (2.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Fodder In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK00906363T 1999-02-22 2000-02-21 Fremgangsmåde til fremstilling af L-valin DK1155139T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19907567A DE19907567B4 (de) 1999-02-22 1999-02-22 Verfahren zur mikrobiellen Herstellung von L-Valin
PCT/EP2000/001405 WO2000050624A1 (de) 1999-02-22 2000-02-21 Verfahren zur mikrobiellen herstellung von l-valin

Publications (2)

Publication Number Publication Date
DK1155139T3 true DK1155139T3 (da) 2003-07-28
DK1155139T4 DK1155139T4 (da) 2009-04-20

Family

ID=7898429

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00906363T DK1155139T4 (da) 1999-02-22 2000-02-21 Fremgangsmåde til fremstilling af L-valin

Country Status (12)

Country Link
US (1) US7632663B1 (da)
EP (1) EP1155139B2 (da)
JP (1) JP4638048B2 (da)
KR (1) KR100614029B1 (da)
AT (1) ATE236991T1 (da)
CZ (1) CZ20013037A3 (da)
DE (2) DE19907567B4 (da)
DK (1) DK1155139T4 (da)
ES (1) ES2197076T5 (da)
PT (1) PT1155139E (da)
SK (1) SK285870B6 (da)
WO (1) WO2000050624A1 (da)

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DE19855312A1 (de) * 1998-12-01 2000-06-08 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure unter Verwendung coryneformer Bakterien
JP2005503758A (ja) * 2001-01-19 2005-02-10 ビーエーエスエフ アクチェンゲゼルシャフト ３−（２−ヒドロキシ−３−メチル−ブチリルアミノ）−プロピオン酸（ｈｍｂｐａ）の製造方法及び微生物
KR100442768B1 (ko) * 2001-05-21 2004-08-04 주식회사 한국표지화합물연구소 방사성동위원소 표지화합물로서 ｌ-발린의 제조방법
KR100451299B1 (ko) * 2002-03-21 2004-10-06 씨제이 주식회사 Ｌ―쓰레오닌의 제조방법
GB2391083B (en) * 2002-07-19 2006-03-01 Picochip Designs Ltd Processor array
DE102004046933A1 (de) * 2004-09-28 2006-03-30 Forschungszentrum Jülich GmbH Verfahren zur fermentativen Herstellung von L-Valin sowie dafür geeigneter Mikroorganismus
DE102005019967A1 (de) 2005-04-29 2006-11-02 Forschungszentrum Jülich GmbH Verfahren zur fermentativen Herstellung von L-Aminosäuren
US8273558B2 (en) 2005-10-26 2012-09-25 Butamax(Tm) Advanced Biofuels Llc Fermentive production of four carbon alcohols
US9303225B2 (en) 2005-10-26 2016-04-05 Butamax Advanced Biofuels Llc Method for the production of isobutanol by recombinant yeast
EP1948814B1 (en) * 2005-10-26 2018-11-21 Butamax (TM) Advanced Biofuels LLC Fermentive production of four carbon alcohols
EP1860193A1 (en) * 2006-05-22 2007-11-28 Evonik Degussa GmbH Promoter-activity modulation for branched-chain amino acid production
JP2010017082A (ja) 2006-10-10 2010-01-28 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
KR100832740B1 (ko) * 2007-01-17 2008-05-27 한국과학기술원 분지쇄 아미노산 생성능이 개선된 변이 미생물 및 이를이용한 분지쇄 아미노산의 제조방법
AU2008212799A1 (en) 2007-02-09 2008-08-14 The Regents Of The University Of California Biofuel production by recombinant microorganisms
JP2011067095A (ja) 2008-01-10 2011-04-07 Ajinomoto Co Inc 発酵法による目的物質の製造法
WO2009093703A1 (ja) 2008-01-23 2009-07-30 Ajinomoto Co., Inc. Ｌ-アミノ酸の製造法
US8623619B2 (en) 2009-02-09 2014-01-07 Kyowa Hakko Bio Co., Ltd. Process for producing L-amino acid
JP5882202B2 (ja) * 2009-06-05 2016-03-09 エボニック デグサ ゲーエムベーハーＥｖｏｎｉｋ Ｄｅｇｕｓｓａ ＧｍｂＨ ２−ケトカルボン酸の製造方法
WO2011013707A1 (ja) 2009-07-29 2011-02-03 味の素株式会社 Ｌ-アミノ酸の製造法
JP2012223091A (ja) 2009-08-25 2012-11-15 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
KR101251540B1 (ko) 2010-10-08 2013-04-08 한국과학기술원 Ｌ-발린 생성능이 개선된 변이 대장균 ｗ 균주 및 이를 이용한 ｌ-발린의 제조방법
KR101117022B1 (ko) 2011-08-16 2012-03-16 씨제이제일제당 (주) Ｌ-발린 생산능이 향상된 미생물 및 이를 이용한 ｌ-발린 제조방법
EP2749638A4 (en) * 2011-08-22 2015-04-22 Res Inst Innovative Tech Earth TRANSFORMANT OF CORNEFORMED BACTERIUM AND METHOD FOR PRODUCING VALINE USING THE SAME
JP5831669B2 (ja) 2013-05-13 2015-12-09 味の素株式会社 Ｌ−アミノ酸の製造法
JP2016165225A (ja) 2013-07-09 2016-09-15 味の素株式会社 有用物質の製造方法
BR112016008830B1 (pt) 2013-10-23 2023-02-23 Ajinomoto Co., Inc Método para produzir uma substância alvo
JP7066977B2 (ja) 2017-04-03 2022-05-16 味の素株式会社 Ｌ－アミノ酸の製造法
JP7124338B2 (ja) 2018-02-27 2022-08-24 味の素株式会社 変異型グルタチオン合成酵素、及び、γ－グルタミルバリルグリシンの製造法
EP3861109A1 (en) 2018-10-05 2021-08-11 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
KR102344689B1 (ko) * 2020-09-01 2021-12-29 씨제이제일제당 주식회사 L-발린 생산 미생물 및 이를 이용한 l-발린 생산 방법
WO2023117708A1 (en) * 2021-12-22 2023-06-29 Chr. Hansen A/S Reduced pantothenic acid levels in fermentative production of oligosaccharides
WO2024096123A1 (ja) * 2022-11-04 2024-05-10 株式会社バイオパレット 遺伝子が改変された微生物およびその生産方法
CN116731933B (zh) * 2023-08-03 2023-10-03 欧铭庄生物科技(天津)有限公司滨海新区分公司 一种谷氨酸棒杆菌及其在生产缬氨酸中的应用

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SU875663A1 (ru) 1978-06-30 1982-09-15 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Штаммы е.coLI ВНИИГенетика VL 334 @ N6 и ВНИИГенетика VL 334 @ N7-продуценты L-треонина и способ их получени
WO1984003301A1 (en) * 1983-02-17 1984-08-30 Kyowa Hakko Kogyo Kk Process for preparing amino acid
JPH0746994B2 (ja) * 1984-10-04 1995-05-24 味の素株式会社 発酵法によるｌ−アミノ酸の製造法
JP2748418B2 (ja) * 1988-08-03 1998-05-06 味の素株式会社 組換えｄｎａ、該組換えｄｎａを有する微生物
DE3942947A1 (de) * 1989-12-23 1991-06-27 Forschungszentrum Juelich Gmbh Verfahren zur herstellung von l-isoleucin und dafuer geeignete mikroorganismen und rekombinante dna
US5534421A (en) * 1991-05-30 1996-07-09 Ajinomoto Co., Inc. Production of isoleucine by escherichia coli having isoleucine auxotrophy and no negative feedback inhibition of isoleucine production
JPH05344893A (ja) * 1992-06-12 1993-12-27 Mitsubishi Petrochem Co Ltd アセトヒドロキシ酸シンターゼをコードする遺伝子ｄｎａ及びその利用
JPH06277067A (ja) * 1993-03-26 1994-10-04 Mitsubishi Petrochem Co Ltd アセトヒドロキシ酸イソメロレダクターゼをコードする遺伝子ｄｎａ
DE4400926C1 (de) * 1994-01-14 1995-06-01 Forschungszentrum Juelich Gmbh Herstellung von L-Isoleucin mittels rekombinanter Mikroorganismen mit deregulierter Threonindehydratase
US5998178A (en) * 1994-05-30 1999-12-07 Ajinomoto Co., Ltd. L-isoleucine-producing bacterium and method for preparing L-isoleucine through fermentation
WO1996006926A1 (fr) * 1994-08-30 1996-03-07 Ajinomoto Co., Inc. Procede pour produire de la l-valine et de la l-leucine
JPH0889249A (ja) * 1994-09-29 1996-04-09 Mitsubishi Chem Corp ジヒドロキシ酸デヒドラターゼをコードする遺伝子を含むｄｎａ断片
DE19855312A1 (de) * 1998-12-01 2000-06-08 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure unter Verwendung coryneformer Bakterien

Also Published As

Publication number Publication date
WO2000050624A1 (de) 2000-08-31
DE19907567B4 (de) 2007-08-09
EP1155139B2 (de) 2009-02-25
ATE236991T1 (de) 2003-04-15
KR20010108172A (ko) 2001-12-07
JP2002537771A (ja) 2002-11-12
US7632663B1 (en) 2009-12-15
SK12052001A3 (sk) 2002-01-07
CZ20013037A3 (cs) 2002-01-16
DE19907567A1 (de) 2000-08-24
JP4638048B2 (ja) 2011-02-23
EP1155139B1 (de) 2003-04-09
ES2197076T5 (es) 2009-05-20
SK285870B6 (sk) 2007-10-04
PT1155139E (pt) 2003-08-29
EP1155139A1 (de) 2001-11-21
ES2197076T3 (es) 2004-01-01
KR100614029B1 (ko) 2006-08-23
DK1155139T4 (da) 2009-04-20
DE50001708D1 (de) 2003-05-15

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