DK1125929T3 - Fremgangsmåde til fremstilling af (-)-(2R,4S)-4-[(3,5-bis-trifluormethyl-benzyl)-methoxycarbonylamino]-2-ethyl-6-trifluormethyl-3,4-dihydro-2H-quinolin-1-carboxylsyreethylester - Google Patents

Fremgangsmåde til fremstilling af (-)-(2R,4S)-4-[(3,5-bis-trifluormethyl-benzyl)-methoxycarbonylamino]-2-ethyl-6-trifluormethyl-3,4-dihydro-2H-quinolin-1-carboxylsyreethylester

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Publication number
DK1125929T3
DK1125929T3 DK00310064T DK00310064T DK1125929T3 DK 1125929 T3 DK1125929 T3 DK 1125929T3 DK 00310064 T DK00310064 T DK 00310064T DK 00310064 T DK00310064 T DK 00310064T DK 1125929 T3 DK1125929 T3 DK 1125929T3
Authority
DK
Denmark
Prior art keywords
trifluoromethyl
methoxycarbonylamino
quinoline
dihydro
benzyl
Prior art date
Application number
DK00310064T
Other languages
Danish (da)
English (en)
Inventor
David Burns Damon
Robert Wayne Dugger
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of DK1125929T3 publication Critical patent/DK1125929T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK00310064T 1999-11-30 2000-11-13 Fremgangsmåde til fremstilling af (-)-(2R,4S)-4-[(3,5-bis-trifluormethyl-benzyl)-methoxycarbonylamino]-2-ethyl-6-trifluormethyl-3,4-dihydro-2H-quinolin-1-carboxylsyreethylester DK1125929T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16796799P 1999-11-30 1999-11-30

Publications (1)

Publication Number Publication Date
DK1125929T3 true DK1125929T3 (da) 2006-04-03

Family

ID=22609556

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00310064T DK1125929T3 (da) 1999-11-30 2000-11-13 Fremgangsmåde til fremstilling af (-)-(2R,4S)-4-[(3,5-bis-trifluormethyl-benzyl)-methoxycarbonylamino]-2-ethyl-6-trifluormethyl-3,4-dihydro-2H-quinolin-1-carboxylsyreethylester

Country Status (44)

Country Link
US (1) US6313142B1 (cg-RX-API-DMAC7.html)
EP (1) EP1125929B1 (cg-RX-API-DMAC7.html)
JP (1) JP3579345B2 (cg-RX-API-DMAC7.html)
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CN (1) CN1173953C (cg-RX-API-DMAC7.html)
AP (1) AP2000002011A0 (cg-RX-API-DMAC7.html)
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CO (1) CO5261552A1 (cg-RX-API-DMAC7.html)
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DE (1) DE60025317T2 (cg-RX-API-DMAC7.html)
DK (1) DK1125929T3 (cg-RX-API-DMAC7.html)
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EA (1) EA003668B1 (cg-RX-API-DMAC7.html)
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ES (1) ES2254109T3 (cg-RX-API-DMAC7.html)
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GT (1) GT200000190A (cg-RX-API-DMAC7.html)
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ID (1) ID28489A (cg-RX-API-DMAC7.html)
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ATE407670T1 (de) 2002-12-20 2008-09-15 Pfizer Prod Inc Dosierungsform enthaltend einen cetp-hemmer und einen hmg-coa reduktase hemmer
WO2004078730A2 (en) * 2003-03-04 2004-09-16 Takasago International Corporation Method for producing optically active amines
AU2004222436A1 (en) * 2003-03-17 2004-09-30 Japan Tobacco Inc. Method for increasing the oral bioavailability of S-(2-(((1- (2-ethylbutyl) cyclohexyl)carbonyl) amino) phenyl)-2-methylpropanethioate
CA2519432C (en) * 2003-03-17 2009-06-09 Japan Tobacco Inc. Pharmaceutical compositions comprising cetp inhibitors and a water-insoluble concentration-enhancing additive for the treatment of cardiovascular disease
TWI393560B (zh) * 2003-05-02 2013-04-21 Japan Tobacco Inc 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
EP2098512A1 (en) * 2003-10-08 2009-09-09 Eli Lilly & Company Compounds and methods for treating dyslipidemia
UA90269C2 (ru) * 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Тетрагидрохинолиновые производные и способ их получения
JP2008504266A (ja) * 2004-06-24 2008-02-14 イーライ リリー アンド カンパニー 異脂肪血症を治療するための化合物及び方法
DOP2005000123A (es) * 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
WO2006033001A1 (en) * 2004-09-23 2006-03-30 Pfizer Products Inc. Quinoline compounds
US7700774B2 (en) * 2004-12-20 2010-04-20 Dr. Reddy's Laboratories Ltd. Heterocyclic compounds and their pharmaceutical compositions
EP1861372A1 (en) * 2005-02-24 2007-12-05 Millennium Pharmaceuticals, Inc. Pgd2 receptor antagonists for the treatment of inflammatory diseases
TW200808731A (en) 2006-03-30 2008-02-16 Tanabe Seiyaku Co A process for preparing tetrahydroquinoline derivatives
CL2008000684A1 (es) 2007-03-09 2008-08-01 Indigene Pharmaceuticals Inc Composicion farmaceutica que comprende metformina r-(+) lipoato y un inhibidor de reductasa hmg-coa; formulacion de dosis unitaria; y uso en el tratamiento de una complicacion diabetica.
CN101429160B (zh) * 2007-11-06 2011-10-19 上海药明康德新药开发有限公司 一种1-r-4-氨基-1,2,3,4-四氢喹啉的合成方法
TWI450896B (zh) 2009-06-30 2014-09-01 Lilly Co Eli 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸
EP4551567A1 (en) 2022-07-05 2025-05-14 NewAmsterdam Pharma B.V. Salts of obicetrapib and processes for their manufacture and intermediates thereof

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Also Published As

Publication number Publication date
ES2254109T3 (es) 2006-06-16
JP3579345B2 (ja) 2004-10-20
PL344208A1 (en) 2001-06-04
IS5715A (is) 2001-05-31
HUP0004747A2 (hu) 2001-10-28
IL139849A (en) 2006-10-31
KR100408177B1 (ko) 2003-12-01
MA25223A1 (fr) 2001-07-02
BG105009A (en) 2001-11-30
CZ20004407A3 (cs) 2002-06-12
AU7178900A (en) 2001-05-31
CN1302800A (zh) 2001-07-11
AU784694B2 (en) 2006-06-01
EA200001129A2 (ru) 2001-06-25
ID28489A (id) 2001-05-31
GEP20022798B (en) 2002-09-25
CY1104989T1 (el) 2010-03-03
NO20006039D0 (no) 2000-11-29
EP1125929B1 (en) 2006-01-04
OA11494A (en) 2004-05-07
TNSN00230A1 (fr) 2005-11-10
DZ3079A1 (fr) 2004-10-24
UY26451A1 (es) 2001-06-29
JP2001163859A (ja) 2001-06-19
KR20010052012A (ko) 2001-06-25
AR029775A1 (es) 2003-07-16
EA200001129A3 (ru) 2001-10-22
GT200000190A (es) 2002-04-27
HU0004747D0 (cg-RX-API-DMAC7.html) 2001-02-28
HRP20000804A2 (en) 2001-06-30
CO5261552A1 (es) 2003-03-31
DE60025317T2 (de) 2006-08-03
EE200000659A (et) 2001-08-15
HK1038007A1 (en) 2002-03-01
DE60025317D1 (de) 2006-03-30
SK17792000A3 (sk) 2002-10-08
IL139849A0 (en) 2002-02-10
CA2327029C (en) 2005-08-09
HN2000000203A (es) 2001-06-13
AP2000002011A0 (en) 2000-12-31
US6313142B1 (en) 2001-11-06
NO20006039L (no) 2001-05-31
NZ508509A (en) 2001-06-29
CN1173953C (zh) 2004-11-03
ZA200006947B (en) 2002-05-27
EP1125929A1 (en) 2001-08-22
BR0005636A (pt) 2001-07-17
TW591016B (en) 2004-06-11
ATE315028T1 (de) 2006-02-15
PA8503801A1 (es) 2002-07-30
UA65615C2 (uk) 2004-04-15
CA2327029A1 (en) 2001-05-30
SG102603A1 (en) 2004-03-26
YU71500A (sh) 2003-02-28
HUP0004747A3 (en) 2002-12-28
PE20010913A1 (es) 2001-09-10
EA003668B1 (ru) 2003-08-28

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