SG102603A1 - Method for making 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinoline - Google Patents

Method for making 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinoline

Info

Publication number
SG102603A1
SG102603A1 SG200006869A SG200006869A SG102603A1 SG 102603 A1 SG102603 A1 SG 102603A1 SG 200006869 A SG200006869 A SG 200006869A SG 200006869 A SG200006869 A SG 200006869A SG 102603 A1 SG102603 A1 SG 102603A1
Authority
SG
Singapore
Prior art keywords
carboxyamino
tetrahydroquinoline
substituted
making
Prior art date
Application number
SG200006869A
Other languages
English (en)
Inventor
Burns Damon David
Wayne Dugger Robert
Original Assignee
Pfizer Product Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Product Inc filed Critical Pfizer Product Inc
Publication of SG102603A1 publication Critical patent/SG102603A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SG200006869A 1999-11-30 2000-11-28 Method for making 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinoline SG102603A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16796799P 1999-11-30 1999-11-30

Publications (1)

Publication Number Publication Date
SG102603A1 true SG102603A1 (en) 2004-03-26

Family

ID=22609556

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200006869A SG102603A1 (en) 1999-11-30 2000-11-28 Method for making 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinoline

Country Status (44)

Country Link
US (1) US6313142B1 (cg-RX-API-DMAC7.html)
EP (1) EP1125929B1 (cg-RX-API-DMAC7.html)
JP (1) JP3579345B2 (cg-RX-API-DMAC7.html)
KR (1) KR100408177B1 (cg-RX-API-DMAC7.html)
CN (1) CN1173953C (cg-RX-API-DMAC7.html)
AP (1) AP2000002011A0 (cg-RX-API-DMAC7.html)
AR (1) AR029775A1 (cg-RX-API-DMAC7.html)
AT (1) ATE315028T1 (cg-RX-API-DMAC7.html)
AU (1) AU784694B2 (cg-RX-API-DMAC7.html)
BG (1) BG105009A (cg-RX-API-DMAC7.html)
BR (1) BR0005636A (cg-RX-API-DMAC7.html)
CA (1) CA2327029C (cg-RX-API-DMAC7.html)
CO (1) CO5261552A1 (cg-RX-API-DMAC7.html)
CY (1) CY1104989T1 (cg-RX-API-DMAC7.html)
CZ (1) CZ20004407A3 (cg-RX-API-DMAC7.html)
DE (1) DE60025317T2 (cg-RX-API-DMAC7.html)
DK (1) DK1125929T3 (cg-RX-API-DMAC7.html)
DZ (1) DZ3079A1 (cg-RX-API-DMAC7.html)
EA (1) EA003668B1 (cg-RX-API-DMAC7.html)
EE (1) EE200000659A (cg-RX-API-DMAC7.html)
ES (1) ES2254109T3 (cg-RX-API-DMAC7.html)
GE (1) GEP20022798B (cg-RX-API-DMAC7.html)
GT (1) GT200000190A (cg-RX-API-DMAC7.html)
HN (1) HN2000000203A (cg-RX-API-DMAC7.html)
HR (1) HRP20000804A2 (cg-RX-API-DMAC7.html)
HU (1) HUP0004747A3 (cg-RX-API-DMAC7.html)
ID (1) ID28489A (cg-RX-API-DMAC7.html)
IL (1) IL139849A (cg-RX-API-DMAC7.html)
IS (1) IS5715A (cg-RX-API-DMAC7.html)
MA (1) MA25223A1 (cg-RX-API-DMAC7.html)
NO (1) NO20006039L (cg-RX-API-DMAC7.html)
NZ (1) NZ508509A (cg-RX-API-DMAC7.html)
OA (1) OA11494A (cg-RX-API-DMAC7.html)
PA (1) PA8503801A1 (cg-RX-API-DMAC7.html)
PE (1) PE20010913A1 (cg-RX-API-DMAC7.html)
PL (1) PL344208A1 (cg-RX-API-DMAC7.html)
SG (1) SG102603A1 (cg-RX-API-DMAC7.html)
SK (1) SK17792000A3 (cg-RX-API-DMAC7.html)
TN (1) TNSN00230A1 (cg-RX-API-DMAC7.html)
TW (1) TW591016B (cg-RX-API-DMAC7.html)
UA (1) UA65615C2 (cg-RX-API-DMAC7.html)
UY (1) UY26451A1 (cg-RX-API-DMAC7.html)
YU (1) YU71500A (cg-RX-API-DMAC7.html)
ZA (1) ZA200006947B (cg-RX-API-DMAC7.html)

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HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.
US7202247B2 (en) 2001-12-19 2007-04-10 Atherogenics, Inc. 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
WO2003053368A2 (en) * 2001-12-19 2003-07-03 Atherogenics, Inc. Chalcone derivatives and their use to treat diseases
EP1492880B1 (en) * 2002-04-11 2008-10-08 Roar Holding LLC Ex vivo method for determination of cetp activity and efficacy of heart disease treatment
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
MXPA05003456A (es) * 2002-10-04 2005-07-05 Millennium Pharm Inc Antagonistas del receptor de pgd2 para el tratamiento de enfermedades inflamatorias.
US7504508B2 (en) * 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7223870B2 (en) * 2002-11-01 2007-05-29 Pfizer Inc. Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
US20040181075A1 (en) * 2002-12-19 2004-09-16 Weingarten M. David Process of making chalcone derivatives
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
BR0317521A (pt) 2002-12-20 2005-11-16 Pfizer Prod Inc Formas de dosagem compreendendo um inibidor da cetp e um inibidor da redutase hmg-coa
JP2006523218A (ja) * 2003-03-04 2006-10-12 高砂香料工業株式会社 光学活性アミン類の製造方法
PT1603553E (pt) * 2003-03-17 2012-02-03 Japan Tobacco Inc Composições farmacêuticas de inibidores de cetp
CA2519458A1 (en) * 2003-03-17 2004-09-30 Japan Tobacco Inc. Method for increasing the oral bioavailability of s-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl]-2-methylpropanethioate
TWI393560B (zh) * 2003-05-02 2013-04-21 Japan Tobacco Inc 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
SI1670768T1 (sl) * 2003-10-08 2010-01-29 Lilly Co Eli Spojine in metode za zdravljenje dislipidemije
UA90269C2 (ru) * 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Тетрагидрохинолиновые производные и способ их получения
EA200700119A1 (ru) * 2004-06-24 2007-10-26 Эли Лилли Энд Компани Соединения и способы лечения дислипидемии
DOP2005000123A (es) * 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
WO2006033001A1 (en) * 2004-09-23 2006-03-30 Pfizer Products Inc. Quinoline compounds
US7700774B2 (en) * 2004-12-20 2010-04-20 Dr. Reddy's Laboratories Ltd. Heterocyclic compounds and their pharmaceutical compositions
CA2598133A1 (en) * 2005-02-24 2006-08-31 Millennium Pharmaceuticals, Inc. Pgd2 receptor antagonists for the treatment of inflammatory diseases
TW200808731A (en) 2006-03-30 2008-02-16 Tanabe Seiyaku Co A process for preparing tetrahydroquinoline derivatives
AR065670A1 (es) 2007-03-09 2009-06-24 Indigene Pharmaceuticals Inc Combinacion de metformina r-(+) lipoato y agentes antihiperlipidemicos para el tratamiento de hiperglucemia diabetica y complicaciones diabeticas
CN101429160B (zh) * 2007-11-06 2011-10-19 上海药明康德新药开发有限公司 一种1-r-4-氨基-1,2,3,4-四氢喹啉的合成方法
TWI450896B (zh) * 2009-06-30 2014-09-01 Lilly Co Eli 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸
EP4551567A1 (en) 2022-07-05 2025-05-14 NewAmsterdam Pharma B.V. Salts of obicetrapib and processes for their manufacture and intermediates thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231102A (en) * 1989-03-08 1993-07-27 Merck Sharp & Dohme, Ltd. Tetrahydroquinoline derivatives useful for neurodegenerative disorders
EP0987251A1 (en) * 1998-09-17 2000-03-22 Pfizer Products Inc. 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as CETP inhibitors
EP0992496A1 (en) * 1998-09-17 2000-04-12 Pfizer Products Inc. Annulated 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as CETP inhibitors

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US3971789A (en) 1972-10-21 1976-07-27 John Wyeth & Brother Limited O-(4-Quinolylamino)benzamides
GB8432091D0 (en) 1984-12-19 1985-01-30 Wyeth John & Brother Ltd 4-aminoquinoline derivatives
US4839368A (en) 1986-05-02 1989-06-13 Mochida Pharmaceutical Co., Ltd. 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives
GB8804444D0 (en) 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
US6197786B1 (en) 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231102A (en) * 1989-03-08 1993-07-27 Merck Sharp & Dohme, Ltd. Tetrahydroquinoline derivatives useful for neurodegenerative disorders
EP0987251A1 (en) * 1998-09-17 2000-03-22 Pfizer Products Inc. 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as CETP inhibitors
EP0992496A1 (en) * 1998-09-17 2000-04-12 Pfizer Products Inc. Annulated 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as CETP inhibitors

Also Published As

Publication number Publication date
CN1173953C (zh) 2004-11-03
GT200000190A (es) 2002-04-27
JP2001163859A (ja) 2001-06-19
PL344208A1 (en) 2001-06-04
HK1038007A1 (en) 2002-03-01
DE60025317T2 (de) 2006-08-03
AP2000002011A0 (en) 2000-12-31
HU0004747D0 (cg-RX-API-DMAC7.html) 2001-02-28
UA65615C2 (uk) 2004-04-15
PE20010913A1 (es) 2001-09-10
EE200000659A (et) 2001-08-15
PA8503801A1 (es) 2002-07-30
NO20006039L (no) 2001-05-31
ES2254109T3 (es) 2006-06-16
HN2000000203A (es) 2001-06-13
CA2327029C (en) 2005-08-09
KR20010052012A (ko) 2001-06-25
CY1104989T1 (el) 2010-03-03
US6313142B1 (en) 2001-11-06
AR029775A1 (es) 2003-07-16
HRP20000804A2 (en) 2001-06-30
CZ20004407A3 (cs) 2002-06-12
OA11494A (en) 2004-05-07
IL139849A0 (en) 2002-02-10
YU71500A (sh) 2003-02-28
TW591016B (en) 2004-06-11
KR100408177B1 (ko) 2003-12-01
EA200001129A2 (ru) 2001-06-25
CO5261552A1 (es) 2003-03-31
UY26451A1 (es) 2001-06-29
ZA200006947B (en) 2002-05-27
DK1125929T3 (da) 2006-04-03
TNSN00230A1 (fr) 2005-11-10
EA200001129A3 (ru) 2001-10-22
DZ3079A1 (fr) 2004-10-24
CA2327029A1 (en) 2001-05-30
ATE315028T1 (de) 2006-02-15
SK17792000A3 (sk) 2002-10-08
AU7178900A (en) 2001-05-31
MA25223A1 (fr) 2001-07-02
EP1125929A1 (en) 2001-08-22
NO20006039D0 (no) 2000-11-29
BR0005636A (pt) 2001-07-17
EA003668B1 (ru) 2003-08-28
DE60025317D1 (de) 2006-03-30
BG105009A (en) 2001-11-30
NZ508509A (en) 2001-06-29
HUP0004747A3 (en) 2002-12-28
GEP20022798B (en) 2002-09-25
IS5715A (is) 2001-05-31
CN1302800A (zh) 2001-07-11
EP1125929B1 (en) 2006-01-04
JP3579345B2 (ja) 2004-10-20
HUP0004747A2 (hu) 2001-10-28
ID28489A (id) 2001-05-31
IL139849A (en) 2006-10-31
AU784694B2 (en) 2006-06-01

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