DK1117627T3 - Fremgangsmåde til overføringshydrogenering - Google Patents

Fremgangsmåde til overføringshydrogenering

Info

Publication number
DK1117627T3
DK1117627T3 DK99949137T DK99949137T DK1117627T3 DK 1117627 T3 DK1117627 T3 DK 1117627T3 DK 99949137 T DK99949137 T DK 99949137T DK 99949137 T DK99949137 T DK 99949137T DK 1117627 T3 DK1117627 T3 DK 1117627T3
Authority
DK
Denmark
Prior art keywords
bidentate ligands
transfer hydrogenation
employed
transfer
preferred
Prior art date
Application number
DK99949137T
Other languages
English (en)
Inventor
Andrew John Blacker
Lynne Campbell
Original Assignee
Avecia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Ltd filed Critical Avecia Ltd
Application granted granted Critical
Publication of DK1117627T3 publication Critical patent/DK1117627T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/04—Formation or introduction of functional groups containing nitrogen of amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10—Quaternary compounds
DK99949137T 1998-09-29 1999-09-22 Fremgangsmåde til overføringshydrogenering DK1117627T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9821067.7A GB9821067D0 (en) 1998-09-29 1998-09-29 Transfer hydrogenation process
PCT/GB1999/003176 WO2000018708A1 (en) 1998-09-29 1999-09-22 Transfer hydrogenation process

Publications (1)

Publication Number Publication Date
DK1117627T3 true DK1117627T3 (da) 2003-09-15

Family

ID=10839587

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99949137T DK1117627T3 (da) 1998-09-29 1999-09-22 Fremgangsmåde til overføringshydrogenering

Country Status (19)

Country Link
US (1) US6509467B1 (da)
EP (1) EP1117627B1 (da)
JP (1) JP2002525342A (da)
KR (1) KR100674631B1 (da)
CN (1) CN1231433C (da)
AT (1) ATE241578T1 (da)
AU (1) AU764996B2 (da)
CA (1) CA2343088C (da)
CZ (1) CZ299368B6 (da)
DE (1) DE69908390T2 (da)
DK (1) DK1117627T3 (da)
ES (1) ES2201780T3 (da)
GB (1) GB9821067D0 (da)
HK (1) HK1042887B (da)
HU (1) HU225492B1 (da)
IL (1) IL142093A (da)
NO (1) NO325921B1 (da)
PT (1) PT1117627E (da)
WO (1) WO2000018708A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6353112B1 (en) 1998-07-17 2002-03-05 The University Of Tennessee Research Corporation Sultams: Solid phase and other synthesis of anti-HIV compounds and compositions
US6562850B1 (en) 1998-07-17 2003-05-13 The University Of Tennessee Research Corporation Methods of synthesizing sultams and anti-viral compositions
US6458962B1 (en) 1999-03-25 2002-10-01 The University Of Tennesseee Research Corporation Sultams: catalyst systems for asymmetric reduction of a C=N intermediate biological compositions and methods for making the sultams
GB0029356D0 (en) 2000-12-01 2001-01-17 Avecia Ltd Transfer hydrogenation
US6743921B2 (en) 2002-01-24 2004-06-01 Dsm Catalytica Pharmaceuticals, Inc. Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol compounds
CA2565130C (en) * 2003-05-02 2011-03-15 Kamaluddin Abdur-Rashid Transfer hydrogenation processes and catalysts
WO2008080138A1 (en) 2006-12-22 2008-07-03 Richmond Chemical Corporation Stereoinversion of amino acids
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
ATE493416T1 (de) * 2007-05-04 2011-01-15 Mallinckrodt Inc Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiaten
NZ582668A (en) * 2007-07-17 2012-02-24 Mallinckrodt Llc Preparation of n-alkylated opiates by reductive amination
AU2008345097A1 (en) 2007-12-27 2009-07-09 Infinity Pharmaceuticals, Inc. Methods for stereoselective reduction
PL2340253T3 (pl) * 2008-09-30 2014-04-30 SpecGx LLC Sposoby selektywnego aminowania ketomorfinanów
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
PL2440562T3 (pl) * 2009-06-11 2017-07-31 Mallinckrodt Llc Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru
ES2465066T3 (es) * 2009-06-11 2014-06-05 Mallinckrodt Llc Aminación reductora de 6-ceto-normorfinanos por transferencia de hidrógeno catalítica
TW201105635A (en) * 2009-06-30 2011-02-16 Actelion Pharmaceuticals Ltd Process for the preparation of an enantiomerically pure trisubstituted 1,2,3,4-tetrahydroisoquinoline derivative
CA2769795C (en) 2009-08-05 2020-01-07 Infinity Pharmaceuticals, Inc. Enzymatic transamination of cyclopamine analogs
WO2012037217A1 (en) 2010-09-14 2012-03-22 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
RU2013157298A (ru) 2011-06-09 2015-07-20 МАЛЛИНКРОДТ Эл-Эл-Си Восстановительное аминирование 6-кетоморфинанов посредством каталитического переноса водорода
RU2014112493A (ru) 2011-09-08 2015-10-20 МАЛЛИНКРОДТ Эл-Эл-Си Получения алкалоидов без выделения промежуточных продуктов
MX2017015681A (es) 2015-06-04 2018-09-11 Pellepharm Inc Formulaciones topicas para suministrar compuestos inhibidores de hedgehog y uso de los mismos.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT333764B (de) * 1972-06-20 1976-12-10 Fujisawa Pharmaceutical Co Verfahren zur herstellung von neuen 1,2,3,4-tetrahydroisochinolinen und deren salzen
JPS553349B2 (da) * 1972-06-20 1980-01-24
JP3149989B2 (ja) * 1992-04-28 2001-03-26 広栄化学工業株式会社 ２−クロロ−５−置換アミノメチルピリジン類の製法
GB9706321D0 (en) * 1997-03-26 1997-05-14 Zeneca Ltd Catalytic hydrogenation

Also Published As

Publication number Publication date
CN1231433C (zh) 2005-12-14
HU225492B1 (en) 2007-01-29
GB9821067D0 (en) 1998-11-18
IL142093A (en) 2005-11-20
JP2002525342A (ja) 2002-08-13
HUP0103510A2 (hu) 2002-01-28
CA2343088C (en) 2009-02-24
ATE241578T1 (de) 2003-06-15
NO20011573D0 (no) 2001-03-28
CZ20011110A3 (cs) 2001-08-15
PT1117627E (pt) 2003-10-31
US6509467B1 (en) 2003-01-21
DE69908390D1 (de) 2003-07-03
HK1042887A1 (en) 2002-08-30
NO325921B1 (no) 2008-08-18
NO20011573L (no) 2001-03-28
ES2201780T3 (es) 2004-03-16
KR20010075408A (ko) 2001-08-09
CA2343088A1 (en) 2000-04-06
AU6212599A (en) 2000-04-17
AU764996B2 (en) 2003-09-04
CZ299368B6 (cs) 2008-07-02
KR100674631B1 (ko) 2007-01-25
WO2000018708A1 (en) 2000-04-06
CN1321140A (zh) 2001-11-07
EP1117627A1 (en) 2001-07-25
HK1042887B (zh) 2006-08-18
EP1117627B1 (en) 2003-05-28
DE69908390T2 (de) 2004-04-22
IL142093A0 (en) 2002-03-10
HUP0103510A3 (en) 2002-04-29

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