HK1042887B - 轉移氫化方法 - Google Patents

轉移氫化方法

Info

Publication number
HK1042887B
HK1042887B HK02102896.9A HK02102896A HK1042887B HK 1042887 B HK1042887 B HK 1042887B HK 02102896 A HK02102896 A HK 02102896A HK 1042887 B HK1042887 B HK 1042887B
Authority
HK
Hong Kong
Prior art keywords
hydrogenation process
transfer hydrogenation
bidentate ligands
employed
transfer
Prior art date
Application number
HK02102896.9A
Other languages
English (en)
Other versions
HK1042887A1 (en
Inventor
John Blacker Andrew
Campbell Lynne
Original Assignee
艾夫西亞有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 艾夫西亞有限公司 filed Critical 艾夫西亞有限公司
Publication of HK1042887A1 publication Critical patent/HK1042887A1/xx
Publication of HK1042887B publication Critical patent/HK1042887B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/04—Formation or introduction of functional groups containing nitrogen of amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10—Quaternary compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
HK02102896.9A 1998-09-29 2002-06-25 轉移氫化方法 HK1042887B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9821067.7A GB9821067D0 (en) 1998-09-29 1998-09-29 Transfer hydrogenation process
PCT/GB1999/003176 WO2000018708A1 (en) 1998-09-29 1999-09-22 Transfer hydrogenation process

Publications (2)

Publication Number Publication Date
HK1042887A1 HK1042887A1 (en) 2002-08-30
HK1042887B true HK1042887B (zh) 2006-08-18

Family

ID=10839587

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02102896.9A HK1042887B (zh) 1998-09-29 2002-06-25 轉移氫化方法

Country Status (19)

Country Link
US (1) US6509467B1 (zh)
EP (1) EP1117627B1 (zh)
JP (1) JP2002525342A (zh)
KR (1) KR100674631B1 (zh)
CN (1) CN1231433C (zh)
AT (1) ATE241578T1 (zh)
AU (1) AU764996B2 (zh)
CA (1) CA2343088C (zh)
CZ (1) CZ299368B6 (zh)
DE (1) DE69908390T2 (zh)
DK (1) DK1117627T3 (zh)
ES (1) ES2201780T3 (zh)
GB (1) GB9821067D0 (zh)
HK (1) HK1042887B (zh)
HU (1) HU225492B1 (zh)
IL (1) IL142093A (zh)
NO (1) NO325921B1 (zh)
PT (1) PT1117627E (zh)
WO (1) WO2000018708A1 (zh)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6353112B1 (en) 1998-07-17 2002-03-05 The University Of Tennessee Research Corporation Sultams: Solid phase and other synthesis of anti-HIV compounds and compositions
US6562850B1 (en) 1998-07-17 2003-05-13 The University Of Tennessee Research Corporation Methods of synthesizing sultams and anti-viral compositions
US6458962B1 (en) 1999-03-25 2002-10-01 The University Of Tennesseee Research Corporation Sultams: catalyst systems for asymmetric reduction of a C=N intermediate biological compositions and methods for making the sultams
GB0029356D0 (en) 2000-12-01 2001-01-17 Avecia Ltd Transfer hydrogenation
US6743921B2 (en) 2002-01-24 2004-06-01 Dsm Catalytica Pharmaceuticals, Inc. Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol compounds
CA2565130C (en) * 2003-05-02 2011-03-15 Kamaluddin Abdur-Rashid Transfer hydrogenation processes and catalysts
US8133717B2 (en) 2006-12-22 2012-03-13 Richmond Chemical Corporation Stereoinversion of amino acids in a single reactor
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
ES2407033T3 (es) * 2007-05-04 2013-06-11 Mallinckrodt Llc Procedimientos mejorados para la preparación de opiáceos 6-alfa-hidroxi-n-alquilados
NZ582668A (en) * 2007-07-17 2012-02-24 Mallinckrodt Llc Preparation of n-alkylated opiates by reductive amination
EP3190121B1 (en) 2007-12-27 2019-02-20 Infinity Pharmaceuticals, Inc. Methods for stereoselective reduction of cyclopamine 4-en-3-one derivative
CA2738628C (en) * 2008-09-30 2017-07-04 Mallinckrodt Inc. Processes for the selective amination of ketomorphinans
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
WO2010144641A1 (en) * 2009-06-11 2010-12-16 Mallinckrodt Inc. Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer
EP2440561B1 (en) * 2009-06-11 2014-04-30 Mallinckrodt LLC Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
TW201105635A (en) * 2009-06-30 2011-02-16 Actelion Pharmaceuticals Ltd Process for the preparation of an enantiomerically pure trisubstituted 1,2,3,4-tetrahydroisoquinoline derivative
CN102574791A (zh) 2009-08-05 2012-07-11 无限药品股份有限公司 环杷明类似物的酶促转氨基反应
WO2012037217A1 (en) 2010-09-14 2012-03-22 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
MX2013013634A (es) 2011-06-09 2013-12-12 Mallinckrodt Llc Aminacion reductiva de 6-ceto-morfinanos por transfrencia catalitica de hidrogeno.
ES2566620T3 (es) 2011-09-08 2016-04-14 Mallinckrodt Llc Procesamiento de alcaloides sin el aislamiento de intermedios
BR112017026103B1 (pt) 2015-06-04 2023-10-03 Sol-Gel Technologies Ltd Composições tópicas com composto inibidor de hedgehog, sistema de entrega tópica e seus usos

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT333764B (de) * 1972-06-20 1976-12-10 Fujisawa Pharmaceutical Co Verfahren zur herstellung von neuen 1,2,3,4-tetrahydroisochinolinen und deren salzen
JPS553349B2 (zh) * 1972-06-20 1980-01-24
JP3149989B2 (ja) * 1992-04-28 2001-03-26 広栄化学工業株式会社 ２−クロロ−５−置換アミノメチルピリジン類の製法
GB9706321D0 (en) * 1997-03-26 1997-05-14 Zeneca Ltd Catalytic hydrogenation

Also Published As

Publication number Publication date
DE69908390T2 (de) 2004-04-22
DK1117627T3 (da) 2003-09-15
CN1231433C (zh) 2005-12-14
CZ299368B6 (cs) 2008-07-02
JP2002525342A (ja) 2002-08-13
CA2343088A1 (en) 2000-04-06
DE69908390D1 (de) 2003-07-03
NO20011573D0 (no) 2001-03-28
KR20010075408A (ko) 2001-08-09
CA2343088C (en) 2009-02-24
NO325921B1 (no) 2008-08-18
ES2201780T3 (es) 2004-03-16
IL142093A (en) 2005-11-20
EP1117627B1 (en) 2003-05-28
ATE241578T1 (de) 2003-06-15
NO20011573L (no) 2001-03-28
GB9821067D0 (en) 1998-11-18
PT1117627E (pt) 2003-10-31
HUP0103510A2 (hu) 2002-01-28
HU225492B1 (en) 2007-01-29
CZ20011110A3 (cs) 2001-08-15
KR100674631B1 (ko) 2007-01-25
HUP0103510A3 (en) 2002-04-29
IL142093A0 (en) 2002-03-10
AU6212599A (en) 2000-04-17
US6509467B1 (en) 2003-01-21
CN1321140A (zh) 2001-11-07
WO2000018708A1 (en) 2000-04-06
HK1042887A1 (en) 2002-08-30
EP1117627A1 (en) 2001-07-25
AU764996B2 (en) 2003-09-04

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20090922