PT1117627E - Processo de hidrogenacao por transferencia - Google Patents
Processo de hidrogenacao por transferenciaInfo
- Publication number
- PT1117627E PT1117627E PT99949137T PT99949137T PT1117627E PT 1117627 E PT1117627 E PT 1117627E PT 99949137 T PT99949137 T PT 99949137T PT 99949137 T PT99949137 T PT 99949137T PT 1117627 E PT1117627 E PT 1117627E
- Authority
- PT
- Portugal
- Prior art keywords
- transfer
- hydrogenation process
- bidentate ligands
- employed
- preferred
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C07B43/04—Formation or introduction of functional groups containing nitrogen of amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/10—Quaternary compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9821067.7A GB9821067D0 (en) | 1998-09-29 | 1998-09-29 | Transfer hydrogenation process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1117627E true PT1117627E (pt) | 2003-10-31 |
Family
ID=10839587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99949137T PT1117627E (pt) | 1998-09-29 | 1999-09-22 | Processo de hidrogenacao por transferencia |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6509467B1 (pt) |
| EP (1) | EP1117627B1 (pt) |
| JP (1) | JP2002525342A (pt) |
| KR (1) | KR100674631B1 (pt) |
| CN (1) | CN1231433C (pt) |
| AT (1) | ATE241578T1 (pt) |
| AU (1) | AU764996B2 (pt) |
| CA (1) | CA2343088C (pt) |
| CZ (1) | CZ299368B6 (pt) |
| DE (1) | DE69908390T2 (pt) |
| DK (1) | DK1117627T3 (pt) |
| ES (1) | ES2201780T3 (pt) |
| GB (1) | GB9821067D0 (pt) |
| HK (1) | HK1042887B (pt) |
| HU (1) | HU225492B1 (pt) |
| IL (1) | IL142093A (pt) |
| NO (1) | NO325921B1 (pt) |
| PT (1) | PT1117627E (pt) |
| WO (1) | WO2000018708A1 (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6562850B1 (en) | 1998-07-17 | 2003-05-13 | The University Of Tennessee Research Corporation | Methods of synthesizing sultams and anti-viral compositions |
| US6353112B1 (en) | 1998-07-17 | 2002-03-05 | The University Of Tennessee Research Corporation | Sultams: Solid phase and other synthesis of anti-HIV compounds and compositions |
| US6458962B1 (en) | 1999-03-25 | 2002-10-01 | The University Of Tennesseee Research Corporation | Sultams: catalyst systems for asymmetric reduction of a C=N intermediate biological compositions and methods for making the sultams |
| GB0029356D0 (en) * | 2000-12-01 | 2001-01-17 | Avecia Ltd | Transfer hydrogenation |
| US6743921B2 (en) | 2002-01-24 | 2004-06-01 | Dsm Catalytica Pharmaceuticals, Inc. | Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol compounds |
| WO2004096735A2 (en) * | 2003-05-02 | 2004-11-11 | Kamaluddin Abdur-Rashid | Transfer hydrogenation processes and catalysts |
| WO2008080138A1 (en) | 2006-12-22 | 2008-07-03 | Richmond Chemical Corporation | Stereoinversion of amino acids |
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| DE602008004245D1 (de) * | 2007-05-04 | 2011-02-10 | Mallinckrodt Inc | Verbessertes verfahren zur herstellung von 6-alpha-hydroxy-n-alkylierten opiaten |
| EP2167505B1 (en) * | 2007-07-17 | 2012-11-28 | Mallinckrodt LLC | Preparation of n-alkylated opiates by reductive amination |
| ES2610130T3 (es) | 2007-12-27 | 2017-04-26 | Infinity Pharmaceuticals, Inc. | Métodos para reducción estereoselectiva |
| AU2009300392B2 (en) * | 2008-09-30 | 2014-10-23 | SpecGx LLC | Processes for the selective amination of ketomorphinans |
| US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| US8471023B2 (en) * | 2009-06-11 | 2013-06-25 | Mallinckrodt Llc | Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer |
| WO2010144641A1 (en) * | 2009-06-11 | 2010-12-16 | Mallinckrodt Inc. | Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer |
| TW201105635A (en) * | 2009-06-30 | 2011-02-16 | Actelion Pharmaceuticals Ltd | Process for the preparation of an enantiomerically pure trisubstituted 1,2,3,4-tetrahydroisoquinoline derivative |
| ES2567134T3 (es) | 2009-08-05 | 2016-04-20 | Infinity Pharmaceuticals, Inc. | Transaminación enzimática de análogos de ciclopamina |
| US9394313B2 (en) | 2010-09-14 | 2016-07-19 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
| ES2698408T3 (es) | 2011-06-09 | 2019-02-04 | SpecGx LLC | Aminación reductora de 6-ceto morfinanos por transferencia de hidrógeno catalítico |
| EP2753622B1 (en) | 2011-09-08 | 2016-01-20 | Mallinckrodt LLC | Production of alkaloids without the isolation of intermediates |
| JP6796638B2 (ja) | 2015-06-04 | 2020-12-09 | ペレファーム, インク.Pellepharm, Inc. | ヘッジホッグ阻害性化合物の送達のための局所的製剤及びその使用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS553349B2 (pt) * | 1972-06-20 | 1980-01-24 | ||
| AT333764B (de) | 1972-06-20 | 1976-12-10 | Fujisawa Pharmaceutical Co | Verfahren zur herstellung von neuen 1,2,3,4-tetrahydroisochinolinen und deren salzen |
| JP3149989B2 (ja) * | 1992-04-28 | 2001-03-26 | 広栄化学工業株式会社 | ２−クロロ−５−置換アミノメチルピリジン類の製法 |
| GB9706321D0 (en) * | 1997-03-26 | 1997-05-14 | Zeneca Ltd | Catalytic hydrogenation |
-
1998
- 1998-09-29 GB GBGB9821067.7A patent/GB9821067D0/en not_active Ceased
-
1999
- 1999-09-22 US US09/787,707 patent/US6509467B1/en not_active Expired - Fee Related
- 1999-09-22 HU HU0103510A patent/HU225492B1/hu not_active IP Right Cessation
- 1999-09-22 AT AT99949137T patent/ATE241578T1/de not_active IP Right Cessation
- 1999-09-22 CN CNB998114472A patent/CN1231433C/zh not_active Expired - Fee Related
- 1999-09-22 CZ CZ20011110A patent/CZ299368B6/cs not_active IP Right Cessation
- 1999-09-22 DE DE69908390T patent/DE69908390T2/de not_active Expired - Fee Related
- 1999-09-22 KR KR1020017003924A patent/KR100674631B1/ko not_active IP Right Cessation
- 1999-09-22 WO PCT/GB1999/003176 patent/WO2000018708A1/en active IP Right Grant
- 1999-09-22 JP JP2000572172A patent/JP2002525342A/ja active Pending
- 1999-09-22 PT PT99949137T patent/PT1117627E/pt unknown
- 1999-09-22 DK DK99949137T patent/DK1117627T3/da active
- 1999-09-22 IL IL14209399A patent/IL142093A/xx not_active IP Right Cessation
- 1999-09-22 CA CA002343088A patent/CA2343088C/en not_active Expired - Fee Related
- 1999-09-22 AU AU62125/99A patent/AU764996B2/en not_active Ceased
- 1999-09-22 ES ES99949137T patent/ES2201780T3/es not_active Expired - Lifetime
- 1999-09-22 EP EP99949137A patent/EP1117627B1/en not_active Expired - Lifetime
-
2001
- 2001-03-28 NO NO20011573A patent/NO325921B1/no not_active IP Right Cessation
-
2002
- 2002-06-25 HK HK02102896.9A patent/HK1042887B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1117627B1 (en) | 2003-05-28 |
| NO325921B1 (no) | 2008-08-18 |
| EP1117627A1 (en) | 2001-07-25 |
| AU6212599A (en) | 2000-04-17 |
| CA2343088A1 (en) | 2000-04-06 |
| ATE241578T1 (de) | 2003-06-15 |
| DK1117627T3 (da) | 2003-09-15 |
| NO20011573D0 (no) | 2001-03-28 |
| GB9821067D0 (en) | 1998-11-18 |
| CZ20011110A3 (cs) | 2001-08-15 |
| JP2002525342A (ja) | 2002-08-13 |
| CA2343088C (en) | 2009-02-24 |
| DE69908390T2 (de) | 2004-04-22 |
| US6509467B1 (en) | 2003-01-21 |
| KR20010075408A (ko) | 2001-08-09 |
| IL142093A0 (en) | 2002-03-10 |
| HUP0103510A2 (hu) | 2002-01-28 |
| HUP0103510A3 (en) | 2002-04-29 |
| IL142093A (en) | 2005-11-20 |
| ES2201780T3 (es) | 2004-03-16 |
| WO2000018708A1 (en) | 2000-04-06 |
| CN1231433C (zh) | 2005-12-14 |
| AU764996B2 (en) | 2003-09-04 |
| HK1042887A1 (en) | 2002-08-30 |
| CN1321140A (zh) | 2001-11-07 |
| DE69908390D1 (de) | 2003-07-03 |
| KR100674631B1 (ko) | 2007-01-25 |
| NO20011573L (no) | 2001-03-28 |
| HU225492B1 (en) | 2007-01-29 |
| CZ299368B6 (cs) | 2008-07-02 |
| HK1042887B (zh) | 2006-08-18 |
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