IL142093A - Transfer hydrogenation process - Google Patents

Transfer hydrogenation process

Info

Publication number
IL142093A
IL142093A IL14209399A IL14209399A IL142093A IL 142093 A IL142093 A IL 142093A IL 14209399 A IL14209399 A IL 14209399A IL 14209399 A IL14209399 A IL 14209399A IL 142093 A IL142093 A IL 142093A
Authority
IL
Israel
Prior art keywords
hydrogenation process
transfer hydrogenation
bidentate ligands
employed
transfer
Prior art date
Application number
IL14209399A
Other languages
English (en)
Other versions
IL142093A0 (en
Original Assignee
Avecia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Ltd filed Critical Avecia Ltd
Publication of IL142093A0 publication Critical patent/IL142093A0/xx
Publication of IL142093A publication Critical patent/IL142093A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/04—Formation or introduction of functional groups containing nitrogen of amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10—Quaternary compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
IL14209399A 1998-09-29 1999-09-22 Transfer hydrogenation process IL142093A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9821067.7A GB9821067D0 (en) 1998-09-29 1998-09-29 Transfer hydrogenation process
PCT/GB1999/003176 WO2000018708A1 (en) 1998-09-29 1999-09-22 Transfer hydrogenation process

Publications (2)

Publication Number Publication Date
IL142093A0 IL142093A0 (en) 2002-03-10
IL142093A true IL142093A (en) 2005-11-20

Family

ID=10839587

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14209399A IL142093A (en) 1998-09-29 1999-09-22 Transfer hydrogenation process

Country Status (19)

Country Link
US (1) US6509467B1 (zh)
EP (1) EP1117627B1 (zh)
JP (1) JP2002525342A (zh)
KR (1) KR100674631B1 (zh)
CN (1) CN1231433C (zh)
AT (1) ATE241578T1 (zh)
AU (1) AU764996B2 (zh)
CA (1) CA2343088C (zh)
CZ (1) CZ299368B6 (zh)
DE (1) DE69908390T2 (zh)
DK (1) DK1117627T3 (zh)
ES (1) ES2201780T3 (zh)
GB (1) GB9821067D0 (zh)
HK (1) HK1042887B (zh)
HU (1) HU225492B1 (zh)
IL (1) IL142093A (zh)
NO (1) NO325921B1 (zh)
PT (1) PT1117627E (zh)
WO (1) WO2000018708A1 (zh)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562850B1 (en) 1998-07-17 2003-05-13 The University Of Tennessee Research Corporation Methods of synthesizing sultams and anti-viral compositions
US6353112B1 (en) 1998-07-17 2002-03-05 The University Of Tennessee Research Corporation Sultams: Solid phase and other synthesis of anti-HIV compounds and compositions
US6458962B1 (en) 1999-03-25 2002-10-01 The University Of Tennesseee Research Corporation Sultams: catalyst systems for asymmetric reduction of a C=N intermediate biological compositions and methods for making the sultams
GB0029356D0 (en) * 2000-12-01 2001-01-17 Avecia Ltd Transfer hydrogenation
US6743921B2 (en) 2002-01-24 2004-06-01 Dsm Catalytica Pharmaceuticals, Inc. Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol compounds
WO2004096735A2 (en) * 2003-05-02 2004-11-11 Kamaluddin Abdur-Rashid Transfer hydrogenation processes and catalysts
WO2008080138A1 (en) 2006-12-22 2008-07-03 Richmond Chemical Corporation Stereoinversion of amino acids
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
DE602008004245D1 (de) * 2007-05-04 2011-02-10 Mallinckrodt Inc Verbessertes verfahren zur herstellung von 6-alpha-hydroxy-n-alkylierten opiaten
NZ582668A (en) * 2007-07-17 2012-02-24 Mallinckrodt Llc Preparation of n-alkylated opiates by reductive amination
CN101917853B (zh) 2007-12-27 2014-03-19 无限药品股份有限公司 立体选择性还原的方法
PL2340253T3 (pl) * 2008-09-30 2014-04-30 SpecGx LLC Sposoby selektywnego aminowania ketomorfinanów
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
PL2440561T3 (pl) * 2009-06-11 2014-09-30 SpecGx LLC Redukcyjne aminowanie 6-keto-normorfinanow przez katalityczne przeniesienie wodoru
JP5697215B2 (ja) * 2009-06-11 2015-04-08 マリンクロッド エルエルシー 触媒的水素移動による６−α−アミノＮ−置換モルフィナンの合成
TW201105635A (en) * 2009-06-30 2011-02-16 Actelion Pharmaceuticals Ltd Process for the preparation of an enantiomerically pure trisubstituted 1,2,3,4-tetrahydroisoquinoline derivative
WO2011017551A1 (en) 2009-08-05 2011-02-10 Infinity Pharmaceuticals, Inc. Enzymatic transamination of cyclopamine analogs
WO2012037217A1 (en) 2010-09-14 2012-03-22 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
AU2012267780B2 (en) 2011-06-09 2016-09-08 SpecGx LLC Reductive amination of 6-keto morphinans by catalytic hydrogen transfer
JP2014526467A (ja) 2011-09-08 2014-10-06 マリンクロッド エルエルシー 中間体の単離なしでのアルカロイドの調製
US10369147B2 (en) 2015-06-04 2019-08-06 PellePharm, Inc. Topical formulations for delivery of hedgehog inhibitor compounds and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS553349B2 (zh) * 1972-06-20 1980-01-24
AT333764B (de) 1972-06-20 1976-12-10 Fujisawa Pharmaceutical Co Verfahren zur herstellung von neuen 1,2,3,4-tetrahydroisochinolinen und deren salzen
JP3149989B2 (ja) * 1992-04-28 2001-03-26 広栄化学工業株式会社 ２−クロロ−５−置換アミノメチルピリジン類の製法
GB9706321D0 (en) * 1997-03-26 1997-05-14 Zeneca Ltd Catalytic hydrogenation

Also Published As

Publication number Publication date
KR20010075408A (ko) 2001-08-09
IL142093A0 (en) 2002-03-10
HK1042887B (zh) 2006-08-18
EP1117627A1 (en) 2001-07-25
NO20011573L (no) 2001-03-28
GB9821067D0 (en) 1998-11-18
CN1321140A (zh) 2001-11-07
ATE241578T1 (de) 2003-06-15
AU6212599A (en) 2000-04-17
JP2002525342A (ja) 2002-08-13
CZ20011110A3 (cs) 2001-08-15
NO20011573D0 (no) 2001-03-28
CN1231433C (zh) 2005-12-14
KR100674631B1 (ko) 2007-01-25
HUP0103510A2 (hu) 2002-01-28
NO325921B1 (no) 2008-08-18
ES2201780T3 (es) 2004-03-16
EP1117627B1 (en) 2003-05-28
WO2000018708A1 (en) 2000-04-06
CA2343088C (en) 2009-02-24
HK1042887A1 (en) 2002-08-30
US6509467B1 (en) 2003-01-21
AU764996B2 (en) 2003-09-04
CZ299368B6 (cs) 2008-07-02
DE69908390T2 (de) 2004-04-22
HUP0103510A3 (en) 2002-04-29
HU225492B1 (en) 2007-01-29
DE69908390D1 (de) 2003-07-03
PT1117627E (pt) 2003-10-31
CA2343088A1 (en) 2000-04-06
DK1117627T3 (da) 2003-09-15

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Legal Events

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FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees