PL2440562T3 - Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru - Google Patents

Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru

Info

Publication number
PL2440562T3
PL2440562T3 PL10724967T PL10724967T PL2440562T3 PL 2440562 T3 PL2440562 T3 PL 2440562T3 PL 10724967 T PL10724967 T PL 10724967T PL 10724967 T PL10724967 T PL 10724967T PL 2440562 T3 PL2440562 T3 PL 2440562T3
Authority
PL
Poland
Prior art keywords
alpha
amino
preparation
hydrogen transfer
catalytic hydrogen
Prior art date
Application number
PL10724967T
Other languages
English (en)
Inventor
Christopher W. Grote
Gary L. Cantrell
Joseph P. Mcclurg
Catherine E. Thomasson
Frank W. Moser
Original Assignee
Mallinckrodt Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Llc filed Critical Mallinckrodt Llc
Publication of PL2440562T3 publication Critical patent/PL2440562T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
PL10724967T 2009-06-11 2010-06-10 Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru PL2440562T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18609109P 2009-06-11 2009-06-11
EP10724967.4A EP2440562B1 (en) 2009-06-11 2010-06-10 Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer

Publications (1)

Publication Number Publication Date
PL2440562T3 true PL2440562T3 (pl) 2017-07-31

Family

ID=42357348

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10724967T PL2440562T3 (pl) 2009-06-11 2010-06-10 Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru

Country Status (8)

Country Link
US (1) US8519133B2 (pl)
EP (1) EP2440562B1 (pl)
JP (2) JP5697215B2 (pl)
CN (1) CN102803267A (pl)
CA (1) CA2764915C (pl)
ES (1) ES2598496T3 (pl)
PL (1) PL2440562T3 (pl)
WO (1) WO2010144641A1 (pl)

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CN102803267A (zh) * 2009-06-11 2012-11-28 马林克罗特有限公司 通过催化氢转移的6-α-氨基N-取代的吗啡喃的制备
US8471023B2 (en) * 2009-06-11 2013-06-25 Mallinckrodt Llc Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
US10363251B2 (en) * 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
AU2010273253B2 (en) * 2009-07-16 2015-03-12 Mallinckrodt Llc (+) - morphinans as antagonists of Toll-like receptor 9 and therapeutic uses thereof
ES2642788T3 (es) 2010-05-10 2017-11-20 Euro-Celtique S.A. Fabricación de gránulos sin principio activo y de comprimidos que comprenden los mismos
AU2011252041B2 (en) 2010-05-10 2014-04-03 Euro-Celtique S.A. Combination of active loaded granules with additional actives
SG184523A1 (en) 2010-05-10 2012-11-29 Euro Celtique Sa Pharmaceutical compositions comprising hydromorphone and naloxone
ES2728701T3 (es) 2010-07-16 2019-10-28 Mallinckrodt Llc (+)-Morfinanos como antagonistas del receptor 9 de tipo Toll y aplicaciones terapéuticas de los mismos
WO2012170759A1 (en) * 2011-06-09 2012-12-13 Mallinckrodt Llc Reductive amination of 6-keto morphinans by catalytic hydrogen transfer
KR20160060768A (ko) 2013-11-13 2016-05-30 유로-셀티큐 에스.에이. 통증 및 오피오이드 장 기능장애 증후군의 치료를 위한 히드로모르폰 및 날록손
BR112017000417B1 (pt) 2014-07-10 2021-06-08 SpecGx LLC processo para preparação de fenilalcanos substituídos
WO2020205735A1 (en) * 2019-03-29 2020-10-08 Humanwell Pharmaceutical US Novel morphinans useful for treating medical disorders

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Also Published As

Publication number Publication date
JP2012529533A (ja) 2012-11-22
JP5697215B2 (ja) 2015-04-08
US8519133B2 (en) 2013-08-27
US20100317683A1 (en) 2010-12-16
EP2440562B1 (en) 2016-08-10
ES2598496T3 (es) 2017-01-27
CN102803267A (zh) 2012-11-28
JP2015057448A (ja) 2015-03-26
CA2764915A1 (en) 2010-12-16
EP2440562A1 (en) 2012-04-18
WO2010144641A1 (en) 2010-12-16
CA2764915C (en) 2017-07-11

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