ATE493416T1 - Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiaten - Google Patents

Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiaten

Info

Publication number
ATE493416T1
ATE493416T1 AT08747498T AT08747498T ATE493416T1 AT E493416 T1 ATE493416 T1 AT E493416T1 AT 08747498 T AT08747498 T AT 08747498T AT 08747498 T AT08747498 T AT 08747498T AT E493416 T1 ATE493416 T1 AT E493416T1
Authority
AT
Austria
Prior art keywords
alpha
hydroxy
producing
improved method
opiates
Prior art date
Application number
AT08747498T
Other languages
English (en)
Inventor
Christopher Grote
Peter Wang
Tao Jiang
Gary Cantrell
Frank Moser
Catherine Thomasson
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE493416T1 publication Critical patent/ATE493416T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT08747498T 2007-05-04 2008-05-02 Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiaten ATE493416T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91596207P 2007-05-04 2007-05-04
US94905507P 2007-07-11 2007-07-11
PCT/US2008/062413 WO2008137672A1 (en) 2007-05-04 2008-05-02 Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates

Publications (1)

Publication Number Publication Date
ATE493416T1 true ATE493416T1 (de) 2011-01-15

Family

ID=39561936

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08747498T ATE493416T1 (de) 2007-05-04 2008-05-02 Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiaten

Country Status (10)

Country Link
US (3) US7985858B2 (de)
EP (3) EP2152715B1 (de)
JP (1) JP2009534472A (de)
AT (1) ATE493416T1 (de)
AU (3) AU2008207580B2 (de)
CA (1) CA2637610A1 (de)
DE (1) DE602008004245D1 (de)
ES (2) ES2468415T3 (de)
MX (1) MX2008013842A (de)
WO (1) WO2008137672A1 (de)

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US9040726B2 (en) * 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
EP2328900B1 (de) 2008-08-11 2013-08-28 Tasmanian Alkaloids Pty. Ltd. VERFAHREN ZUR HERSTELLUNG VON MORPHINAN-6 alpha-OLS
ES2439015T3 (es) * 2008-09-30 2014-01-21 Mallinckrodt Llc Procedimientos de aminación selectiva de cetomorfinanos
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
PL2440561T3 (pl) * 2009-06-11 2014-09-30 SpecGx LLC Redukcyjne aminowanie 6-keto-normorfinanow przez katalityczne przeniesienie wodoru
EP2440562B1 (de) * 2009-06-11 2016-08-10 Mallinckrodt LLC Herstellung von 6-alpha-amino-n-substituierten morphinanen durch katalytischen wasserstofftransfer
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
GB0914338D0 (en) 2009-08-17 2009-09-30 Johnson Matthey Plc Improved process
BR112012007275B1 (pt) 2009-10-02 2021-08-10 Dow Global Technologies Llc Vulcanizado termoplástico e artigo
EP2580218B1 (de) 2010-06-11 2015-02-25 Rhodes Technologies Verfahren zur n-dealkylierung von tertiären aminen
CA2936749C (en) 2010-06-11 2019-07-09 Joshua R. Giguere Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
WO2012025944A2 (en) * 2010-08-27 2012-03-01 Usv Limited Sitagliptin, salts and polymorphs thereof
JP5685046B2 (ja) * 2010-10-14 2015-03-18 高砂香料工業株式会社 光学純度低下防止方法
JP2014516085A (ja) 2011-06-09 2014-07-07 マリンクロッド エルエルシー 触媒的水素移動による６−ケトモルフィナンの還元的アミノ化
WO2013065189A1 (ja) 2011-11-04 2013-05-10 高砂香料工業株式会社 光学純度低下防止方法
PL2812336T3 (pl) 2012-02-08 2017-07-31 Mallinckrodt Llc Sposób wytwarzania 6-hydroksyIowej pochodnej opiatu nal w jednym naczyniu
WO2015066443A1 (en) * 2013-11-01 2015-05-07 Mallinckrodt Llc Convenient preparation of n-substituted morphinan-6-ols from morphinan-6-ones
MX2016005187A (es) * 2013-11-07 2016-08-08 Mallinckrodt Llc Produccion de 6-hidroxi morfinanos sin el aislamiento de intermediarios.
US9701687B2 (en) * 2014-05-05 2017-07-11 Noramco, Inc. Process for the preparation of opioid compounds
US9701688B2 (en) * 2014-05-05 2017-07-11 Noramco, Inc. Process for the preparation of opioid compounds
GB201719667D0 (en) * 2017-11-27 2018-01-10 Johnson Matthey Plc Process
KR20200097309A (ko) 2017-12-12 2020-08-18 살루드 테라퓨틱스 인코포레이티드 모르피난의 할로겐화 유도체 및 그의 용도

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Also Published As

Publication number Publication date
AU2010200188B2 (en) 2012-02-02
DE602008004245D1 (de) 2011-02-10
US20100041888A1 (en) 2010-02-18
US7985858B2 (en) 2011-07-26
AU2010200191A1 (en) 2010-02-04
AU2008207580A1 (en) 2009-11-19
ES2468415T3 (es) 2014-06-16
JP2009534472A (ja) 2009-09-24
EP2180000A1 (de) 2010-04-28
WO2008137672A1 (en) 2008-11-13
EP2152715B1 (de) 2010-12-29
US8273888B2 (en) 2012-09-25
EP2189460B1 (de) 2014-04-23
US20100081818A1 (en) 2010-04-01
AU2010200188A1 (en) 2010-02-04
AU2008207580B2 (en) 2011-04-14
AU2010200191B2 (en) 2012-02-09
EP2152715A1 (de) 2010-02-17
CA2637610A1 (en) 2008-11-04
EP2180000B1 (de) 2013-03-27
MX2008013842A (es) 2009-03-06
ES2407033T3 (es) 2013-06-11
US20100113788A1 (en) 2010-05-06
US8524904B2 (en) 2013-09-03
EP2189460A1 (de) 2010-05-26

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