DK1013647T3 - Fremgangsmåde til fremstilling af N-(amino-4,6-dihalogenpyrimidin)-formamider - Google Patents

Fremgangsmåde til fremstilling af N-(amino-4,6-dihalogenpyrimidin)-formamider

Info

Publication number
DK1013647T3
DK1013647T3 DK99125042T DK99125042T DK1013647T3 DK 1013647 T3 DK1013647 T3 DK 1013647T3 DK 99125042 T DK99125042 T DK 99125042T DK 99125042 T DK99125042 T DK 99125042T DK 1013647 T3 DK1013647 T3 DK 1013647T3
Authority
DK
Denmark
Prior art keywords
diamino
dihalogenpyrimidine
formamides
amino
preparation
Prior art date
Application number
DK99125042T
Other languages
Danish (da)
English (en)
Inventor
Elie Dr Saikali
Walter Dr Brieden
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Application granted granted Critical
Publication of DK1013647T3 publication Critical patent/DK1013647T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
DK99125042T 1998-12-21 1999-12-15 Fremgangsmåde til fremstilling af N-(amino-4,6-dihalogenpyrimidin)-formamider DK1013647T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP98124188 1998-12-21
EP99100788 1999-01-18
EP99107161 1999-04-12
US14610699P 1999-07-29 1999-07-29

Publications (1)

Publication Number Publication Date
DK1013647T3 true DK1013647T3 (da) 2003-03-10

Family

ID=27443679

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99125042T DK1013647T3 (da) 1998-12-21 1999-12-15 Fremgangsmåde til fremstilling af N-(amino-4,6-dihalogenpyrimidin)-formamider

Country Status (16)

Country Link
US (2) US6271376B1 (ko)
EP (2) EP1188750B1 (ko)
JP (1) JP3543709B2 (ko)
KR (1) KR100645270B1 (ko)
CN (1) CN1156449C (ko)
AT (2) ATE252087T1 (ko)
CA (1) CA2293011C (ko)
CZ (2) CZ296753B6 (ko)
DE (2) DE59903535D1 (ko)
DK (1) DK1013647T3 (ko)
ES (2) ES2204798T3 (ko)
HU (1) HUP9904608A3 (ko)
NO (1) NO313878B1 (ko)
PL (1) PL337354A1 (ko)
PT (1) PT1013647E (ko)
SK (2) SK285222B6 (ko)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208011B2 (en) * 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US7208010B2 (en) * 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
GB2344550A (en) * 1998-12-09 2000-06-14 Ibm Pad design for electronic package
ATE387169T1 (de) 2000-10-16 2008-03-15 Conor Medsystems Inc Expandierbare medizinische vorrichtung zum zuführen eines heilmittels
US20040204756A1 (en) * 2004-02-11 2004-10-14 Diaz Stephen Hunter Absorbent article with improved liquid acquisition capacity
US7056338B2 (en) * 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
US20040249443A1 (en) * 2001-08-20 2004-12-09 Shanley John F. Expandable medical device for treating cardiac arrhythmias
AU2003234670B2 (en) * 2002-05-24 2010-06-10 Angiotech International Ag Compositions and methods for coating medical implants
WO2004043511A1 (en) * 2002-11-08 2004-05-27 Conor Medsystems, Inc. Method and apparatus for treating vulnerable artherosclerotic plaque
US20040142014A1 (en) * 2002-11-08 2004-07-22 Conor Medsystems, Inc. Method and apparatus for reducing tissue damage after ischemic injury
WO2004043509A1 (en) * 2002-11-08 2004-05-27 Conor Medsystems, Inc. Expandable medical device and method for treating chronic total occlusions with local delivery of an angiogenic factor
FR2849030A1 (fr) * 2002-12-20 2004-06-25 Isochem Sa Procede de preparation des n-(2-amino-4, 6-dihalogenopyrimidin-5-yl) formamides
US20050010170A1 (en) * 2004-02-11 2005-01-13 Shanley John F Implantable medical device with beneficial agent concentration gradient
US20040202692A1 (en) * 2003-03-28 2004-10-14 Conor Medsystems, Inc. Implantable medical device and method for in situ selective modulation of agent delivery
EP1610823B1 (en) 2003-03-28 2011-09-28 Innovational Holdings, LLC Implantable medical device with continuous agent concentration gradient
WO2004103979A1 (ja) * 2003-05-26 2004-12-02 Sumitomo Chemical Company, Limited Ｎ－（２－アミノ－４，６－ジクロロピリミジン－５－イル）ホルムアミドの製造方法
US7208596B2 (en) * 2003-11-25 2007-04-24 Bristol-Myers Squibb Pharma Company Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof
US20050287287A1 (en) * 2004-06-24 2005-12-29 Parker Theodore L Methods and systems for loading an implantable medical device with beneficial agent
CN101003511B (zh) * 2007-01-19 2010-06-09 中国科学院上海有机化学研究所 制备2-氨基-4,6-二氯-5-甲酰氨基嘧啶的方法
CZ305457B6 (cs) 2011-02-28 2015-09-30 Ústav organické chemie a biochemie, Akademie věd ČR v. v. i. Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití
WO2014023681A1 (en) * 2012-08-06 2014-02-13 Enantia, S.L. A process for the preparation of an intermediate for a triazolopyrimidine carbonucleoside
CN103936681B (zh) * 2014-04-04 2015-07-29 苏州开元民生科技股份有限公司 2-氨基-4,6-二氯-5-甲酰胺基嘧啶的制备方法
CN115536595B (zh) * 2022-11-29 2023-03-10 苏州开元民生科技股份有限公司 一种2-氨基-4,6-二氯-5-甲酰胺基嘧啶的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445293A1 (de) * 1984-12-12 1986-06-12 Bayer Ag, 5090 Leverkusen Neue 2,4-diaminopyrimidine
US4965270A (en) * 1987-05-30 1990-10-23 Beecham Group P.L.C. Purine derivatives
CN1019575B (zh) * 1988-02-19 1992-12-23 石原产业株式会社 2-氨基-4，6-二氯嘧啶的生产方法
DE3900471A1 (de) * 1989-01-10 1990-07-12 Basf Ag Verfahren zur herstellung von 2-amino-4-fluorpyrimidinderivaten
GB8916698D0 (en) * 1989-07-21 1989-09-06 Beecham Group Plc Novel process
CZ287049B6 (cs) * 1992-01-22 2000-08-16 Lonza A. G. N-5-chráněné 2,5-diamino-4,6-dichlorpyrimidiny a způsob jejich přípravy
GB9402161D0 (en) * 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
CA2145928C (en) * 1994-04-27 2007-10-09 Gerhard Stucky N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide, and a process for its preparation
AT402924B (de) * 1994-05-13 1997-09-25 Chemie Linz Gmbh Verfahren zur herstellung von 2-amino-4,6-dichloro-pyrimidin

Also Published As

Publication number Publication date
EP1013647B1 (de) 2002-11-27
CN1265393A (zh) 2000-09-06
ATE252087T1 (de) 2003-11-15
US6271376B1 (en) 2001-08-07
CZ296753B6 (cs) 2006-06-14
DE59903535D1 (de) 2003-01-09
NO313878B1 (no) 2002-12-16
KR100645270B1 (ko) 2006-11-13
JP2000191647A (ja) 2000-07-11
KR20000052540A (ko) 2000-08-25
EP1013647A3 (de) 2000-10-04
EP1013647A2 (de) 2000-06-28
SK178499A3 (en) 2000-09-12
ES2204798T3 (es) 2004-05-01
SK283681B6 (sk) 2003-11-04
PL337354A1 (en) 2000-07-03
EP1188750B1 (de) 2003-10-15
CA2293011A1 (en) 2000-06-21
SK285222B6 (sk) 2006-09-07
HUP9904608A2 (hu) 2000-08-28
PT1013647E (pt) 2003-04-30
CZ296832B6 (cs) 2006-06-14
CN1156449C (zh) 2004-07-07
ATE228508T1 (de) 2002-12-15
HU9904608D0 (en) 2000-03-28
CZ9904598A3 (cs) 2001-03-14
CA2293011C (en) 2004-08-10
NO996325D0 (no) 1999-12-20
ES2187112T3 (es) 2003-05-16
US6716981B2 (en) 2004-04-06
NO996325L (no) 2000-06-22
EP1188750A1 (de) 2002-03-20
DE59907401D1 (de) 2003-11-20
US20010031868A1 (en) 2001-10-18
JP3543709B2 (ja) 2004-07-21
HUP9904608A3 (en) 2001-03-28

Similar Documents

Publication Publication Date Title
DK1013647T3 (da) Fremgangsmåde til fremstilling af N-(amino-4,6-dihalogenpyrimidin)-formamider
AU587372B2 (en) Organic amines containing hydroxyalkyl carbamate groups and method of making the same
ATE25249T1 (de) N-phenylsulfonyl-n'-pyrimidinyl- und triazinylharnstoffe.
KR927003544A (ko) 2, 5-디아미노-4, 6-디클로로 피리미딘의 제조방법
AU8866482A (en) Oxazolo- thiazolo- imidazolo (5,4-b) pyridines
ATE108447T1 (de) Sulfonylharnstoffe als herbizide.
DK0684227T3 (da) Fremgangsmåde til fremstilling af guanidiner
ATE174912T1 (de) Diamino-s-triazinonderivate
BR9600151A (pt) Processo para a preparação de 2-cloro piridinas 5-substituídas
DE69315712D1 (de) 2,4-Diamino-1,3,5-Triazinyl-6-Phosphonsäurederivate
DK0682018T3 (da) Fremgangsmåde til fremstilling af 2-amino-4,6-dichlorpyrimidin
DK0429331T3 (da) Fremgangsmåde til fremstilling af perfluoralkylbromider
ATE233731T1 (de) Verfahren zur herstellung von arylvinylsulfonen
DE59905818D1 (de) Verfahren zur Herstellung von O-Alkylisoharnstoff
FI824298A0 (fi) N,n-disubstituerade alkenamider och fenylalkenamider, deras framstaellningsfoerfaranden och anvaendning som laekemedel
SU1496220A1 (ru) Трис(2-гидроксиэтил)аммониевые соли гетерилтиоуксусных кислот, обладающие гиполипидемическим действием
DK665087D0 (da) Fremgangsmaade til fremstilling af phosphorholdige herbicidmellemprodukter
DE59002904D1 (de) Cyclopropanthiocarbonsaeureamide.
FI821912A0 (fi) Nya dihydropyroner, foerfaranden foer deras framstaellning samt haervid anvaenda nya utgaongsproduktmedel vilka innehaoller de nya dihydropyronerna som aktivaemnen och deras anvaendning foer bekaempniav ograes