DK0984013T3 - Antiviral aktivitet og opspaltning af 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolan - Google Patents
Antiviral aktivitet og opspaltning af 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolanInfo
- Publication number
- DK0984013T3 DK0984013T3 DK99203367T DK99203367T DK0984013T3 DK 0984013 T3 DK0984013 T3 DK 0984013T3 DK 99203367 T DK99203367 T DK 99203367T DK 99203367 T DK99203367 T DK 99203367T DK 0984013 T3 DK0984013 T3 DK 0984013T3
- Authority
- DK
- Denmark
- Prior art keywords
- oxathiolane
- hydroxymethyl
- fluorocytosin
- cleavage
- antiviral activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/659,760 US5210085A (en) | 1990-02-01 | 1991-02-22 | Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds |
US73608991A | 1991-07-26 | 1991-07-26 | |
US83115392A | 1992-02-12 | 1992-02-12 | |
EP19920908027 EP0575482A1 (en) | 1991-02-22 | 1992-02-20 | Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0984013T3 true DK0984013T3 (da) | 2004-10-25 |
Family
ID=35276919
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99203367T DK0984013T3 (da) | 1991-02-22 | 1992-02-20 | Antiviral aktivitet og opspaltning af 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolan |
DK04076245.2T DK1439177T3 (da) | 1991-02-22 | 1992-02-20 | Antiviral aktivitet og genopløsning af 2-hydroxymethyl-5-(5-fluorcytosin-1-yl)-1,3-oxathiolan |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04076245.2T DK1439177T3 (da) | 1991-02-22 | 1992-02-20 | Antiviral aktivitet og genopløsning af 2-hydroxymethyl-5-(5-fluorcytosin-1-yl)-1,3-oxathiolan |
Country Status (25)
Country | Link |
---|---|
EP (3) | EP0984013B1 (ja) |
JP (2) | JP2901160B2 (ja) |
KR (1) | KR0172590B1 (ja) |
CN (4) | CN1037682C (ja) |
AT (2) | ATE469147T1 (ja) |
AU (2) | AU679649B2 (ja) |
BG (1) | BG62053B1 (ja) |
BR (1) | BR9205661A (ja) |
CA (2) | CA2513440C (ja) |
CZ (1) | CZ295074B6 (ja) |
DE (2) | DE69233379T2 (ja) |
DK (2) | DK0984013T3 (ja) |
ES (2) | ES2224547T3 (ja) |
FI (2) | FI114915B (ja) |
HK (1) | HK1026419A1 (ja) |
HU (2) | HU227823B1 (ja) |
IE (1) | IE920545A1 (ja) |
IL (1) | IL100965A (ja) |
MX (1) | MX9200747A (ja) |
MY (1) | MY114350A (ja) |
NO (3) | NO312399B1 (ja) |
NZ (2) | NZ241625A (ja) |
PT (1) | PT100151B (ja) |
RO (2) | RO119365B1 (ja) |
WO (1) | WO1992014743A2 (ja) |
Families Citing this family (75)
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US6175008B1 (en) | 1988-04-11 | 2001-01-16 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
US5466806A (en) * | 1989-02-08 | 1995-11-14 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
DK0674634T3 (da) * | 1989-02-08 | 2003-08-04 | Iaf Biochem Int | Fremgangsmåde til fremstilling af substituerede 1,3-oxathiolaner med antivirale egenskaber |
US5827727A (en) * | 1990-02-01 | 1998-10-27 | Emory University | Method of resolution of 1,3-oxathiolane nucleoside enantiomers |
US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
US5276151A (en) * | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
US5914331A (en) * | 1990-02-01 | 1999-06-22 | Emory University | Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane |
US6703396B1 (en) | 1990-02-01 | 2004-03-09 | Emory University | Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers |
US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
IL100502A (en) * | 1991-01-03 | 1995-12-08 | Iaf Biochem Int | PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (- |
ATE361293T1 (de) * | 1991-03-06 | 2007-05-15 | Univ Emory | Salze und amide von (-) cis 5-fluoro-2'-deoxy-3'- thiacytidine geeignet für die behandlung von hepatitis b |
US6812233B1 (en) | 1991-03-06 | 2004-11-02 | Emory University | Therapeutic nucleosides |
US5817667A (en) * | 1991-04-17 | 1998-10-06 | University Of Georgia Research Foudation | Compounds and methods for the treatment of cancer |
GB9110874D0 (en) * | 1991-05-20 | 1991-07-10 | Iaf Biochem Int | Medicaments |
ZA923641B (en) * | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
GB9116601D0 (en) * | 1991-08-01 | 1991-09-18 | Iaf Biochem Int | 1,3-oxathiolane nucleoside analogues |
US6177435B1 (en) | 1992-05-13 | 2001-01-23 | Glaxo Wellcome Inc. | Therapeutic combinations |
AU4079593A (en) * | 1992-05-13 | 1993-12-13 | Wellcome Foundation Limited, The | Therapeutic combinations |
GB9226927D0 (en) * | 1992-12-24 | 1993-02-17 | Iaf Biochem Int | Dideoxy nucleoside analogues |
TW374087B (en) * | 1993-05-25 | 1999-11-11 | Univ Yale | L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents |
US5627160A (en) * | 1993-05-25 | 1997-05-06 | Yale University | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents |
US20020120130A1 (en) | 1993-09-10 | 2002-08-29 | Gilles Gosselin | 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents |
WO1995007086A1 (en) * | 1993-09-10 | 1995-03-16 | Emory University | Nucleosides with anti-hepatitis b virus activity |
GB9320316D0 (en) * | 1993-10-01 | 1993-11-17 | Smithkline Beecham Plc | Pharmaceuticals |
US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
IL115156A (en) | 1994-09-06 | 2000-07-16 | Univ Georgia | Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines |
US5703058A (en) * | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
US6391859B1 (en) | 1995-01-27 | 2002-05-21 | Emory University | [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides |
US5808040A (en) * | 1995-01-30 | 1998-09-15 | Yale University | L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides |
US5869461A (en) * | 1995-03-16 | 1999-02-09 | Yale University | Reducing toxicity of L-nucleosides with D-nucleosides |
DE69636734T2 (de) * | 1995-06-07 | 2007-10-18 | Emory University | Nucleoside mit anti-hepatitis b virus wirksamkeit |
PL330747A1 (en) | 1996-06-25 | 1999-05-24 | Glaxo Group Ltd | Vx478, zidovudin, ftc and/or 3tc containing combinations for use in treating hiv infections |
US5753789A (en) * | 1996-07-26 | 1998-05-19 | Yale University | Oligonucleotides containing L-nucleosides |
CN1196701C (zh) * | 1997-03-19 | 2005-04-13 | 埃莫里大学 | 1,3-氧硒戊环核苷的合成及抗人类免疫缺陷病毒和抗乙肝病毒活性 |
IT1290447B1 (it) * | 1997-03-28 | 1998-12-03 | Zambon Spa | Derivati 1,3-ossatiolanici ad attivita' antivirale |
AU6898498A (en) | 1997-04-07 | 1998-10-30 | Triangle Pharmaceuticals, Inc. | Use of mkc-442 in combination with other antiviral agents |
US6461858B1 (en) | 1998-01-26 | 2002-10-08 | Pharm-Eco Laboratories, Inc. | Enzyme activated supports for enantiomeric separations |
DK1058686T3 (da) | 1998-02-25 | 2007-03-05 | Univ Emory | 2'-fluornukleosider |
WO2000009494A1 (en) * | 1998-08-12 | 2000-02-24 | Triangle Pharmaceuticals, Inc. | Method of manufacture of 1,3-oxathiolane nucleosides |
US6979561B1 (en) | 1998-10-09 | 2005-12-27 | Gilead Sciences, Inc. | Non-homogeneous systems for the resolution of enantiomeric mixtures |
ID30477A (id) | 1998-12-23 | 2001-12-13 | Shire Biochem Inc | Analog nukleosida antivirus |
KR100339786B1 (ko) * | 1999-04-02 | 2002-06-07 | 안용현 | 라세미 혼합물 상태로 존재하는 뉴클레오시드로부터 거울상 이성질체의 분리 방법 |
EP1600452A3 (en) | 1999-11-12 | 2008-09-10 | Pharmasset, Inc. | Synthesis of 2'-deoxy-L-nucleosides |
US6436948B1 (en) | 2000-03-03 | 2002-08-20 | University Of Georgia Research Foundation Inc. | Method for the treatment of psoriasis and genital warts |
CA2308559C (en) | 2000-05-16 | 2005-07-26 | Brantford Chemicals Inc. | 1,3-oxathiolan-5-ones useful in the production of antiviral nucleoside analogues |
PT1411954E (pt) | 2000-10-18 | 2011-03-16 | Pharmasset Inc | Nucleosídeos modificados para o tratamento de infecções virais e proliferação celular anormal |
US6828119B2 (en) * | 2001-01-04 | 2004-12-07 | Bristol Myers Squibb Company | Enzymatic deprotection of amines and hydroxides |
DE10104231A1 (de) | 2001-01-31 | 2002-08-08 | Consortium Elektrochem Ind | Verfahren zur enzymatischen Herstellung von enantiomerenreinen 1,3-Dioxolan-4-on-Derivaten |
AU2008202336B2 (en) * | 2001-03-01 | 2011-11-10 | Abbvie Inc. | Polymorphic and other crystalline forms of cis-FTC |
CN1503796B (zh) | 2001-03-01 | 2012-07-04 | 三角药品公司 | 顺-ftc的多晶型物及其它晶型 |
CN1329407C (zh) | 2002-04-12 | 2007-08-01 | 阿奇林医药品公司 | 合成β-L-5-氟-2′,3′-双脱氧-2′,3′-双脱氢胞嘧啶核苷的方法 |
WO2004048590A1 (en) * | 2002-11-18 | 2004-06-10 | Shire Biochem Inc. | Stereoselective process for the production of dioxolane nucleoside analogues |
WO2004064846A1 (en) | 2003-01-14 | 2004-08-05 | Gilead Sciences, Inc. | Compositions and methods for combination antiviral therapy |
ITMI20030578A1 (it) * | 2003-03-24 | 2004-09-25 | Clariant Lsm Italia Spa | Processo ed intermedi per la preparazione di emtricitabina |
CA2599825C (en) * | 2005-03-14 | 2012-06-19 | Shire Biochem Inc. | Process and methods for the preparation of optically active cis-2-hydroxymethyl-4-(cytosin-1'-yl)-1,3-oxathiolane or pharmaceutically acceptable salts thereof |
TWI375560B (en) | 2005-06-13 | 2012-11-01 | Gilead Sciences Inc | Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same |
TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
AU2008219622A1 (en) | 2007-02-28 | 2008-09-04 | Conatus Pharmaceuticals, Inc. | Methods for the treatment of liver diseases using specified matrix metalloproteinase (MMP) inhibitors |
CN101328171A (zh) | 2007-06-18 | 2008-12-24 | 张中能 | 一种溴苯基-取代的噻唑二氢嘧啶 |
US8350030B2 (en) | 2007-12-07 | 2013-01-08 | Matrix Laboratories Limited | Process for producing 5-fluoro-1-(2R, 5S)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine |
JPWO2009107692A1 (ja) | 2008-02-29 | 2011-07-07 | 株式会社カネカ | 2’−水酸基が保護されたリボヌクレオシド誘導体およびその製造方法 |
CL2009002208A1 (es) | 2008-12-23 | 2010-10-29 | Gilead Pharmasset Llc | Un compuesto (2s)-2-((((2r,3r,4r,5r)-5-(2-amino-6-etoxi-9h-purin-9-il)-4-fluoro-3-hidroxi-4-metiltetrahidrofuran-2-il)metoxi)(hidroxi)fosforilamino)propanoico, inhibidores de la replicacion de arn viral; composicion farmaceutica; y su uso en el tratamiento de infeccion por hepatitis c, virus del nilo occidental, entre otras. |
KR20110104074A (ko) | 2008-12-23 | 2011-09-21 | 파마셋 인코포레이티드 | 퓨린 뉴클레오시드의 합성 |
SG172359A1 (en) | 2008-12-23 | 2011-07-28 | Pharmasset Inc | Nucleoside phosphoramidates |
EP2377862A1 (en) | 2010-03-29 | 2011-10-19 | Esteve Química, S.A. | Process for obtaining emtricitabine |
KR101715981B1 (ko) | 2010-03-31 | 2017-03-13 | 길리애드 파마셋 엘엘씨 | 뉴클레오사이드 포스포르아미데이트 |
SG10201912527XA (en) | 2010-11-19 | 2020-02-27 | Gilead Sciences Inc | Therapeutic compositions comprising rilpivirine hcl and tenofovir disoproxil fumarate |
WO2013167743A1 (en) | 2012-05-11 | 2013-11-14 | Akron Molecules Gmbh | Use of compounds for the treatment of pain |
JP2015536940A (ja) | 2012-10-29 | 2015-12-24 | シプラ・リミテッド | 抗ウイルス性ホスホネート類似体及びその製造方法 |
CN102911167B (zh) * | 2012-11-09 | 2014-06-25 | 合肥工业大学 | 一种高光学纯度的核苷类中间体的制备方法 |
CN104059057A (zh) * | 2014-01-03 | 2014-09-24 | 石家庄龙泽制药有限公司 | 拉米夫定杂质3-tu的制备方法 |
CN108285895B (zh) * | 2018-01-26 | 2020-06-23 | 中国科学院南海海洋研究所 | 一种酯酶EstC11及其编码基因和应用 |
KR102069443B1 (ko) | 2018-08-31 | 2020-01-22 | (주)대한뷰티산업진흥원 | 울금, 비트 및 무 추출물을 포함하는 바이오셀룰로오스 및 이의 제조방법 |
US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
US20230271993A1 (en) * | 2020-07-14 | 2023-08-31 | Sichuan University | 3-deoxy-2-ketoaldonic acid nitrogen-containing derivative, preparation method thereof, and use thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4914028A (en) * | 1988-02-10 | 1990-04-03 | Eli Lilly And Company | Method of preparing beta-2',2'-difluoronucleosides |
US5047407A (en) * | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
CA2095613C (en) * | 1990-11-13 | 2001-01-02 | Bernard Belleau | Substituted 1, 3-oxathiolanes and substituted 1, 3-dithiolanes with antiviral properties |
ATE361293T1 (de) | 1991-03-06 | 2007-05-15 | Univ Emory | Salze und amide von (-) cis 5-fluoro-2'-deoxy-3'- thiacytidine geeignet für die behandlung von hepatitis b |
-
1992
- 1992-02-17 NZ NZ241625A patent/NZ241625A/en not_active IP Right Cessation
- 1992-02-17 IL IL10096592A patent/IL100965A/en not_active IP Right Cessation
- 1992-02-17 NZ NZ250842A patent/NZ250842A/en not_active IP Right Cessation
- 1992-02-20 RO RO93-01137A patent/RO119365B1/ro unknown
- 1992-02-20 DE DE69233379T patent/DE69233379T2/de not_active Expired - Lifetime
- 1992-02-20 AT AT04076245T patent/ATE469147T1/de active
- 1992-02-20 DE DE69233786T patent/DE69233786D1/de not_active Expired - Lifetime
- 1992-02-20 CA CA2513440A patent/CA2513440C/en not_active Expired - Lifetime
- 1992-02-20 EP EP99203367A patent/EP0984013B1/en not_active Expired - Lifetime
- 1992-02-20 JP JP4507549A patent/JP2901160B2/ja not_active Expired - Lifetime
- 1992-02-20 EP EP19920908027 patent/EP0575482A1/en not_active Ceased
- 1992-02-20 CA CA002104399A patent/CA2104399C/en not_active Expired - Lifetime
- 1992-02-20 DK DK99203367T patent/DK0984013T3/da active
- 1992-02-20 ES ES99203367T patent/ES2224547T3/es not_active Expired - Lifetime
- 1992-02-20 KR KR1019930702516A patent/KR0172590B1/ko not_active IP Right Cessation
- 1992-02-20 CZ CS1992497A patent/CZ295074B6/cs not_active IP Right Cessation
- 1992-02-20 ES ES04076245T patent/ES2345102T3/es not_active Expired - Lifetime
- 1992-02-20 RO ROA200400584A patent/RO122814B1/ro unknown
- 1992-02-20 HU HU9302377A patent/HU227823B1/hu active Protection Beyond IP Right Term
- 1992-02-20 DK DK04076245.2T patent/DK1439177T3/da active
- 1992-02-20 AT AT99203367T patent/ATE270291T1/de active
- 1992-02-20 EP EP04076245A patent/EP1439177B1/en not_active Expired - Lifetime
- 1992-02-20 BR BR9205661A patent/BR9205661A/pt not_active Application Discontinuation
- 1992-02-20 WO PCT/US1992/001339 patent/WO1992014743A2/en active IP Right Grant
- 1992-02-21 IE IE054592A patent/IE920545A1/en not_active Application Discontinuation
- 1992-02-21 PT PT100151A patent/PT100151B/pt not_active IP Right Cessation
- 1992-02-21 MY MYPI92000287A patent/MY114350A/en unknown
- 1992-02-21 MX MX9200747A patent/MX9200747A/es active IP Right Grant
- 1992-02-22 CN CN92101981A patent/CN1037682C/zh not_active Expired - Lifetime
-
1993
- 1993-08-20 NO NO19932980A patent/NO312399B1/no active IP Right Maintenance
- 1993-08-20 BG BG98062A patent/BG62053B1/bg unknown
- 1993-08-20 FI FI933684A patent/FI114915B/fi not_active IP Right Cessation
-
1995
- 1995-06-28 HU HU95P/P00510P patent/HU211344A9/hu unknown
- 1995-08-18 CN CN95109814A patent/CN1109108C/zh not_active Expired - Lifetime
- 1995-11-20 AU AU37943/95A patent/AU679649B2/en not_active Withdrawn - After Issue
-
1997
- 1997-11-06 JP JP34046997A patent/JP3292830B2/ja not_active Expired - Lifetime
-
1998
- 1998-05-15 CN CN98108905A patent/CN1084745C/zh not_active Expired - Lifetime
- 1998-08-17 AU AU80773/98A patent/AU8077398A/en not_active Abandoned
- 1998-12-28 HK HK00105566A patent/HK1026419A1/xx not_active IP Right Cessation
-
2002
- 2002-09-30 CN CNB021440336A patent/CN100396785C/zh not_active Expired - Lifetime
-
2003
- 2003-06-24 FI FI20030932A patent/FI20030932A/fi unknown
-
2005
- 2005-07-01 NO NO2005015C patent/NO2005015I2/no not_active Application Discontinuation
-
2008
- 2008-06-13 NO NO2008010C patent/NO2008010I1/no unknown
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