DK0964856T3 - Bicycliske aromatiske aminosyrer - Google Patents

Bicycliske aromatiske aminosyrer

Info

Publication number
DK0964856T3
DK0964856T3 DK98908063T DK98908063T DK0964856T3 DK 0964856 T3 DK0964856 T3 DK 0964856T3 DK 98908063 T DK98908063 T DK 98908063T DK 98908063 T DK98908063 T DK 98908063T DK 0964856 T3 DK0964856 T3 DK 0964856T3
Authority
DK
Denmark
Prior art keywords
amino acids
aromatic amino
bicyclic aromatic
bicyclic
acids
Prior art date
Application number
DK98908063T
Other languages
Danish (da)
English (en)
Inventor
Simon Goodman
Joachim Maerz
Peter Raddatz
Friedrich Rippmann
Matthias Wiesner
Beate Diefenbach
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK0964856T3 publication Critical patent/DK0964856T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK98908063T 1997-02-13 1998-02-06 Bicycliske aromatiske aminosyrer DK0964856T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19705450A DE19705450A1 (de) 1997-02-13 1997-02-13 Bicyclische aromatische Aminosäuren
PCT/EP1998/000636 WO1998035949A1 (de) 1997-02-13 1998-02-06 Bicyclische aromatische aminosäuren

Publications (1)

Publication Number Publication Date
DK0964856T3 true DK0964856T3 (da) 2003-02-10

Family

ID=7820093

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98908063T DK0964856T3 (da) 1997-02-13 1998-02-06 Bicycliske aromatiske aminosyrer

Country Status (25)

Country Link
EP (1) EP0964856B1 (cs)
JP (1) JP4327257B2 (cs)
KR (1) KR20000071030A (cs)
CN (1) CN1085205C (cs)
AR (1) AR010894A1 (cs)
AT (1) ATE225776T1 (cs)
AU (1) AU735313B2 (cs)
BR (1) BR9807345A (cs)
CA (1) CA2280727C (cs)
CY (1) CY2341B1 (cs)
CZ (1) CZ297366B6 (cs)
DE (2) DE19705450A1 (cs)
DK (1) DK0964856T3 (cs)
ES (1) ES2183332T3 (cs)
HU (1) HUP0001138A3 (cs)
ID (1) ID22533A (cs)
NO (1) NO313289B1 (cs)
PL (1) PL335101A1 (cs)
PT (1) PT964856E (cs)
RU (1) RU2187506C2 (cs)
SI (1) SI0964856T1 (cs)
SK (1) SK284646B6 (cs)
TR (1) TR199901962T2 (cs)
WO (1) WO1998035949A1 (cs)
ZA (1) ZA981178B (cs)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040063790A1 (en) * 1996-05-31 2004-04-01 The Scripps Research Institute Methods for inhibition of angiogenesis
EP1074543B1 (en) 1998-04-09 2012-01-25 Meiji Seika Pharma Co., Ltd. Aminopiperidine derivatives as integrin alpha v beta 3 antagonists
EP1171435A2 (de) 1999-04-13 2002-01-16 Basf Aktiengesellschaft Pyrimidin-2-on derivate als integrinrezeptorliganden
WO2001010844A1 (fr) 1999-08-05 2001-02-15 Meiji Seika Kaisha, Ltd. DERIVES D'ACIDE φ-AMINO-α-HYDROXYCARBOXYLIQUE POSSEDANT UN ANTAGONISME αvβ3 D'INTEGRINE
US20030199571A1 (en) * 1999-12-24 2003-10-23 Gordon Bruton (Hetero) Bicyclymethanesulfonylamino-substituted hydroxamic acid derivatives
US6617461B2 (en) * 2000-01-25 2003-09-09 Kaneka Corporation Process for preparation of optically active N-substituted azetidine-2-carboxylic acids
SK5902003A3 (en) 2000-11-01 2003-08-05 Merck Patent Gmbh Methods and compositions for the treatment of diseases of the eye
CN100571772C (zh) * 2000-11-01 2009-12-23 默克专利有限公司 整联蛋白受体αvβ3和/或αvβ5的拮抗剂在制备用于治疗眼疾的药物中的用途
CA2449054C (en) 2001-05-30 2011-01-04 The Scripps Research Institute Integrin targeting liposome for nucleic acid delivery
CN1536998A (zh) * 2001-08-01 2004-10-13 Ĭ��ר�����޹�˾ 用于治疗眼病的整联蛋白抑制剂
KR20040091002A (ko) * 2002-02-14 2004-10-27 메르크 파텐트 게엠베하 안질환을 치료하기 위한 방법 및 조성물
FR2847254B1 (fr) * 2002-11-19 2005-01-28 Aventis Pharma Sa Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant
DE10305784A1 (de) * 2003-02-12 2004-08-26 Merck Patent Gmbh Verfahren zur Herstellug bicyclischer aromatischer Aminosäuren sowie deren Zwischenprodukte
DE10337863A1 (de) 2003-08-18 2005-03-17 Merck Patent Gmbh Verwendung von Chromen-4-on-Derivaten
DK2484365T3 (da) * 2004-06-04 2013-12-02 Scripps Research Inst Sammensætninger og fremgangsmåde til behandling af neovaskulære sygdomme
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
TWI436986B (zh) * 2008-12-26 2014-05-11 Dainippon Sumitomo Pharma Co 新穎之２環性雜環化合物
WO2011024987A1 (ja) * 2009-08-31 2011-03-03 塩野義製薬株式会社 芳香族縮合へテロ環誘導体およびそれらを含有する医薬組成物
CA2866471A1 (en) 2012-03-06 2013-09-12 Boehringer Ingelheim International Gmbh Benzodioxanes in combination with other actives for inhibiting leukotriene production
JP6256467B2 (ja) 2012-07-17 2018-01-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成を阻害するピラゾール誘導体
JP2016523982A (ja) 2013-07-15 2016-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成の阻害剤
WO2015009609A1 (en) 2013-07-15 2015-01-22 Boehringer Ingelheim International Gmbh Inhibitors of leukotriene production
EP3148587B1 (en) 2014-05-30 2021-02-24 Pfizer Inc Carbonitrile derivatives as selective androgen receptor modulators
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators
EP4426284A4 (en) 2021-11-01 2025-11-12 Alkahest Inc Benzodioxane Leukotriene A4 Hydrolase (LTA4H) Modulators for the Prevention and Treatment of Age-Related Diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3151690A1 (de) * 1981-12-29 1983-07-07 Hoechst Ag, 6230 Frankfurt "neue derivate bicyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung"
FR2674854B1 (fr) * 1991-04-04 1995-03-03 Bouchara Nouvelles quinolones leur procede de preparation et les compositions pharmaceutiques en refermant.
WO1994012181A1 (en) * 1992-12-01 1994-06-09 Merck & Co., Inc. Fibrinogen receptor antagonists
CA2190870A1 (en) * 1994-05-27 1995-12-07 George D. Hartman Compounds for inhibiting osteoclast-mediated bone resorption
DE19548709A1 (de) * 1995-12-23 1997-07-03 Merck Patent Gmbh Tyrosinderivate
DE19654483A1 (de) * 1996-06-28 1998-01-02 Merck Patent Gmbh Phenylalanin-Derivate
WO1998000395A1 (de) * 1996-06-28 1998-01-08 Merck Patent Gmbh Phenylalanin-derivate als integrin-inhibitoren

Also Published As

Publication number Publication date
CZ297366B6 (cs) 2006-11-15
JP2001511789A (ja) 2001-08-14
SI0964856T1 (en) 2003-04-30
CA2280727A1 (en) 1998-08-20
CA2280727C (en) 2008-05-06
WO1998035949A1 (de) 1998-08-20
ATE225776T1 (de) 2002-10-15
PT964856E (pt) 2003-02-28
CN1252064A (zh) 2000-05-03
BR9807345A (pt) 2000-03-21
EP0964856B1 (de) 2002-10-09
EP0964856A1 (de) 1999-12-22
AR010894A1 (es) 2000-07-12
KR20000071030A (ko) 2000-11-25
JP4327257B2 (ja) 2009-09-09
NO993901L (no) 1999-10-12
NO993901D0 (no) 1999-08-12
HUP0001138A2 (hu) 2001-05-28
HUP0001138A3 (en) 2002-10-28
DE19705450A1 (de) 1998-08-20
ZA981178B (en) 1999-05-21
RU2187506C2 (ru) 2002-08-20
DE59805895D1 (de) 2002-11-14
AU735313B2 (en) 2001-07-05
CZ287599A3 (cs) 1999-11-17
CN1085205C (zh) 2002-05-22
ID22533A (id) 1999-10-28
CY2341B1 (en) 2004-02-06
PL335101A1 (en) 2000-04-10
NO313289B1 (no) 2002-09-09
AU6620698A (en) 1998-09-08
TR199901962T2 (xx) 1999-12-21
ES2183332T3 (es) 2003-03-16
SK107199A3 (en) 2000-05-16
SK284646B6 (sk) 2005-08-04

Similar Documents

Publication Publication Date Title
DK0964856T3 (da) Bicycliske aromatiske aminosyrer
DK0877018T3 (da) Sulfonylaminocarboxylsyrer
NO20002990L (no) Nytt overflateprotein
NO2010013I1 (no) Rekombinant FSH-CTP
DE69841226D1 (de) Mehrfach substituierte protease Varianten
NO985680L (no) Peptidderivater
NO980692D0 (no) Bryter
NO983849D0 (no) Peptidderivater
DE59803277D1 (de) Schalter
DE59804564D1 (de) Flachstrahler
DE59809916D1 (de) Flachstrahler
TR199701666A3 (tr) Sismanliga karsi proteinler
FI974049A7 (fi) Kytkin
DE69813719D1 (de) Schalter
FR2759452B3 (fr) Fontaines pyro-aquatiques
FI973099A0 (fi) Installationsanordning hos balkongglasering
DE59806788D1 (de) Lauflichtanlage
DE69802830D1 (de) Aromatische substituierte naphtopyranen
DK1017798T3 (da) Lunasinpeptider
NO20000976D0 (no) Peptider
KR980004878U (ko) 회전식 광고 게시대
FI970511A0 (fi) Lutbart plan
FI3265U1 (fi) Liitäntäkeskus
DK0918991T3 (da) Assayfremgangsmåde