AR010894A1 - Aminoacidos aromaticos biciclicos, un procedimiento para prepararlos, preparaciones farmaceuticas que lo contienen y el empleo de los mismos parapreparar un medicamento que actua como inhibidor de la integrina. - Google Patents

Aminoacidos aromaticos biciclicos, un procedimiento para prepararlos, preparaciones farmaceuticas que lo contienen y el empleo de los mismos parapreparar un medicamento que actua como inhibidor de la integrina.

Info

Publication number
AR010894A1
AR010894A1 ARP980100654A ARP980100654A AR010894A1 AR 010894 A1 AR010894 A1 AR 010894A1 AR P980100654 A ARP980100654 A AR P980100654A AR P980100654 A ARP980100654 A AR P980100654A AR 010894 A1 AR010894 A1 AR 010894A1
Authority
AR
Argentina
Prior art keywords
prepare
contain
pharmaceutical preparations
acts
procedure
Prior art date
Application number
ARP980100654A
Other languages
English (en)
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of AR010894A1 publication Critical patent/AR010894A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

El invento se refiere a los compuestos de formula (I), en donde X, Y, R1, R2, R3, R4, R5, R7, R8, R11, m y n tienen los significados indicados en lareivindicaion 1, y a sus sales aceptables desde el punto de vista fisiologico. El invento tambiense refiere a un procedimiento para preparar estos compuestos,a las preparaciones farmacéuticas que contienen y al empleo de los mismos en calidad de inhibidores de la integrina, en particular para la profilaxis y eltratamiento de las enfermedadesdel sistema circulatorio, de trombosis, infarto de miocardio, enfermedades coronarias, arterioscleorosis, osteoporosis, procesospatologicos que se mantienen o se propagan por angiogenesis y en la terapia de los tumores.
ARP980100654A 1997-02-13 1998-02-13 Aminoacidos aromaticos biciclicos, un procedimiento para prepararlos, preparaciones farmaceuticas que lo contienen y el empleo de los mismos parapreparar un medicamento que actua como inhibidor de la integrina. AR010894A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19705450A DE19705450A1 (de) 1997-02-13 1997-02-13 Bicyclische aromatische Aminosäuren

Publications (1)

Publication Number Publication Date
AR010894A1 true AR010894A1 (es) 2000-07-12

Family

ID=7820093

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980100654A AR010894A1 (es) 1997-02-13 1998-02-13 Aminoacidos aromaticos biciclicos, un procedimiento para prepararlos, preparaciones farmaceuticas que lo contienen y el empleo de los mismos parapreparar un medicamento que actua como inhibidor de la integrina.

Country Status (25)

Country Link
EP (1) EP0964856B1 (es)
JP (1) JP4327257B2 (es)
KR (1) KR20000071030A (es)
CN (1) CN1085205C (es)
AR (1) AR010894A1 (es)
AT (1) ATE225776T1 (es)
AU (1) AU735313B2 (es)
BR (1) BR9807345A (es)
CA (1) CA2280727C (es)
CY (1) CY2341B1 (es)
CZ (1) CZ297366B6 (es)
DE (2) DE19705450A1 (es)
DK (1) DK0964856T3 (es)
ES (1) ES2183332T3 (es)
HU (1) HUP0001138A3 (es)
ID (1) ID22533A (es)
NO (1) NO313289B1 (es)
PL (1) PL335101A1 (es)
PT (1) PT964856E (es)
RU (1) RU2187506C2 (es)
SI (1) SI0964856T1 (es)
SK (1) SK284646B6 (es)
TR (1) TR199901962T2 (es)
WO (1) WO1998035949A1 (es)
ZA (1) ZA981178B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040063790A1 (en) * 1996-05-31 2004-04-01 The Scripps Research Institute Methods for inhibition of angiogenesis
ATE542797T1 (de) 1998-04-09 2012-02-15 Meiji Seika Pharma Co Ltd Aminopiperidinderivate als integrin alpha v beta 3 antagonisten
TR200102944T2 (tr) 1999-04-13 2002-08-21 Basf Aktiengesellschaft İntegrin reseptör ligandları
AU6316900A (en) 1999-08-05 2001-03-05 Meiji Seika Kaisha Ltd. Omega-amino-alpha-hydroxycarboxylic acid derivatives having integrin alphavbeta3antagonism
US20030199571A1 (en) * 1999-12-24 2003-10-23 Gordon Bruton (Hetero) Bicyclymethanesulfonylamino-substituted hydroxamic acid derivatives
US6617461B2 (en) * 2000-01-25 2003-09-09 Kaneka Corporation Process for preparation of optically active N-substituted azetidine-2-carboxylic acids
ATE415163T1 (de) * 2000-11-01 2008-12-15 Merck Patent Gmbh Verfahren und zusammensetzungen zur behandlung von augenerkrankungen
CN100384480C (zh) 2001-05-30 2008-04-30 斯克里普斯研究学院 核酸传递系统
RU2311177C2 (ru) * 2001-08-01 2007-11-27 Мерк Патент Гмбх Ингибиторы интегрина для лечения заболевания глаз
JP2005517038A (ja) * 2002-02-14 2005-06-09 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 眼疾患を治療するための方法および組成物
DE10305784A1 (de) * 2003-02-12 2004-08-26 Merck Patent Gmbh Verfahren zur Herstellug bicyclischer aromatischer Aminosäuren sowie deren Zwischenprodukte
DE10337863A1 (de) 2003-08-18 2005-03-17 Merck Patent Gmbh Verwendung von Chromen-4-on-Derivaten
PL1765362T3 (pl) * 2004-06-04 2012-08-31 Scripps Research Inst Kompozycje i sposoby do leczenia chorób związanych z neowaskularyzacją
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
PT2380881T (pt) * 2008-12-26 2017-04-18 Sumitomo Dainippon Pharma Co Ltd Novo composto heterocíclico bicíclico
WO2011024987A1 (ja) * 2009-08-31 2011-03-03 塩野義製薬株式会社 芳香族縮合へテロ環誘導体およびそれらを含有する医薬組成物
AU2013229560A1 (en) 2012-03-06 2014-08-28 Boehringer Ingelheim International Gmbh Benzodioxanes in combination with other actives for inhibiting leukotriene production
JP6256467B2 (ja) 2012-07-17 2018-01-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成を阻害するピラゾール誘導体
WO2015009609A1 (en) 2013-07-15 2015-01-22 Boehringer Ingelheim International Gmbh Inhibitors of leukotriene production
WO2015009611A1 (en) 2013-07-15 2015-01-22 Boehringer Ingelheim International Gmbh Inhibitors of leukotriene production
BR112016027778A2 (pt) 2014-05-30 2017-08-15 Pfizer Usos de derivados de carbonitrila, sua combinação e sua composição farmacêutica
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators
CA3221177A1 (en) 2021-11-01 2023-05-04 Meghan Kerrisk Campbell Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU675689B2 (en) * 1992-12-01 1997-02-13 Merck & Co., Inc. Fibrinogen receptor antagonists
ES2186720T3 (es) * 1994-05-27 2003-05-16 Merck & Co Inc Composiciones para inhibir la reabsorcion osea mediada por osteoclastos.
DE19548709A1 (de) * 1995-12-23 1997-07-03 Merck Patent Gmbh Tyrosinderivate
DE19654483A1 (de) * 1996-06-28 1998-01-02 Merck Patent Gmbh Phenylalanin-Derivate
JP2000516575A (ja) * 1996-06-28 2000-12-12 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング インテグリンインヒビターとしてのフェニルアラニン誘導体

Also Published As

Publication number Publication date
EP0964856B1 (de) 2002-10-09
ATE225776T1 (de) 2002-10-15
JP2001511789A (ja) 2001-08-14
EP0964856A1 (de) 1999-12-22
DK0964856T3 (da) 2003-02-10
ZA981178B (en) 1999-05-21
AU6620698A (en) 1998-09-08
RU2187506C2 (ru) 2002-08-20
CN1252064A (zh) 2000-05-03
SK107199A3 (en) 2000-05-16
CY2341B1 (en) 2004-02-06
CZ297366B6 (cs) 2006-11-15
WO1998035949A1 (de) 1998-08-20
KR20000071030A (ko) 2000-11-25
DE19705450A1 (de) 1998-08-20
CA2280727A1 (en) 1998-08-20
PT964856E (pt) 2003-02-28
ID22533A (id) 1999-10-28
NO993901D0 (no) 1999-08-12
CN1085205C (zh) 2002-05-22
AU735313B2 (en) 2001-07-05
SK284646B6 (sk) 2005-08-04
NO313289B1 (no) 2002-09-09
ES2183332T3 (es) 2003-03-16
JP4327257B2 (ja) 2009-09-09
BR9807345A (pt) 2000-03-21
HUP0001138A3 (en) 2002-10-28
TR199901962T2 (xx) 1999-12-21
CA2280727C (en) 2008-05-06
SI0964856T1 (en) 2003-04-30
PL335101A1 (en) 2000-04-10
NO993901L (no) 1999-10-12
CZ287599A3 (cs) 1999-11-17
DE59805895D1 (de) 2002-11-14
HUP0001138A2 (hu) 2001-05-28

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