DK0960105T3 - Benzofurazanforbindelser, der foröger AMPA-receptoraktivitet - Google Patents
Benzofurazanforbindelser, der foröger AMPA-receptoraktivitetInfo
- Publication number
- DK0960105T3 DK0960105T3 DK98906358T DK98906358T DK0960105T3 DK 0960105 T3 DK0960105 T3 DK 0960105T3 DK 98906358 T DK98906358 T DK 98906358T DK 98906358 T DK98906358 T DK 98906358T DK 0960105 T3 DK0960105 T3 DK 0960105T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- ampa receptor
- receptor activity
- receptors
- ampa
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Luminescent Compositions (AREA)
- Furan Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/800,108 US6110935A (en) | 1997-02-13 | 1997-02-13 | Benzofurazan compounds for enhancing glutamatergic synaptic responses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0960105T3 true DK0960105T3 (da) | 2004-08-30 |
Family
ID=25177504
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98906358T DK0960105T3 (da) | 1997-02-13 | 1998-02-13 | Benzofurazanforbindelser, der foröger AMPA-receptoraktivitet |
| DK04075259T DK1428534T3 (da) | 1997-02-13 | 1998-02-13 | Benzofurazanderivater til forögelse af glutaminerge synaptiske responser |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04075259T DK1428534T3 (da) | 1997-02-13 | 1998-02-13 | Benzofurazanderivater til forögelse af glutaminerge synaptiske responser |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US6110935A (https=) |
| EP (2) | EP0960105B1 (https=) |
| JP (1) | JP4446023B2 (https=) |
| KR (1) | KR100544295B1 (https=) |
| CN (1) | CN1085206C (https=) |
| AT (2) | ATE266649T1 (https=) |
| AU (1) | AU737802C (https=) |
| BR (1) | BR9807333B1 (https=) |
| CA (1) | CA2279319C (https=) |
| CZ (1) | CZ299765B6 (https=) |
| DE (2) | DE69823803T2 (https=) |
| DK (2) | DK0960105T3 (https=) |
| ES (2) | ES2264078T3 (https=) |
| GB (1) | GB2325225B (https=) |
| HU (1) | HUP0002303A3 (https=) |
| ID (1) | ID22342A (https=) |
| IL (1) | IL131200A (https=) |
| NO (1) | NO318935B1 (https=) |
| NZ (1) | NZ336980A (https=) |
| PL (1) | PL199135B1 (https=) |
| PT (2) | PT960105E (https=) |
| RU (1) | RU2189984C2 (https=) |
| TR (1) | TR199901941T2 (https=) |
| WO (1) | WO1998035950A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN188837B (https=) | 1998-05-22 | 2002-11-09 | Torrent Pharmaceuticals Ltd | |
| AU2002366756A1 (en) * | 2001-12-20 | 2003-07-09 | Alangudi Sankaranarayanan | Use of benzofuroxan derivatives as antiplatelet agents |
| KR20050094840A (ko) * | 2003-01-13 | 2005-09-28 | 코텍스 파마슈티칼스, 인크. | 수면 부족 및 스트레스로 인한 인식 저하의 치료방법 |
| WO2004103994A1 (en) * | 2003-05-23 | 2004-12-02 | Basilea Pharmaceutica Ag | Furazanobenzimidazoles |
| US20050228019A1 (en) * | 2004-01-26 | 2005-10-13 | Cortex Pharmaceuticals, Inc. | Enhancement of ampakine-Induced facilitation of synaptic responses by cholinesterase inhibitors |
| CN101600436A (zh) * | 2006-08-31 | 2009-12-09 | 艾伯塔大学校董 | 使用正变构ampa受体调节剂抑制呼吸抑制的方法 |
| BRPI0720323A2 (pt) * | 2007-01-03 | 2016-08-09 | Cortex Pharma Inc | composto, método de tratamento, composição farmacêutica e uso do composto |
| GEP20125438B (en) * | 2007-01-03 | 2012-03-26 | Servier Lab | 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses |
| WO2008143963A1 (en) * | 2007-05-17 | 2008-11-27 | Cortex Pharmaceuticals, Inc. | Di-substituted amides for enhancing glutamatergic synaptic responses |
| CA2695742C (en) | 2007-08-10 | 2012-11-27 | Rudolf Mueller | Bicyclic amides for enhancing glutamatergic synaptic responses |
| US8119632B2 (en) | 2007-08-10 | 2012-02-21 | Cortex Pharmaceuticals, Inc. | Bicyclic amide derivatives for enhancing glutamatergic synaptic responses |
| US8071914B2 (en) * | 2007-12-26 | 2011-12-06 | Noboru Oshima | Heating apparatus |
| WO2010054336A2 (en) * | 2008-11-10 | 2010-05-14 | The Regents Of The University Of California | Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction |
| CA2751285A1 (en) * | 2009-02-02 | 2010-08-05 | Cortex Pharmaceuticals, Inc. Eveleth, Gary S. Lynch) | Bicyclic amide derivatives for enhancing glutamatergic synaptic responses |
| US20130058915A1 (en) | 2010-03-02 | 2013-03-07 | Children's Medica Center Corporation | Methods and compositions for treatment of angelman syndrome and autism spectrum disorders |
| US20110257186A1 (en) * | 2010-04-15 | 2011-10-20 | Staubli Ursula V | Compositions and methods for treating visual disorders |
| EP2801377B1 (en) | 2011-03-04 | 2019-08-07 | The Regents of The University of California | Hydrogel comprising cells for local release of growth factors to mediate motor recovery after stroke |
| CN102633731B (zh) * | 2012-03-13 | 2014-04-30 | 四川大学华西医院 | 6-喹喔啉甲酸酰胺化合物、制备方法和应用 |
| KR101421032B1 (ko) * | 2012-12-28 | 2014-07-22 | 주식회사 레고켐 바이오사이언스 | (2-메틸-1-(3-메틸벤질)-1Ｈ-벤조[d]이미다졸-5일)(피페리딘-5-일)메탄온의 제조방법 |
| EP3008167A4 (en) | 2013-06-13 | 2017-06-07 | VeroScience LLC | Compositions and methods for treating metabolic disorders |
| EP3436021A4 (en) | 2016-03-29 | 2019-11-06 | RespireRx Pharmaceuticals Inc. | COMPOSITIONS AND METHODS FOR TREATING ATTENTION DEFICIT DISORDER |
| CN107286114B (zh) | 2016-04-13 | 2020-08-18 | 中国人民解放军军事医学科学院毒物药物研究所 | Ampa受体增效剂的脑靶向前药及其医药用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3981864A (en) * | 1973-09-08 | 1976-09-21 | Eisai Co., Ltd. | 1,3-Benzodioxol derivatives |
| FR2499991A1 (fr) * | 1981-02-19 | 1982-08-20 | Sandoz Sa | Nouveaux 2,1,3-benzothiadiazoles et 2,1,3-benzoxadiazoles, leur preparation et leur application comme medicaments |
| US4420485A (en) * | 1982-09-29 | 1983-12-13 | Hoechst-Roussel Pharmaceuticals Inc. | 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines] |
| SU1657189A1 (ru) * | 1988-05-23 | 1991-06-23 | Научно-Исследовательский Институт Экспериментальной Медицины Амн Ссср | Способ коррекции апато-абулических состо ний при шизофрении |
| SU1587050A1 (ru) * | 1988-12-23 | 1990-08-23 | Институт медицинской паразитологии и тропической медицины им.Е.И.Марциновского | Производные (7-бромбензо-2,1,3-тиадиазол-4-сульфонил)амина в качестве промежуточных продуктов в синтезе 2-[(7-бромбензо-2,1,3-тиадиазол-4-сульфонил)амино]-5-бром-N-(4-хлорфенил)бензамида, обладающего антигельминтной активностью |
| US5032604A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Class III antiarrhythmic agents |
| US5112824A (en) * | 1989-12-08 | 1992-05-12 | Merck & Co., Inc. | Benzofuran compounds as class III antiarrhythmic agents |
| IL96507A0 (en) * | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
| EP0651746B1 (en) * | 1992-07-24 | 2002-03-27 | The Regents of the University of California | Drugs that enhance synaptic responses mediated by ampa receptors |
| ATE174915T1 (de) * | 1994-10-31 | 1999-01-15 | Merck Patent Gmbh | Benzylpiperidinderivate mit hoher affinität zu bindungsstellen von aminosäure-rezeptoren |
| US5650409A (en) * | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
| US5736543A (en) * | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
| US5985871A (en) | 1997-12-24 | 1999-11-16 | Cortex Pharmaceuticals, Inc. | Benzoxazine compounds for enhancing synaptic response |
-
1997
- 1997-02-13 US US08/800,108 patent/US6110935A/en not_active Expired - Lifetime
-
1998
- 1998-02-13 RU RU99119488/04A patent/RU2189984C2/ru not_active IP Right Cessation
- 1998-02-13 EP EP98906358A patent/EP0960105B1/en not_active Expired - Lifetime
- 1998-02-13 BR BRPI9807333-8A patent/BR9807333B1/pt not_active IP Right Cessation
- 1998-02-13 IL IL13120098A patent/IL131200A/xx not_active IP Right Cessation
- 1998-02-13 ID IDW990855A patent/ID22342A/id unknown
- 1998-02-13 KR KR1019997007369A patent/KR100544295B1/ko not_active Expired - Fee Related
- 1998-02-13 CN CN98802541A patent/CN1085206C/zh not_active Expired - Fee Related
- 1998-02-13 DE DE69823803T patent/DE69823803T2/de not_active Expired - Lifetime
- 1998-02-13 CZ CZ0279599A patent/CZ299765B6/cs not_active IP Right Cessation
- 1998-02-13 ES ES04075259T patent/ES2264078T3/es not_active Expired - Lifetime
- 1998-02-13 DK DK98906358T patent/DK0960105T3/da active
- 1998-02-13 DE DE69834590T patent/DE69834590T2/de not_active Expired - Lifetime
- 1998-02-13 JP JP53589698A patent/JP4446023B2/ja not_active Expired - Fee Related
- 1998-02-13 EP EP04075259A patent/EP1428534B1/en not_active Expired - Lifetime
- 1998-02-13 DK DK04075259T patent/DK1428534T3/da active
- 1998-02-13 PL PL335058A patent/PL199135B1/pl not_active IP Right Cessation
- 1998-02-13 AT AT98906358T patent/ATE266649T1/de active
- 1998-02-13 WO PCT/US1998/002713 patent/WO1998035950A1/en not_active Ceased
- 1998-02-13 PT PT98906358T patent/PT960105E/pt unknown
- 1998-02-13 HU HU0002303A patent/HUP0002303A3/hu unknown
- 1998-02-13 ES ES98906358T patent/ES2221152T3/es not_active Expired - Lifetime
- 1998-02-13 US US09/355,139 patent/US6313115B1/en not_active Expired - Fee Related
- 1998-02-13 TR TR1999/01941T patent/TR199901941T2/xx unknown
- 1998-02-13 AU AU61599/98A patent/AU737802C/en not_active Ceased
- 1998-02-13 AT AT04075259T patent/ATE326221T1/de active
- 1998-02-13 PT PT04075259T patent/PT1428534E/pt unknown
- 1998-02-13 NZ NZ336980A patent/NZ336980A/xx not_active IP Right Cessation
- 1998-02-13 GB GB9809221A patent/GB2325225B/en not_active Expired - Fee Related
- 1998-02-13 CA CA002279319A patent/CA2279319C/en not_active Expired - Fee Related
-
1999
- 1999-08-04 NO NO19993768A patent/NO318935B1/no not_active IP Right Cessation
-
2001
- 2001-04-27 US US09/845,128 patent/US6730677B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0960105T3 (da) | Benzofurazanforbindelser, der foröger AMPA-receptoraktivitet | |
| DK0891365T3 (da) | Benzoxaziner til forstærkning af synaptiske responser | |
| DE69811363D1 (de) | Piperazin-derivate und ihre verwendung als entzündungshemmende mittel | |
| DE69920497D1 (de) | Liponsaürederivate und deren verwendung bei der behandlung von krankheiten | |
| UY26249A1 (es) | Moléculas pequenas útiles en el tratamiento de las enfermedades inflamatorias ley 17164 art. 127 | |
| DE60024588D1 (de) | Substituierte porphyrine und deren therapeutische verwendungen | |
| PT839134E (pt) | Benzoilpiperidinas/pirrolidinas para melhoramento da resposta sinaptica | |
| DE69829412D1 (de) | Hemmung der raf-kinase unter verwendung von symmetrisch und unsymmetrisch substituierten harnstoffen | |
| DE69435303D1 (de) | Er behandlung von krankheiten bei denen eine cytok | |
| DK1054673T3 (da) | Benzoxazinforbindelser til forstærkelse af synaptisk reaktion | |
| EA200500934A1 (ru) | Соединения, модулирующие активность киназного белка множественных линий, и способы лечения нейродегенеративных и воспалительных заболеваний | |
| PT1067935E (pt) | Acilbenzoxazinas para melhorar resposta (s) sinaptica (s) | |
| BR9612074A (pt) | Novos 4-(1h-benzimidazol-2-il)(1,4) diazepanos substituidos úteis para o tratamento de doenças alérgicas | |
| ATE112557T1 (de) | Azetidinderivate, zusammensetzungen und ihre verwendung. | |
| ATE113591T1 (de) | 4-benzyl-5-phenyl-2,4-dihydro-3h-1,2,4-triazol- - one und ihre verwendung als antikonvulsiva. | |
| BR0015402A (pt) | Derivados de ácido 15-hidroxieicosatetraenóico de cadeia Èmega modificada e métodos de seu uso para o tratamento de olho seco | |
| DE69827706D1 (de) | 5-(Heteroaryl)alkyl)-3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid (PBI) Derivate zur Behandlung von Störungen des zentralen Nervensystems | |
| TH28200B (th) | การใช้ (สูตร) il -อะโกนิสท์สำหรับรักษาการกลั้นปัสสาวะไม่อยู่ |