JP4446023B2 - Ａｍｐａレセプタの活性を高めるベンゾフラザン化合物 - Google Patents
Ａｍｐａレセプタの活性を高めるベンゾフラザン化合物 Download PDFInfo
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- JP4446023B2 JP4446023B2 JP53589698A JP53589698A JP4446023B2 JP 4446023 B2 JP4446023 B2 JP 4446023B2 JP 53589698 A JP53589698 A JP 53589698A JP 53589698 A JP53589698 A JP 53589698A JP 4446023 B2 JP4446023 B2 JP 4446023B2
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- ylcarbonyl
- compound
- benzofurazan
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
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- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Luminescent Compositions (AREA)
- Furan Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US08/800,108 | 1997-02-13 | ||
| US08/800,108 US6110935A (en) | 1997-02-13 | 1997-02-13 | Benzofurazan compounds for enhancing glutamatergic synaptic responses |
| PCT/US1998/002713 WO1998035950A1 (en) | 1997-02-13 | 1998-02-13 | Benzofurazan compounds which enhance ampa receptor activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001512459A JP2001512459A (ja) | 2001-08-21 |
| JP2001512459A5 JP2001512459A5 (https=) | 2005-08-11 |
| JP4446023B2 true JP4446023B2 (ja) | 2010-04-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP53589698A Expired - Fee Related JP4446023B2 (ja) | 1997-02-13 | 1998-02-13 | Ａｍｐａレセプタの活性を高めるベンゾフラザン化合物 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US6110935A (https=) |
| EP (2) | EP0960105B1 (https=) |
| JP (1) | JP4446023B2 (https=) |
| KR (1) | KR100544295B1 (https=) |
| CN (1) | CN1085206C (https=) |
| AT (2) | ATE266649T1 (https=) |
| AU (1) | AU737802C (https=) |
| BR (1) | BR9807333B1 (https=) |
| CA (1) | CA2279319C (https=) |
| CZ (1) | CZ299765B6 (https=) |
| DE (2) | DE69823803T2 (https=) |
| DK (2) | DK0960105T3 (https=) |
| ES (2) | ES2264078T3 (https=) |
| GB (1) | GB2325225B (https=) |
| HU (1) | HUP0002303A3 (https=) |
| ID (1) | ID22342A (https=) |
| IL (1) | IL131200A (https=) |
| NO (1) | NO318935B1 (https=) |
| NZ (1) | NZ336980A (https=) |
| PL (1) | PL199135B1 (https=) |
| PT (2) | PT960105E (https=) |
| RU (1) | RU2189984C2 (https=) |
| TR (1) | TR199901941T2 (https=) |
| WO (1) | WO1998035950A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| IN188837B (https=) | 1998-05-22 | 2002-11-09 | Torrent Pharmaceuticals Ltd | |
| AU2002366756A1 (en) * | 2001-12-20 | 2003-07-09 | Alangudi Sankaranarayanan | Use of benzofuroxan derivatives as antiplatelet agents |
| KR20050094840A (ko) * | 2003-01-13 | 2005-09-28 | 코텍스 파마슈티칼스, 인크. | 수면 부족 및 스트레스로 인한 인식 저하의 치료방법 |
| WO2004103994A1 (en) * | 2003-05-23 | 2004-12-02 | Basilea Pharmaceutica Ag | Furazanobenzimidazoles |
| US20050228019A1 (en) * | 2004-01-26 | 2005-10-13 | Cortex Pharmaceuticals, Inc. | Enhancement of ampakine-Induced facilitation of synaptic responses by cholinesterase inhibitors |
| CN101600436A (zh) * | 2006-08-31 | 2009-12-09 | 艾伯塔大学校董 | 使用正变构ampa受体调节剂抑制呼吸抑制的方法 |
| BRPI0720323A2 (pt) * | 2007-01-03 | 2016-08-09 | Cortex Pharma Inc | composto, método de tratamento, composição farmacêutica e uso do composto |
| GEP20125438B (en) * | 2007-01-03 | 2012-03-26 | Servier Lab | 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses |
| WO2008143963A1 (en) * | 2007-05-17 | 2008-11-27 | Cortex Pharmaceuticals, Inc. | Di-substituted amides for enhancing glutamatergic synaptic responses |
| CA2695742C (en) | 2007-08-10 | 2012-11-27 | Rudolf Mueller | Bicyclic amides for enhancing glutamatergic synaptic responses |
| US8119632B2 (en) | 2007-08-10 | 2012-02-21 | Cortex Pharmaceuticals, Inc. | Bicyclic amide derivatives for enhancing glutamatergic synaptic responses |
| US8071914B2 (en) * | 2007-12-26 | 2011-12-06 | Noboru Oshima | Heating apparatus |
| WO2010054336A2 (en) * | 2008-11-10 | 2010-05-14 | The Regents Of The University Of California | Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction |
| CA2751285A1 (en) * | 2009-02-02 | 2010-08-05 | Cortex Pharmaceuticals, Inc. Eveleth, Gary S. Lynch) | Bicyclic amide derivatives for enhancing glutamatergic synaptic responses |
| US20130058915A1 (en) | 2010-03-02 | 2013-03-07 | Children's Medica Center Corporation | Methods and compositions for treatment of angelman syndrome and autism spectrum disorders |
| US20110257186A1 (en) * | 2010-04-15 | 2011-10-20 | Staubli Ursula V | Compositions and methods for treating visual disorders |
| EP2801377B1 (en) | 2011-03-04 | 2019-08-07 | The Regents of The University of California | Hydrogel comprising cells for local release of growth factors to mediate motor recovery after stroke |
| CN102633731B (zh) * | 2012-03-13 | 2014-04-30 | 四川大学华西医院 | 6-喹喔啉甲酸酰胺化合物、制备方法和应用 |
| KR101421032B1 (ko) * | 2012-12-28 | 2014-07-22 | 주식회사 레고켐 바이오사이언스 | (2-메틸-1-(3-메틸벤질)-1Ｈ-벤조[d]이미다졸-5일)(피페리딘-5-일)메탄온의 제조방법 |
| EP3008167A4 (en) | 2013-06-13 | 2017-06-07 | VeroScience LLC | Compositions and methods for treating metabolic disorders |
| EP3436021A4 (en) | 2016-03-29 | 2019-11-06 | RespireRx Pharmaceuticals Inc. | COMPOSITIONS AND METHODS FOR TREATING ATTENTION DEFICIT DISORDER |
| CN107286114B (zh) | 2016-04-13 | 2020-08-18 | 中国人民解放军军事医学科学院毒物药物研究所 | Ampa受体增效剂的脑靶向前药及其医药用途 |
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| US3981864A (en) * | 1973-09-08 | 1976-09-21 | Eisai Co., Ltd. | 1,3-Benzodioxol derivatives |
| FR2499991A1 (fr) * | 1981-02-19 | 1982-08-20 | Sandoz Sa | Nouveaux 2,1,3-benzothiadiazoles et 2,1,3-benzoxadiazoles, leur preparation et leur application comme medicaments |
| US4420485A (en) * | 1982-09-29 | 1983-12-13 | Hoechst-Roussel Pharmaceuticals Inc. | 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines] |
| SU1657189A1 (ru) * | 1988-05-23 | 1991-06-23 | Научно-Исследовательский Институт Экспериментальной Медицины Амн Ссср | Способ коррекции апато-абулических состо ний при шизофрении |
| SU1587050A1 (ru) * | 1988-12-23 | 1990-08-23 | Институт медицинской паразитологии и тропической медицины им.Е.И.Марциновского | Производные (7-бромбензо-2,1,3-тиадиазол-4-сульфонил)амина в качестве промежуточных продуктов в синтезе 2-[(7-бромбензо-2,1,3-тиадиазол-4-сульфонил)амино]-5-бром-N-(4-хлорфенил)бензамида, обладающего антигельминтной активностью |
| US5032604A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Class III antiarrhythmic agents |
| US5112824A (en) * | 1989-12-08 | 1992-05-12 | Merck & Co., Inc. | Benzofuran compounds as class III antiarrhythmic agents |
| IL96507A0 (en) * | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
| EP0651746B1 (en) * | 1992-07-24 | 2002-03-27 | The Regents of the University of California | Drugs that enhance synaptic responses mediated by ampa receptors |
| ATE174915T1 (de) * | 1994-10-31 | 1999-01-15 | Merck Patent Gmbh | Benzylpiperidinderivate mit hoher affinität zu bindungsstellen von aminosäure-rezeptoren |
| US5650409A (en) * | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
| US5736543A (en) * | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
| US5985871A (en) | 1997-12-24 | 1999-11-16 | Cortex Pharmaceuticals, Inc. | Benzoxazine compounds for enhancing synaptic response |
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1997
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1998
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- 1998-02-13 EP EP98906358A patent/EP0960105B1/en not_active Expired - Lifetime
- 1998-02-13 BR BRPI9807333-8A patent/BR9807333B1/pt not_active IP Right Cessation
- 1998-02-13 IL IL13120098A patent/IL131200A/xx not_active IP Right Cessation
- 1998-02-13 ID IDW990855A patent/ID22342A/id unknown
- 1998-02-13 KR KR1019997007369A patent/KR100544295B1/ko not_active Expired - Fee Related
- 1998-02-13 CN CN98802541A patent/CN1085206C/zh not_active Expired - Fee Related
- 1998-02-13 DE DE69823803T patent/DE69823803T2/de not_active Expired - Lifetime
- 1998-02-13 CZ CZ0279599A patent/CZ299765B6/cs not_active IP Right Cessation
- 1998-02-13 ES ES04075259T patent/ES2264078T3/es not_active Expired - Lifetime
- 1998-02-13 DK DK98906358T patent/DK0960105T3/da active
- 1998-02-13 DE DE69834590T patent/DE69834590T2/de not_active Expired - Lifetime
- 1998-02-13 JP JP53589698A patent/JP4446023B2/ja not_active Expired - Fee Related
- 1998-02-13 EP EP04075259A patent/EP1428534B1/en not_active Expired - Lifetime
- 1998-02-13 DK DK04075259T patent/DK1428534T3/da active
- 1998-02-13 PL PL335058A patent/PL199135B1/pl not_active IP Right Cessation
- 1998-02-13 AT AT98906358T patent/ATE266649T1/de active
- 1998-02-13 WO PCT/US1998/002713 patent/WO1998035950A1/en not_active Ceased
- 1998-02-13 PT PT98906358T patent/PT960105E/pt unknown
- 1998-02-13 HU HU0002303A patent/HUP0002303A3/hu unknown
- 1998-02-13 ES ES98906358T patent/ES2221152T3/es not_active Expired - Lifetime
- 1998-02-13 US US09/355,139 patent/US6313115B1/en not_active Expired - Fee Related
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- 1998-02-13 AU AU61599/98A patent/AU737802C/en not_active Ceased
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- 1998-02-13 PT PT04075259T patent/PT1428534E/pt unknown
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