KR100544295B1 - 에이엠피에이 수용체 활성을 증가시키는 벤조퓨란 화합물 - Google Patents

에이엠피에이 수용체 활성을 증가시키는 벤조퓨란 화합물 Download PDF

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KR100544295B1
KR100544295B1 KR1019997007369A KR19997007369A KR100544295B1 KR 100544295 B1 KR100544295 B1 KR 100544295B1 KR 1019997007369 A KR1019997007369 A KR 1019997007369A KR 19997007369 A KR19997007369 A KR 19997007369A KR 100544295 B1 KR100544295 B1 KR 100544295B1
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compound
ylcarbonyl
benzofuran
crr
hydrogen
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Korean (ko)
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KR20000071082A (ko
Inventor
개리 에이. 로저스
크리스토퍼 엠. 마스
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리전츠 오브 더 유니버시티 오브 캘리포니아
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Publication of KR20000071082A publication Critical patent/KR20000071082A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Luminescent Compositions (AREA)
  • Furan Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
KR1019997007369A 1997-02-13 1998-02-13 에이엠피에이 수용체 활성을 증가시키는 벤조퓨란 화합물 Expired - Fee Related KR100544295B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/800,108 1997-02-13
US08/800,108 US6110935A (en) 1997-02-13 1997-02-13 Benzofurazan compounds for enhancing glutamatergic synaptic responses
US8/800,108 1997-02-13
PCT/US1998/002713 WO1998035950A1 (en) 1997-02-13 1998-02-13 Benzofurazan compounds which enhance ampa receptor activity

Publications (2)

Publication Number Publication Date
KR20000071082A KR20000071082A (ko) 2000-11-25
KR100544295B1 true KR100544295B1 (ko) 2006-01-23

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ID=25177504

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KR1019997007369A Expired - Fee Related KR100544295B1 (ko) 1997-02-13 1998-02-13 에이엠피에이 수용체 활성을 증가시키는 벤조퓨란 화합물

Country Status (24)

Country Link
US (3) US6110935A (https=)
EP (2) EP0960105B1 (https=)
JP (1) JP4446023B2 (https=)
KR (1) KR100544295B1 (https=)
CN (1) CN1085206C (https=)
AT (2) ATE266649T1 (https=)
AU (1) AU737802C (https=)
BR (1) BR9807333B1 (https=)
CA (1) CA2279319C (https=)
CZ (1) CZ299765B6 (https=)
DE (2) DE69823803T2 (https=)
DK (2) DK0960105T3 (https=)
ES (2) ES2264078T3 (https=)
GB (1) GB2325225B (https=)
HU (1) HUP0002303A3 (https=)
ID (1) ID22342A (https=)
IL (1) IL131200A (https=)
NO (1) NO318935B1 (https=)
NZ (1) NZ336980A (https=)
PL (1) PL199135B1 (https=)
PT (2) PT960105E (https=)
RU (1) RU2189984C2 (https=)
TR (1) TR199901941T2 (https=)
WO (1) WO1998035950A1 (https=)

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IN188837B (https=) 1998-05-22 2002-11-09 Torrent Pharmaceuticals Ltd
AU2002366756A1 (en) * 2001-12-20 2003-07-09 Alangudi Sankaranarayanan Use of benzofuroxan derivatives as antiplatelet agents
KR20050094840A (ko) * 2003-01-13 2005-09-28 코텍스 파마슈티칼스, 인크. 수면 부족 및 스트레스로 인한 인식 저하의 치료방법
WO2004103994A1 (en) * 2003-05-23 2004-12-02 Basilea Pharmaceutica Ag Furazanobenzimidazoles
US20050228019A1 (en) * 2004-01-26 2005-10-13 Cortex Pharmaceuticals, Inc. Enhancement of ampakine-Induced facilitation of synaptic responses by cholinesterase inhibitors
CN101600436A (zh) * 2006-08-31 2009-12-09 艾伯塔大学校董 使用正变构ampa受体调节剂抑制呼吸抑制的方法
BRPI0720323A2 (pt) * 2007-01-03 2016-08-09 Cortex Pharma Inc composto, método de tratamento, composição farmacêutica e uso do composto
GEP20125438B (en) * 2007-01-03 2012-03-26 Servier Lab 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses
WO2008143963A1 (en) * 2007-05-17 2008-11-27 Cortex Pharmaceuticals, Inc. Di-substituted amides for enhancing glutamatergic synaptic responses
CA2695742C (en) 2007-08-10 2012-11-27 Rudolf Mueller Bicyclic amides for enhancing glutamatergic synaptic responses
US8119632B2 (en) 2007-08-10 2012-02-21 Cortex Pharmaceuticals, Inc. Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
US8071914B2 (en) * 2007-12-26 2011-12-06 Noboru Oshima Heating apparatus
WO2010054336A2 (en) * 2008-11-10 2010-05-14 The Regents Of The University Of California Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
CA2751285A1 (en) * 2009-02-02 2010-08-05 Cortex Pharmaceuticals, Inc. Eveleth, Gary S. Lynch) Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
US20130058915A1 (en) 2010-03-02 2013-03-07 Children's Medica Center Corporation Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
US20110257186A1 (en) * 2010-04-15 2011-10-20 Staubli Ursula V Compositions and methods for treating visual disorders
EP2801377B1 (en) 2011-03-04 2019-08-07 The Regents of The University of California Hydrogel comprising cells for local release of growth factors to mediate motor recovery after stroke
CN102633731B (zh) * 2012-03-13 2014-04-30 四川大学华西医院 6-喹喔啉甲酸酰胺化合物、制备方法和应用
KR101421032B1 (ko) * 2012-12-28 2014-07-22 주식회사 레고켐 바이오사이언스 (2-메틸-1-(3-메틸벤질)-1Ｈ-벤조[d]이미다졸-5일)(피페리딘-5-일)메탄온의 제조방법
EP3008167A4 (en) 2013-06-13 2017-06-07 VeroScience LLC Compositions and methods for treating metabolic disorders
EP3436021A4 (en) 2016-03-29 2019-11-06 RespireRx Pharmaceuticals Inc. COMPOSITIONS AND METHODS FOR TREATING ATTENTION DEFICIT DISORDER
CN107286114B (zh) 2016-04-13 2020-08-18 中国人民解放军军事医学科学院毒物药物研究所 Ampa受体增效剂的脑靶向前药及其医药用途

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US3981864A (en) * 1973-09-08 1976-09-21 Eisai Co., Ltd. 1,3-Benzodioxol derivatives
FR2499991A1 (fr) * 1981-02-19 1982-08-20 Sandoz Sa Nouveaux 2,1,3-benzothiadiazoles et 2,1,3-benzoxadiazoles, leur preparation et leur application comme medicaments
US4420485A (en) * 1982-09-29 1983-12-13 Hoechst-Roussel Pharmaceuticals Inc. 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines]
SU1657189A1 (ru) * 1988-05-23 1991-06-23 Научно-Исследовательский Институт Экспериментальной Медицины Амн Ссср Способ коррекции апато-абулических состо ний при шизофрении
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Also Published As

Publication number Publication date
EP1428534B1 (en) 2006-05-17
AU6159998A (en) 1998-09-08
DK1428534T3 (da) 2006-06-12
DE69834590D1 (de) 2006-06-22
EP1428534A1 (en) 2004-06-16
HUP0002303A2 (hu) 2001-04-28
ATE266649T1 (de) 2004-05-15
CZ279599A3 (cs) 2000-01-12
ES2264078T3 (es) 2006-12-16
BR9807333B1 (pt) 2011-10-18
IL131200A0 (en) 2001-01-28
DE69823803T2 (de) 2005-04-14
ATE326221T1 (de) 2006-06-15
CA2279319C (en) 2008-08-05
JP4446023B2 (ja) 2010-04-07
AU737802B2 (en) 2001-08-30
CN1247534A (zh) 2000-03-15
AU737802C (en) 2005-05-12
NO993768L (no) 1999-09-23
NZ336980A (en) 2000-08-25
ES2221152T3 (es) 2004-12-16
NO993768D0 (no) 1999-08-04
NO318935B1 (no) 2005-05-30
US6110935A (en) 2000-08-29
HUP0002303A3 (en) 2002-09-30
PL335058A1 (en) 2000-03-27
GB2325225B (en) 1999-03-03
GB9809221D0 (https=) 1998-07-01
TR199901941T2 (xx) 1999-12-21
BR9807333A (pt) 2000-04-18
IL131200A (en) 2005-06-19
GB2325225A8 (en) 1999-02-17
WO1998035950A1 (en) 1998-08-20
CA2279319A1 (en) 1998-08-20
DE69823803D1 (de) 2004-06-17
US6730677B2 (en) 2004-05-04
CZ299765B6 (cs) 2008-11-19
DK0960105T3 (da) 2004-08-30
EP0960105B1 (en) 2004-05-12
GB2325225A (en) 1998-11-18
ID22342A (id) 1999-09-30
JP2001512459A (ja) 2001-08-21
CN1085206C (zh) 2002-05-22
US6313115B1 (en) 2001-11-06
PT960105E (pt) 2004-09-30
EP0960105A1 (en) 1999-12-01
DE69834590T2 (de) 2007-04-26
PL199135B1 (pl) 2008-08-29
US20020055508A1 (en) 2002-05-09
PT1428534E (pt) 2006-07-31
KR20000071082A (ko) 2000-11-25
RU2189984C2 (ru) 2002-09-27

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Not in force date: 20120112

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000