DK1054673T3 - Benzoxazinforbindelser til forstærkelse af synaptisk reaktion - Google Patents

Benzoxazinforbindelser til forstærkelse af synaptisk reaktion

Info

Publication number
DK1054673T3
DK1054673T3 DK98964112T DK98964112T DK1054673T3 DK 1054673 T3 DK1054673 T3 DK 1054673T3 DK 98964112 T DK98964112 T DK 98964112T DK 98964112 T DK98964112 T DK 98964112T DK 1054673 T3 DK1054673 T3 DK 1054673T3
Authority
DK
Denmark
Prior art keywords
compounds
ampa receptors
disclosed
methods
benzoxazine compounds
Prior art date
Application number
DK98964112T
Other languages
English (en)
Inventor
Gary A Rogers
Christopher Marrs
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of DK1054673T3 publication Critical patent/DK1054673T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK98964112T 1997-12-24 1998-12-16 Benzoxazinforbindelser til forstærkelse af synaptisk reaktion DK1054673T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/998,300 US5985871A (en) 1997-12-24 1997-12-24 Benzoxazine compounds for enhancing synaptic response
PCT/US1998/027027 WO1999033469A1 (en) 1997-12-24 1998-12-16 Benzoxazine compounds for enhancing synaptic response

Publications (1)

Publication Number Publication Date
DK1054673T3 true DK1054673T3 (da) 2004-07-05

Family

ID=25545024

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98964112T DK1054673T3 (da) 1997-12-24 1998-12-16 Benzoxazinforbindelser til forstærkelse af synaptisk reaktion

Country Status (22)

Country Link
US (1) US5985871A (da)
EP (1) EP1054673B1 (da)
JP (1) JP4620244B2 (da)
KR (1) KR100561049B1 (da)
CN (1) CN1160360C (da)
AT (1) ATE261306T1 (da)
AU (1) AU746971B2 (da)
BR (1) BR9814478A (da)
CA (1) CA2316356C (da)
DE (1) DE69822344T2 (da)
DK (1) DK1054673T3 (da)
ES (1) ES2217615T3 (da)
HU (1) HUP0102056A3 (da)
IL (1) IL136783A (da)
MX (1) MXPA00006155A (da)
NO (1) NO325764B1 (da)
NZ (1) NZ505212A (da)
PL (1) PL194905B1 (da)
PT (1) PT1054673E (da)
RU (1) RU2246497C2 (da)
TR (1) TR200001971T2 (da)
WO (1) WO1999033469A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110935A (en) 1997-02-13 2000-08-29 The Regents Of The University Of California Benzofurazan compounds for enhancing glutamatergic synaptic responses
US6124278A (en) * 1998-04-03 2000-09-26 The Regents Of The University Of California Acylbenzoxazines for enhancing synaptic response
DE10004572A1 (de) * 2000-02-02 2001-08-09 Boehringer Ingelheim Pharma Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
TWI232863B (en) 2001-06-11 2005-05-21 Akzo Nobel Nv Benzoxazepine derivatives
HUP0400196A3 (en) 2001-06-14 2007-05-02 Organon Nv (pyrido/thieno)[f]oxazepin-5-one derivatives, their use and pharmaceutical compositions containing them
NZ540468A (en) 2003-01-13 2008-03-28 Univ California Method of treating cognitive decline due to sleep deprivation and stress using an AMPA receptor potentiator
US20060063707A1 (en) * 2004-09-17 2006-03-23 Lifelike Biomatic, Inc. Compositions for enhancing memory and methods therefor
US20100041647A1 (en) * 2007-01-03 2010-02-18 Cortex Pharmaceuticals, Inc. 3-Substituted-[1,2,3]-Benzotriazinone compounds for enhancing glutamatergic synaptic responses
AU2007342365B2 (en) * 2007-01-03 2012-11-15 Les Laboratoires Servier 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses
JP5694765B2 (ja) 2007-05-17 2015-04-01 コーテックス ファーマシューティカルズ， インコーポレイテッド グルタミン酸作動性シナプス反応を増強するための二置換アミド
BRPI0814149A2 (pt) 2007-08-10 2011-09-13 Cortex Pharma Inc composto, composição farmacêutica, métodos de tratamento e uso do composto
US8119632B2 (en) 2007-08-10 2012-02-21 Cortex Pharmaceuticals, Inc. Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
US20110218190A1 (en) * 2008-11-10 2011-09-08 The Regents Of The University Of California Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
WO2011109398A2 (en) 2010-03-02 2011-09-09 President And Fellows Of Harvard College Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
EP2701727B1 (en) 2011-03-04 2019-05-08 The Regents of The University of California Locally released growth factors to mediate motor recovery after stroke
MY163187A (en) * 2011-04-06 2017-08-15 Taiho Pharmaceutical Co Ltd Novel imidazo-oxazine compound or salt thereof
BR112015031249A2 (pt) 2013-06-13 2017-07-25 Veroscience Llc método de tratamento, método para tratar um distúrbio metabólico ou um elemento chave do mesmo, método para normalizar um ritmo diário de liberação de dopamina no sumn, método para estimular a liberação de dopamina de neurônios dopaminérgicos no sumn de um indivíduo e composição farmacêutica

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE253909T1 (de) * 1992-07-24 2003-11-15 Univ California Arzneimittel die den durch ampa rezeptoren vermittelten synaptischen response erhöhen
JPH0943929A (ja) * 1995-05-19 1997-02-14 Matsushita Electric Ind Co Ltd 電子写真複写装置
US5650409A (en) * 1995-06-02 1997-07-22 Cortex Pharmaceuticals, Inc. Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en) * 1996-04-03 1998-04-07 The Regents Of The University Of California Benzoxazines for enhancing synaptic response

Also Published As

Publication number Publication date
ATE261306T1 (de) 2004-03-15
NZ505212A (en) 2003-02-28
NO20003166L (no) 2000-08-07
JP2001527045A (ja) 2001-12-25
ES2217615T3 (es) 2004-11-01
CA2316356C (en) 2009-11-03
HUP0102056A3 (en) 2003-03-28
US5985871A (en) 1999-11-16
HUP0102056A2 (hu) 2001-11-28
NO325764B1 (no) 2008-07-14
TR200001971T2 (tr) 2001-01-22
IL136783A (en) 2005-11-20
BR9814478A (pt) 2000-10-10
CA2316356A1 (en) 1999-07-08
KR100561049B1 (ko) 2006-03-16
PL194905B1 (pl) 2007-07-31
AU746971B2 (en) 2002-05-09
EP1054673B1 (en) 2004-03-10
CN1283114A (zh) 2001-02-07
JP4620244B2 (ja) 2011-01-26
MXPA00006155A (es) 2002-04-24
DE69822344T2 (de) 2005-02-17
PT1054673E (pt) 2004-08-31
EP1054673A1 (en) 2000-11-29
DE69822344D1 (de) 2004-04-15
NO20003166D0 (no) 2000-06-19
WO1999033469A1 (en) 1999-07-08
RU2246497C2 (ru) 2005-02-20
CN1160360C (zh) 2004-08-04
KR20010033615A (ko) 2001-04-25
PL341427A1 (en) 2001-04-09
IL136783A0 (en) 2001-06-14
EP1054673A4 (en) 2001-07-18
AU1930599A (en) 1999-07-19

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