BR9814478A - "compostos de benzoxazina para aumentar resposta sináptica" - Google Patents

"compostos de benzoxazina para aumentar resposta sináptica"

Info

Publication number
BR9814478A
BR9814478A BR9814478-2A BR9814478A BR9814478A BR 9814478 A BR9814478 A BR 9814478A BR 9814478 A BR9814478 A BR 9814478A BR 9814478 A BR9814478 A BR 9814478A
Authority
BR
Brazil
Prior art keywords
compounds
ampa receptors
methods
synaptic response
increase
Prior art date
Application number
BR9814478-2A
Other languages
English (en)
Inventor
Gary A Rogers
Christopher Marrs
Original Assignee
Cortex Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cortex Pharma Inc filed Critical Cortex Pharma Inc
Publication of BR9814478A publication Critical patent/BR9814478A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Patente de Invenção: <B>"COMPOSTOS DE BENZOXAZINA PARA AUMENTAR RESPOSTA SINáPTICA"<D>. A presente invenção refere-se a compostos que apresentam um certo sistema de anel benzoxazina e seus precursores, os quais são úteis para aumentar respostas sinápticas mediadas por receptores de AMPA. Também apresentados são métodos para preparar tais compostos e métodos para seu uso em tratamento de indivíduos que sofrem de funcionamento nervoso ou intelectual prejudicado devido a deficiência no número de sinapses excitativas ou no número de receptores de AMPA. Os compostos da invenção podem também ser usados para o tratamento de indivíduos não-prejudicados, para aumentar desempenho nas tarefas sensorio-motores e cognitivas que dependem de redes cerebrais que utilizam receptores de AMPA e para aperfeiçoar codificação de memória.
BR9814478-2A 1997-12-24 1998-12-16 "compostos de benzoxazina para aumentar resposta sináptica" BR9814478A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/998,300 US5985871A (en) 1997-12-24 1997-12-24 Benzoxazine compounds for enhancing synaptic response
PCT/US1998/027027 WO1999033469A1 (en) 1997-12-24 1998-12-16 Benzoxazine compounds for enhancing synaptic response

Publications (1)

Publication Number Publication Date
BR9814478A true BR9814478A (pt) 2000-10-10

Family

ID=25545024

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814478-2A BR9814478A (pt) 1997-12-24 1998-12-16 "compostos de benzoxazina para aumentar resposta sináptica"

Country Status (22)

Country Link
US (1) US5985871A (pt)
EP (1) EP1054673B1 (pt)
JP (1) JP4620244B2 (pt)
KR (1) KR100561049B1 (pt)
CN (1) CN1160360C (pt)
AT (1) ATE261306T1 (pt)
AU (1) AU746971B2 (pt)
BR (1) BR9814478A (pt)
CA (1) CA2316356C (pt)
DE (1) DE69822344T2 (pt)
DK (1) DK1054673T3 (pt)
ES (1) ES2217615T3 (pt)
HU (1) HUP0102056A3 (pt)
IL (1) IL136783A (pt)
MX (1) MXPA00006155A (pt)
NO (1) NO325764B1 (pt)
NZ (1) NZ505212A (pt)
PL (1) PL194905B1 (pt)
PT (1) PT1054673E (pt)
RU (1) RU2246497C2 (pt)
TR (1) TR200001971T2 (pt)
WO (1) WO1999033469A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110935A (en) 1997-02-13 2000-08-29 The Regents Of The University Of California Benzofurazan compounds for enhancing glutamatergic synaptic responses
US6124278A (en) * 1998-04-03 2000-09-26 The Regents Of The University Of California Acylbenzoxazines for enhancing synaptic response
DE10004572A1 (de) * 2000-02-02 2001-08-09 Boehringer Ingelheim Pharma Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
TWI232863B (en) 2001-06-11 2005-05-21 Akzo Nobel Nv Benzoxazepine derivatives
IL158928A0 (en) 2001-06-14 2004-05-12 Akzo Nobel Nv (PYRIDO/THIENO)-[f]-OXAZEPIN-5-ONE DERIVATIVES
WO2004062616A2 (en) 2003-01-13 2004-07-29 Cortex Pharmaceuticals, Inc. Method of treating cognitive decline due to sleep deprivation and stress
US20060063707A1 (en) * 2004-09-17 2006-03-23 Lifelike Biomatic, Inc. Compositions for enhancing memory and methods therefor
AP2009004915A0 (en) * 2007-01-03 2009-08-31 Cortex Pharma Inc 3-substituted-[1,2,3] benzotriazinone compounds for enhancing glutamatergic synaptic responses
ME00819B (me) 2007-01-03 2012-03-20 Servier Lab 3-supstituisan-[1,2,3]-benzotriazinon jedinjenje za pojačavanje glutamatergičnih sinaptičkih odgovora
EA200901546A1 (ru) 2007-05-17 2010-04-30 Кортекс Фармасеутикалс, Инк. Дизамещенные амиды для усиления глутаматергических синаптических ответов
NZ583823A (en) 2007-08-10 2011-07-29 Cortex Pharma Inc Furazanes for enhancing glutamatergic synaptic responses
US8119632B2 (en) 2007-08-10 2012-02-21 Cortex Pharmaceuticals, Inc. Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
US20110218190A1 (en) * 2008-11-10 2011-09-08 The Regents Of The University Of California Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
WO2011109398A2 (en) 2010-03-02 2011-09-09 President And Fellows Of Harvard College Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
WO2012121971A2 (en) 2011-03-04 2012-09-13 The Regents Of The University Of California Locally released growth factors to mediate motor recovery after stroke
MX342064B (es) * 2011-04-06 2016-09-12 Taiho Pharmaceutical Co Ltd Novedoso compuesto de imidazo-oxazina o sal del mismo.
EP3311842A1 (en) 2013-06-13 2018-04-25 VeroScience LLC Compositions and methods for treating metabolic disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69331761T2 (de) * 1992-07-24 2002-09-12 The Regents Of The University Of California, Oakland Arzneimittel, die den durch ampa rezeptoren vermittelten synaptischen respons erhöhen
JPH0943929A (ja) * 1995-05-19 1997-02-14 Matsushita Electric Ind Co Ltd 電子写真複写装置
US5650409A (en) * 1995-06-02 1997-07-22 Cortex Pharmaceuticals, Inc. Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en) * 1996-04-03 1998-04-07 The Regents Of The University Of California Benzoxazines for enhancing synaptic response

Also Published As

Publication number Publication date
KR100561049B1 (ko) 2006-03-16
CA2316356C (en) 2009-11-03
IL136783A (en) 2005-11-20
KR20010033615A (ko) 2001-04-25
EP1054673B1 (en) 2004-03-10
ATE261306T1 (de) 2004-03-15
MXPA00006155A (es) 2002-04-24
DK1054673T3 (da) 2004-07-05
HUP0102056A2 (hu) 2001-11-28
WO1999033469A1 (en) 1999-07-08
NO20003166L (no) 2000-08-07
JP2001527045A (ja) 2001-12-25
HUP0102056A3 (en) 2003-03-28
CN1283114A (zh) 2001-02-07
DE69822344D1 (de) 2004-04-15
PL341427A1 (en) 2001-04-09
EP1054673A1 (en) 2000-11-29
AU1930599A (en) 1999-07-19
PT1054673E (pt) 2004-08-31
EP1054673A4 (en) 2001-07-18
CA2316356A1 (en) 1999-07-08
NO20003166D0 (no) 2000-06-19
CN1160360C (zh) 2004-08-04
AU746971B2 (en) 2002-05-09
TR200001971T2 (tr) 2001-01-22
ES2217615T3 (es) 2004-11-01
DE69822344T2 (de) 2005-02-17
NO325764B1 (no) 2008-07-14
JP4620244B2 (ja) 2011-01-26
NZ505212A (en) 2003-02-28
US5985871A (en) 1999-11-16
RU2246497C2 (ru) 2005-02-20
IL136783A0 (en) 2001-06-14
PL194905B1 (pl) 2007-07-31

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL: C07D 498/04, C07D 498/14, A61K 31/535, A61P 25/24, A61P 25/28, A61P 25/18

Ipc: C07D 498/04 (2007.10), C07D 498/14 (2007.10), A61K

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE NAO ATENDE AOS ARTIGOS 24 E 25 LPI

B12B Appeal against refusal [chapter 12.2 patent gazette]