ES2069528T3 - 5-aril-3h-1,2,4-triazol-3-onas y su uso en el tratamiento de trastornos neurodegenerativos. - Google Patents
5-aril-3h-1,2,4-triazol-3-onas y su uso en el tratamiento de trastornos neurodegenerativos.Info
- Publication number
- ES2069528T3 ES2069528T3 ES87118727T ES87118727T ES2069528T3 ES 2069528 T3 ES2069528 T3 ES 2069528T3 ES 87118727 T ES87118727 T ES 87118727T ES 87118727 T ES87118727 T ES 87118727T ES 2069528 T3 ES2069528 T3 ES 2069528T3
- Authority
- ES
- Spain
- Prior art keywords
- triazol
- treatment
- neurodegenerative disorders
- onas
- aril
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
ESTA INVENCION SE REFIERE A 5-ARIL-3H-1,2,4-TRIAZOL-3-ONAS Y A SU USO EN EL TRATAMIENTO DE TRASTORNOS NEURODEGENERATIVOS, TALES COMO TREMOR Y ESPASTICIDAD, ISQUEMIA CEREBRAL Y APOPLEJIA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94463486A | 1986-12-19 | 1986-12-19 | |
US10700187A | 1987-10-16 | 1987-10-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2069528T3 true ES2069528T3 (es) | 1995-05-16 |
Family
ID=26804275
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87118727T Expired - Lifetime ES2069528T3 (es) | 1986-12-19 | 1987-12-17 | 5-aril-3h-1,2,4-triazol-3-onas y su uso en el tratamiento de trastornos neurodegenerativos. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0273309B1 (es) |
JP (1) | JP2593084B2 (es) |
KR (1) | KR880007495A (es) |
AT (1) | ATE116851T1 (es) |
DE (1) | DE3750979T2 (es) |
DK (1) | DK172668B1 (es) |
ES (1) | ES2069528T3 (es) |
GR (1) | GR3015685T3 (es) |
IE (1) | IE65857B1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4966909A (en) * | 1989-12-20 | 1990-10-30 | Merrell Dow Pharmaceuticals | 4-benzyl-5-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-ones and their use as anticonvulsants |
AU644500B2 (en) * | 1990-12-20 | 1993-12-09 | Merrell Dow Pharmaceuticals Inc. | 3-aryl-5-alkylthio-4h-1,2,4-triazoles for treatment of hyperreflexia due to spinal trauma |
US5840746A (en) * | 1993-06-24 | 1998-11-24 | Merck Frosst Canada, Inc. | Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases |
DE19816882A1 (de) * | 1998-04-17 | 1999-10-21 | Boehringer Ingelheim Pharma | Triazolone mit neuroprotektiver Wirkung |
TW200505441A (en) | 2003-03-24 | 2005-02-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitorsⅠ |
MX2007000788A (es) | 2004-07-27 | 2007-03-23 | Hoffmann La Roche | Compuestos de benciltriazolona como inhibidores no nucleosidos de transcriptasa inversa. |
US8293778B2 (en) | 2004-07-27 | 2012-10-23 | Roche Palo Alto Llc | Heterocyclic antiviral compounds |
BRPI0809617A2 (pt) | 2007-03-29 | 2014-09-16 | Hoffmann La Roche | Inibidores não-nucleosídicos da transcriptase reversa |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1126882B (de) * | 1960-05-03 | 1962-04-05 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von 1,2,4-Triazolonen-(5) |
BE621842A (es) * | 1962-08-27 | |||
DE1545646B1 (de) * | 1965-12-15 | 1969-09-18 | Boehringer Sohn Ingelheim | 1,3-Dimethyl-4-(2',4'-dichlorphenyl)-1,2,4-triazolon-(5) und Verfahren zu dessen Herstellung |
DD153953A3 (de) * | 1980-04-01 | 1982-02-17 | Gottfried Schuster | Mittel zur chemotherapie von virosen der kulturpflanzen |
DD160447A1 (de) * | 1981-03-26 | 1983-08-03 | Johannes Dost | Herbizide mittel, die 1,2,4-triazolinone-(5) enthalten |
AR243171A1 (es) * | 1985-10-29 | 1993-07-30 | Merrell Pharma Inc | Procedimiento para preparar 5-aril-2,4-dialquil-3h-1,2,4-triazol-3-tionas. |
-
1987
- 1987-12-15 JP JP62315427A patent/JP2593084B2/ja not_active Expired - Lifetime
- 1987-12-17 AT AT87118727T patent/ATE116851T1/de not_active IP Right Cessation
- 1987-12-17 DE DE3750979T patent/DE3750979T2/de not_active Expired - Fee Related
- 1987-12-17 ES ES87118727T patent/ES2069528T3/es not_active Expired - Lifetime
- 1987-12-17 EP EP87118727A patent/EP0273309B1/en not_active Expired - Lifetime
- 1987-12-18 DK DK198706711A patent/DK172668B1/da not_active IP Right Cessation
- 1987-12-18 IE IE345987A patent/IE65857B1/en not_active IP Right Cessation
- 1987-12-19 KR KR870014559A patent/KR880007495A/ko not_active Application Discontinuation
-
1995
- 1995-04-04 GR GR950400832T patent/GR3015685T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPS63170312A (ja) | 1988-07-14 |
DK671187D0 (da) | 1987-12-18 |
EP0273309A3 (en) | 1991-01-09 |
DE3750979D1 (de) | 1995-02-23 |
GR3015685T3 (en) | 1995-07-31 |
IE65857B1 (en) | 1995-11-29 |
JP2593084B2 (ja) | 1997-03-19 |
ATE116851T1 (de) | 1995-01-15 |
DE3750979T2 (de) | 1995-05-24 |
KR880007495A (ko) | 1988-08-27 |
DK172668B1 (da) | 1999-05-10 |
DK671187A (da) | 1988-06-20 |
EP0273309A2 (en) | 1988-07-06 |
IE873459L (en) | 1989-04-16 |
EP0273309B1 (en) | 1995-01-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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