ATE226206T1 - Benzoxazine zur erhöhung der synaptischen reaktionen - Google Patents
Benzoxazine zur erhöhung der synaptischen reaktionenInfo
- Publication number
- ATE226206T1 ATE226206T1 AT97919965T AT97919965T ATE226206T1 AT E226206 T1 ATE226206 T1 AT E226206T1 AT 97919965 T AT97919965 T AT 97919965T AT 97919965 T AT97919965 T AT 97919965T AT E226206 T1 ATE226206 T1 AT E226206T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- subjects
- ampa receptors
- benzoxazine
- reactions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/624,335 US5736543A (en) | 1996-04-03 | 1996-04-03 | Benzoxazines for enhancing synaptic response |
PCT/US1997/005184 WO1997036907A1 (en) | 1996-04-03 | 1997-03-28 | Benzoxazines for enhancing synaptic response |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE226206T1 true ATE226206T1 (de) | 2002-11-15 |
Family
ID=24501596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97919965T ATE226206T1 (de) | 1996-04-03 | 1997-03-28 | Benzoxazine zur erhöhung der synaptischen reaktionen |
Country Status (10)
Country | Link |
---|---|
US (2) | US5736543A (de) |
EP (1) | EP0891365B1 (de) |
JP (1) | JP3170294B2 (de) |
AT (1) | ATE226206T1 (de) |
AU (1) | AU708212B2 (de) |
DE (1) | DE69716414T2 (de) |
DK (1) | DK0891365T3 (de) |
ES (1) | ES2185932T3 (de) |
NZ (1) | NZ331992A (de) |
WO (1) | WO1997036907A1 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU721936B2 (en) * | 1996-04-03 | 2000-07-20 | Regents Of The University Of California, The | Benzoxazines for enhancing synaptic response |
US6110935A (en) * | 1997-02-13 | 2000-08-29 | The Regents Of The University Of California | Benzofurazan compounds for enhancing glutamatergic synaptic responses |
US6166008A (en) * | 1997-10-27 | 2000-12-26 | Cortex Pharmaceuticals, Inc. | Treatment of schizophrenia with ampakines and neuroleptics |
US5985871A (en) * | 1997-12-24 | 1999-11-16 | Cortex Pharmaceuticals, Inc. | Benzoxazine compounds for enhancing synaptic response |
US6943159B1 (en) | 1998-02-18 | 2005-09-13 | Neurosearch A/S | Compounds and their use as positive AMPA receptor modulators |
US6124278A (en) * | 1998-04-03 | 2000-09-26 | The Regents Of The University Of California | Acylbenzoxazines for enhancing synaptic response |
US6011991A (en) * | 1998-12-07 | 2000-01-04 | Technology Patents, Llc | Communication system and method including brain wave analysis and/or use of brain activity |
US7455836B2 (en) * | 2000-05-08 | 2008-11-25 | The University Of Melbourne | Method of treatment and agents useful for same |
TWI232863B (en) | 2001-06-11 | 2005-05-21 | Akzo Nobel Nv | Benzoxazepine derivatives |
MXPA03011562A (es) | 2001-06-14 | 2004-03-18 | Akzo Nobel Nv | Derivados de (pirido/tieno)-(f)-oxazepin-5-ona como moduladores positivos del receptor ampa. |
SK2292004A3 (en) * | 2001-11-26 | 2004-09-08 | Cortex Pharma Inc | Carbonyl benzoxazine compounds for enhancement of glutamatergic synaptic responses |
BR0314172A (pt) | 2002-09-09 | 2005-07-26 | Nektar Therapeutics Al Corp | Polìmero solúvel em água, composição, forma de hidrato ou acetal, composto,composição, usos do composto e do conjugado, e, processo para preparar o conjugado |
CA2509251A1 (en) | 2003-01-13 | 2004-07-29 | Cortex Pharmaceuticals, Inc. | Method of treating cognitive decline due to sleep deprivation and stress |
WO2006034196A1 (en) * | 2004-09-17 | 2006-03-30 | Lifelike Biomatic Inc. | Compositions for enhancing memory and methods therefor |
TW200800959A (en) | 2005-06-10 | 2008-01-01 | Wyeth Corp | Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor |
WO2008028903A2 (en) | 2006-09-04 | 2008-03-13 | Neurosearch A/S | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer |
PL2144506T3 (pl) * | 2007-01-03 | 2012-04-30 | Servier Lab | 3-podstawiony-[1,2,3]-benzotriazynon jako związek do wzmacniania odpowiedzi glutaminianergicznych |
AP2009004915A0 (en) * | 2007-01-03 | 2009-08-31 | Cortex Pharma Inc | 3-substituted-[1,2,3] benzotriazinone compounds for enhancing glutamatergic synaptic responses |
CL2008000119A1 (es) | 2007-01-16 | 2008-05-16 | Wyeth Corp | Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia. |
MX2009009937A (es) * | 2007-03-23 | 2009-09-24 | Univ California | Tratamiento de la disfuncion sexual femenina mediante compuestos que modulan de manera positiva los receptores de glutamato tipo ampa. |
AU2008254960B2 (en) | 2007-05-17 | 2014-11-27 | Cortex Pharmaceuticals, Inc. | Di-substituted amides for enhancing glutamatergic synaptic responses |
CN101896183B (zh) * | 2007-08-10 | 2013-11-27 | 科泰克斯药品公司 | 用于增强谷氨酸能突触反应的二环酰胺 |
US8119632B2 (en) | 2007-08-10 | 2012-02-21 | Cortex Pharmaceuticals, Inc. | Bicyclic amide derivatives for enhancing glutamatergic synaptic responses |
US8071914B2 (en) | 2007-12-26 | 2011-12-06 | Noboru Oshima | Heating apparatus |
US20110218190A1 (en) * | 2008-11-10 | 2011-09-08 | The Regents Of The University Of California | Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction |
WO2011109398A2 (en) | 2010-03-02 | 2011-09-09 | President And Fellows Of Harvard College | Methods and compositions for treatment of angelman syndrome and autism spectrum disorders |
EP2801377B1 (de) | 2011-03-04 | 2019-08-07 | The Regents of The University of California | Hydrogel enthaltend Zellen zur lokalen Freisetzung von Wachstumsfaktoren zur Rückgewinnung der Bewegungsfähigkeit nach einem Schlaganfall |
EP3485882A1 (de) | 2013-01-25 | 2019-05-22 | Case Western Reserve University | Zusammensetzungen zur behandlung von erkrankungen mit pervasiver entwicklung |
CA2915405A1 (en) | 2013-06-13 | 2014-12-18 | Veroscience Llc | Compositions and methods for treating metabolic disorders |
CN107286114B (zh) | 2016-04-13 | 2020-08-18 | 中国人民解放军军事医学科学院毒物药物研究所 | Ampa受体增效剂的脑靶向前药及其医药用途 |
US11723579B2 (en) | 2017-09-19 | 2023-08-15 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement |
US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
WO2019133997A1 (en) | 2017-12-31 | 2019-07-04 | Neuroenhancement Lab, LLC | System and method for neuroenhancement to enhance emotional response |
US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
EP3849410A4 (de) | 2018-09-14 | 2022-11-02 | Neuroenhancement Lab, LLC | System und verfahren zur verbesserung des schlafs |
US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3257396A (en) * | 1962-06-11 | 1966-06-21 | Geigy Chem Corp | Certain 1, 3-benzoxazinone derivatives |
PT651746E (pt) * | 1992-07-24 | 2002-09-30 | Univ California | Drogas que intensificam as respostas sinapticas mediadas por receptores de ampa |
US5650409A (en) * | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
-
1996
- 1996-04-03 US US08/624,335 patent/US5736543A/en not_active Expired - Lifetime
-
1997
- 1997-03-28 DE DE69716414T patent/DE69716414T2/de not_active Expired - Lifetime
- 1997-03-28 DK DK97919965T patent/DK0891365T3/da active
- 1997-03-28 AU AU24274/97A patent/AU708212B2/en not_active Ceased
- 1997-03-28 EP EP97919965A patent/EP0891365B1/de not_active Expired - Lifetime
- 1997-03-28 JP JP53548897A patent/JP3170294B2/ja not_active Expired - Fee Related
- 1997-03-28 NZ NZ331992A patent/NZ331992A/xx unknown
- 1997-03-28 ES ES97919965T patent/ES2185932T3/es not_active Expired - Lifetime
- 1997-03-28 WO PCT/US1997/005184 patent/WO1997036907A1/en active IP Right Grant
- 1997-03-28 AT AT97919965T patent/ATE226206T1/de not_active IP Right Cessation
-
1998
- 1998-02-06 US US09/019,883 patent/US5962447A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP3170294B2 (ja) | 2001-05-28 |
ES2185932T3 (es) | 2003-05-01 |
AU708212B2 (en) | 1999-07-29 |
JP2000503664A (ja) | 2000-03-28 |
WO1997036907A1 (en) | 1997-10-09 |
NZ331992A (en) | 1999-02-25 |
DK0891365T3 (da) | 2003-02-10 |
EP0891365A1 (de) | 1999-01-20 |
EP0891365B1 (de) | 2002-10-16 |
DE69716414T2 (de) | 2003-06-12 |
US5736543A (en) | 1998-04-07 |
DE69716414D1 (de) | 2002-11-21 |
AU2427497A (en) | 1997-10-22 |
US5962447A (en) | 1999-10-05 |
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DE69910552D1 (de) | Acylbenzoxazine zur erhöhung der synaptischen reaktion(en) | |
EA200400584A1 (ru) | Соединения карбонилбензоксазина для усиления глутаматергических синаптических ответов | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |