MXPA03011562A - Derivados de (pirido/tieno)-(f)-oxazepin-5-ona como moduladores positivos del receptor ampa. - Google Patents
Derivados de (pirido/tieno)-(f)-oxazepin-5-ona como moduladores positivos del receptor ampa.Info
- Publication number
- MXPA03011562A MXPA03011562A MXPA03011562A MXPA03011562A MXPA03011562A MX PA03011562 A MXPA03011562 A MX PA03011562A MX PA03011562 A MXPA03011562 A MX PA03011562A MX PA03011562 A MXPA03011562 A MX PA03011562A MX PA03011562 A MXPA03011562 A MX PA03011562A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- derivatives
- thieno
- pyrido
- alkyloxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invencion se refiere a derivados de (pirido/tieno)-[f]-oxazepin-5-ona que tienen la formula general (I) en donde R1, R2 y R3 son independientemente H o alquilo de 1 a 4 atomos de carbono; Ar representa un anillo de tiofeno o piridina fusionado substituido opcionalmente con uno o mas substituyentes seleccionados de alquilo de 1 a 4 atomos de carbono, alquiloxi de 1 a 4 atomos de carbono, alquiloxi de 1 a 4 atomos de carbono-alquilo de 1 a 4 atomos de carbono, CF3, halogeno, nitro, ciano, NR4R5, NR4COR6, y CONR4R5; R4 y R5 son independientemente H o alquilo de 1 a 4 atomos de carbono; o R4 y R5 forman juntos con el atomo de nitrogeno al cual estan unidos un anillo heterociclico saturado de 5 o 6 miembros, conteniendo opcionalmente un heteroatomo adicional seleccionado de O, S o NR6; R6 es alquilo de 1 a 4 atomos de carbono; A representa el residuo de un anillo heterociclico saturado de 4 a 7 miembros, conteniendo opcionalmente un atomo de oxigeno, estando el anillo substituido opcionalmente con 1 a 3 substituyentes seleccionados de alquilo de 1 a 4 atomos de carbono, alquiloxi de 1 a 4 atomos de carbono, hidroxi, halogeno y oxo; o una sal del mismo farmaceuticamente aceptable. La invencion se refiere tambien a composiciones farmaceuticas que comprenden dichos derivados y al uso de estos derivados de (pirido/tieno)-[f]-oxazepin-5-ona en el tratamiento de enfermedades neurologicas y desordenes psiquiatricos que respondan al aumento de respuestas sinapticas mediadas por receptores AMPA en el sistema nervioso central.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01202284 | 2001-06-14 | ||
| PCT/EP2002/006364 WO2002102808A2 (en) | 2001-06-14 | 2002-06-10 | (PYRIDO/THIENO)-[f]-OXAZEPIN-5-ONE DERIVATIVES AS POSITIVE MODULATORS OF THE AMPA RECEPTOR |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03011562A true MXPA03011562A (es) | 2004-03-18 |
Family
ID=8180476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03011562A MXPA03011562A (es) | 2001-06-14 | 2002-06-10 | Derivados de (pirido/tieno)-(f)-oxazepin-5-ona como moduladores positivos del receptor ampa. |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US7345036B2 (es) |
| EP (1) | EP1446407A2 (es) |
| JP (1) | JP4435562B2 (es) |
| KR (1) | KR100864267B1 (es) |
| CN (2) | CN101029051B (es) |
| AR (1) | AR034482A1 (es) |
| AU (1) | AU2002320841B2 (es) |
| BR (1) | BR0210307A (es) |
| CA (1) | CA2449215C (es) |
| CO (1) | CO5550448A2 (es) |
| CZ (1) | CZ296217B6 (es) |
| EC (1) | ECSP034890A (es) |
| HR (1) | HRP20031013A2 (es) |
| HU (1) | HUP0400196A3 (es) |
| IL (2) | IL158928A0 (es) |
| IS (1) | IS7042A (es) |
| MX (1) | MXPA03011562A (es) |
| NO (1) | NO328710B1 (es) |
| NZ (1) | NZ529671A (es) |
| PE (1) | PE20030271A1 (es) |
| PL (1) | PL367185A1 (es) |
| RU (1) | RU2286347C2 (es) |
| SK (1) | SK287583B6 (es) |
| WO (1) | WO2002102808A2 (es) |
| ZA (1) | ZA200309096B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200817385A (en) * | 2006-07-04 | 2008-04-16 | Organon Nv | Heterocyclic derivatives |
| FR2964969B1 (fr) * | 2010-09-16 | 2012-08-24 | Servier Lab | Nouveaux derives dihydrobenzoxathiazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1238719A (es) * | 1968-11-01 | 1971-07-07 | ||
| ATE215079T1 (de) | 1992-07-24 | 2002-04-15 | Univ California | Arzneimittel, die den durch ampa rezeptoren vermittelten synaptischen respons erhöhen |
| US6174881B1 (en) * | 1995-01-06 | 2001-01-16 | Hoffman-La Roche Inc. | Hydroxymethylimidazodiazepines and their esters |
| US5650409A (en) * | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
| US5736543A (en) * | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
| DE69831446T2 (de) | 1997-06-09 | 2006-06-14 | Pfizer Prod Inc | Chinazolin-4-on AMPA Antagonisten |
| US5985871A (en) | 1997-12-24 | 1999-11-16 | Cortex Pharmaceuticals, Inc. | Benzoxazine compounds for enhancing synaptic response |
| EP1071426A2 (en) | 1998-02-18 | 2001-01-31 | Neurosearch A/S | Novel compounds and their use as positive ampa receptor modulators |
| US6124278A (en) | 1998-04-03 | 2000-09-26 | The Regents Of The University Of California | Acylbenzoxazines for enhancing synaptic response |
| DE60035591D1 (de) | 1999-05-12 | 2007-08-30 | Us Health | Thiazepin-hemmer von hiv-1 integrase |
| TWI232863B (en) | 2001-06-11 | 2005-05-21 | Akzo Nobel Nv | Benzoxazepine derivatives |
-
2002
- 2002-06-10 KR KR1020037016248A patent/KR100864267B1/ko not_active IP Right Cessation
- 2002-06-10 RU RU2004100702/04A patent/RU2286347C2/ru not_active IP Right Cessation
- 2002-06-10 SK SK1526-2003A patent/SK287583B6/sk not_active IP Right Cessation
- 2002-06-10 IL IL15892802A patent/IL158928A0/xx active IP Right Grant
- 2002-06-10 EP EP02754652A patent/EP1446407A2/en not_active Withdrawn
- 2002-06-10 CA CA2449215A patent/CA2449215C/en not_active Expired - Fee Related
- 2002-06-10 CN CN2006100598858A patent/CN101029051B/zh not_active Expired - Fee Related
- 2002-06-10 MX MXPA03011562A patent/MXPA03011562A/es active IP Right Grant
- 2002-06-10 HU HU0400196A patent/HUP0400196A3/hu unknown
- 2002-06-10 PL PL02367185A patent/PL367185A1/xx unknown
- 2002-06-10 BR BR0210307-9A patent/BR0210307A/pt not_active Application Discontinuation
- 2002-06-10 WO PCT/EP2002/006364 patent/WO2002102808A2/en active IP Right Grant
- 2002-06-10 CZ CZ20033392A patent/CZ296217B6/cs not_active IP Right Cessation
- 2002-06-10 JP JP2003506280A patent/JP4435562B2/ja not_active Expired - Fee Related
- 2002-06-10 CN CNB028118154A patent/CN1255413C/zh not_active Expired - Fee Related
- 2002-06-10 NZ NZ529671A patent/NZ529671A/en unknown
- 2002-06-10 AU AU2002320841A patent/AU2002320841B2/en not_active Ceased
- 2002-06-10 US US10/480,569 patent/US7345036B2/en not_active Expired - Fee Related
- 2002-06-13 AR ARP020102223A patent/AR034482A1/es unknown
- 2002-06-13 PE PE2002000511A patent/PE20030271A1/es not_active Application Discontinuation
-
2003
- 2003-11-17 IS IS7042A patent/IS7042A/is unknown
- 2003-11-18 IL IL158928A patent/IL158928A/en not_active IP Right Cessation
- 2003-11-21 ZA ZA200309096A patent/ZA200309096B/en unknown
- 2003-12-08 HR HR20031013A patent/HRP20031013A2/hr not_active Application Discontinuation
- 2003-12-11 NO NO20035523A patent/NO328710B1/no not_active IP Right Cessation
- 2003-12-11 EC EC2003004890A patent/ECSP034890A/es unknown
- 2003-12-16 CO CO03109961A patent/CO5550448A2/es not_active Application Discontinuation
-
2008
- 2008-02-01 US US12/024,597 patent/US7566778B2/en not_active Expired - Fee Related
-
2009
- 2009-02-20 US US12/389,968 patent/US8034804B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20210146389A (ko) | 단백질 티로신 포스파타제 억제제 | |
| EA199700156A1 (ru) | Производные индола как антагонисты рецептора 5-нт | |
| YU40300A (sh) | Aril fuzirana azapoliciklična jedinjenja | |
| YU59602A (sh) | Aril fuzionisana azapoliciklična jedinjenja | |
| EA200600811A1 (ru) | НОВЫЕ ПРОИЗВОДНЫЕ ТЕТРАГИДРОСПИРО {ПИПЕРИДИН-2,7'-ПИРРОЛО [3,2-b]ПИРИДИНА} И НОВЫЕ ПРОИЗВОДНЫЕ ИНДОЛА, ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ РАССТРОЙСТВ, СВЯЗАННЫХ С 5-HT-РЕЦЕПТОРОМ | |
| BR9206500A (pt) | Heterociclos contendo, nitrogênio tricíclico condensado como antagonistas de substancia receptora P | |
| SG146694A1 (en) | 1,1,1-trifluoro-4-phenyl-4-methyl-2-(1h-pyrrolo-2,3-c pyridin-2- ylmethyl)pentan-2-ol derivatives and related compounds as glucocorticoid ligands for the treatment of inflammatory diseases and diabetes | |
| MXPA06002618A (es) | Antagonistas del factor de liberacion de corticotropina (crf) y compuestos heterobiciclicos. | |
| IL174678A0 (en) | Arylindenophyridines and arylindenophyrimidines and their use as adenosine a2a receptor antagonist | |
| CA2239705A1 (en) | Quinazoline-4-one ampa antagonists | |
| SE8307133D0 (sv) | Carboxamido-derivatives of 5h-1,3,4-thiadiazolo(3,2-a)pyrimidines and process for their preparation | |
| YU64400A (sh) | Aril fuzirana azapoliciklična jedinjenja | |
| DE69409796T2 (de) | Neue verwendung bis-heterocyclische verbindungen und dessen zusammensetzungen | |
| HUP0003624A2 (hu) | 1,2,3,4-Tetrahidro-benzofuro[3,2-c]piridin-származékok, az ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra | |
| MXPA03011563A (es) | Derivados de benzoxazepina y su uso como estimuladores de receptor ampa. | |
| MXPA03011562A (es) | Derivados de (pirido/tieno)-(f)-oxazepin-5-ona como moduladores positivos del receptor ampa. | |
| DE602005006840D1 (de) | 1,2,3,3a;8,8a-hexahydro-2,7a-diazacyclopentaäaüinden-7-onderivate, die sich an neuronale nikotinische acetylcholinspezifische rezeptorstellen binden und zur modulation der cholinergen funktion und zur behandlung von suchterkrankungen eignen | |
| MXPA06000892A (es) | Compuestos azapoliciclicos arilo fusionados. | |
| NZ535183A (en) | Fused bicyclic pyrimidine derivatives | |
| DK1373218T3 (da) | Imidazolylderivater til anvendelse som histamin H3-receptorligander | |
| TH68031A (th) | อนุพันธ์(พัยริโด/ไธอีโน)-[เอฟ]-ออกซาซีพิน-5-โอน | |
| TH77892A (th) | อนุพันธ์เบนซ์ออกซาซีพีน |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or rights | ||
| FG | Grant or registration |