AR034482A1 - Un derivado (pirido/tieno)-[f]-oxazepin-5-ona, su utilizacion para preparar un medicamento y una composicion farmaceutica que lo comprende - Google Patents
Un derivado (pirido/tieno)-[f]-oxazepin-5-ona, su utilizacion para preparar un medicamento y una composicion farmaceutica que lo comprendeInfo
- Publication number
- AR034482A1 AR034482A1 ARP020102223A ARP020102223A AR034482A1 AR 034482 A1 AR034482 A1 AR 034482A1 AR P020102223 A ARP020102223 A AR P020102223A AR P020102223 A ARP020102223 A AR P020102223A AR 034482 A1 AR034482 A1 AR 034482A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- derivative
- ring
- formula
- oxazepin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Un derivado (pirido/tieno)-[f]-oxazepin-5-ona con la fórmula general (1), en la cual: R1, R2 y R3 son independientemente H o C1-4 alquil; Ar representa un anillo de piridina o tiofeno fusionado sustituido opcionalmente con uno o más sustituyentes seleccionados de C1-4 alquil, C1-4 alquiloxi C1-4 alquil, CF3, halógeno, nitro, ciano, NR4R5, NR4COR6 y CONR4R5; R4 y R5 son independientemente H o C1-4 alquil; o R4 y R5 forman juntos con el átomo de nitrógeno al cual se encuentran unidos, un anillo heterocíclico saturado con 5 o 6 miembros, el cual contiene opcionalmente otro heteroátomo seleccionado de O, S o NR6, R6 es C1-4 alquil; A representa el residuo de un anillo heterocíclico saturado con 4-7 miembros, que contiene opcionalmente un átomo de oxígeno, el anillo se sustituye opcionalmente con 1-3 sustituyentes seleccionados de C1-4 alquil, C1-4 alquiloxi, hidroxi, halógeno y oxo; o una sal farmacéuticamente aceptable del mismo; con la condición que se excluya el compuesto de fórmula (1), donde Ar es un anillo de piridina [3,2-f] fusionado; cada uno de R1-R3 sea H y A representa (CH2)3. Un derivado (pirido/tieno)-[f]-oxazepin-5-ona con la fórmula general (1), en la cual: R1, R2, R3 y Ar son como se define arriba; A representa el residuo de un anillo heterocíclico saturado con 4-7 miembros, que contiene opcionalmente un átomo de oxígeno, el anillo se sustituye opcionalmente con 1-3 sustituyentes seleccionados de C1-4 alquil, C1-4 alquiloxi, hidroxi, halógeno y oxo; o una sal farmacéuticamente aceptable del mismo; para utilizar en terapia. Una composición farmacéutica que comprende el derivado de fórmula (1) en la preparación de un medicamento. El derivado de fórmula (1) es útil para el tratamiento de enfermedades neurológicas y desórdenes psiquiátricos, los cuales son responsables del incremento de respuestas sinápticas mediadas por los receptores AMPA en el sistema nervioso central, tales como desorden de atención, trauma, apoplejía, epilepsia, enfermedad de Alzheimer, depresión, esquizofrenia, desórdenes sicóticos, ansiedad, disfunciones sexuales, autismo o un desorden o enfermedad resultante de agentes neuróticos o abuso de sustancias e intoxicación con alcohol.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01202284 | 2001-06-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR034482A1 true AR034482A1 (es) | 2004-02-25 |
Family
ID=8180476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020102223A AR034482A1 (es) | 2001-06-14 | 2002-06-13 | Un derivado (pirido/tieno)-[f]-oxazepin-5-ona, su utilizacion para preparar un medicamento y una composicion farmaceutica que lo comprende |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US7345036B2 (es) |
| EP (1) | EP1446407A2 (es) |
| JP (1) | JP4435562B2 (es) |
| KR (1) | KR100864267B1 (es) |
| CN (2) | CN1255413C (es) |
| AR (1) | AR034482A1 (es) |
| AU (1) | AU2002320841B2 (es) |
| BR (1) | BR0210307A (es) |
| CA (1) | CA2449215C (es) |
| CO (1) | CO5550448A2 (es) |
| CZ (1) | CZ296217B6 (es) |
| EC (1) | ECSP034890A (es) |
| HR (1) | HRP20031013A2 (es) |
| HU (1) | HUP0400196A3 (es) |
| IL (2) | IL158928A0 (es) |
| IS (1) | IS7042A (es) |
| MX (1) | MXPA03011562A (es) |
| NO (1) | NO328710B1 (es) |
| NZ (1) | NZ529671A (es) |
| PE (1) | PE20030271A1 (es) |
| PL (1) | PL367185A1 (es) |
| RU (1) | RU2286347C2 (es) |
| SK (1) | SK287583B6 (es) |
| WO (1) | WO2002102808A2 (es) |
| ZA (1) | ZA200309096B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200817385A (en) * | 2006-07-04 | 2008-04-16 | Organon Nv | Heterocyclic derivatives |
| FR2964969B1 (fr) * | 2010-09-16 | 2012-08-24 | Servier Lab | Nouveaux derives dihydrobenzoxathiazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1238719A (es) | 1968-11-01 | 1971-07-07 | ||
| PT651746E (pt) | 1992-07-24 | 2002-09-30 | Univ California | Drogas que intensificam as respostas sinapticas mediadas por receptores de ampa |
| WO1996020941A1 (de) * | 1995-01-06 | 1996-07-11 | F. Hoffmann-La Roche Ag | Hydroxymethyl-imidazodiazepine und deren ester |
| US5650409A (en) * | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
| US5736543A (en) | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
| ES2245015T3 (es) * | 1997-06-09 | 2005-12-16 | Pfizer Products Inc. | Quinazolin-4-onas como antagonistas de ampa. |
| US5985871A (en) | 1997-12-24 | 1999-11-16 | Cortex Pharmaceuticals, Inc. | Benzoxazine compounds for enhancing synaptic response |
| RU2214405C2 (ru) * | 1998-02-18 | 2003-10-20 | НьюроСёрч А/С | Новые соединения и их применение в качестве положительных модуляторов амра-рецепторов |
| US6124278A (en) | 1998-04-03 | 2000-09-26 | The Regents Of The University Of California | Acylbenzoxazines for enhancing synaptic response |
| EP1187837B1 (en) | 1999-05-12 | 2007-07-18 | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Thiazepine inhibitors of hiv-1 integrase |
| TWI232863B (en) | 2001-06-11 | 2005-05-21 | Akzo Nobel Nv | Benzoxazepine derivatives |
-
2002
- 2002-06-10 MX MXPA03011562A patent/MXPA03011562A/es active IP Right Grant
- 2002-06-10 US US10/480,569 patent/US7345036B2/en not_active Expired - Fee Related
- 2002-06-10 RU RU2004100702/04A patent/RU2286347C2/ru not_active IP Right Cessation
- 2002-06-10 CA CA2449215A patent/CA2449215C/en not_active Expired - Fee Related
- 2002-06-10 AU AU2002320841A patent/AU2002320841B2/en not_active Ceased
- 2002-06-10 CN CNB028118154A patent/CN1255413C/zh not_active Expired - Fee Related
- 2002-06-10 IL IL15892802A patent/IL158928A0/xx active IP Right Grant
- 2002-06-10 WO PCT/EP2002/006364 patent/WO2002102808A2/en active IP Right Grant
- 2002-06-10 NZ NZ529671A patent/NZ529671A/en unknown
- 2002-06-10 KR KR1020037016248A patent/KR100864267B1/ko not_active IP Right Cessation
- 2002-06-10 CN CN2006100598858A patent/CN101029051B/zh not_active Expired - Fee Related
- 2002-06-10 HU HU0400196A patent/HUP0400196A3/hu unknown
- 2002-06-10 BR BR0210307-9A patent/BR0210307A/pt not_active Application Discontinuation
- 2002-06-10 EP EP02754652A patent/EP1446407A2/en not_active Withdrawn
- 2002-06-10 SK SK1526-2003A patent/SK287583B6/sk not_active IP Right Cessation
- 2002-06-10 PL PL02367185A patent/PL367185A1/xx unknown
- 2002-06-10 JP JP2003506280A patent/JP4435562B2/ja not_active Expired - Fee Related
- 2002-06-10 CZ CZ20033392A patent/CZ296217B6/cs not_active IP Right Cessation
- 2002-06-13 PE PE2002000511A patent/PE20030271A1/es not_active Application Discontinuation
- 2002-06-13 AR ARP020102223A patent/AR034482A1/es unknown
-
2003
- 2003-11-17 IS IS7042A patent/IS7042A/is unknown
- 2003-11-18 IL IL158928A patent/IL158928A/en not_active IP Right Cessation
- 2003-11-21 ZA ZA200309096A patent/ZA200309096B/en unknown
- 2003-12-08 HR HR20031013A patent/HRP20031013A2/hr not_active Application Discontinuation
- 2003-12-11 EC EC2003004890A patent/ECSP034890A/es unknown
- 2003-12-11 NO NO20035523A patent/NO328710B1/no not_active IP Right Cessation
- 2003-12-16 CO CO03109961A patent/CO5550448A2/es not_active Application Discontinuation
-
2008
- 2008-02-01 US US12/024,597 patent/US7566778B2/en not_active Expired - Fee Related
-
2009
- 2009-02-20 US US12/389,968 patent/US8034804B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |