CO5550448A2 - Composiciones de derivados de (pirido/tieno)-[f]-oxazepin 5-ona - Google Patents
Composiciones de derivados de (pirido/tieno)-[f]-oxazepin 5-onaInfo
- Publication number
- CO5550448A2 CO5550448A2 CO03109961A CO03109961A CO5550448A2 CO 5550448 A2 CO5550448 A2 CO 5550448A2 CO 03109961 A CO03109961 A CO 03109961A CO 03109961 A CO03109961 A CO 03109961A CO 5550448 A2 CO5550448 A2 CO 5550448A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- oxazepin
- alkyloxy
- ring
- pyrido
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1.- Un derivado de (pirido/tieno)-[f]-oxazepin-5-ona quetiene la fórmula general I En dondeR1, R2 y R3 son independientemente H o alquilo(C1-4);Ar representa un tiofeno fundido o un anillo de piridina opcionalmente sustituido con uno o más sustituyentes seleccionados a partir de alquilo(C1-4), alquiloxi (C1-4), (C1-4) alquiloxi (C1-4) alquilo, CF3, halógeno, nitro, ciano, NR4R5, NR4COR6, y CONR4R5; R4 y R5 son independientemente H o alquilo (C1-4); o R4 y R5 forman juntos con el átomo de nitrógeno a los cuales ellos están ligados un anillo heterocíclico saturado con 5 o 6 miembros, opcionalmente que contiene un heteroátomo adicional seleccionado a partir de O, S o NR6;R6 es alquilo (C1-4);A representa el residuo de un anillo heterocíclico saturado de 4-7 miembros, que opcionalmente contiene un átomo de oxígeno, el anillo esta opcionalmente sustituido con 1-3 sustituyentes seleccionados a partir de alquilo (C1-4), alquiloxi (C1-4), hidroxi, halógeno, y oxo; o una sal farmacéuticamente aceptable de los mismos;Con la condición de que el compuesto de formula 1 en donde Ar es un anillo [3,2-f] piridina fusionado; cada uno de R1-R3 es H, y A representa (CH2)3; es excluido.2.- El derivado de (pirido/tieno)-[f]-oxazepin-5-ona de la reivindicación 1, en donde R1, R2 y R3 son H.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01202284 | 2001-06-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5550448A2 true CO5550448A2 (es) | 2005-08-31 |
Family
ID=8180476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO03109961A CO5550448A2 (es) | 2001-06-14 | 2003-12-16 | Composiciones de derivados de (pirido/tieno)-[f]-oxazepin 5-ona |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US7345036B2 (es) |
| EP (1) | EP1446407A2 (es) |
| JP (1) | JP4435562B2 (es) |
| KR (1) | KR100864267B1 (es) |
| CN (2) | CN101029051B (es) |
| AR (1) | AR034482A1 (es) |
| AU (1) | AU2002320841B2 (es) |
| BR (1) | BR0210307A (es) |
| CA (1) | CA2449215C (es) |
| CO (1) | CO5550448A2 (es) |
| CZ (1) | CZ296217B6 (es) |
| EC (1) | ECSP034890A (es) |
| HR (1) | HRP20031013A2 (es) |
| HU (1) | HUP0400196A3 (es) |
| IL (2) | IL158928A0 (es) |
| IS (1) | IS7042A (es) |
| MX (1) | MXPA03011562A (es) |
| NO (1) | NO328710B1 (es) |
| NZ (1) | NZ529671A (es) |
| PE (1) | PE20030271A1 (es) |
| PL (1) | PL367185A1 (es) |
| RU (1) | RU2286347C2 (es) |
| SK (1) | SK287583B6 (es) |
| WO (1) | WO2002102808A2 (es) |
| ZA (1) | ZA200309096B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200817385A (en) * | 2006-07-04 | 2008-04-16 | Organon Nv | Heterocyclic derivatives |
| FR2964969B1 (fr) * | 2010-09-16 | 2012-08-24 | Servier Lab | Nouveaux derives dihydrobenzoxathiazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1238719A (es) * | 1968-11-01 | 1971-07-07 | ||
| ATE215079T1 (de) | 1992-07-24 | 2002-04-15 | Univ California | Arzneimittel, die den durch ampa rezeptoren vermittelten synaptischen respons erhöhen |
| US6174881B1 (en) * | 1995-01-06 | 2001-01-16 | Hoffman-La Roche Inc. | Hydroxymethylimidazodiazepines and their esters |
| US5650409A (en) * | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
| US5736543A (en) * | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
| DE69831446T2 (de) | 1997-06-09 | 2006-06-14 | Pfizer Prod Inc | Chinazolin-4-on AMPA Antagonisten |
| US5985871A (en) | 1997-12-24 | 1999-11-16 | Cortex Pharmaceuticals, Inc. | Benzoxazine compounds for enhancing synaptic response |
| EP1071426A2 (en) | 1998-02-18 | 2001-01-31 | Neurosearch A/S | Novel compounds and their use as positive ampa receptor modulators |
| US6124278A (en) | 1998-04-03 | 2000-09-26 | The Regents Of The University Of California | Acylbenzoxazines for enhancing synaptic response |
| DE60035591D1 (de) | 1999-05-12 | 2007-08-30 | Us Health | Thiazepin-hemmer von hiv-1 integrase |
| TWI232863B (en) | 2001-06-11 | 2005-05-21 | Akzo Nobel Nv | Benzoxazepine derivatives |
-
2002
- 2002-06-10 KR KR1020037016248A patent/KR100864267B1/ko not_active IP Right Cessation
- 2002-06-10 RU RU2004100702/04A patent/RU2286347C2/ru not_active IP Right Cessation
- 2002-06-10 SK SK1526-2003A patent/SK287583B6/sk not_active IP Right Cessation
- 2002-06-10 IL IL15892802A patent/IL158928A0/xx active IP Right Grant
- 2002-06-10 EP EP02754652A patent/EP1446407A2/en not_active Withdrawn
- 2002-06-10 CA CA2449215A patent/CA2449215C/en not_active Expired - Fee Related
- 2002-06-10 CN CN2006100598858A patent/CN101029051B/zh not_active Expired - Fee Related
- 2002-06-10 MX MXPA03011562A patent/MXPA03011562A/es active IP Right Grant
- 2002-06-10 HU HU0400196A patent/HUP0400196A3/hu unknown
- 2002-06-10 PL PL02367185A patent/PL367185A1/xx unknown
- 2002-06-10 BR BR0210307-9A patent/BR0210307A/pt not_active Application Discontinuation
- 2002-06-10 WO PCT/EP2002/006364 patent/WO2002102808A2/en active IP Right Grant
- 2002-06-10 CZ CZ20033392A patent/CZ296217B6/cs not_active IP Right Cessation
- 2002-06-10 JP JP2003506280A patent/JP4435562B2/ja not_active Expired - Fee Related
- 2002-06-10 CN CNB028118154A patent/CN1255413C/zh not_active Expired - Fee Related
- 2002-06-10 NZ NZ529671A patent/NZ529671A/en unknown
- 2002-06-10 AU AU2002320841A patent/AU2002320841B2/en not_active Ceased
- 2002-06-10 US US10/480,569 patent/US7345036B2/en not_active Expired - Fee Related
- 2002-06-13 AR ARP020102223A patent/AR034482A1/es unknown
- 2002-06-13 PE PE2002000511A patent/PE20030271A1/es not_active Application Discontinuation
-
2003
- 2003-11-17 IS IS7042A patent/IS7042A/is unknown
- 2003-11-18 IL IL158928A patent/IL158928A/en not_active IP Right Cessation
- 2003-11-21 ZA ZA200309096A patent/ZA200309096B/en unknown
- 2003-12-08 HR HR20031013A patent/HRP20031013A2/hr not_active Application Discontinuation
- 2003-12-11 NO NO20035523A patent/NO328710B1/no not_active IP Right Cessation
- 2003-12-11 EC EC2003004890A patent/ECSP034890A/es unknown
- 2003-12-16 CO CO03109961A patent/CO5550448A2/es not_active Application Discontinuation
-
2008
- 2008-02-01 US US12/024,597 patent/US7566778B2/en not_active Expired - Fee Related
-
2009
- 2009-02-20 US US12/389,968 patent/US8034804B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted | ||
| FD | Application lapsed |